Toward clinical application of the Keap1-Nrf2 pathway

Trends in Pharmacological Sciences

Volumn 34, Issue 6, 2013, Pages 340-346

  Suzuki, Takafumi ^a   Motohashi, Hozumi ^b   Yamamoto, Masayuki ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Cul3 based ubiquitin E3 ligase; cysteine code; hinge and latch model; stress response; two site substrate recognition model

Indexed keywords

BARDOXOLONE METHYL; BRUSATOL; CARBOPLATIN; CISPLATIN; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; FUMARIC ACID DIMETHYL ESTER; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LUTEOLIN; TRANSCRIPTION FACTOR NRF2;

ANTIOXIDANT RESPONSIVE ELEMENT; ATHEROSCLEROSIS; AUTOPHAGY; CANCER RESISTANCE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CHRONIC KIDNEY DISEASE; HUMAN; KEAP1 GENE; KIDNEY TUMOR; LIVER DYSFUNCTION; MULTIPLE SCLEROSIS; NEOPLASM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NRF2 GENE; ONCOGENE; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SOMATIC MUTATION; UBIQUITINATION; UNSPECIFIED SIDE EFFECT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS;

EID: 84878572136     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2013.04.005     Document Type: Review

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