High doses of in vitro beta-carotene, alpha-tocopherol and ascorbic acid induce oxidative stress and secretion of IL-6 in peripheral blood mononuclear cells from healthy donors

Current Aging Science

Volumn 5, Issue 2, 2012, Pages 148-156

  de Oliveira, Barbara Fonseca ^a   Veloso, Clara Araújo ^a   Nogueira Machado, José Augusto ^b   Chaves, Miriam Martins ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b Santa Casa de Belo Horizonte (SCBH)   (Brazil)

Author keywords

Free radicals; Immune system; In vitro; Interleukins; Oxidative stress; Vitamins

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; FREE RADICAL; INTERLEUKIN 6;

ADULT; AGED; ANTIOXIDANT ACTIVITY; ARTICLE; CHEMOLUMINESCENCE; CONCENTRATION RESPONSE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GROUPS BY AGE; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TEMPERATURE; INFLAMMATION; MALE; NORMAL HUMAN; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL;

EID: 84862624100     PISSN: 18746098     EISSN: 18746128     Source Type: Journal    
DOI: 10.2174/1874609811205020148     Document Type: Article

References (50)

1. Harman, D. The aging process. Proc Natl Acad Sci USA 1981; 78: 7124-128.
2. Aoi W, Sakuma K. Oxidative stress and skeletal muscle dysfunction with aging. Curr Aging Sci 2011;4(2):101-9.
3. Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottaviani E, et al. Inflamm-aging: An Evolutionary Perspective on Immunosenescence. Ann NY Acad Sci 2000; 98: 244-54.
4. Park KW, Baik HH, Jin BK. Interleukin-4-induced oxidative stress via microglial NADPH oxidase contributes to the death of hippocampal neurons in vivo. Curr Aging Sci 2008; 1(3): 192-1.
5. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007; 39: 44-84.
6. Alonso-Fernández P, De la Fuente M. Role of the immune system in aging and longevity. Curr Aging Sci 2011;4(2):78-100.
7. Sies H and Stahl W. Vitamins E and C, beta-carotene and other carotenoids as antioxidants. Am J Clin Nutr 1995; 32: 1315S-21S.
8. Komatsu F, Kagawa Y, Kawabata T, Kaneko Y, Chimedregzen U, Purvee B, et al. A high accumulation of hair minerals in Mongolian people: 2(nd) report; influence of manganese, iron, lead, cadmium and aluminum to oxidative stress, Parkinsonism and arthritis. Curr Aging Sci 2011;4(1):42-56.
9. Komatsu F, Kagawa Y, Kawabata T, Kaneko Y, Ishiguro K. Relationship of dietary habits and obesity to oxidative stress in Palauan people: compared with Japanese and Mongolian people. Curr Aging Sci 2009; 2(3):214-22.
10. Halliwell B and Gutteridge JM. The definition and measurement of antioxidants in biological systems. Free Radic Biol Med 1995;18:125-126.
11. Chaves MM, Rocha-Vieira E, de Lima Silva R, Pereira dos Reis A and Nogueira-Machado JA. Host defenses in the aged: evaluation of the balance between oxidizing species generation and reducing power in phagocyting human granulocytes. Mech Ageing Dev 1998; 104: 103-9.
12. Chaves MM, Costa DC, Pereira CC, Andrade TR, Horta BC and Nogueira-Machado JA. Role of inositol 1,4,5 activated protein kinase in reactive oxygen species generation by granulocytes in a cyclic AMP-dependent manner: an age-related phenomenon. Gerontology 2007; 53: 228-33.
13. Ligthart GJ, Schuit, HRE and Hijmans, W. Subpopulations of mononuclear cells in ageing: expansion of the null cell compartment and decrease in the number of T and B cells in human blood. Immunology 1985; 55:15-21.
14. WHO Technical Report Series. Obesity: preventing and managing the global epidemic. Report of a WHO Consultation.Geneva: World Health Organization, 2000.
15. American Diabetes Association. Standards of medical care in diabetes. Diabetes Care 2011, 34(1): S11-61.
16. Miller M, Stone NJ, Ballantyne C, Bittner V, Criqui MH, Ginsberg HN, et al. Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation 2011, 123:2292-333.
17. National Committee for Clinical Laboratory Standards. How to define, determine and utilize reference intervals in the clinical laboratory: Proposed guidelines. 2000, NCCLS document C28-A2.
18. Bicalho HMS, Gontijo, MC and Nogueira-Machado, JA. A simple technique for simultaneous human leukocytes separation. J Immunol Methods 1981; 40:115-16.
19. International Standardization Organization - ISO. Biological evaluation of medical devices. Part 5. Test for cytotoxicity: in vitro methods. 10993-5. 2009.
20. Bergman M, Salman H, Djaldetti M, Fish L, Punsky I, Bessler H. In vitro immune response of human peripheral blood cells to vitamins C and E. J Nutr Biochem 2004; 15: 45-50.
21. Prabhala RH, Maxey V, Hicks MJ and Watson RR. Enhancement of the expression of activation markers on human peripheral blood mononuclear cells by in vitro culture with retinoids and carotenoids. J Leukoc Biol 1989; 45: 249-54.
22. Zhang P and Omaye ST. Beta-carotene and Protein Oxidation: effects of ascorbic acid and alpha-tocopherol. Toxicology 2000; 146: 37-47.
23. Niki E, Noguchi N, Tsuchihashi H and Gotoh N. Interaction among vitamin C, vitamin E and beta-carotene. Am J Clin Nutr 1995; 62:1322-26.
24. Hercberg S, Galan P, Preziosi P, Bertrais S, Mennen L, Malvy D, et al. The SU.VI.MAX Study - A Randomized, Placebo-Controlled Trial of the Health Effects of Antioxidant Vitamins and Minerals. Arch Internl Med 2004; 164: 2335-42.
25. Hamilton IM, Gilmore WS, Benzie IF, Mulholland CW, Strain JJ. Interactions between vitamins c and E in human subjects. Brit J Nutr 2000; 84: 261-67.
26. Fotouhi N, Meydani M, Santos MS, Meydani SN, Hennekens CH and Gaziano JM. Carotenoid and tocopherol concentrations in plasma, peripheral blood mononuclear cells, and red blood cells after long-term beta-carotene supplementation in men. J Clinl Nutr 1996; 63: 553-58.
27. Yamada H, Yamada K, Waki M and Umegaki, K. Lymphocyte and Plasma Vitamin C Levels in Type 2 Diabetic Patients With and Without Diabetes Complications. Diabetes Care 2004; 27: 2491-92.
28. Bergsten P, Amitai G, Kehrl J, Dhariwal KR, Klein HG and Levine M. Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation. J Biol Chem 1990; 265: 2584-87.
29. Miller ER 3rd, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-Analysis: high dosage vitamin E supplementation may increase all cause mortality. Ann Internl Med 2005; 142: 37-46.
30. Bouwens M, Afman LA and Muller M. Fasting induces changes in peripheral blood mononuclear cell gene expression profiles related to increases in fatty acid β-oxidation: functional role of peroxisome proliferator-activated receptor α in human peripheral blood mononuclear cells. Am J Clin Nutr 2007; 86: 1515-23.
31. Galan P, Viteri FE, Bertrais S, Czernichow S, Faure H, Arnaud J, et al. Serum concentrations of beta-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population. Eur J Clin Nutr 2005; 55: 1181-90.
32. Palozza P, Serini S, Trombino S, Lauriola L, Ranelleti FO and Calviello G. Dual role of beta-carotene in combination with cigarette smoke aqueous extract on the formation of mutagenic lipid peroxidation products in lung membranes: dependence on pO2. Carcinogenesis 2006; 27: 2383-91.
33. Brambilla D, Mancuso C, Scuderi MR, Bosco P, Cantarella G, Lempereur L, et al. The role of antioxidant supplement in immune system, neuplastic and neurodegenerative disorders: a point of view for an assessment of the risk/benefit profile. Nutr J 2008; 7: 1-9.
34. Zureik M, Galan P, Bertrais S, Mennen L, Czernichow S, Blacher J, et al. Effects of Long-Term Daily Low-Dose Supplementation with Antioxidant Vitamins and Minerals on Structure and Function of Large Arteries. Arteriosclerosis, Thrombosis and Vascular Biology. J Am Heart Assoc 2004; 24:1485-91.
35. Bjelakovic G, Nikolova D, Simonetti RG and Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Coch Collab 2008; 2.
36. Crisostomo AG, Moreno RB, Navaratnam S, Wilkinson JA and Bisby RH. Generation of superoxide and singlet oxygen from atocopherolquinone and analogues. Free Rad Res 2007; 41: 730-37.
37. Evans P and Haliwell B. Micronutrientes: oxidant/antioxidant status. Brit J Nutr 2001; 85: S67-94.
38. Santos KMO and Barros Filho AA. Consumo de produtos vitamínicos entre universitários de São Paulo. Rev de Saúde Púb 2002; 3.
39. Stanner SA, Hughes J, Kelly CN, Buttriss J. A review of the epidemiological evidence for the antioxidant hypothesis. Pub Health Nutr 2003; 7:407-22.
40. Daudu PA, Kelley DS, Taylor PC, Burri BJ and Wu MM. Effect of a low beta-carotene diet on the immune functions of adult women. Am J Clin Nutr 1994; 60: 969-72.
41. National Academy of Sciences. Institute of Medicine. Food and Nutrition Board Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids 2000.
42. Jones DP. Extracellular Redox State: Refining the Definition of Oxidative Stress in Aging. Rej Res 2006; 9: 169-81.
43. Das S, Mandal AK, Ghosh A, Panda S, Das N, Sarkar S. Nanoparticulated quercetin in combating age related cerebral oxidative injury. Curr Aging Sci 2008;1(3):169-74.
44. Landrier JF, Gouranton E, El Yazidi C, Malezet C, Balaguer P, Borel P, et al. Adiponectin expression is induced by vitamin E via a peroxisome proliferator-activated receptor gamma-dependent mechanism. Endocrinology 2009; 150: 5318-25.
45. Ju J, Picinich SC, Yang Z, Zhao Y, Suh N, Kong AN, et al. Cancer- preventive activities of tocopherols and tocotrienols. Carcinogenesis 2010; 31: 533-42.
46. Gray M, Whitney J. Does Vitamin C Supplementation Promote Pressure Ulcer Healing? J Wound Ostomy Continence Nurs 2003; 30: 245-49.
47. Winklhofer-Roob BM, Meinitzer A, Maritschnegg M, Roob JM, Khoschsorur G, Ribalta J, et al. Effects of Vitamin E Depletion/ Repletion on Biomarkers of Oxidative Stress in Healthy Aging. Ann NY Acad Sci 2004; 1031: 361-64.
48. Soni MG, et al. Safety of vitamins and minerals: controversies and perspective. Toxicol Sci 2010; 118: 348-55.
49. Lin J, Cook NR, Albert C, Zaharris E, Gaziano JM, Van Denburgh M, et al. Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial. J Natl Cancer Inst 2009; 101: 14-23.
50. Maserejian NN, Giovanucci EL, McVary KT and McKinlay JB. Dietary, but not supplemental, intakes of carotenoids and vitamin C are associated with decreased odds of lower urinary tract symptoms in men. J Nutr 2011; 141: 267-73.