Rationally engineered Cas9 nucleases with improved specificity

Science

Volumn 351, Issue 6268, 2016, Pages 84-88

  Slaymaker, Ian M ^a,b,c,d   Gao, Linyi ^a,d   Zetsche, Bernd ^a,b,c,d   Scott, David A ^a,b,c,d   Yan, Winston X ^a,e,f   Zhang, Feng ^a,b,c,d  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d Massachusetts Institute of Technology Cambridge   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAS9 PROTEIN; ENDONUCLEASE; GUIDE RNA; HELICASE; UNCLASSIFIED DRUG; VASCULOTROPIN A; BACTERIAL PROTEIN;

DNA; GENOME; RNA;

ARTICLE; DNA CLEAVAGE; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVITY; HUMAN; HUMAN GENOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; STREPTOCOCCUS PYOGENES; CHEMISTRY; ENZYMOLOGY; GENETICS; MUTAGENESIS; POINT MUTATION; PROTEIN CONFORMATION;

STREPTOCOCCUS PYOGENES;

BACTERIAL PROTEINS; DNA CLEAVAGE; ENDONUCLEASES; HUMANS; MUTAGENESIS; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN ENGINEERING; RNA, GUIDE; STREPTOCOCCUS PYOGENES;

EID: 84952943845     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad5227     Document Type: Article

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