Targeting lipoic acid to mitochondria: Synthesis and characterization of a triphenylphosphonium-conjugated α-lipoyl derivative

Free Radical Biology and Medicine

Volumn 42, Issue 12, 2007, Pages 1766-1780

  Brown, Stephanie E ^a   Ross, Meredith F ^a   Sanjuan Pla, Alejandra ^b   Manas, Abdul Rahman B ^c   Smith, Robin A J ^c   Murphy, Michael P ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b UNIVERSITY OF VALENCIA   (Spain)

^c UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Antioxidant; Dihydrolipoic acid; Lipoic acid; Methylase; Mitochondria; Thioredoxin; Thioredoxin reductase; Triphenylphosphonium

Indexed keywords

(5 [1,2]DITHIOLAN 3 YLPENTYL)TRIPHENYLPHOSPHONIUM; ANTIOXIDANT; DIHYDROLIPOAMIDE DEHYDROGENASE; DIHYDROLIPOATE; THIOCTIC ACID; THIOREDOXIN; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BIOACCUMULATION; CELL ISOLATION; CELL PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; DRUG METABOLISM; DRUG SYNTHESIS; DRUG TARGETING; LIPOPHILICITY; MEMBRANE POTENTIAL; METHYLATION; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT;

ANIMALS; ANTIOXIDANTS; DIHYDROLIPOAMIDE DEHYDROGENASE; MITOCHONDRIA, LIVER; ORGANOPHOSPHORUS COMPOUNDS; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES; THIOCTIC ACID; THIOREDOXIN; THIOREDOXIN REDUCTASE (NADPH);

EID: 34248525050     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2007.02.033     Document Type: Article

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