Coenzyme Q10 improves contractility of dysfunctional myocardium in chronic heart failure

BioFactors

Volumn 25, Issue 1-4, 2005, Pages 137-145

  Belardinelli, Romualdo ^a   Muçaj, Andi ^a   Lacalaprice, Francesca ^a   Solenghi, Maridia ^b   Principi, Federica ^c   Tiano, Luca ^c   Littarru, Gian Paolo ^c  

^a Ospedale Monospecialistico Cardiologico GM Lancisi   (Italy)

^b Azienda Ospedaliera Umberto I   (Italy)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Chronic heart failure; Coenzyme Q10; Functional capacity; Left ventricular contractility

Indexed keywords

DOBUTAMINE; PLACEBO; Q ABSORB; UBIDECARENONE; DRUG DERIVATIVE; UBIQUINONE;

ABSENCE OF SIDE EFFECTS; ADULT; AGED; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; FEMALE; FUNCTIONAL STATUS; HEART EJECTION FRACTION; HEART FAILURE; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART MUSCLE; HEART MUSCLE CONTRACTILITY; HUMAN; ISCHEMIC HEART DISEASE; MALE; OXYGEN SATURATION; PRIORITY JOURNAL; STRESS ECHOCARDIOGRAPHY; SUPPLEMENTATION; ARTICLE; CHRONIC DISEASE; DRUG EFFECT; EXERCISE TEST; FORWARD HEART FAILURE; HEART CONTRACTION; HEART LEFT VENTRICLE FUNCTION; MIDDLE AGED; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

AGED; CARDIAC OUTPUT, LOW; CHRONIC DISEASE; EXERCISE TEST; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL CONTRACTION; UBIQUINONE; VENTRICULAR FUNCTION, LEFT;

EID: 33746074807     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.5520250115     Document Type: Conference Paper

References (30)

1. 10 protects ischemic myocardium in an open-chest swine model, Clin Invest 71 (1993), s103-s111.
2. 10 as adjunctive therapy in heart failure, Molec Aspects Med 15 (1994), s287-s294.
3. W.L. Beaver, W. Wasserman and B.J. Whipp, A new method for detecting the anaerobic threshold by gas exchange, J Appl Physiol 60 (1986), 2020-2027.
4. R. Belardinelli, D. Georgiou and A. Purcaro, Low dose dobutamine echocardiography predicts improvement in functional capacity after exercise training in patients with ischemic cardiomyopathy: Prognostic implication, J Am Coll Cardiol 31 (1998), 1027-1034.
5. F.L. Crane, Y. Hatefi, P.L. Lester and C. Widmer, Isolation of a quinone from beef heart mitochondria, Biochim Biophys Acta 25 (1957), 220-221.
6. L. Ernster and P. Forsmark-Andrée, Ubiquinol: an endogenous antioxidant in aerobic organisms, Clin Investig 71 (1993), S60-S65.
7. F. Mosca, D. Fattorini, S. Bompadre and G.P. Littarru, Assay of coenzyme Q(10) in plasma by a single dilution step, Anal Biochem 305 (2002), 49-54.
8. K. Folkers, P. Langsjoen, R. Willis, P. Richardson, L. Xia et al., Lovastatin decreases coenzyme Q levels in humans, Proc Nat Acad Sci USA 87 (1990), 8931-8934.
9. R. Hambrecht, E. Fiehn, C. Weigl et al., Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure, Circulation 98 (1998), 2709-2715.
10. 10 as an adjunctive in treatment of congestive heart failure, J Cardiac Failure 1 (1995), 101-107.
11. 10 on exercise tolerance in stable angina pectoris, Am J Cardiol 56 (1985), 247-251.
12. M. Khatta, B.S. Alexander, C.M. Krichten, M.L. Fisher, R. Freudenberger, S.W. Robinson and S.S. Gottlieb, The effect of Coenzyme Q in patients with congestive heart failure, Ann Int Med 132 (2000), 636-640.
13. 10 in cardiovascular disease, BioFactors 9 (1999), 273-284.
14. P. Langsjoen, Lack of effect of Coenzyme Q on left ventricular function in patients with congestive heart failure, J Am Coll Cardiol 35 (2000), 816-817.
15. 10. A review of animal and human publications, BioFactors 18 (2003), 101-112.
16. 10 therapy for idiopathic dilated cardiomyopathy, Am J Cardiol 65 (1990), 521-523.
17. 10 supplementation on human skeletal muscle, Free Radical Research 36 (2002), 445-453.
18. 10 in human heart disease - part I, Int J Vit Nut Res 42 (1972), 291-305.
19. 10 in human heart disease - part II, Int J Vit Nutr Res 42 (1972), 413-434.
20. 10 in patients with chronic stable effort angina and moderate heart failure, Curr Therap Res 6 (1987), 923-928.
21. M.F. McCarty, Coenzyme Q versus hypertension: does CoQ decrease endothelial superoxide generation? Med Hypothesis 53 (1999), 300-304.
22. 10 therapy in patients with congestive heart failure: a long-term multicenter randomized study. K. Folkers, S.A. Mortensen, G.P. Littarru, T. Yamagami and G. Lenaz, eds, Clin Invest 71 (1993), s134-s136.
23. 10 therapy: a major advance in the management of resistant myocardial failure, Drugs Under Exptl & Clin Res 11 (1985), 581-593.
24. S. Passi, A. Stancato, E. Aleo, A. Dmitrieva and G.P. Littarru, Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA, BioFactors 18 (2003), 113-124.
25. 10 and superoxide anion. Could ubiquinones mimic superoxide dismutase (SOD)? Res Chem Intermed 26 (2000), 269-282.
26. W.H. Schaefer, J.W. Lawrence, A.F. Loughlin, D.A. Stoffregen, L.A. Mixson, D.C. Dean, C.E. Raab, N.X. Yu, G.R. Lankas and C.B. Fredrick, Evaluation of ubiquinone concentration and mitochondrial function relative to cerivastatin-induced skeletal myopathy in rats, Toxicology and Applied Pharmacology 194 (2004), 10-23.
27. 10 illuminated by meta-analyses of clinical trials, Molecular Aspects of Medicine 18 (1997), s159-s168.
28. 10 ratio as a possible marker of increased risk for atherosclerosis, BioFactors 9 (1999), 231-240.
29. P.S. Watson, G.M. Scalia, A. Galbraith, D.J. Burstow, N. Bett and C.N. Aroney, Lack of effect of coenzyme Q on left ventricular function in patients with congestive heart failure, J Am Coll Cardiol 33 (1999), 1549-1552.
30. Y. Yamamoto and S. Yamashita, Plasma ubiquinone to ubiquinol ratio in patients with hepatitis, cirrhosis and hepatoma, and in patients treated with percutaneous transluminal coronary reperfusion, BioFactors 9 (1999), 241-246.