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Volumn 22, Issue 8, 2015, Pages 686-729

Molecular strategies for targeting antioxidants to mitochondria: Therapeutic implications

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; AMINO ACID DERIVATIVE; ANTIOXIDANT; BERBERINE; CATION; CELL PENETRATING PEPTIDE; DECYLRHODAMINE 19; DECYLTRIPHENYLPHOSPHONIUM; DEQUALINIUM; LIPOSOME; MACROGOL; MANGANESE PORPHYRIN; MITOQUINONE; NANOCARRIER; PALMATINE; PLASTOQUINONE; POLYGLACTIN; PORPHYRIN; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; RHODAMINE; SS 31; TETRAPEPTIDE; UNCLASSIFIED DRUG; XJB PEPTIDE;

EID: 84923914528     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2014.5952     Document Type: Review
Times cited : (234)

References (380)
  • 1
    • 0035940625 scopus 로고    scopus 로고
    • Controlled trial of n-Acetylcysteine for patients with probable alzheimers disease
    • Adair JC, Knoefel JE, and Morgan N. Controlled trial of N-Acetylcysteine for patients with probable Alzheimers disease. Neurology 57: 1515-1517, 2001
    • (2001) Neurology , vol.57 , pp. 1515-1517
    • Adair, J.C.1    Knoefel, J.E.2    Morgan, N.3
  • 4
    • 35848931018 scopus 로고    scopus 로고
    • Prophylactic effect of liposomal n-Acetylcysteine against lps-induced liver injuries
    • Alipour M, Omri A, Smith MG, and Suntres ZE. Prophylactic effect of liposomal N-Acetylcysteine against LPS-induced liver injuries. J Endotoxin Res 13: 297-304, 2007
    • (2007) J Endotoxin Res , vol.13 , pp. 297-304
    • Alipour, M.1    Omri, A.2    Smith, M.G.3    Suntres, Z.E.4
  • 5
    • 33750526651 scopus 로고    scopus 로고
    • The mitochondrial fission protein hfis1 requires the endoplasmic reticulum gateway to induce apoptosis
    • Alirol E, James D, Huber D, Marchetto A, Vergani L, Martinou JC, and Scorrano L. The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis. Mol Biol Cell 17: 4593-4605, 2006
    • (2006) Mol Biol Cell , vol.17 , pp. 4593-4605
    • Alirol, E.1    James, D.2    Huber, D.3    Marchetto, A.4    Vergani, L.5    Martinou, J.C.6    Scorrano, L.7
  • 6
    • 79958025800 scopus 로고    scopus 로고
    • Putting bioactivation reactions to work: Targeting antioxidants to mitochondria
    • Anders MW. Putting bioactivation reactions to work: targeting antioxidants to mitochondria. Chem Biol Interact 192: 8-13, 2011
    • (2011) Chem Biol Interact , vol.192 , pp. 8-13
    • Anders, M.W.1
  • 8
    • 84055223546 scopus 로고    scopus 로고
    • Aldehyde stress and upregulation of nrf2 mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fed n3 polyunsaturated fatty acids
    • Anderson EJ, Thayne K, Harris M, Carraway K, and Shaikh SR. Aldehyde stress and upregulation of Nrf2 mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fed n3 polyunsaturated fatty acids. Biochem J 441: 359-366, 2012
    • (2012) Biochem J , vol.441 , pp. 359-366
    • Anderson, E.J.1    Thayne, K.2    Harris, M.3    Carraway, K.4    Shaikh, S.R.5
  • 9
    • 79953146106 scopus 로고    scopus 로고
    • Mitochondrial production of reactive oxygen species contributes to the badrenergic stimulation of mouse cardiomycytes
    • Andersson DC, Fauconnier J, Yamada T, Lacampagne A, Zhang SJ, Katz A, and Westerblad H. Mitochondrial production of reactive oxygen species contributes to the badrenergic stimulation of mouse cardiomycytes. J Physiol 589: 1791-1801, 2011
    • (2011) J Physiol , vol.589 , pp. 1791-1801
    • Andersson, D.C.1    Fauconnier, J.2    Yamada, T.3    Lacampagne, A.4    Zhang, S.J.5    Katz, A.6    Westerblad, H.7
  • 14
    • 0032522985 scopus 로고    scopus 로고
    • Paraoxonase inhibits highdensity lipoprotein oxidation and preserves its functions a possible peroxidative role for paraoxonase
    • Aviram M, Rosenblat M, Bisgaier CL, Newton RS, Primo-Parmo SL, and La Du BN. Paraoxonase inhibits highdensity lipoprotein oxidation and preserves its functions A possible peroxidative role for paraoxonase. J Clin Invest 101: 1581-1590, 1998
    • (1998) J Clin Invest , vol.101 , pp. 1581-1590
    • Aviram, M.1    Rosenblat, M.2    Bisgaier, C.L.3    Newton, R.S.4    Primo-Parmo, S.L.5    La Du, B.N.6
  • 15
    • 60749108379 scopus 로고    scopus 로고
    • Regulation of autophagy by reactive oxygen species (ros): Implications for cancer progression and treatment
    • Azad MB, Chen Y, and Gibson SB. Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment. Antioxid Redox Signal 11: 777-790, 2009
    • (2009) Antioxid Redox Signal , vol.11 , pp. 777-790
    • Azad, M.B.1    Chen, Y.2    Gibson, S.B.3
  • 17
    • 0031911994 scopus 로고    scopus 로고
    • Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury
    • Baker K, Bucay-Marcus C, Huffman C, Kruk H, Malfroy B, and Doctrow SR. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther 284: 215-221, 1998
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 215-221
    • Baker, K.1    Bucay-Marcus, C.2    Huffman, C.3    Kruk, H.4    Malfroy, B.5    Doctrow, S.R.6
  • 19
    • 80054850980 scopus 로고    scopus 로고
    • Development of guidelines for caregivers of people with bipolar disorder: A delphi expert consensus study
    • Berk L, Jorm AF, Kelly CM, Dodd S, and Berk M. Development of guidelines for caregivers of people with bipolar disorder: a Delphi expert consensus study. Bipolar Disord 13: 556-570, 2011
    • (2011) Bipolar Disord , vol.13 , pp. 556-570
    • Berk, L.1    Jorm, A.F.2    Kelly, C.M.3    Dodd, S.4    Berk, M.5
  • 20
    • 84865181393 scopus 로고    scopus 로고
    • Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus
    • Bhatt JK, Thomas S, and Nanjan MJ. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutr Res 32: 537-541, 2012
    • (2012) Nutr Res , vol.32 , pp. 537-541
    • Bhatt, J.K.1    Thomas, S.2    Nanjan, M.J.3
  • 23
    • 84897388046 scopus 로고    scopus 로고
    • Targeting mitochondrial cardiolipin and the cytochrome c/cardiolipin complex to promote electron transport and optimize mitochondrial atp synthesis
    • Birk AV, Chao WM, Bracken C, Warren JD, and Szeto HH. Targeting mitochondrial cardiolipin and the cytochrome c/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis. Br J Pharmacol 171: 2017-2028, 2014
    • (2014) Br J Pharmacol , vol.171 , pp. 2017-2028
    • Birk, A.V.1    Chao, W.M.2    Bracken, C.3    Warren, J.D.4    Szeto, H.H.5
  • 24
    • 84860662855 scopus 로고    scopus 로고
    • Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-peg-pe conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo
    • Biswas S, Dodwadkar NS, Deshpande PP, and Torchilin VP. Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo. J Control Release 159: 393-402, 2012
    • (2012) J Control Release , vol.159 , pp. 393-402
    • Biswas, S.1    Dodwadkar, N.S.2    Deshpande, P.P.3    Torchilin, V.P.4
  • 25
    • 33747484566 scopus 로고    scopus 로고
    • Targeting dinitrophenol to mitochondria: Limitations to the development of a selflimiting mitochondrial protonophore
    • Blaikie FH, Brown SE, Samuelsson LM, Brand MD, Smith RA, and Murphy MP. Targeting dinitrophenol to mitochondria: limitations to the development of a selflimiting mitochondrial protonophore. Biosci Rep 26: 231-243, 2006
    • (2006) Biosci Rep , vol.26 , pp. 231-243
    • Blaikie, F.H.1    Brown, S.E.2    Samuelsson, L.M.3    Brand, M.D.4    Smith, R.A.5    Murphy, M.P.6
  • 26
    • 52049115848 scopus 로고    scopus 로고
    • Organelle-Targeted nanocarriers: Specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo
    • Boddapati SV, DSouza GG, Erdogan S, Torchilin VP, and Weissig V. Organelle-Targeted nanocarriers: specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo. Nano Lett 8: 2559-2563, 2008
    • (2008) Nano Lett , vol.8 , pp. 2559-2563
    • Boddapati, S.V.1    Dsouza, G.G.2    Erdogan, S.3    Torchilin, V.P.4    Weissig, V.5
  • 28
    • 84875492209 scopus 로고    scopus 로고
    • Redox and reactive oxygen species regulation of mitochondrial cytochrome c oxidase biogenesis
    • Bourens M, Fontanesi F, Soto IC, Liu J, and Barrientos A. Redox and reactive oxygen species regulation of mitochondrial cytochrome c oxidase biogenesis. Antioxid Redox Signal 19: 1940-1952, 2013
    • (2013) Antioxid Redox Signal , vol.19 , pp. 1940-1952
    • Bourens, M.1    Fontanesi, F.2    Soto, I.C.3    Liu, J.4    Barrientos, A.5
  • 30
  • 31
    • 34248525050 scopus 로고    scopus 로고
    • Targeting lipoic acid to mitochondria: Synthesis and characterization of a triphenylphosphoniumconjugated alpha-lipoyl derivative
    • Brown SE, Ross MF, Sanjuan-Pla A, Manas AR, Smith RA, and Murphy MP. Targeting lipoic acid to mitochondria: synthesis and characterization of a triphenylphosphoniumconjugated alpha-lipoyl derivative. Free Radic Biol Med 42: 1766-1780, 2007
    • (2007) Free Radic Biol Med , vol.42 , pp. 1766-1780
    • Brown, S.E.1    Ross, M.F.2    Sanjuan-Pla, A.3    Manas, A.R.4    Smith, R.A.5    Murphy, M.P.6
  • 32
    • 84862639554 scopus 로고    scopus 로고
    • Effects of exogenous hydrogen sulphide on calcium signalling, background (task) k channel activity and mitochondrial function in chemoreceptor cells
    • Buckler KJ. Effects of exogenous hydrogen sulphide on calcium signalling, background (TASK) K channel activity and mitochondrial function in chemoreceptor cells. Pflugers Arch 463: 743-754, 2012
    • (2012) Pflugers Arch , vol.463 , pp. 743-754
    • Buckler, K.J.1
  • 33
    • 0021362463 scopus 로고
    • Beta-carotene: An unusual type of lipid antioxidant
    • Burton GW and Ingold KU. Beta-carotene: an unusual type of lipid antioxidant. Science 224: 569-573, 1984
    • (1984) Science , vol.224 , pp. 569-573
    • Burton, G.W.1    Ingold, K.U.2
  • 35
    • 77956230098 scopus 로고    scopus 로고
    • Mitochondrial shape changes: Orchestrating cell pathophysiology
    • Campello S and Scorrano L. Mitochondrial shape changes: orchestrating cell pathophysiology. EMBO Rep 11: 678-684, 2010
    • (2010) EMBO Rep , vol.11 , pp. 678-684
    • Campello, S.1    Scorrano, L.2
  • 36
    • 77957851365 scopus 로고    scopus 로고
    • Inhibition of drp1-dependent mitochondrial fragmentation and apoptosis by a polypeptide antagonist of calcineurin
    • Cereghetti GM, Costa V, and Scorrano L. Inhibition of Drp1-dependent mitochondrial fragmentation and apoptosis by a polypeptide antagonist of calcineurin. Cell Death Differ 17: 1785-1794, 2010
    • (2010) Cell Death Differ , vol.17 , pp. 1785-1794
    • Cereghetti, G.M.1    Costa, V.2    Scorrano, L.3
  • 41
    • 70349341899 scopus 로고    scopus 로고
    • Downstream targets and intracellular compartmentalization in nox signaling
    • Chen K, Craige SE, and Keaney JF, Jr. Downstream targets and intracellular compartmentalization in Nox signaling. Antioxid Redox Signal 11: 2467-2480, 2009
    • (2009) Antioxid Redox Signal , vol.11 , pp. 2467-2480
    • Chen, K.1    Craige, S.E.2    Keaney, J.F.3
  • 43
    • 67549084381 scopus 로고    scopus 로고
    • Superoxide is the major reactive oxygen species regulating autophagy
    • Chen Y, Azad MB, and Gibson SB. Superoxide is the major reactive oxygen species regulating autophagy. Cell Death Differ 16: 1040-1052, 2009
    • (2009) Cell Death Differ , vol.16 , pp. 1040-1052
    • Chen, Y.1    Azad, M.B.2    Gibson, S.B.3
  • 44
    • 38349043984 scopus 로고    scopus 로고
    • Mitochondrial electron-Transport-chain inhibitors of complexes i and ii induce autophagic cell death mediated by reactive oxygen species
    • Chen Y, McMillan-Ward E, Kong J, Israels SJ, and Gibson SB. Mitochondrial electron-Transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. J Cell Sci 120: 4155-4166, 2007
    • (2007) J Cell Sci , vol.120 , pp. 4155-4166
    • Chen, Y.1    McMillan-Ward, E.2    Kong, J.3    Israels, S.J.4    Gibson, S.B.5
  • 46
    • 34247209532 scopus 로고    scopus 로고
    • Potent mitochondria-Targeted peptides reduce myocardial infarction in rats
    • Cho J, Won K, Wu D, Soong Y, Liu S, Szeto HH, and Hong MK. Potent mitochondria-Targeted peptides reduce myocardial infarction in rats. Coron Artery Dis 18: 215-220, 2007
    • (2007) Coron Artery Dis , vol.18 , pp. 215-220
    • Cho, J.1    Won, K.2    Wu, D.3    Soong, Y.4    Liu, S.5    Szeto, H.H.6    Hong, M.K.7
  • 47
    • 33947495568 scopus 로고    scopus 로고
    • A novel cell-permeable antioxidant peptide, ss31, attenuates ischemic brain injury by down-regulating cd36
    • Cho S, Szeto HH, Kim E, Kim H, Tolhurst AT, and Pinto JT A novel cell-permeable antioxidant peptide, SS31, attenuates ischemic brain injury by down-regulating CD36. J Biol Chem 282: 4634-4642, 2007
    • (2007) J Biol Chem , vol.282 , pp. 4634-4642
    • Cho, S.1    Szeto, H.H.2    Kim, E.3    Kim, H.4    Tolhurst, A.T.5    Pinto, J.T.6
  • 51
    • 84885178528 scopus 로고    scopus 로고
    • Multiplicity of effectors of the cardioprotective agent, diazoxide
    • Coetzee WA. Multiplicity of effectors of the cardioprotective agent, diazoxide. Pharmacol Ther 140: 167-175, 2013
    • (2013) Pharmacol Ther , vol.140 , pp. 167-175
    • Coetzee, W.A.1
  • 54
    • 34548040480 scopus 로고    scopus 로고
    • A randomized factorial trial of vitamins c and e and beta carotene in the secondary prevention of cardiovascular events in women: Results from the womens antioxidant cardiovascular study
    • Cook NR, Albert CM, Gaziano JM, Zaharris E, MacFadyen J, Danielson E, Buring JE, and Manson JE A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Womens Antioxidant Cardiovascular Study. Arch Intern Med 167: 1610-1618, 2007
    • (2007) Arch Intern Med , vol.167 , pp. 1610-1618
    • Cook, N.R.1    Albert, C.M.2    Gaziano, J.M.3    Zaharris, E.4    MacFadyen, J.5    Danielson, E.6    Buring, J.E.7    Manson, J.E.8
  • 55
    • 34447509483 scopus 로고    scopus 로고
    • Nitric oxide regulation of mitochondrial oxygen consumption II. Molecular mechanism and tissue physiology
    • Cooper CE and Giulivi C. Nitric oxide regulation of mitochondrial oxygen consumption II. molecular mechanism and tissue physiology. Am J Physiol Cell Physiol 292: 1993-2003, 2007
    • (2007) Am J Physiol Cell Physiol , vol.292 , pp. 1993-2003
    • Cooper, C.E.1    Giulivi, C.2
  • 56
    • 81955160758 scopus 로고    scopus 로고
    • Cyanide preconditioning protects brain endothelial and nt2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and hif-1a
    • Correia SC, Santos RX, Cardoso SM, Santos MS, Oliveira CR, and Moreira PI. Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: role of mitochondrial reactive oxygen species and HIF-1a. Neurobiol Dis 45: 206-218, 2012
    • (2012) Neurobiol Dis , vol.45 , pp. 206-218
    • Correia, S.C.1    Santos, R.X.2    Cardoso, S.M.3    Santos, M.S.4    Oliveira, C.R.5    Moreira, P.I.6
  • 57
    • 84903770556 scopus 로고    scopus 로고
    • The many faces of autophagy dysfunction in huntingtons disease: From mechanism to therapy
    • Cortes CJ and La Spada AR. The many faces of autophagy dysfunction in Huntingtons disease: from mechanism to therapy. Drug Discov Today 19: 963-971, 2014
    • (2014) Drug Discov Today , vol.19 , pp. 963-971
    • Cortes, C.J.1    La Spada, A.R.2
  • 63
    • 33744527052 scopus 로고    scopus 로고
    • Persistent s-nitrosation of complex i and other mitochondrial membrane proteins by s-nitrosothiols but not nitric oxide or peroxynitrite: Implications for the interaction of nitric oxide with mitochondria
    • Dahm CC, Moore K, and Murphy MP. Persistent S-nitrosation of complex I and other mitochondrial membrane proteins by S-nitrosothiols but not nitric oxide or peroxynitrite: implications for the interaction of nitric oxide with mitochondria. J Biol Chem 281: 10056-10065, 2006
    • (2006) J Biol Chem , vol.281 , pp. 10056-10065
    • Dahm, C.C.1    Moore, K.2    Murphy, M.P.3
  • 65
    • 77953807521 scopus 로고    scopus 로고
    • Redox signaling (cross-Talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species
    • Daiber A. Redox signaling (cross-Talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species. Biochim Biophys Acta 1797: 897-906, 2010
    • (2010) Biochim Biophys Acta , vol.1797 , pp. 897-906
    • Daiber, A.1
  • 66
    • 42649144101 scopus 로고    scopus 로고
    • Oxidative and nitrative protein modifications in parkinsons disease
    • Danielson SR and Andersen JK. Oxidative and nitrative protein modifications in Parkinsons disease. Free Radic Biol Med 44: 1787-1794, 2008
    • (2008) Free Radic Biol Med , vol.44 , pp. 1787-1794
    • Danielson, S.R.1    Andersen, J.K.2
  • 67
    • 57349100367 scopus 로고    scopus 로고
    • Mitofusin 2 tethers endoplasmic reticulum to mitochondria
    • de Brito OM and Scorrano L. Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 456: 605-610, 2008
    • (2008) Nature , vol.456 , pp. 605-610
    • De Brito, O.M.1    Scorrano, L.2
  • 68
    • 84862624100 scopus 로고    scopus 로고
    • High doses of in vitro beta-carotene, alpha-Tocopherol and ascorbic acid induce oxidative stress and secretion of il-6 in peripheral blood mononuclear cells from healthy donors
    • de Oliveira BF, Veloso CA, Nogueira-Machado JA, and Martins Chaves M. High doses of in vitro beta-carotene, alpha-Tocopherol and ascorbic acid induce oxidative stress and secretion of IL-6 in peripheral blood mononuclear cells from healthy donors. Curr Aging Sci 5: 148-156, 2012
    • (2012) Curr Aging Sci , vol.5 , pp. 148-156
    • De Oliveira, B.F.1    Veloso, C.A.2    Nogueira-Machado, J.A.3    Martins Chaves, M.4
  • 69
    • 84877290780 scopus 로고    scopus 로고
    • Mitochondrial localization and the persistent migration of epithelial cancer cells
    • Desai SP, Bhatia SN, Toner M, and Irimia D. Mitochondrial localization and the persistent migration of epithelial cancer cells. Biophys J 104: 2077-2088, 2013
    • (2013) Biophys J , vol.104 , pp. 2077-2088
    • Desai, S.P.1    Bhatia, S.N.2    Toner, M.3    Irimia, D.4
  • 71
    • 26444444018 scopus 로고    scopus 로고
    • Mitochondrial leader sequence-plasmid dna conjugates delivered into mammalian cells by dqasomes co-localize with mitochondria
    • DSouza GG, Boddapati SV, and Weissig V. Mitochondrial leader sequence-plasmid DNA conjugates delivered into mammalian cells by DQAsomes co-localize with mitochondria. Mitochondrion 5: 352-358, 2005
    • (2005) Mitochondrion , vol.5 , pp. 352-358
    • Dsouza, G.G.1    Boddapati, S.V.2    Weissig, V.3
  • 72
    • 49149124239 scopus 로고    scopus 로고
    • Nanocarrier-Assisted sub-cellular targeting to the site of mitochondria improves the pro-Apoptotic activity of paclitaxel
    • DSouza GG, Cheng SM, Boddapati SV, Horobin RW, and Weissig V. Nanocarrier-Assisted sub-cellular targeting to the site of mitochondria improves the pro-Apoptotic activity of paclitaxel. J Drug Target 16: 578-585, 2008
    • (2008) J Drug Target , vol.16 , pp. 578-585
    • Dsouza, G.G.1    Cheng, S.M.2    Boddapati, S.V.3    Horobin, R.W.4    Weissig, V.5
  • 75
    • 84889098462 scopus 로고    scopus 로고
    • Salen mn complexes are superoxide dismutase/catalase mimetics that protect the mitochondria
    • Doctrow SR, Liesa M, Melov S, Shirihai OS, and Tofilon P. Salen Mn complexes are superoxide dismutase/catalase mimetics that protect the mitochondria. Curr Inorg Chem 2: 325-334, 2012
    • (2012) Curr Inorg Chem , vol.2 , pp. 325-334
    • Doctrow, S.R.1    Liesa, M.2    Melov, S.3    Shirihai, O.S.4    Tofilon, P.5
  • 77
    • 35448968884 scopus 로고    scopus 로고
    • Mitochondrial redox cycling of mitoquinone leads to superoxide production and cellular apoptosis
    • Doughan AK and Dikalov SI. Mitochondrial redox cycling of mitoquinone leads to superoxide production and cellular apoptosis. Antioxid Redox Signal 9: 1825-1836, 2007
    • (2007) Antioxid Redox Signal , vol.9 , pp. 1825-1836
    • Doughan, A.K.1    Dikalov, S.I.2
  • 78
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Dröge W. Free radicals in the physiological control of cell function. Physiol Rev 82: 47-49, 2002
    • (2002) Physiol Rev , vol.82 , pp. 47-49
    • Dröge, W.1
  • 79
    • 84902242573 scopus 로고    scopus 로고
    • Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation
    • Dröse S, Brandt U, and Wittig I. Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation. Biochim Biophys Acta 1844: 1344-1354, 2014
    • (2014) Biochim Biophys Acta , vol.1844 , pp. 1344-1354
    • Dröse, S.1    Brandt, U.2    Wittig, I.3
  • 80
    • 67349133591 scopus 로고    scopus 로고
    • Ambivalent effects of diazoxide on mitochondrial ros production at respiratory chain complexes i and iii
    • Dröse S, Hanley PJ, and Brandt U. Ambivalent effects of diazoxide on mitochondrial ROS production at respiratory chain complexes I and III. Biochim Biophys Acta 1790: 558-565, 2009
    • (2009) Biochim Biophys Acta , vol.1790 , pp. 558-565
    • Dröse, S.1    Hanley, P.J.2    Brandt, U.3
  • 81
    • 84912151028 scopus 로고    scopus 로고
    • The protective effects of trolox-loaded chitosan nanoparticles against hypoxia-mediated cell apoptosis
    • Du L, Miao X, Gao Y, Jia H, Liu K, and Liu Y. The protective effects of Trolox-loaded chitosan nanoparticles against hypoxia-mediated cell apoptosis. Nanomedicine 10: 1411-1420, 2014
    • (2014) Nanomedicine , vol.10 , pp. 1411-1420
    • Du, L.1    Miao, X.2    Gao, Y.3    Jia, H.4    Liu, K.5    Liu, Y.6
  • 82
    • 77957983292 scopus 로고    scopus 로고
    • A nutrient approach to prostate cancer prevention: The selenium and vitamin e cancer prevention trial (select
    • Dunn BK, Richmond ES, Minasian LM, Ryan AM, and Ford LG A nutrient approach to prostate cancer prevention: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Nutr Cancer 62: 896-918, 2010
    • (2010) Nutr Cancer , vol.62 , pp. 896-918
    • Dunn, B.K.1    Richmond, E.S.2    Minasian, L.M.3    Ryan, A.M.4    Ford, L.G.5
  • 83
    • 0036182681 scopus 로고    scopus 로고
    • Prevention of hypertension, insulin resistance, and oxidative stress by alphalipoic acid
    • El Midaoui A and de Champlain J. Prevention of hypertension, insulin resistance, and oxidative stress by alphalipoic acid. Hypertension 39: 303-307, 2002
    • (2002) Hypertension , vol.39 , pp. 303-307
    • El Midaoui, A.1    De Champlain, J.2
  • 85
    • 17844403964 scopus 로고    scopus 로고
    • Role of mitochondria in toxic oxidative stress cationic antioxidants as a powerful tool against mitochondrial oxidative stress
    • Fariss MW, Chan CB, Patel M, Van Houten B, and Orrenius S. Role of mitochondria in toxic oxidative stress. Cationic antioxidants as a powerful tool against mitochondrial oxidative stress. Mol Interv 5: 94-111, 2005
    • (2005) Mol Interv , vol.5 , pp. 94-111
    • Fariss, M.W.1    Chan, C.B.2    Patel, M.3    Van Houten, B.4    Orrenius, S.5
  • 88
    • 33745829019 scopus 로고    scopus 로고
    • Reduction of manganese porphyrins by flavoenzymes and submitochondrial particles: A catalytic cycle for the reduction of peroxynitrite
    • Ferrer-Sueta G, Hannibal L, Batinic-Haberle I, and Radi R. Reduction of manganese porphyrins by flavoenzymes and submitochondrial particles: a catalytic cycle for the reduction of peroxynitrite. Free Radic Biol Med 41: 503-512, 2006
    • (2006) Free Radic Biol Med , vol.41 , pp. 503-512
    • Ferrer-Sueta, G.1    Hannibal, L.2    Batinic-Haberle, I.3    Radi, R.4
  • 89
    • 74249118039 scopus 로고    scopus 로고
    • Mitochondriatargeted antioxidant skqr1 selectively protects mdr (pgp 170)-negative cells against oxidative stress
    • Fetisova EK, Avetisyan AV, Izyumov DS, Korotetskaya MV, Chernyak BV, and Skulachev VP. Mitochondriatargeted antioxidant SkQR1 selectively protects MDR (Pgp 170)-negative cells against oxidative stress. FEBS Lett 584: 562-566, 2010
    • (2010) FEBS Lett , vol.584 , pp. 562-566
    • Fetisova, E.K.1    Avetisyan, A.V.2    Izyumov, D.S.3    Korotetskaya, M.V.4    Chernyak, B.V.5    Skulachev, V.P.6
  • 90
    • 33845724468 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function
    • Fialkow L, Wang Y, and Downey GP. Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic Biol Med 42: 153-164, 2007
    • (2007) Free Radic Biol Med , vol.42 , pp. 153-164
    • Fialkow, L.1    Wang, Y.2    Downey, G.P.3
  • 91
    • 21244448078 scopus 로고    scopus 로고
    • Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic. Insights into the interaction of ebselen with mitochondria
    • Filipovska A, Kelso GF, Brown SE, Beer SM, Smith RA, and Murphy MP. Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic. Insights into the interaction of ebselen with mitochondria. J Biol Chem 280: 24113-24126, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 24113-24126
    • Filipovska, A.1    Kelso, G.F.2    Brown, S.E.3    Beer, S.M.4    Smith, R.A.5    Murphy, M.P.6
  • 92
    • 84864542395 scopus 로고    scopus 로고
    • Bioenergetic effects of mitochondrial-Targeted coenzyme q analogs in endothelial cells
    • Fink BD, Herlein JA, Yorek MA, Fenner, Kerns RJ, and Sivitz WI. Bioenergetic effects of mitochondrial-Targeted coenzyme Q analogs in endothelial cells. JPET 342: 709-719, 2012
    • (2012) JPET , vol.342 , pp. 709-719
    • Fink, B.D.1    Herlein, J.A.2    Yorek, M.A.3    Fenner Kerns, R.J.4    Sivitz, W.I.5
  • 94
    • 84864050485 scopus 로고    scopus 로고
    • Role of peroxisomes in ros/rns-metabolism: Implications for human disease
    • Fransen M, Nordgren M, Wang B, and Apanasets O. Role of peroxisomes in ROS/RNS-metabolism: implications for human disease. Biochim Biophys Acta 1822: 1363-1373, 2012
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 1363-1373
    • Fransen, M.1    Nordgren, M.2    Wang, B.3    Apanasets, O.4
  • 95
    • 77953508445 scopus 로고    scopus 로고
    • Mitochondria as a target in treatment
    • Frantz MC and Wipf P. Mitochondria as a target in treatment. Environ Mol Mutagen 51: 462-475, 2010
    • (2010) Environ Mol Mutagen , vol.51 , pp. 462-475
    • Frantz, M.C.1    Wipf, P.2
  • 96
    • 84859485101 scopus 로고    scopus 로고
    • Evidence for a relationship between mitochondrial complex i activity and mitochondrial aldehyde dehydrogenase during nitroglycerin tolerance: Effects of mitochondrial antioxidants
    • Garcia-Bou R, Rocha M, Apostolova N, Herance R, Hernandez-Mijares A, and Victor VM. Evidence for a relationship between mitochondrial complex I activity and mitochondrial aldehyde dehydrogenase during nitroglycerin tolerance: effects of mitochondrial antioxidants. Biochim Biophys Acta 1817: 828-837, 2012
    • (2012) Biochim Biophys Acta , vol.1817 , pp. 828-837
    • Garcia-Bou, R.1    Rocha, M.2    Apostolova, N.3    Herance, R.4    Hernandez-Mijares, A.5    Victor, V.M.6
  • 99
    • 84902303333 scopus 로고    scopus 로고
    • Mitochondria-Targeted antioxidant (mitoq) ameliorates age-related arterial endothelial dysfunction in mice
    • Gioscia-Ryan RA, LaRocca TJ, Sindler AL, Zigler MC, Murphy MP, and Seals DR. Mitochondria-Targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice. J Physiol 592: 2549-2561, 2014
    • (2014) J Physiol , vol.592 , pp. 2549-2561
    • Gioscia-Ryan, R.A.1    Larocca, T.J.2    Sindler, A.L.3    Zigler, M.C.4    Murphy, M.P.5    Seals, D.R.6
  • 100
    • 66949161132 scopus 로고    scopus 로고
    • The ligand binding battle at cytochrome c oxidase: How no regulates oxygen gradients in tissue
    • Gladwin MT and Shiva S. The ligand binding battle at cytochrome c oxidase: how NO regulates oxygen gradients in tissue. Circ Res 104: 1136-1138, 2009
    • (2009) Circ Res , vol.104 , pp. 1136-1138
    • Gladwin, M.T.1    Shiva, S.2
  • 101
    • 33646573053 scopus 로고    scopus 로고
    • Antioxidant activity of beta-blockers: An effect mediated by scavenging reactive oxygen and nitrogen species?
    • Gomes A, Costa D, Lima JL, and Fernandes E. Antioxidant activity of beta-blockers: an effect mediated by scavenging reactive oxygen and nitrogen species?. Bioorg Med Chem 14: 4568-4577, 2006
    • (2006) Bioorg Med Chem , vol.14 , pp. 4568-4577
    • Gomes, A.1    Costa, D.2    Lima, J.L.3    Fernandes, E.4
  • 102
    • 50949115617 scopus 로고    scopus 로고
    • High levels of fis1, a profission mitochondrial protein, trigger autophagy
    • Gomes LC and Scorrano L. High levels of Fis1, a profission mitochondrial protein, trigger autophagy. Biochim Biophys Acta 1777: 860-866, 2008
    • (2008) Biochim Biophys Acta , vol.1777 , pp. 860-866
    • Gomes, L.C.1    Scorrano, L.2
  • 103
    • 10644263516 scopus 로고    scopus 로고
    • The beta-carotene and retinol efficacy trial: Incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements
    • Goodman GE, Thornquist MD, Balmes J, Cullen MR, Meyskens FL, Jr., Omenn GS, Valanis B, and Williams JH, Jr. The Beta-Carotene and Retinol Efficacy Trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements. J Natl Cancer Inst 96: 1743-1750, 2004
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1743-1750
    • Goodman, G.E.1    Thornquist, M.D.2    Balmes, J.3    Cullen, M.R.4    Meyskens, F.L.5    Omenn, G.S.6    Valanis, B.7    Williams, J.H.8
  • 106
    • 77149167604 scopus 로고    scopus 로고
    • N-Acetylcysteine (nac) in young marijuana users: An open-label pilot study
    • Gray KM, Watson NL, Carpenter MJ, and LaRowe SD. N-Acetylcysteine (NAC) in young marijuana users: an open-label pilot study. Am J Addict 19: 187-189, 2010
    • (2010) Am J Addict , vol.19 , pp. 187-189
    • Gray, K.M.1    Watson, N.L.2    Carpenter, M.J.3    Larowe, S.D.4
  • 107
  • 109
    • 79961167173 scopus 로고    scopus 로고
    • 2, 4-dinitrophenol (dnp): A weight loss agent with significant acute toxicity and risk of death
    • Grundlingh J, Dargan PI, El-Zanfaly M, and Wood DM. 2, 4-Dinitrophenol (DNP): a weight loss agent with significant acute toxicity and risk of death. J Med Toxicol 7: 205-212, 2011
    • (2011) J Med Toxicol , vol.7 , pp. 205-212
    • Grundlingh, J.1    Dargan, P.I.2    El-Zanfaly, M.3    Wood, D.M.4
  • 110
    • 0033042929 scopus 로고    scopus 로고
    • R alphalipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate
    • Hagen TM, Ingersoll RT, Lykkesfeldt J, Liu J, Wehr CM, Vinarsky V, Bartholomew JC, and Ames AB. (R)-Alphalipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J 13: 411-418, 1999
    • (1999) FASEB J , vol.13 , pp. 411-418
    • Hagen, T.M.1    Ingersoll, R.T.2    Lykkesfeldt, J.3    Liu, J.4    Wehr, C.M.5    Vinarsky, V.6    Bartholomew, J.C.7    Ames, A.B.8
  • 112
    • 84857501489 scopus 로고    scopus 로고
    • Role of haeme oxygenase-1 in resolution of oxidative stressrelated pathologies: Focus on cardiovascular, lung, neurological and kidney disorders
    • Haines DD, Lekli I, Teissier P, Bak I, and Tosaki A. Role of haeme oxygenase-1 in resolution of oxidative stressrelated pathologies: focus on cardiovascular, lung, neurological and kidney disorders. Acta Physiol (Oxf) 204: 487-501, 2012
    • (2012) Acta Physiol (Oxf , vol.204 , pp. 487-501
    • Haines, D.D.1    Lekli, I.2    Teissier, P.3    Bak, I.4    Tosaki, A.5
  • 113
    • 0037174138 scopus 로고    scopus 로고
    • Cardiolipin: A proton trap for oxidative phosphorylation
    • Haines TH and Dencher NA. Cardiolipin: a proton trap for oxidative phosphorylation. FEBS Lett 528: 35-39, 2002
    • (2002) FEBS Lett , vol.528 , pp. 35-39
    • Haines, T.H.1    Dencher, N.A.2
  • 116
    • 33744809562 scopus 로고    scopus 로고
    • Mitochondrial thioredoxin-2 has a key role in determining tumor necrosis factor-Alpha-induced reactive oxygen species generation nf-kappab activation, and apoptosis
    • Hansen JM, Zhang H, and Jones DP. Mitochondrial thioredoxin-2 has a key role in determining tumor necrosis factor-Alpha-induced reactive oxygen species generation, NF-kappaB activation, and apoptosis. Toxicol Sci 91: 643-650, 2006
    • (2006) Toxicol Sci , vol.91 , pp. 643-650
    • Hansen, J.M.1    Zhang, H.2    Jones, D.P.3
  • 117
    • 0031026392 scopus 로고    scopus 로고
    • Cytosolic and mitochondrial systems for nadh-And nadph-dependent reduction of alpha-lipoic acid
    • Haramaki N, Han D, Handelman GJ, Tritschler HJ, and Packer L. Cytosolic and mitochondrial systems for NADH-And NADPH-dependent reduction of alpha-lipoic acid. Free Radic Biol Med 22: 535-542, 1997
    • (1997) Free Radic Biol Med , vol.22 , pp. 535-542
    • Haramaki, N.1    Han, D.2    Handelman, G.J.3    Tritschler, H.J.4    Packer, L.5
  • 118
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 11: 298-300, 1956
    • (1956) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 120
    • 84875450015 scopus 로고    scopus 로고
    • Dissociation of bcl-2-beclin1 complex by activated ampk enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes
    • He C, Zhu H, Li H, Zou MH, and Xie Z. Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes. Diabetes 62: 1270-1281, 2013
    • (2013) Diabetes , vol.62 , pp. 1270-1281
    • He, C.1    Zhu, H.2    Li, H.3    Zou, M.H.4    Xie, Z.5
  • 121
    • 0029868538 scopus 로고    scopus 로고
    • Vitamin c-driven free radical generation from iron
    • Herbert V, Shaw S, and Jayatilleke E. Vitamin C-driven free radical generation from iron. J Nutr 126: 1213S-1220S, 1996
    • (1996) J Nutr , vol.126 , pp. 1213S-1220S
    • Herbert, V.1    Shaw, S.2    Jayatilleke, E.3
  • 122
    • 84880926594 scopus 로고    scopus 로고
    • Effects of resveratrol and sirt1 on pgc-1alpha activity and mitochondrial biogenesis: A reevaluation
    • Higashida K, Kim SH, Jung SR, Asaka M, Holloszy JO, and Han DH. Effects of resveratrol and SIRT1 on PGC-1alpha activity and mitochondrial biogenesis: a reevaluation. PLoS Biol 11: e1001603, 2013
    • (2013) PLoS Biol , vol.11 , pp. e1001603
    • Higashida, K.1    Kim, S.H.2    Jung, S.R.3    Asaka, M.4    Holloszy, J.O.5    Han, D.H.6
  • 124
    • 34247213490 scopus 로고    scopus 로고
    • Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stressinduced caspase activation
    • Horke S, Witte I, Wilgenbus P, Kruger M, Strand D, and Forstermann U. Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stressinduced caspase activation. Circulation 115: 2055-2064, 2007
    • (2007) Circulation , vol.115 , pp. 2055-2064
    • Horke, S.1    Witte, I.2    Wilgenbus, P.3    Kruger, M.4    Strand, D.5    Forstermann, U.6
  • 126
    • 0030982181 scopus 로고    scopus 로고
    • Mitochondrial regulation of store operated calcium signaling in t lymphocytes
    • Hoth M, Fanger CM, and Lewis RS. Mitochondrial regulation of store operated calcium signaling in T lymphocytes. J Cell Biol 137: 633-648, 1997
    • (1997) J Cell Biol , vol.137 , pp. 633-648
    • Hoth, M.1    Fanger, C.M.2    Lewis, R.S.3
  • 127
    • 0037459089 scopus 로고    scopus 로고
    • Regulation of mitochondrial morphology by membrane potential, and drp1-dependent division and fzo1-dependent fusion reaction in mammalian cells
    • Ishihara N, Jofuku A, Eura Y, and Mihara K. Regulation of mitochondrial morphology by membrane potential, and DRP1-dependent division and FZO1-dependent fusion reaction in mammalian cells. Biochem Biophys Res Commun 301: 891-898, 2003
    • (2003) Biochem Biophys Res Commun , vol.301 , pp. 891-898
    • Ishihara, N.1    Jofuku, A.2    Eura, Y.3    Mihara, K.4
  • 129
    • 34147142547 scopus 로고    scopus 로고
    • The production of reactive oxygen and nitrogen species by skeletal muscle
    • Jackson MJ, Pye D, and Palomero J. The production of reactive oxygen and nitrogen species by skeletal muscle. J Appl Physiol 102: 1664-1670, 2007
    • (2007) J Appl Physiol , vol.102 , pp. 1664-1670
    • Jackson, M.J.1    Pye, D.2    Palomero, J.3
  • 130
    • 1042278892 scopus 로고    scopus 로고
    • Antioxidant and prooxidant properties of mitochondrial coenzyme q
    • James AM, Smith RA, and Murphy MP. Antioxidant and prooxidant properties of mitochondrial Coenzyme Q. Arch Biochem Biophys 423: 47-56, 2004
    • (2004) Arch Biochem Biophys , vol.423 , pp. 47-56
    • James, A.M.1    Smith, R.A.2    Murphy, M.P.3
  • 131
    • 0141592470 scopus 로고    scopus 로고
    • Hfis1, a novel component of the mammalian mitochondrial fission machinery
    • James DI, Parone PA, Mattenberger Y, and Martinou JC. hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem 278: 36373-36379, 2003
    • (2003) J Biol Chem , vol.278 , pp. 36373-36379
    • James, D.I.1    Parone, P.A.2    Mattenberger, Y.3    Martinou, J.C.4
  • 132
    • 0348136710 scopus 로고    scopus 로고
    • Mitochondria-Targeted antioxidants protect friedreich ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants
    • Jauslin ML, Meier T, Smith RA, and Murphy MP. Mitochondria-Targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J 17: 1972-1974, 2003
    • (2003) FASEB J , vol.17 , pp. 1972-1974
    • Jauslin, M.L.1    Meier, T.2    Smith, R.A.3    Murphy, M.P.4
  • 135
    • 78649685455 scopus 로고    scopus 로고
    • Mitochondrial membrane potential regulates pink1 import and proteolytic destabilization by parl
    • Jin SM, Lazarou M, Wang C, Kane LA, Narendra DP, and Youle RJ. Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol 191: 933-942, 2010
    • (2010) J Cell Biol , vol.191 , pp. 933-942
    • Jin, S.M.1    Lazarou, M.2    Wang, C.3    Kane, L.A.4    Narendra, D.P.5    Youle, R.J.6
  • 136
    • 77957315403 scopus 로고    scopus 로고
    • Redox compartmentalization and cellular stress
    • Jones DP and Go YM. Redox compartmentalization and cellular stress. Diabetes Obes Metab 12: 116-125, 2010
    • (2010) Diabetes Obes Metab , vol.12 , pp. 116-125
    • Jones, D.P.1    Go, Y.M.2
  • 137
    • 0038678733 scopus 로고    scopus 로고
    • Peroxidation of docosahexaenoic acid is responsible for its effects on i to and i ss in ratventricular myocytes
    • Judé S, Bedut S, Roger S, Pinault M, Champeroux P, White E, and Le Guennec JY. Peroxidation of docosahexaenoic acid is responsible for its effects on I TO and I SS in ratventricular myocytes. Br J Pharmacol 139: 816-822, 2003
    • (2003) Br J Pharmacol , vol.139 , pp. 816-822
    • Judé, S.1    Bedut, S.2    Roger, S.3    Pinault, M.4    Champeroux, P.5    White, E.6    Le Guennec, J.Y.7
  • 138
    • 0035947221 scopus 로고    scopus 로고
    • Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model
    • Jung C, Rong Y, Doctrow S, Baudry M, Malfroy B, and Xu Z. Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model. Neurosci Lett 304: 157-160, 2001
    • (2001) Neurosci Lett , vol.304 , pp. 157-160
    • Jung, C.1    Rong, Y.2    Doctrow, S.3    Baudry, M.4    Malfroy, B.5    Xu, Z.6
  • 142
    • 0019950040 scopus 로고
    • Studies on ergothioneine vi distribution and fluctuations of ergothioneine in rats
    • Kawano H, Otani M, Takeyama K, Kawai Y, Mayumi T, and Hama T. Studies on ergothioneine. VI. Distribution and fluctuations of ergothioneine in rats. Chem Pharm Bull (Tokyo) 30: 1760-1765, 1982
    • (1982) Chem Pharm Bull (Tokyo , vol.30 , pp. 1760-1765
    • Kawano, H.1    Otani, M.2    Takeyama, K.3    Kawai, Y.4    Mayumi, T.5    Hama, T.6
  • 143
    • 0032725723 scopus 로고    scopus 로고
    • Effects of physical activity on insulin action and glucose tolerance in obesity
    • Kelley DE and Goodpaster BH. Effects of physical activity on insulin action and glucose tolerance in obesity. Med Sci Sports Exerc 31: S619-S623, 1999
    • (1999) Med Sci Sports Exerc , vol.31 , pp. S619-S623
    • Kelley, D.E.1    Goodpaster, B.H.2
  • 145
    • 33645640345 scopus 로고    scopus 로고
    • High density of octaarginine stimulates macropinocytosis leading to efficient intracellular trafficking for gene expression
    • Khalil IA, Kogure K, Futaki S, and Harashima H. High density of octaarginine stimulates macropinocytosis leading to efficient intracellular trafficking for gene expression. J Biol Chem 281: 3544-3551, 2006
    • (2006) J Biol Chem , vol.281 , pp. 3544-3551
    • Khalil, I.A.1    Kogure, K.2    Futaki, S.3    Harashima, H.4
  • 147
    • 79551598347 scopus 로고    scopus 로고
    • Ampk and mtor regulate autophagy through direct phosphorylation of ulk1
    • Kim J, Kundu M, Viollet B, and Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13: 132-141, 2011
    • (2011) Nat Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 149
    • 4644273585 scopus 로고    scopus 로고
    • Uth1p is involved in the autophagic degradation of mitochondria
    • Kissova I, Deffieu M, Manon S, and Camougrand N. Uth1p is involved in the autophagic degradation of mitochondria. J Biol Chem 279: 39068-39074, 2004
    • (2004) J Biol Chem , vol.279 , pp. 39068-39074
    • Kissova, I.1    Deffieu, M.2    Manon, S.3    Camougrand, N.4
  • 152
    • 38949151892 scopus 로고    scopus 로고
    • Multifunctional envelope-Type nano device (mend) as a nonviral gene delivery system
    • Kogure K, Akita H, Yamada Y, and Harashima H. Multifunctional envelope-Type nano device (MEND) as a nonviral gene delivery system. Adv Drug Deliv Rev 60: 559-571, 2008
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 559-571
    • Kogure, K.1    Akita, H.2    Yamada, Y.3    Harashima, H.4
  • 153
    • 84923891705 scopus 로고    scopus 로고
    • Resveratrol supplementation restores high-fat diet-induced insulin secretion dysfunction by increasing mitochondrial function in islet
    • Epub ahead of print]
    • Kong W, Chen LL, Zheng J, Zhang HH, Hu X, Zeng TS, and Hu D. Resveratrol supplementation restores high-fat diet-induced insulin secretion dysfunction by increasing mitochondrial function in islet. Exp Biol Med 2014 [Epub ahead of print]; pii: 1535370214548998
    • (2014) Exp Biol Med
    • Kong, W.1    Chen, L.L.2    Zheng, J.3    Zhang, H.H.4    Hu, X.5    Zeng, T.S.6    Hu, D.7
  • 157
    • 0034685751 scopus 로고    scopus 로고
    • Carvedilol: A beta blocker with antioxidant property protects against gentamicin-induced nephrotoxicity in rats
    • Kumar KV, Shifow AA, Naidu MU, and Ratnakar KS. Carvedilol: a beta blocker with antioxidant property protects against gentamicin-induced nephrotoxicity in rats. Life Sci 66: 2603-2611, 2000
    • (2000) Life Sci , vol.66 , pp. 2603-2611
    • Kumar, K.V.1    Shifow, A.A.2    Naidu, M.U.3    Ratnakar, K.S.4
  • 159
    • 33744801418 scopus 로고    scopus 로고
    • Novel localization of octn1, an organic cation/carnitine transporter, to mammalian mitochondria
    • Lamhonwah AM and Tein I. Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria. Biochem Biophys Res Commun 345: 1315-1325, 2006
    • (2006) Biochem Biophys Res Commun , vol.345 , pp. 1315-1325
    • Lamhonwah, A.M.1    Tein, I.2
  • 160
    • 33745102429 scopus 로고    scopus 로고
    • Partial volume rat lung irradiation: The protective/mitigating effects of eukarion-189, a superoxide dismutase-catalase mimetic
    • Langan AR, Khan MA, Yeung IW, Van Dyk J, and Hill RP. Partial volume rat lung irradiation: the protective/mitigating effects of Eukarion-189, a superoxide dismutase-catalase mimetic. Radiother Oncol 79: 231-238, 2008
    • (2008) Radiother Oncol , vol.79 , pp. 231-238
    • Langan, A.R.1    Khan, M.A.2    Yeung, I.W.3    Van Dyk, J.4    Hill, R.P.5
  • 162
    • 84905458903 scopus 로고    scopus 로고
    • Trolox inhibits osteolytic bone metastasis of breast cancer through both pge2-dependent and independent mechanisms
    • Lee JH, Kim B, Jin WJ, Kim JW, Kim HH, Ha H, and Lee ZH. Trolox inhibits osteolytic bone metastasis of breast cancer through both PGE2-dependent and independent mechanisms. Biochem Pharmacol 91: 51-60, 2014
    • (2014) Biochem Pharmacol , vol.91 , pp. 51-60
    • Lee, J.H.1    Kim, B.2    Jin, W.J.3    Kim, J.W.4    Kim, H.H.5    Ha, H.6    Lee, Z.H.7
  • 163
    • 2542595368 scopus 로고    scopus 로고
    • Effect of trolox on hypoxia/reoxygenation-induced injury in isolated perfused rat liver
    • Lee SM and Cho TS. Effect of Trolox on hypoxia/reoxygenation-induced injury in isolated perfused rat liver. Arch Pharm Res 20: 471-475, 1997
    • (1997) Arch Pharm Res , vol.20 , pp. 471-475
    • Lee, S.M.1    Cho, T.S.2
  • 164
    • 84883162994 scopus 로고    scopus 로고
    • Both pka and epac pathways mediate n-Acetylcysteine-induced connexin43 preservation in rats with myocardial infarction
    • Lee TM, Lin SZ, and Chang NC. Both PKA and Epac pathways mediate N-Acetylcysteine-induced Connexin43 preservation in rats with myocardial infarction. PLoS One 8: e71878, 2013
    • (2013) PLoS One , vol.8 , pp. e71878
    • Lee, T.M.1    Lin, S.Z.2    Chang, N.C.3
  • 165
    • 16844366524 scopus 로고    scopus 로고
    • Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging
    • Lemasters JJ. Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res 8: 3-5, 2005
    • (2005) Rejuvenation Res , vol.8 , pp. 3-5
    • Lemasters, J.J.1
  • 166
    • 67349229199 scopus 로고    scopus 로고
    • Elegans longevity pathways converge to decrease mitochondrial membrane potential
    • Lemire BD, Behrendt M, DeCorby A, and Gásková D. C. elegans longevity pathways converge to decrease mitochondrial membrane potential. Mech Ageing Dev 130: 461-465, 2009
    • (2009) Mech Ageing Dev , vol.130 , pp. 461-465
    • Lemire, B.D.1    Behrendt, M.2    Decorby, A.3    Gásková, D.C.4
  • 167
    • 57649221155 scopus 로고    scopus 로고
    • The mitochondrial antioxidants mitoe(2) and mitoq 10) increase mitochondrial ca 2 + ) load upon cell stimulation by inhibiting ca(2 + ) efflux from the organelle
    • Leo S, Szabadkai G, and Rizzuto R. The mitochondrial antioxidants MitoE(2) and MitoQ(10) increase mitochondrial Ca(2 + ) load upon cell stimulation by inhibiting Ca(2 + ) efflux from the organelle. Ann N Y Acad Sci 1147: 264-274, 2008
    • (2008) Ann N y Acad Sci , vol.1147 , pp. 264-274
    • Leo, S.1    Szabadkai, G.2    Rizzuto, R.3
  • 168
    • 0035864342 scopus 로고    scopus 로고
    • Pon2 gene variants are associated with clinical manifestations of cardiovascular disease in familial hypercholesterolemia patients
    • Leus FR, Zwart M, Kastelein JJ, and Voorbij HA. PON2 gene variants are associated with clinical manifestations of cardiovascular disease in familial hypercholesterolemia patients. Atherosclerosis 154: 641-649, 2001
    • (2001) Atherosclerosis , vol.154 , pp. 641-649
    • Leus, F.R.1    Zwart, M.2    Kastelein, J.J.3    Voorbij, H.A.4
  • 169
    • 78650918259 scopus 로고    scopus 로고
    • Mitochondria-Targeted antioxidant peptide ss31 attenuates high glucose-induced injury on human retinal endothelial cells
    • Li J, Chen X, Xiao W, Ma W, Li T, Huang J, Liu X, Liang X, Tang S, and Luo Y. Mitochondria-Targeted antioxidant peptide SS31 attenuates high glucose-induced injury on human retinal endothelial cells. Biochem Biophys Res Commun 404: 349-356, 2011
    • (2011) Biochem Biophys Res Commun , vol.404 , pp. 349-356
    • Li, J.1    Chen, X.2    Xiao, W.3    Ma, W.4    Li, T.5    Huang, J.6    Liu, X.7    Liang, X.8    Tang, S.9    Luo, Y.10
  • 170
    • 84862777886 scopus 로고    scopus 로고
    • Cardiovascular effects and molecular targets of resveratrol
    • Li H, Xia N, and Förstermann U. Cardiovascular effects and molecular targets of resveratrol. Nitric Oxide 26: 102-110, 2012
    • (2012) Nitric Oxide , vol.26 , pp. 102-110
    • Li, H.1    Xia, N.2    Förstermann, U.3
  • 171
    • 83755207504 scopus 로고    scopus 로고
    • Mitochondria-Targeted antioxidants protect pancreatic bcells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity
    • Lim S, Rashid MA, Jang M, Kim Y, Won H, Lee J, Woo JT, Kim YS, Murphy MP, Ali L, Ha J, and Kim SS. Mitochondria-Targeted antioxidants protect pancreatic bcells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity. Cell Physiol Biochem 28: 873-886, 2011
    • (2011) Cell Physiol Biochem , vol.28 , pp. 873-886
    • Lim, S.1    Rashid, M.A.2    Jang, M.3    Kim, Y.4    Won, H.5    Lee, J.6    Woo, J.T.7    Kim, Y.S.8    Murphy, M.P.9    Ali, L.10    Ha, J.11    Kim, S.S.12
  • 173
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski CA, Lombardo F, Dominy BW, and Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 46: 3-26, 2001
    • (2001) Adv Drug Deliv Rev , vol.46 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 174
    • 0038491473 scopus 로고    scopus 로고
    • Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics
    • Liu R, Liu IY, Bi X, Thompson RF, Doctrow SR, Malfroy B, and Baudry M. Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics. Proc Natl Acad Sci U S A 100: 8526-8531, 2003
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8526-8531
    • Liu, R.1    Liu, I.Y.2    Bi, X.3    Thompson, R.F.4    Doctrow, S.R.5    Malfroy, B.6    Baudry, M.7
  • 175
    • 84900534164 scopus 로고    scopus 로고
    • Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation and fibrosis
    • Liu S, Soong Y, Seshan SV, and Szeto HH. Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation and fibrosis. Am J Physiol Renal Physiol 306: 970-980, 2014
    • (2014) Am J Physiol Renal Physiol , vol.306 , pp. 970-980
    • Liu, S.1    Soong, Y.2    Seshan, S.V.3    Szeto, H.H.4
  • 176
    • 67650921433 scopus 로고    scopus 로고
    • Vitamin e paradox in alzheimers disease: It does not prevent loss of cognition and may even be detrimental
    • Lloret A, Badía MC, Mora NJ, Pallardó FV, Alonso MD, and Viña J. Vitamin E paradox in Alzheimers disease: it does not prevent loss of cognition and may even be detrimental. J Alzheimers Dis 17: 143-149, 2009
    • (2009) J Alzheimers Dis , vol.17 , pp. 143-149
    • Lloret, A.1    Badía, M.C.2    Mora, N.J.3    Pallardó, F.V.4    Alonso, M.D.5    Viña, J.6
  • 178
    • 0036834582 scopus 로고    scopus 로고
    • Effects of vitamin e on cardiovascular and microvascular outcomes in high-risk patients with diabetes: Results of the hope study and micro-hope substudy
    • Lonn E, Yusuf S, Hoogwerf B, Pogue J, Yi Q, Zinman B, Bosch J, Dagenais G, Mann JF, and Gerstein HC. Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy. Diabetes Care 25: 1919-1927, 2002
    • (2002) Diabetes Care , vol.25 , pp. 1919-1927
    • Lonn, E.1    Yusuf, S.2    Hoogwerf, B.3    Pogue, J.4    Yi, Q.5    Zinman, B.6    Bosch, J.7    Dagenais, G.8    Mann, J.F.9    Gerstein, H.C.10
  • 180
    • 56049120778 scopus 로고    scopus 로고
    • The mitochondria-Targeted antioxidant mitoq protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis
    • Lowes DA, Thottakam BM, Webster NR, Murphy MP, and Galley HF. The mitochondria-Targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis. Free Radic Biol Med 45: 1559-1565, 2008
    • (2008) Free Radic Biol Med , vol.45 , pp. 1559-1565
    • Lowes, D.A.1    Thottakam, B.M.2    Webster, N.R.3    Murphy, M.P.4    Galley, H.F.5
  • 181
    • 34447635692 scopus 로고    scopus 로고
    • Serum vitamin e and oxidative protein modification in hemodialysis: A randomized clinical trial
    • Lu L, Erhard P, Salomon RG, and Weiss MF. Serum vitamin E and oxidative protein modification in hemodialysis: a randomized clinical trial. Am J Kidney Dis 50: 305-313, 2007
    • (2007) Am J Kidney Dis , vol.50 , pp. 305-313
    • Lu, L.1    Erhard, P.2    Salomon, R.G.3    Weiss, M.F.4
  • 182
  • 186
    • 77955509429 scopus 로고    scopus 로고
    • Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes
    • Makino A, Scott BT, and Dillmann WH. Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes. Diabetologia 53: 1783-1794, 2010
    • (2010) Diabetologia , vol.53 , pp. 1783-1794
    • Makino, A.1    Scott, B.T.2    Dillmann, W.H.3
  • 188
    • 57449103542 scopus 로고    scopus 로고
    • Reactivity of ubiquinone and ubiquinol with superoxide and the hydroperoxyl radical: Implications for in vivo antioxidant activity
    • Maroz A, Anderson RF, Smith RA, and Murphy MP. Reactivity of ubiquinone and ubiquinol with superoxide and the hydroperoxyl radical: implications for in vivo antioxidant activity. Free Radic Biol Med 46: 105-109, 2009
    • (2009) Free Radic Biol Med , vol.46 , pp. 105-109
    • Maroz, A.1    Anderson, R.F.2    Smith, R.A.3    Murphy, M.P.4
  • 189
    • 84867089289 scopus 로고    scopus 로고
    • Engineering of blended nanoparticle platform for delivery of mitochondria-Acting therapeutics
    • Marrache S and Dhar S. Engineering of blended nanoparticle platform for delivery of mitochondria-Acting therapeutics. Proc Natl Acad Sci U S A 109: 16288-16293, 2012
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 16288-16293
    • Marrache, S.1    Dhar, S.2
  • 190
    • 84859598872 scopus 로고    scopus 로고
    • Biology of mitochondria in neurodegenerative diseases
    • Martin LJ. Biology of mitochondria in neurodegenerative diseases. Prog Mol Biol Transl Sci 107: 355-415, 2012
    • (2012) Prog Mol Biol Transl Sci , vol.107 , pp. 355-415
    • Martin, L.J.1
  • 192
    • 31444433077 scopus 로고    scopus 로고
    • Nitric oxide inhibition of respiration involves both competitive (heme) and noncompetitive (copper) binding to cytochrome c oxidase
    • Mason MG, Nicholls P, Wilson MT, and Cooper CE. Nitric oxide inhibition of respiration involves both competitive (heme) and noncompetitive (copper) binding to cytochrome c oxidase. Proc Natl Acad Sci U S A 103: 708-713, 2006
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 708-713
    • Mason, M.G.1    Nicholls, P.2    Wilson, M.T.3    Cooper, C.E.4
  • 193
    • 77749254802 scopus 로고    scopus 로고
    • P38 mapk links oxidative stress to autophagy-related gene expression in cachectic muscle wasting
    • McClung JM, Judge AR, Powers SK, and Yan Z. p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting. Am J Physiol Cell Physiol 298: C542-C549, 2010
    • (2010) Am J Physiol Cell Physiol , vol.298 , pp. C542-C549
    • McClung, J.M.1    Judge, A.R.2    Powers, S.K.3    Yan, Z.4
  • 194
    • 84894067221 scopus 로고    scopus 로고
    • Combined therapeutic benefit of mitochondria-Targeted antioxidant, mitoq10, and angiotensin receptor blocker, losartan, on cardiovascular function
    • McLachlan J, Beattie E, MurphyMP, Koh-Tan CH, Olson E, Beattie W, Dominiczak AF, Nicklin SA, and Graham D.combined therapeutic benefit of mitochondria-Targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function. J Hypertens 32: 555-564, 2014
    • (2014) J Hypertens , vol.32 , pp. 555-564
    • McLachlan, J.1    Beattie, E.2    Murphymp Koh-Tan, C.H.3    Olson, E.4    Beattie, W.5    Dominiczak, A.F.6    Nicklin, S.A.7    Graham, D.8
  • 195
  • 197
    • 0035503501 scopus 로고    scopus 로고
    • Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics
    • Melov S, Doctrow SR, Schneider JA, Haberson J, Patel M, Coskun PE, Huffman K, Wallace DC, and Malfroy B. Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics. J Neurosci 21: 8348-8353, 2001
    • (2001) J Neurosci , vol.21 , pp. 8348-8353
    • Melov, S.1    Doctrow, S.R.2    Schneider, J.A.3    Haberson, J.4    Patel, M.5    Coskun, P.E.6    Huffman, K.7    Wallace, D.C.8    Malfroy, B.9
  • 198
    • 10844277858 scopus 로고    scopus 로고
    • Mice transgenic for alzheimer disease beta-Amyloid develop lens cataracts that are rescued by antioxidant treatment
    • Melov S, Wolf N, Strozyk D, Doctrow SR, and Bush AI. Mice transgenic for Alzheimer disease beta-Amyloid develop lens cataracts that are rescued by antioxidant treatment. Free Radic Biol Med 38: 258-261, 2005
    • (2005) Free Radic Biol Med , vol.38 , pp. 258-261
    • Melov, S.1    Wolf, N.2    Strozyk, D.3    Doctrow, S.R.4    Bush, A.I.5
  • 200
    • 83455235224 scopus 로고    scopus 로고
    • Metabolic correction in the management of diabetic peripheral neuropathy: Improving clinical results beyond symptom control
    • Miranda-Massari JR, Gonzalez MJ, Jimenez FJ, Allende-Vigo MZ, and Duconge J. Metabolic correction in the management of diabetic peripheral neuropathy: improving clinical results beyond symptom Control. Curr Clin Pharmacol 6: 260-273, 2011
    • (2011) Curr Clin Pharmacol , vol.6 , pp. 260-273
    • Miranda-Massari, J.R.1    Gonzalez, M.J.2    Jimenez, F.J.3    Allende-Vigo, M.Z.4    Duconge, J.5
  • 202
    • 57349111179 scopus 로고    scopus 로고
    • A novel cell-permeable antioxidant peptide decreases renal tubular apoptosis and damage in unilateral ureteral obstruction
    • Mizuguchi Y, Chen J, Seshan SV, Poppas DP, Szeto HH, and Felsen D A novel cell-permeable antioxidant peptide decreases renal tubular apoptosis and damage in unilateral ureteral obstruction. Am J Physiol Renal Physiol 295: 1545-1553, 2008
    • (2008) Am J Physiol Renal Physiol , vol.295 , pp. 1545-1553
    • Mizuguchi, Y.1    Chen, J.2    Seshan, S.V.3    Poppas, D.P.4    Szeto, H.H.5    Felsen, D.6
  • 203
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: Process and function
    • Mizushima N. Autophagy: process and function. Genes Dev 21: 2861-2873, 2007
    • (2007) Genes Dev , vol.21 , pp. 2861-2873
    • Mizushima, N.1
  • 204
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima N, Levine B, Cuervo AM, and Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 451: 1069-1075, 2008
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 206
    • 34848890388 scopus 로고    scopus 로고
    • Lipoic acid and n-Acetyl cysteine decrease mitochondrial-related oxidative stress in alzheimer disease patient fibroblasts
    • Moreira PI, Harris PL, Zhu X, Santos MS, Oliveira CR, Smith MA, and Perry G. Lipoic acid and N-Acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J Alzheimers Dis 12: 195-206, 2007
    • (2007) J Alzheimers Dis , vol.12 , pp. 195-206
    • Moreira, P.I.1    Harris, P.L.2    Zhu, X.3    Santos, M.S.4    Oliveira, C.R.5    Smith, M.A.6    Perry, G.7
  • 207
    • 26244447857 scopus 로고    scopus 로고
    • Coq10 therapy attenuates amyloid betapeptide toxicity in brain mitochondria isolated from aged diabetic rats
    • Moreira PI, Santos MS, Sena C, Nunes E, Seiça R, and Oliveira CR. CoQ10 therapy attenuates amyloid betapeptide toxicity in brain mitochondria isolated from aged diabetic rats. Exp Neurol 196: 112-119, 2005
    • (2005) Exp Neurol , vol.196 , pp. 112-119
    • Moreira, P.I.1    Santos, M.S.2    Sena, C.3    Nunes, E.4    Seiça, R.5    Oliveira, C.R.6
  • 208
    • 79953743040 scopus 로고    scopus 로고
    • A potential design flaw of randomized trials of vitamin supplements
    • Morris MC and Tangney CC A potential design flaw of randomized trials of vitamin supplements. JAMA 305: 1348-1349, 2011
    • (2011) JAMA , vol.305 , pp. 1348-1349
    • Morris, M.C.1    Tangney, C.C.2
  • 210
    • 0343986284 scopus 로고    scopus 로고
    • Drug delivery to mitochondria: The key to mitochondrial medicine
    • Murphy MP and Smith RA. Drug delivery to mitochondria: the key to mitochondrial medicine. Adv Drug Deliv Rev 41: 235-250, 2000
    • (2000) Adv Drug Deliv Rev , vol.41 , pp. 235-250
    • Murphy, M.P.1    Smith, R.A.2
  • 211
    • 33847071146 scopus 로고    scopus 로고
    • Targeting antioxidants to mitochondria by conjugation to lipophilic cations
    • Murphy MP and Smith RA. Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol 47: 629-656, 2007
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 629-656
    • Murphy, M.P.1    Smith, R.A.2
  • 212
    • 84867534243 scopus 로고    scopus 로고
    • Susceptibility of mitochondrial electron-Transport complexes to oxidative damage focus on cytochrome c oxidase
    • Musatov A and Robinson NC. Susceptibility of mitochondrial electron-Transport complexes to oxidative damage. Focus on cytochrome c oxidase. Free Radic Res 46: 1313-1326, 2012
    • (2012) Free Radic Res , vol.46 , pp. 1313-1326
    • Musatov, A.1    Robinson, N.C.2
  • 213
    • 84905043685 scopus 로고    scopus 로고
    • At the right distance: Er-mitochondria juxtaposition in cell life and death
    • Naon D and Scorrano L. At the right distance: ER-mitochondria juxtaposition in cell life and death. Biochim Biophys Acta 1843: 2184-2194, 2014
    • (2014) Biochim Biophys Acta , vol.1843 , pp. 2184-2194
    • Naon, D.1    Scorrano, L.2
  • 216
    • 50949097371 scopus 로고    scopus 로고
    • Crosstalk between autophagy and apoptosis in heart disease
    • Nishida K, Yamaguchi O, and Otsu K. Crosstalk between autophagy and apoptosis in heart disease. Circ Res 103: 343-351, 2008
    • (2008) Circ Res , vol.103 , pp. 343-351
    • Nishida, K.1    Yamaguchi, O.2    Otsu, K.3
  • 219
    • 0019444843 scopus 로고
    • Trna punctuation model of rna processing in human mitochondria
    • Ojala D, Montoya J, and Attardi G. tRNA punctuation model of RNA processing in human mitochondria. Nature 290: 470-474, 1981
    • (1981) Nature , vol.290 , pp. 470-474
    • Ojala, D.1    Montoya, J.2    Attardi, G.3
  • 220
    • 0033588087 scopus 로고    scopus 로고
    • 4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress. Identification of proteasomes as target molecules
    • Okada K, Wangpoengtrakul C, Osawa T, Toyokuni S, Tanaka K, and Uchida K. 4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress. Identification of proteasomes as target molecules. J Biol Chem 274: 23787-23793, 1999
    • (1999) J Biol Chem , vol.274 , pp. 23787-23793
    • Okada, K.1    Wangpoengtrakul, C.2    Osawa, T.3    Toyokuni, S.4    Tanaka, K.5    Uchida, K.6
  • 221
    • 0037424239 scopus 로고    scopus 로고
    • Loss of opa1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis
    • Olichon A, Baricault L, Gas N, Guillou E, Valette A, Belenguer P, and Lenaers G. Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J Biol Chem 278: 7743-7746, 2003
    • (2003) J Biol Chem , vol.278 , pp. 7743-7746
    • Olichon, A.1    Baricault, L.2    Gas, N.3    Guillou, E.4    Valette, A.5    Belenguer, P.6    Lenaers, G.7
  • 222
    • 33947434544 scopus 로고    scopus 로고
    • Opa1 alternate splicing uncouples an evolutionary conserved function in mitochondrial fusion from a vertebrate restricted function in apoptosis
    • Olichon A, Elachouri G, Baricault L, Delettre C, Belenguer P, and Lenaers G. OPA1 alternate splicing uncouples an evolutionary conserved function in mitochondrial fusion from a vertebrate restricted function in apoptosis. Cell Death Differ 14: 682-692, 2007
    • (2007) Cell Death Differ , vol.14 , pp. 682-692
    • Olichon, A.1    Elachouri, G.2    Baricault, L.3    Delettre, C.4    Belenguer, P.5    Lenaers, G.6
  • 224
    • 81155137932 scopus 로고    scopus 로고
    • Hydrogen sulfide is an oxygen sensor in the carotid body
    • Olson KR. Hydrogen sulfide is an oxygen sensor in the carotid body. Respir Physiol Neurobiol 179: 103-110, 2011
    • (2011) Respir Physiol Neurobiol , vol.179 , pp. 103-110
    • Olson, K.R.1
  • 225
    • 77950801465 scopus 로고    scopus 로고
    • Hydrogen sulfide and oxygen sensing in the cardiovascular system
    • Olson KR and Whitfield NL. Hydrogen sulfide and oxygen sensing in the cardiovascular system. Antioxid Redox Signal 12: 1219-1234, 2010
    • (2010) Antioxid Redox Signal , vol.12 , pp. 1219-1234
    • Olson, K.R.1    Whitfield, N.L.2
  • 226
    • 84894628671 scopus 로고    scopus 로고
    • Inhibition of oxidative hemolysis in erythrocytes by mitochondria-Targeted antioxidants of skq series
    • Omarova EO and Antonenko YN. Inhibition of oxidative hemolysis in erythrocytes by mitochondria-Targeted antioxidants of SkQ series. Biochemistry (Mosc) 79: 139-145, 2014
    • (2014) Biochemistry (Mosc , vol.79 , pp. 139-145
    • Omarova, E.O.1    Antonenko, Y.N.2
  • 228
    • 84894518203 scopus 로고    scopus 로고
    • Comparing the effects of mitochondrial targeted and localized antioxidants with cellular antioxidants in human skin cells exposed to uva and hydrogen peroxide
    • Oyewole AO, Wilmot MC, Fowler M, and Birch-Machin MA.comparing the effects of mitochondrial targeted and localized antioxidants with cellular antioxidants in human skin cells exposed to UVA and hydrogen peroxide. FASEB J 28: 485-494, 2014
    • (2014) FASEB J , vol.28 , pp. 485-494
    • Oyewole, A.O.1    Wilmot, M.C.2    Fowler, M.3    Birch-Machin, M.A.4
  • 231
    • 84900887397 scopus 로고    scopus 로고
    • Palmitate-induced cell death and mitochondrial respiratory dysfunction in myoblasts are not prevented by mitochondria-Targeted antioxidants
    • Patková J, Anděl M, and Trnka J. Palmitate-induced cell death and mitochondrial respiratory dysfunction in myoblasts are not prevented by mitochondria-Targeted antioxidants. Cell Physiol Biochem 33: 1439-1451, 2014
    • (2014) Cell Physiol Biochem , vol.33 , pp. 1439-1451
    • Patková, J.1    Anděl, M.2    Trnka, J.3
  • 232
    • 84877739237 scopus 로고    scopus 로고
    • Paraoxonase 1: A better atherosclerotic risk predictor than hdl in type 2 diabetes mellitus
    • Patra SK, Singh K, and Singh R. Paraoxonase 1: a better atherosclerotic risk predictor than HDL in type 2 diabetes mellitus. Diabetes Metab Syndr 7: 108-111, 2013
    • (2013) Diabetes Metab Syndr , vol.7 , pp. 108-111
    • Patra, S.K.1    Singh, K.2    Singh, R.3
  • 233
    • 77953620630 scopus 로고    scopus 로고
    • The unusual amino acid lergothioneine is a physiologic cytoprotectant
    • Paul BD and Snyder SH. The unusual amino acid Lergothioneine is a physiologic cytoprotectant. Cell Death Differ 17: 1134-1140, 2010
    • (2010) Cell Death Differ , vol.17 , pp. 1134-1140
    • Paul, B.D.1    Snyder, S.H.2
  • 235
    • 23844483173 scopus 로고    scopus 로고
    • Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: Implications for parkinson disease
    • Peng J, Stevenson FF, Doctrow SR, and Andersen JK. Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implications for Parkinson disease. J Biol Chem 280: 29194-29198, 2005
    • (2005) J Biol Chem , vol.280 , pp. 29194-29198
    • Peng, J.1    Stevenson, F.F.2    Doctrow, S.R.3    Andersen, J.K.4
  • 236
    • 84862528769 scopus 로고    scopus 로고
    • Coenzyme q10 prevents gdpsensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes
    • Persson MF, Franzen S, Catrina SB, Dallner G, Hansell P, Brismar K, and Palm F. Coenzyme Q10 prevents GDPsensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes. Diabetologia 55: 1535-1543, 2012
    • (2012) Diabetologia , vol.55 , pp. 1535-1543
    • Persson, M.F.1    Franzen, S.2    Catrina, S.B.3    Dallner, G.4    Hansell, P.5    Brismar, K.6    Palm, F.7
  • 238
    • 84868560653 scopus 로고    scopus 로고
    • Redox regulation of mitochondrial biogenesis
    • Piantadosi CA and Suliman HB. Redox regulation of mitochondrial biogenesis. Free Radic Biol Med 53: 2043-2053, 2012
    • (2012) Free Radic Biol Med , vol.53 , pp. 2043-2053
    • Piantadosi, C.A.1    Suliman, H.B.2
  • 245
    • 0025338423 scopus 로고
    • On the microassembly of integral membrane proteins
    • Popot JL and de Vitry C. On the microassembly of integral membrane proteins. Annu Rev Biophys Biophys Chem 19: 369-403, 1990
    • (1990) Annu Rev Biophys Biophys Chem , vol.19 , pp. 369-403
    • Popot, J.L.1    De Vitry, C.2
  • 246
    • 77955266918 scopus 로고    scopus 로고
    • Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: Implications for mitochondria-specific therapies and probes
    • Porteous CM, Logan A, Evans C, Ledgerwood EC, Menon DK, Aigbirhio F, Smith RA, and Murphy MP. Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: implications for mitochondria-specific therapies and probes. Biochim Biophys Acta 1800: 1009-1017, 2010
    • (2010) Biochim Biophys Acta , vol.1800 , pp. 1009-1017
    • Porteous, C.M.1    Logan, A.2    Evans, C.3    Ledgerwood, E.C.4    Menon, D.K.5    Aigbirhio, F.6    Smith, R.A.7    Murphy, M.P.8
  • 247
  • 248
    • 55949118714 scopus 로고    scopus 로고
    • Exercise-induced oxidative stress: Cellular mechanisms and impact on muscle force production
    • Powers SK and Jackson MJ. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev 88: 1243-1276, 2008
    • (2008) Physiol Rev , vol.88 , pp. 1243-1276
    • Powers, S.K.1    Jackson, M.J.2
  • 249
    • 56349145099 scopus 로고    scopus 로고
    • Oxidative stress hypothesis in alzheimers disease: A reappraisal
    • Praticò D. Oxidative stress hypothesis in Alzheimers disease: a reappraisal. Trends Pharmacol Sci 29: 609-615, 2008
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 609-615
    • Praticò, D.1
  • 251
    • 0034923201 scopus 로고    scopus 로고
    • Pharmacologic treatment of the stunned myocardium: The concepts and the challenges
    • Przyklenk K. Pharmacologic treatment of the stunned myocardium: the concepts and the challenges. Coron Artery Dis 12: 363-369, 2001
    • (2001) Coron Artery Dis , vol.12 , pp. 363-369
    • Przyklenk, K.1
  • 254
    • 0028275459 scopus 로고
    • Inhibition of mitochondrial electron transport by peroxynitrite
    • Radi R, Rodriguez M, Castro L, and Telleri R. Inhibition of mitochondrial electron transport by peroxynitrite. Arch Biochem Biophys 308: 89-95, 1994
    • (1994) Arch Biochem Biophys , vol.308 , pp. 89-95
    • Radi, R.1    Rodriguez, M.2    Castro, L.3    Telleri, R.4
  • 255
    • 0034190372 scopus 로고    scopus 로고
    • Regulation of redox glutathione levels and gene transcription in lung inflammation: Therapeutic approaches
    • Rahman I and MacNee W. Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches. Free Radic Biol Med 28: 1405-1420, 2000
    • (2000) Free Radic Biol Med , vol.28 , pp. 1405-1420
    • Rahman, I.1    MacNee, W.2
  • 257
    • 84867148236 scopus 로고    scopus 로고
    • The impact of lipoic acid on endothelial function and proteinuria in quinapriltreated diabetic patients with stage i hypertension: Results from the quality study
    • Rahman ST, Merchant N, Haque T, Wahi J, Bhaheetharan S, Ferdinand KC, and Khan BV. The impact of lipoic acid on endothelial function and proteinuria in Quinapriltreated diabetic patients with stage I hypertension: results from the quality study. J Cardiovasc Pharmacol Ther 17: 139-145, 2012
    • (2012) J Cardiovasc Pharmacol Ther , vol.17 , pp. 139-145
    • Rahman, S.T.1    Merchant, N.2    Haque, T.3    Wahi, J.4    Bhaheetharan, S.5    Ferdinand, K.C.6    Khan, B.V.7
  • 258
    • 79551470306 scopus 로고    scopus 로고
    • Oxidative stress, insulin signaling, and diabetes
    • Rains JL and Jain SK. Oxidative stress, insulin signaling, and diabetes. Free Radic Biol Med 50: 567-575, 2011
    • (2011) Free Radic Biol Med , vol.50 , pp. 567-575
    • Rains, J.L.1    Jain, S.K.2
  • 260
    • 0030916162 scopus 로고    scopus 로고
    • Randomised trial of alphatocopherol and beta-carotene supplements on incidence of major coronary events in men with previous myocardial infarction
    • Rapola JM, Virtamo J, Ripatti S, Huttunen JK, Albanes D, Taylor PR, and Heinonen OP. Randomised trial of alphatocopherol and beta-carotene supplements on incidence of major coronary events in men with previous myocardial infarction. Lancet 349: 1715-1720, 1997
    • (1997) Lancet , vol.349 , pp. 1715-1720
    • Rapola, J.M.1    Virtamo, J.2    Ripatti, S.3    Huttunen, J.K.4    Albanes, D.5    Taylor, P.R.6    Heinonen, O.P.7
  • 263
    • 0037423550 scopus 로고    scopus 로고
    • Beta-Adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-jun nh2-Terminal kinase-dependent activation of the mitochondrial pathway
    • Remondino A, Kwon SH, Communal C, Pimentel DR, Sawyer DB, Singh K, and Colucci WS. Beta-Adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-Terminal kinase-dependent activation of the mitochondrial pathway. Circ Res 92: 136-138, 2003
    • (2003) Circ Res , vol.92 , pp. 136-138
    • Remondino, A.1    Kwon, S.H.2    Communal, C.3    Pimentel, D.R.4    Sawyer, D.B.5    Singh, K.6    Colucci, W.S.7
  • 264
    • 59249103720 scopus 로고    scopus 로고
    • Oral sulforaphane increases phase ii antioxidant enzymes in the human upper airway
    • Riedl MA, Saxon A, and Diaz-Sanchez D. Oral sulforaphane increases phase II antioxidant enzymes in the human upper airway. Clin Immunol 130: 244-251, 2009
    • (2009) Clin Immunol , vol.130 , pp. 244-251
    • Riedl, M.A.1    Saxon, A.2    Diaz-Sanchez, D.3
  • 265
    • 84872715073 scopus 로고    scopus 로고
    • High dietary fat selectively increases catalase expression within cardiac mitochondria
    • Rindler PM, Plafker SM, Szweda LI, and Kinter M. High dietary fat selectively increases catalase expression within cardiac mitochondria. J Biol Chem 288: 1979-1990, 2013
    • (2013) J Biol Chem , vol.288 , pp. 1979-1990
    • Rindler, P.M.1    Plafker, S.M.2    Szweda, L.I.3    Kinter, M.4
  • 267
    • 66149115664 scopus 로고    scopus 로고
    • Synthesis of n-Arylpyridinium salts bearing a nitrone spin trap as potential mitochondria-Targeted antioxidants
    • Robertson L and Hartley RC. Synthesis of N-Arylpyridinium salts bearing a nitrone spin trap as potential mitochondria-Targeted antioxidants. Tetrahedron 65: 5284-5292, 2009
    • (2009) Tetrahedron , vol.65 , pp. 5284-5292
    • Robertson, L.1    Hartley, R.C.2
  • 268
    • 84895057773 scopus 로고    scopus 로고
    • Perspectives and potential applications of mitochondria-Targeted antioxidants in cardiometabolic diseases and type 2 diabetes
    • Rocha M, Apostolova N, Herance JR, Rovira-Llopis S, Hernandez-Mijares A, and Victor VM. Perspectives and potential applications of mitochondria-Targeted antioxidants in cardiometabolic diseases and type 2 diabetes. Med Res Rev 34: 160-189, 2014
    • (2014) Med Res Rev , vol.34 , pp. 160-189
    • Rocha, M.1    Apostolova, N.2    Herance, J.R.3    Rovira-Llopis, S.4    Hernandez-Mijares, A.5    Victor, V.M.6
  • 272
    • 75849164405 scopus 로고    scopus 로고
    • Mitochondrial biotransformation of omega-(phenoxy)alkanoic acids, 3-(phenoxy)acrylic acids, and omega-(1-methyl-1h-imidazol-2-ylthio)alkanoic acids: A prodrug strategy for targeting cytoprotective antioxidants to mitochondria
    • Roser KS, Brookes PS, Wojtovich AP, Olson LP, Shojaie J, Parton RL, and Anders MW. Mitochondrial biotransformation of omega-(phenoxy)alkanoic acids, 3-(phenoxy)acrylic acids, and omega-(1-methyl-1H-imidazol-2-ylthio)alkanoic acids: a prodrug strategy for targeting cytoprotective antioxidants to mitochondria. Bioorg Med Chem 18: 1441-1448, 2010
    • (2010) Bioorg Med Chem , vol.18 , pp. 1441-1448
    • Roser, K.S.1    Brookes, P.S.2    Wojtovich, A.P.3    Olson, L.P.4    Shojaie, J.5    Parton, R.L.6    Anders, M.W.7
  • 274
    • 0023990311 scopus 로고
    • Deactivation of singlet molecular oxygen by thiols and related compounds, possible protectors against skin photosensitivity
    • Rougee M, Bensasson RV, Land EJ, and Pariente R. Deactivation of singlet molecular oxygen by thiols and related compounds, possible protectors against skin photosensitivity. Photochem Photobiol 47: 485-489, 1988
    • (1988) Photochem Photobiol , vol.47 , pp. 485-489
    • Rougee, M.1    Bensasson, R.V.2    Land, E.J.3    Pariente, R.4
  • 277
    • 20444419056 scopus 로고    scopus 로고
    • Paraoxonase 1 (pon1) attenuates macrophage oxidative status: Studies in pon1 transfected cells and in pon1 transgenic mice
    • Rozenberg O, Shih DM, and Aviram M. Paraoxonase 1 (PON1) attenuates macrophage oxidative status: studies in PON1 transfected cells and in PON1 transgenic mice. Atherosclerosis 181: 9-18, 2005
    • (2005) Atherosclerosis , vol.181 , pp. 9-18
    • Rozenberg, O.1    Shih, D.M.2    Aviram, M.3
  • 279
    • 73449143152 scopus 로고    scopus 로고
    • Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and n-Acetylcysteine
    • Saito C, Zwingmann C, and Jaeschke H. Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-Acetylcysteine. Hepatology 51: 246-254, 2010
    • (2010) Hepatology , vol.51 , pp. 246-254
    • Saito, C.1    Zwingmann, C.2    Jaeschke, H.3
  • 283
    • 33745742255 scopus 로고    scopus 로고
    • Shared components of mitochondrial and peroxisomal division
    • Schrader M. Shared components of mitochondrial and peroxisomal division. Biochim Biophys Acta 1763: 531-541, 2006
    • (2006) Biochim Biophys Acta , vol.1763 , pp. 531-541
    • Schrader, M.1
  • 284
    • 34247186472 scopus 로고    scopus 로고
    • Reactive oxygen species are essential for autophagy and specifically regulate the activity of atg4
    • Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, and Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 26: 1749-1760, 2007
    • (2007) EMBO J , vol.26 , pp. 1749-1760
    • Scherz-Shouval, R.1    Shvets, E.2    Fass, E.3    Shorer, H.4    Gil, L.5    Elazar, Z.6
  • 285
    • 2342567868 scopus 로고    scopus 로고
    • Oxidative stress, antioxidants, and endothelial function
    • Schulz E, Anter E, and Keaney JF. Oxidative stress, antioxidants, and endothelial function. Curr Med Chem 11: 1093-1104, 2004
    • (2004) Curr Med Chem , vol.11 , pp. 1093-1104
    • Schulz, E.1    Anter, E.2    Keaney, J.F.3
  • 286
    • 84874645124 scopus 로고    scopus 로고
    • Mitochondrialassociated nitric oxide synthase activity inhibits cytochrome c oxidase: Implications for breast cancer
    • Sen S, Kawahara B, and Chaudhuri G. Mitochondrialassociated nitric oxide synthase activity inhibits cytochrome c oxidase: implications for breast cancer. Free Radic Biol Med 57: 210-220, 2013
    • (2013) Free Radic Biol Med , vol.57 , pp. 210-220
    • Sen, S.1    Kawahara, B.2    Chaudhuri, G.3
  • 287
    • 77955650026 scopus 로고    scopus 로고
    • Targeting mitochondria: A new promising approach for the treatment of liver diseases
    • Serviddio G, Bellanti F, Sastre J, Vendemiale G, and Altomare E. Targeting mitochondria: a new promising approach for the treatment of liver diseases. Curr Med Chem 17: 2325-2337, 2010
    • (2010) Curr Med Chem , vol.17 , pp. 2325-2337
    • Serviddio, G.1    Bellanti, F.2    Sastre, J.3    Vendemiale, G.4    Altomare, E.5
  • 292
    • 84888012439 scopus 로고    scopus 로고
    • Cationic antioxidants as a powerful tool against mitochondrial oxidative stress
    • Skulachev VP. Cationic antioxidants as a powerful tool against mitochondrial oxidative stress. Biochem Biophys Res Commun 441: 275-279, 2013
    • (2013) Biochem Biophys Res Commun , vol.441 , pp. 275-279
    • Skulachev, V.P.1
  • 296
    • 77955283395 scopus 로고    scopus 로고
    • Animal and human studies with the mitochondria-Targeted antioxidant mitoq
    • Smith RA and Murphy MP. Animal and human studies with the mitochondria-Targeted antioxidant MitoQ. Ann N Y Acad Sci 1201: 96-103, 2010
    • (2010) Ann N y Acad Sci , vol.1201 , pp. 96-103
    • Smith, R.A.1    Murphy, M.P.2
  • 297
    • 79957764437 scopus 로고    scopus 로고
    • Mitochondria-Targeted antioxidants as therapies
    • Smith RA and Murphy MP. Mitochondria-Targeted antioxidants as therapies. Discov Med 11: 106-114, 2011
    • (2011) Discov Med , vol.11 , pp. 106-114
    • Smith, R.A.1    Murphy, M.P.2
  • 300
    • 33749018509 scopus 로고    scopus 로고
    • Recent advances in fluorescent probes for the detection of reactive oxygen species
    • Soh N. Recent advances in fluorescent probes for the detection of reactive oxygen species. Anal Bioanal Chem 386: 532-543, 2006
    • (2006) Anal Bioanal Chem , vol.386 , pp. 532-543
    • Soh, N.1
  • 304
    • 45849100922 scopus 로고    scopus 로고
    • Evaluation of euk-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure
    • Srinivasan V, Doctrow S, Singh VK, and Whitnall MH. Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol 30: 271-290, 2008
    • (2008) Immunopharmacol Immunotoxicol , vol.30 , pp. 271-290
    • Srinivasan, V.1    Doctrow, S.2    Singh, V.K.3    Whitnall, M.H.4
  • 305
    • 84889684332 scopus 로고    scopus 로고
    • Alzheimers disease-like pathology in senescence-Accelerated oxys rats can be partially retarded with mitochondria-Targeted antioxidant skq1
    • Stefanova NA, Muraleva NA, Skulachev VP, and Kolosova NG. Alzheimers disease-like pathology in senescence-Accelerated OXYS rats can be partially retarded with mitochondria-Targeted antioxidant SkQ1. J Alzheimers Dis 38: 681-694, 2014
    • (2014) J Alzheimers Dis , vol.38 , pp. 681-694
    • Stefanova, N.A.1    Muraleva, N.A.2    Skulachev, V.P.3    Kolosova, N.G.4
  • 306
    • 84872865639 scopus 로고    scopus 로고
    • Oxidative stress and sarcomeric proteins
    • Steinberg SF. Oxidative stress and sarcomeric proteins. Circ Res 112: 393-405, 2013
    • (2013) Circ Res , vol.112 , pp. 393-405
    • Steinberg, S.F.1
  • 307
    • 0033898870 scopus 로고    scopus 로고
    • The effect of oral n-Acetylcysteine in chronic bronchitis: A quantitative systematic review
    • Stey C, Steurer J, Bachmann S, Medici TC, and Tramer MR. The effect of oral N-Acetylcysteine in chronic bronchitis: a quantitative systematic review. Eur Respir J 16: 253-262, 2000
    • (2000) Eur Respir J , vol.16 , pp. 253-262
    • Stey, C.1    Steurer, J.2    Bachmann, S.3    Medici, T.C.4    Tramer, M.R.5
  • 308
    • 16644396973 scopus 로고    scopus 로고
    • Therapeutic uses of antioxidant liposomes
    • Stone WL and Smith M. Therapeutic uses of antioxidant liposomes. Mol Biotechnol 27: 217-230, 2004
    • (2004) Mol Biotechnol , vol.27 , pp. 217-230
    • Stone, W.L.1    Smith, M.2
  • 309
    • 33746861543 scopus 로고    scopus 로고
    • Protective effect of vitamin e supplements on experimental atherosclerosis is modest and depends on preexisting vitamin e deficiency
    • Suarna C, Wu BJ, Choy K, Mori T, Croft K, Cynshi O, and Stocker R. Protective effect of vitamin E supplements on experimental atherosclerosis is modest and depends on preexisting vitamin E deficiency. Free Radic Biol Med 41: 722-730, 2006
    • (2006) Free Radic Biol Med , vol.41 , pp. 722-730
    • Suarna, C.1    Wu, B.J.2    Choy, K.3    Mori, T.4    Croft, K.5    Cynshi, O.6    Stocker, R.7
  • 310
    • 0035087926 scopus 로고    scopus 로고
    • Oxidative stress in the aging rat heart is reversed by dietary supplementation with (r)-(alpha)-lipoic acid
    • Suh JH, Shigeno ET, Morrow JD, Cox B, Rocha AE, Frei B, and Hagen TM. Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid. FASEB J 15: 700-706, 2001
    • (2001) FASEB J , vol.15 , pp. 700-706
    • Suh, J.H.1    Shigeno, E.T.2    Morrow, J.D.3    Cox, B.4    Rocha, A.E.5    Frei, B.6    Hagen, T.M.7
  • 311
    • 77950674153 scopus 로고    scopus 로고
    • Interaction of yeast mitochondria with fatty acids and mitochondria-Targeted lipophilic cations
    • Sukhanova EI, Trendeleva TA, and Zvyagilskaya RA. Interaction of yeast mitochondria with fatty acids and mitochondria-Targeted lipophilic cations. Biochemistry (Mosc) 75: 139-144, 2010
    • (2010) Biochemistry (Mosc , vol.75 , pp. 139-144
    • Sukhanova, E.I.1    Trendeleva, T.A.2    Zvyagilskaya, R.A.3
  • 312
    • 1442314722 scopus 로고    scopus 로고
    • Early vitamin e supplementation in young but not aged mice reduces abeta levels and amyloid deposition in a transgenic model of alzheimers disease
    • Sung S, Yao Y, Uryu K, Yang H, Lee VM, Trojanowski JQ, and Praticò D. Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimers disease. FASEB J 18: 323-325, 2004
    • (2004) FASEB J , vol.18 , pp. 323-325
    • Sung, S.1    Yao, Y.2    Uryu, K.3    Yang, H.4    Lee, V.M.5    Trojanowski, J.Q.6    Praticò, D.7
  • 314
    • 84878572136 scopus 로고    scopus 로고
    • Toward clinical application of the keap1-nrf2 pathway
    • Suzuki T, Motohashi H, and Yamamoto M. Toward clinical application of the Keap1-Nrf2 pathway. Trends Pharmacol Sci 34: 340-346, 2013
    • (2013) Trends Pharmacol Sci , vol.34 , pp. 340-346
    • Suzuki, T.1    Motohashi, H.2    Yamamoto, M.3
  • 315
    • 33646369165 scopus 로고    scopus 로고
    • Cell-permeable, mitochondrial-Targeted, peptide antioxidants
    • Szeto HH. Cell-permeable, mitochondrial-Targeted, peptide antioxidants. AAPS J 8: 277-283, 2006
    • (2006) AAPS J , vol.8 , pp. 277-283
    • Szeto, H.H.1
  • 316
    • 38349010993 scopus 로고    scopus 로고
    • Mitochondria-Targeted cytoprotective peptides for ischemia-reperfusion injury
    • Szeto HH. Mitochondria-Targeted cytoprotective peptides for ischemia-reperfusion injury. Antioxid Redox Signal 10: 601-619, 2008
    • (2008) Antioxid Redox Signal , vol.10 , pp. 601-619
    • Szeto, H.H.1
  • 317
    • 84856228755 scopus 로고    scopus 로고
    • Novel therapies targeting inner mitochondrial membrane-from discovery to clinical development
    • Szeto HH and Schiller PW. Novel therapies targeting inner mitochondrial membrane-from discovery to clinical development. Pharm Res 28: 2669-2679, 2011
    • (2011) Pharm Res , vol.28 , pp. 2669-2679
    • Szeto, H.H.1    Schiller, P.W.2
  • 318
    • 84901826643 scopus 로고    scopus 로고
    • The er mitochondria calcium cycle and er stress response as therapeutic targets in amyotrophic lateral sclerosis
    • Tadic V, Prell T, Lautenschlaeger J, and Grosskreutz J. The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis. Front Cell Neurosci 8: 147, 2014
    • (2014) Front Cell Neurosci , vol.8 , Issue.147
    • Tadic, V.1    Prell, T.2    Lautenschlaeger, J.3    Grosskreutz, J.4
  • 319
    • 77950901103 scopus 로고    scopus 로고
    • Induction of manganese superoxide dismutase by nuclear translocation and activation of sirt1 promotes cell survival in chronic heart failure
    • Tanno M, Kuno A, Yano T, Miura T, Hisahara S, Ishikawa S, Shimamoto K, and Horio Y. Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. J Biol Chem 285: 8375-8382, 2010
    • (2010) J Biol Chem , vol.285 , pp. 8375-8382
    • Tanno, M.1    Kuno, A.2    Yano, T.3    Miura, T.4    Hisahara, S.5    Ishikawa, S.6    Shimamoto, K.7    Horio, Y.8
  • 320
    • 0020602234 scopus 로고
    • Acetylcysteine (fabrol) in chronic bronchitis-A study on general practice
    • Tattersall AB, Bridgman KM, and Huitson A. Acetylcysteine (Fabrol) in chronic bronchitis-A study on general practice. J Int Med Res 11: 279-284, 1983
    • (1983) J Int Med Res , vol.11 , pp. 279-284
    • Tattersall, A.B.1    Bridgman, K.M.2    Huitson, A.3
  • 321
    • 0023392045 scopus 로고
    • Efficacy of pt(rh-123)2 as a radiosensitizer with fractionated x rays
    • Teicher BA, Holden SA, and Cathcart KN. Efficacy of Pt(Rh-123)2 as a radiosensitizer with fractionated X rays. Int J Radiat Oncol Biol Phys 13: 1217-1224, 1987
    • (1987) Int J Radiat Oncol Biol Phys , vol.13 , pp. 1217-1224
    • Teicher, B.A.1    Holden, S.A.2    Cathcart, K.N.3
  • 322
    • 0010607277 scopus 로고
    • The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers inmale smokers
    • The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers inmale smokers. N Engl J Med 330: 1029-1035, 1994
    • (1994) N Engl J Med , vol.330 , pp. 1029-1035
  • 324
    • 84880349078 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol in obesity and type 2 diabetes: New avenues for health benefits
    • Timmers S, Hesselink MK, and Schrauwen P. Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits? Ann N Y Acad Sci 1290: 83-89, 2013
    • (2013) Ann N y Acad Sci , vol.1290 , pp. 83-89
    • Timmers, S.1    Hesselink, M.K.2    Schrauwen, P.3
  • 327
  • 328
    • 84895063161 scopus 로고    scopus 로고
    • Characterization of acute and chronic neuropathies induced by oxaliplatin in mice and differential effects of a novel mitochondria-Targeted antioxidant on the neuropathies
    • Toyama S, Shimoyama N, Ishida Y, Koyasu T, Szeto HH, and Shimoyama M. Characterization of acute and chronic neuropathies induced by oxaliplatin in mice and differential effects of a novel mitochondria-Targeted antioxidant on the neuropathies. Anesthesiology 120: 459-473, 2014
    • (2014) Anesthesiology , vol.120 , pp. 459-473
    • Toyama, S.1    Shimoyama, N.2    Ishida, Y.3    Koyasu, T.4    Szeto, H.H.5    Shimoyama, M.6
  • 329
    • 84867490368 scopus 로고    scopus 로고
    • N-Acetylcysteine inhibits platelet-monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: A randomised controlled trial
    • Treweeke AT, Winterburn TJ, MacKenzie I, Barrett F, Barr C, Rushworth GF, Dransfield I, MacRury SM, and Megson IL. N-Acetylcysteine inhibits platelet-monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial. Diabetologia 55: 2920-2928, 2012
    • (2012) Diabetologia , vol.55 , pp. 2920-2928
    • Treweeke, A.T.1    Winterburn, T.J.2    MacKenzie, I.3    Barrett, F.4    Barr, C.5    Rushworth, G.F.6    Dransfield, I.7    MacRury, S.M.8    Megson, I.L.9
  • 330
    • 40949161089 scopus 로고    scopus 로고
    • A mitochondria-Targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria
    • Trnka J, Blaikie FH, Smith RA, and Murphy MP A mitochondria-Targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria. Free Radic Biol Med 44: 1406-1419, 2008
    • (2008) Free Radic Biol Med , vol.44 , pp. 1406-1419
    • Trnka, J.1    Blaikie, F.H.2    Smith, R.A.3    Murphy, M.P.4
  • 334
    • 84880392788 scopus 로고    scopus 로고
    • What is new for resveratrol is a new set of recommendations necessary
    • Vang O. What is new for resveratrol? Is a new set of recommendations necessary? Ann N Y Acad Sci 1290: 1-11, 2013
    • (2013) Ann N y Acad Sci , vol.1290 , pp. 1-11
    • Vang, O.1
  • 336
    • 84855223468 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial dysfunction in type 2 diabetes
    • Victor VM, Rocha M, Herance R, and Hernandez-Mijares A. Oxidative stress and mitochondrial dysfunction in type 2 diabetes. Curr Pharm Des 17: 3947-3958, 2011
    • (2011) Curr Pharm des , vol.17 , pp. 3947-3958
    • Victor, V.M.1    Rocha, M.2    Herance, R.3    Hernandez-Mijares, A.4
  • 337
    • 84921927792 scopus 로고    scopus 로고
    • Resveratrol preserves mitochondrial function stimulates mitochondrial biogenesis and attenuates oxidative stress in regulatory t cells of mice fed a high-fat diet
    • Wang B, Sun J, Ma Y, Wu G, Tian Y, Shi Y, and Le G. Resveratrol preserves mitochondrial function, stimulates mitochondrial biogenesis, and attenuates oxidative stress in regulatory T cells of mice fed a high-fat diet. J Food Sci 79: 1823-1831, 2014
    • (2014) J Food Sci , vol.79 , pp. 1823-1831
    • Wang, B.1    Sun, J.2    Ma, Y.3    Wu, G.4    Tian, Y.5    Shi, Y.6    Le, G.7
  • 338
    • 78651232227 scopus 로고    scopus 로고
    • Mir-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1
    • Wang JX, Jiao JQ, Li Q, Long B, Wang K, Liu JP, Li YR, and Li PF. miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nat Med 17: 71-78, 2011
    • (2011) Nat Med , vol.17 , pp. 71-78
    • Wang, J.X.1    Jiao, J.Q.2    Li, Q.3    Long, B.4    Wang, K.5    Liu, J.P.6    Li, Y.R.7    Li, P.F.8
  • 339
    • 84864067411 scopus 로고    scopus 로고
    • Quantitative assessment of the influence of paraoxonase 1 activity and coronary heart disease risk
    • Wang M, Lang X, Cui S, Zou L, Cao J, Wang S, and Wu X. Quantitative assessment of the influence of paraoxonase 1 activity and coronary heart disease risk. DNA Cell Biol 31: 975-982, 2012
    • (2012) DNA Cell Biol , vol.31 , pp. 975-982
    • Wang, M.1    Lang, X.2    Cui, S.3    Zou, L.4    Cao, J.5    Wang, S.6    Wu, X.7
  • 341
    • 80052823577 scopus 로고    scopus 로고
    • Alpha lipoic acid protects against myocardial ischemia/reperfusion injury via multiple target effects
    • Wang X, Yu Y, Ji L, Liang X, Zhang T, and Hai C. Alpha lipoic acid protects against myocardial ischemia/reperfusion injury via multiple target effects. Food Chem Toxicol 49: 2750-2757, 2011
    • (2011) Food Chem Toxicol , vol.49 , pp. 2750-2757
    • Wang, X.1    Yu, Y.2    Ji, L.3    Liang, X.4    Zhang, T.5    Hai, C.6
  • 342
    • 80053602345 scopus 로고    scopus 로고
    • Protective efficacy of mitochondrial targeted antioxidant mitoq against dichlorvos induced oxidative stress and cell death in rat brain
    • Wani WY, Gudup S, Sunkaria A, Bal A, Singh PP, Kandimalla RJ, Sharma DR, and Gill KD. Protective efficacy of mitochondrial targeted antioxidant MitoQ against dichlorvos induced oxidative stress and cell death in rat brain. Neuropharmacology 61: 1193-1201, 2011
    • (2011) Neuropharmacology , vol.61 , pp. 1193-1201
    • Wani, W.Y.1    Gudup, S.2    Sunkaria, A.3    Bal, A.4    Singh, P.P.5    Kandimalla, R.J.6    Sharma, D.R.7    Gill, K.D.8
  • 343
    • 33645236199 scopus 로고    scopus 로고
    • Health benefits of physical activity: The evidence
    • Warburton DE, Nicol CW, and Bredin SS. Health benefits of physical activity: the evidence. Can Med Ass J 174: 801-809, 2006
    • (2006) Can Med Ass J , vol.174 , pp. 801-809
    • Warburton, D.E.1    Nicol, C.W.2    Bredin, S.S.3
  • 344
    • 34248182897 scopus 로고    scopus 로고
    • Bax/bak promote sumoylation of drp1 and its stable association with mitochondria turing apoptotic cell death
    • Wasiak S, Zunino R, and McBride HM. Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria Turing apoptotic cell death. J Cell Biol 177: 439-450, 2007
    • (2007) J Cell Biol , vol.177 , pp. 439-450
    • Wasiak, S.1    Zunino, R.2    McBride, H.M.3
  • 345
    • 0033133426 scopus 로고    scopus 로고
    • Lack of effect of coenzyme q on left ventricular function in patients with congestive heart failure
    • Watson PS, Scalia GM, Galbraith A, Burstow DJ, Bett N, and Aroney CN. Lack of effect of coenzyme Q on left ventricular function in patients with congestive heart failure. J Am Coll Cardiol 33: 1549-1552, 1999
    • (1999) J Am Coll Cardiol , vol.33 , pp. 1549-1552
    • Watson, P.S.1    Scalia, G.M.2    Galbraith, A.3    Burstow, D.J.4    Bett, N.5    Aroney, C.N.6
  • 346
    • 33750449016 scopus 로고    scopus 로고
    • Increases in mitochondrial reactive oxygen species trigger hypoxia-induced calcium responses in pulmonary artery smooth muscle cells
    • Waypa GB, Guzy R, Mungai PT, Mack MM, Marks JD, Roe MW, and Schumacker PT. Increases in mitochondrial reactive oxygen species trigger hypoxia-induced calcium responses in pulmonary artery smooth muscle cells. Circ Res 99: 970-978, 2006
    • (2006) Circ Res , vol.99 , pp. 970-978
    • Waypa, G.B.1    Guzy, R.2    Mungai, P.T.3    MacK, M.M.4    Marks, J.D.5    Roe, M.W.6    Schumacker, P.T.7
  • 348
    • 84911875444 scopus 로고    scopus 로고
    • Role of reactive oxygen species in neonatal pulmonary vascular disease
    • Wedgwood S and Steinhorn RH. Role of reactive oxygen species in neonatal pulmonary vascular disease. Antioxid Redox Signal 21: 1926-1942, 2014
    • (2014) Antioxid Redox Signal , vol.21 , pp. 1926-1942
    • Wedgwood, S.1    Steinhorn, R.H.2
  • 349
    • 0035839167 scopus 로고    scopus 로고
    • Dqasome/dna complexes release dna upon contact with isolated mouse liver mitochondria
    • Weissig V, DSouza GG, and Torchilin VP. DQAsome/DNA complexes release DNA upon contact with isolated mouse liver mitochondria. J Control Release 75: 401-408, 2001
    • (2001) J Control Release , vol.75 , pp. 401-408
    • Weissig, V.1    Dsouza, G.G.2    Torchilin, V.P.3
  • 352
    • 38349002464 scopus 로고    scopus 로고
    • Do mitochondriotropic antioxidants prevent chlorinative stress-induced mitochondrial and cellular injury
    • Whiteman M, Spencer JP, Szeto HH, and Armstrong JS. Do mitochondriotropic antioxidants prevent chlorinative stress-induced mitochondrial and cellular injury? Antioxid Redox Signal 10: 641-650, 2008
    • (2008) Antioxid Redox Signal , vol.10 , pp. 641-650
    • Whiteman, M.1    Spencer, J.P.2    Szeto, H.H.3    Armstrong, J.S.4
  • 353
    • 58149084932 scopus 로고    scopus 로고
    • Chemistry and antihypertensive effects of tempol and other nitroxides
    • Wilcox CS and Pearlman A. Chemistry and antihypertensive effects of tempol and other nitroxides. Pharmacol Rev 60: 418-469, 2008
    • (2008) Pharmacol Rev , vol.60 , pp. 418-469
    • Wilcox, C.S.1    Pearlman, A.2
  • 354
    • 24744454824 scopus 로고    scopus 로고
    • Mitochondrial targeting of selective electron scavengers: Synthesis and biological analysis of hemigramicidin-Tempo conjugates
    • Wipf P, Xiao J, Jiang J, Belikova NA, Tyurin VA, Fink MP, and Kagan VE. Mitochondrial targeting of selective electron scavengers: synthesis and biological analysis of hemigramicidin-TEMPO conjugates. J Am Chem Soc 127: 12460-12461, 2005
    • (2005) J Am Chem Soc , vol.127 , pp. 12460-12461
    • Wipf, P.1    Xiao, J.2    Jiang, J.3    Belikova, N.A.4    Tyurin, V.A.5    Fink, M.P.6    Kagan, V.E.7
  • 355
    • 77955423341 scopus 로고    scopus 로고
    • Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by rosdependent erk and jnk activation
    • Wong CH, Iskandar KB, Yadav SK, Hirpara JL, Loh T, and Pervaiz S. Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROSdependent ERK and JNK activation. PLoS One 5: e9996, 2010
    • (2010) PLoS One , vol.5 , pp. e9996
    • Wong, C.H.1    Iskandar, K.B.2    Yadav, S.K.3    Hirpara, J.L.4    Loh, T.5    Pervaiz, S.6
  • 357
    • 0025897521 scopus 로고
    • Trolox protects rat hepatocytes against oxyradical damage and the ischemic rat liver from reperfusion injury
    • Wu TW, Hashimoto N, Au JX, Wu J, Mickle DA, and Carey D. Trolox protects rat hepatocytes against oxyradical damage and the ischemic rat liver from reperfusion injury. Hepatology 13: 575-580, 1991
    • (1991) Hepatology , vol.13 , pp. 575-580
    • Wu, T.W.1    Hashimoto, N.2    Au, J.X.3    Wu, J.4    Mickle, D.A.5    Carey, D.6
  • 360
    • 0032482126 scopus 로고    scopus 로고
    • Inhibition of rat cardiac muscle contraction and mitochondrial respiration by endogenous peroxynitrite formation during posthypoxic reoxygenation
    • Xie YW, Kaminski PM, and Wolin MS. Inhibition of rat cardiac muscle contraction and mitochondrial respiration by endogenous peroxynitrite formation during posthypoxic reoxygenation. Circ Res 82: 891-897, 1998
    • (1998) Circ Res , vol.82 , pp. 891-897
    • Xie, Y.W.1    Kaminski, P.M.2    Wolin, M.S.3
  • 361
    • 79961023252 scopus 로고    scopus 로고
    • Dual function mito-porter, a nano carrier integrating both efficient cytoplasmic delivery and mitochondrial macromolecule delivery
    • Yamada Y, Furukawa R, Yasuzaki Y, and Harashima H. Dual function MITO-Porter, a nano carrier integrating both efficient cytoplasmic delivery and mitochondrial macromolecule delivery. Mol Ther 19: 1449-1456, 2011
    • (2011) Mol Ther , vol.19 , pp. 1449-1456
    • Yamada, Y.1    Furukawa, R.2    Yasuzaki, Y.3    Harashima, H.4
  • 362
    • 51249109260 scopus 로고    scopus 로고
    • Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases
    • Yamada Y and Harashima H. Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases. Adv Drug Deliv Rev 60: 1439-1462, 2008
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 1439-1462
    • Yamada, Y.1    Harashima, H.2
  • 363
    • 84882827086 scopus 로고    scopus 로고
    • Enhancement in selective mitochondrial association by direct modification of a mitochondrial targeting signal peptide on a liposomal based nanocarrier
    • Yamada Y and Harashima H. Enhancement in selective mitochondrial association by direct modification of a mitochondrial targeting signal peptide on a liposomal based nanocarrier. Mitochondrion 13: 526-532, 2013
    • (2013) Mitochondrion , vol.13 , pp. 526-532
    • Yamada, Y.1    Harashima, H.2
  • 364
    • 0030881686 scopus 로고    scopus 로고
    • Oxidative damage during aging targets mitochondrial aconitase
    • Yan LJ, Levine RL, and Sohal RS. Oxidative damage during aging targets mitochondrial aconitase. Proc Natl Acad Sci U S A 94: 11168-11172, 1997
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 11168-11172
    • Yan, L.J.1    Levine, R.L.2    Sohal, R.S.3
  • 365
    • 46649120102 scopus 로고    scopus 로고
    • Reactive oxygen species and nitric oxide regulate mitochondria-dependent apoptosis and autophagy in evodiamine-Treated human cervix carcinoma hela cells
    • Yang J, Wu LJ, Tashino S, Onodera S, and Ikejima T. Reactive oxygen species and nitric oxide regulate mitochondria-dependent apoptosis and autophagy in evodiamine-Treated human cervix carcinoma HeLa cells. Free Radic Res 42: 492-504, 2008
    • (2008) Free Radic Res , vol.42 , pp. 492-504
    • Yang, J.1    Wu, L.J.2    Tashino, S.3    Onodera, S.4    Ikejima, T.5
  • 366
    • 68949213947 scopus 로고    scopus 로고
    • Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1 2 3, 6-Tetrahydropyridine neurotoxicity
    • Yang L, Zhao K, Calingasan NY, Luo G, Szeto HH, and Beal MF. Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1, 2, 3, 6-Tetrahydropyridine neurotoxicity. Antioxid Redox Signal 11: 2095-2104, 2009
    • (2009) Antioxid Redox Signal , vol.11 , pp. 2095-2104
    • Yang, L.1    Zhao, K.2    Calingasan, N.Y.3    Luo, G.4    Szeto, H.H.5    Beal, M.F.6
  • 367
    • 0035956862 scopus 로고    scopus 로고
    • Zinc metallothionein imported into liver mitochondria modulates respiration
    • Ye B, Maret W, and Vallee BL. Zinc metallothionein imported into liver mitochondria modulates respiration. Proc Natl Acad Sci U S A 98: 2317-2322, 2001
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 2317-2322
    • Ye, B.1    Maret, W.2    Vallee, B.L.3
  • 368
    • 84900299463 scopus 로고    scopus 로고
    • The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C Elegans
    • Yee C, Yang W, and Hekimi S. The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. Cell 157: 897-909, 2014
    • (2014) Cell , vol.157 , pp. 897-909
    • Yee, C.1    Yang, W.2    Hekimi, S.3
  • 370
    • 70349554126 scopus 로고    scopus 로고
    • Mitochondria-penetrating peptides: Sequence effects and model cargo transport
    • Yousif LF, Stewart KM, Horton KL, and Kelley SO. Mitochondria-penetrating peptides: sequence effects and model cargo transport. Chembiochem 10: 2081-2088, 2009
    • (2009) Chembiochem , vol.10 , pp. 2081-2088
    • Yousif, L.F.1    Stewart, K.M.2    Horton, K.L.3    Kelley, S.O.4
  • 371
    • 70349554208 scopus 로고    scopus 로고
    • Targeting mitochondria with organelle-specific compounds: Strategies and applications
    • Yousif LF, Stewart KM, and Kelley SO. Targeting mitochondria with organelle-specific compounds: strategies and applications. Chembiochem 10: 1939-1950, 2009
    • (2009) Chembiochem , vol.10 , pp. 1939-1950
    • Yousif, L.F.1    Stewart, K.M.2    Kelley, S.O.3
  • 372
    • 33644552417 scopus 로고    scopus 로고
    • Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology
    • Yu T, Robotham JL, and Yoon Y. Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci U S A 103: 2653-2658, 2006
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2653-2658
    • Yu, T.1    Robotham, J.L.2    Yoon, Y.3
  • 374
    • 79851514312 scopus 로고    scopus 로고
    • Newly developed strategies for multifunctional mitochondriatargeted agents in cancer therapy
    • Zhang E, Zhang C, Su Y, Cheng T, and Shi C. Newly developed strategies for multifunctional mitochondriatargeted agents in cancer therapy. Drug Discov Today 16: 140-146, 2011
    • (2011) Drug Discov Today , vol.16 , pp. 140-146
    • Zhang, E.1    Zhang, C.2    Su, Y.3    Cheng, T.4    Shi, C.5
  • 375
    • 67650727404 scopus 로고    scopus 로고
    • Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma u251 cells
    • Zhang H, Kong X, Kang J, Su J, Li Y, Zhong J, and Sun L. Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci 110: 376-388, 2009
    • (2009) Toxicol Sci , vol.110 , pp. 376-388
    • Zhang, H.1    Kong, X.2    Kang, J.3    Su, J.4    Li, Y.5    Zhong, J.6    Sun, L.7
  • 376
    • 79960834542 scopus 로고    scopus 로고
    • Amelioration of lipid abnormalities by alipoic acid through antioxidative and anti-inflammatory effects
    • Zhang Y, Han P, Wu N, He B, Lu Y, Li S, Liu Y, Zhao S, Liu L, and Li Y. Amelioration of lipid abnormalities by alipoic acid through antioxidative and anti-inflammatory effects. Obesity (Silver Spring) 19: 1647-1653, 2011
    • (2011) Obesity (Silver Spring , vol.19 , pp. 1647-1653
    • Zhang, Y.1    Han, P.2    Wu, N.3    He, B.4    Lu, Y.5    Li, S.6    Liu, Y.7    Zhao, S.8    Liu, L.9    Li, Y.10
  • 377
    • 0037215549 scopus 로고    scopus 로고
    • Transcellular transport of a highly polar 3 + net charge opioid tetrapeptide
    • Zhao K, Luo G, Zhao GM, Schiller PW, and Szeto HH. Transcellular transport of a highly polar 3 + net charge opioid tetrapeptide. J Pharmacol Exp Ther 304: 425-432, 2003
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 425-432
    • Zhao, K.1    Luo, G.2    Zhao, G.M.3    Schiller, P.W.4    Szeto, H.H.5
  • 378
    • 4544370680 scopus 로고    scopus 로고
    • Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury
    • Zhao K, Zhao GM, Wu D, Soong Y, Birk AV, Schiller PW, and Szeto HH. Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury. J Biol Chem 279: 34682-34690, 2004
    • (2004) J Biol Chem , vol.279 , pp. 34682-34690
    • Zhao, K.1    Zhao, G.M.2    Wu, D.3    Soong, Y.4    Birk, A.V.5    Schiller, P.W.6    Szeto, H.H.7
  • 379
    • 78651469381 scopus 로고    scopus 로고
    • Ergothioneine prevents copper-induced oxidative damage to dna and protein by forming a redox-inactive ergothioneine-copper complex
    • Zhu BZ, Mao L, Fan RM, Zhu JG, Zhang YN, Wang J, Kalyanaraman B, and Frei B. Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex. Chem Res Toxicol 24: 30-34, 2011
    • (2011) Chem Res Toxicol , vol.24 , pp. 30-34
    • Zhu, B.Z.1    Mao, L.2    Fan, R.M.3    Zhu, J.G.4    Zhang, Y.N.5    Wang, J.6    Kalyanaraman, B.7    Frei, B.8


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