Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics

Journal of Neuroscience

Volumn 21, Issue 21, 2001, Pages 8348-8353

  Melov, Simon ^a   Doctrow, Susan R ^b   Schneider, Julie A ^c   Haberson, Joanna ^a   Patel, Manisha ^d   Coskun, Pinar E ^e   Huffman, Karl ^b   Wallace, Douglas C ^e   Malfroy, Bernard ^b  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b Eukarion Inc   (United States)

^c RUSH UNIVERSITY MEDICAL CENTER   (United States)

^d NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^e EMORY UNIVERSITY   (United States)

Author keywords

Antioxidants; Mitochondria; Neurodegeneration; Oxidative stress; Spongiform encephalopathy; Superoxide dismutase

Indexed keywords

ANTIOXIDANT; CATALASE; EUK 189; MANGANESE 5,10,15,20 TETRAKIS(4 BENZOIC ACID)PORPHYRIN; MANGANESE DERIVATIVE; MANGANESE N,N' ETHYLENEBIS(3 METHOXYSALICYLIDENEAMINE); MANGANESE SALEN CHLORIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; BRAIN MITOCHONDRION; BRAIN SPONGIOSIS; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DEGENERATIVE DISEASE; LIFESPAN; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0035503501     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-21-08348.2001     Document Type: Article

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