TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 13, 2015, Pages E1530-E1539

  Wu, Haibo ^a   Zhang, Yong ^a   Wang, Yongsheng ^a   Zhang, Yan ^a   Yang, Mingqi ^a   Lv, Jiaxing ^a   Liu, Jun ^a  

^a NORTHWEST A F UNIVERSITY   (China)

Author keywords

Disease resistance; Homologous recombination; Single strand break; TALEN; Tuberculosis

Indexed keywords

GENOMIC DNA; PROTEIN; SP110 PROTEIN; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NICKASE; UNCLASSIFIED DRUG; DEOXYRIBONUCLEASE I; ENDONUCLEASE; NUCLEAR PROTEIN; SP110 PROTEIN, BOVINE; SP110 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BACTERIAL GROWTH; BACTERIAL LOAD; BACTERIUM COLONY; BOVINE TUBERCULOSIS; CELL NUCLEUS TRANSPLANTATION; CONTROLLED STUDY; DNA MODIFICATION; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FLOW CYTOMETRY; HOLSTEIN-FRIESIAN CATTLE; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INDEL MUTATION; MOUSE; MYCOBACTERIUM BOVIS; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; TRANSGENIC CATTLE; WESTERN BLOTTING; ANIMAL; BOVINE; GENE TARGETING; GENE TRANSFER; GENETIC TRANSCRIPTION; GENETICS; GENOME; HEK293 CELL LINE; MACROPHAGE; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; SINGLE STRANDED DNA BREAK; TUBERCULOSIS, BOVINE;

ANIMALIA; BOS; MYCOBACTERIUM BOVIS; SUIDAE;

ANIMALS; APOPTOSIS; CATTLE; DEOXYRIBONUCLEASE I; DNA BREAKS, SINGLE-STRANDED; ENDONUCLEASES; ENZYME-LINKED IMMUNOSPOT ASSAY; FEMALE; GENE KNOCK-IN TECHNIQUES; GENE TRANSFER TECHNIQUES; GENOME; HEK293 CELLS; HUMANS; MACROPHAGES; MICE; MYCOBACTERIUM BOVIS; NUCLEAR PROTEINS; TRANSCRIPTION, GENETIC; TUBERCULOSIS, BOVINE;

EID: 84961290146     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1421587112     Document Type: Article

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