메뉴 건너뛰기




Volumn 93, Issue 2, 2005, Pages 493-501

Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity

Author keywords

MPTP; Parkinson; Uncoupling protein 2

Indexed keywords

1,2,3,6 METHYLPHENYLTETRAHYDROPYRIDINE; PYRIDINE DERIVATIVE; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2;

EID: 20244377700     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03052.x     Document Type: Article
Times cited : (96)

References (53)
  • 1
    • 0031594295 scopus 로고    scopus 로고
    • Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice
    • Beal M. F., Matthews R., T., Tieleman A. and Shults C. W. (1998) Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. Brain Res. 783, 109-114.
    • (1998) Brain Res. , vol.783 , pp. 109-114
    • Beal, M.F.1    Matthews, R.T.2    Tieleman, A.3    Shults, C.W.4
  • 2
    • 0036683694 scopus 로고    scopus 로고
    • Brain mitochondrial uncoupling protein 2 (UCP2): A protective stress signal in neuronal injury
    • Bechmann I., Diano S., Warden C. H., Bartfai T., Nitsch R. and Horvath T. L. (2002) Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochem. Pharmacol. 64, 363-367.
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 363-367
    • Bechmann, I.1    Diano, S.2    Warden, C.H.3    Bartfai, T.4    Nitsch, R.5    Horvath, T.L.6
  • 3
    • 0035283161 scopus 로고    scopus 로고
    • Homologues of the uncoupling protein from brown adipose tissue (UCP1) Ucp2, Ucp3, Bmcp1 Ucp4
    • Bouillaud F., Couplan E., Pecqueur C. and Ricquier D. (2001) Homologues of the uncoupling protein from brown adipose tissue (UCP1) Ucp2, Ucp3, Bmcp1 Ucp4. Biochim. Biophys. Acta 1504, 107-119.
    • (2001) Biochim. Biophys. Acta , vol.1504 , pp. 107-119
    • Bouillaud, F.1    Couplan, E.2    Pecqueur, C.3    Ricquier, D.4
  • 4
    • 0036326074 scopus 로고    scopus 로고
    • Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease
    • Breidert T., Callebert J., Heneka M. T., Landreth G., Latinay J. M. and Hirsch E. C. (2002) Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease. J. Neurochem. 82, 615-624.
    • (2002) J. Neurochem. , vol.82 , pp. 615-624
    • Breidert, T.1    Callebert, J.2    Heneka, M.T.3    Landreth, G.4    Latinay, J.M.5    Hirsch, E.C.6
  • 5
    • 0346188737 scopus 로고    scopus 로고
    • Kainic acid upregulates uncoupling protein-2 mRNA expression in the mouse brain
    • Clavel S., Paradis E., Ricquier D. and Richard D. (2003) Kainic acid upregulates uncoupling protein-2 mRNA expression in the mouse brain. Neuroreport. 14, 2015-2017.
    • (2003) Neuroreport. , vol.14 , pp. 2015-2017
    • Clavel, S.1    Paradis, E.2    Ricquier, D.3    Richard, D.4
  • 6
    • 0026567764 scopus 로고
    • A consideration of neural counting methods
    • Coggeshall R. E. (1992) A consideration of neural counting methods. Trends Neurosci. 15, 9-13.
    • (1992) Trends Neurosci. , vol.15 , pp. 9-13
    • Coggeshall, R.E.1
  • 7
    • 0032496756 scopus 로고    scopus 로고
    • Histological and temporal characteristics of nigral transneuronal degeneration after striatal injury
    • DeGiorgio L. A., Dibinis C., Milner T. A., Saji M. and Volpe B. T. (1998) Histological and temporal characteristics of nigral transneuronal degeneration after striatal injury. Brain Res. 795, 1-9.
    • (1998) Brain Res. , vol.795 , pp. 1-9
    • DeGiorgio, L.A.1    Dibinis, C.2    Milner, T.A.3    Saji, M.4    Volpe, B.T.5
  • 8
    • 0042521076 scopus 로고    scopus 로고
    • The environment and Parkinson's disease: Is the nigrostriatal system preferentially targeted by neurotoxins?
    • Di Monte D. A. (2003) The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins? Lancet Neurol. 2, 531-538.
    • (2003) Lancet Neurol. , vol.2 , pp. 531-538
    • Di Monte, D.A.1
  • 9
    • 0242468451 scopus 로고    scopus 로고
    • Uncoupling protein 2 prevents neuronal death including that occurring during seizures: A mechanism for preconditioning
    • Diano S., Matthews R., Patrylo P., Yang L., Beal M., Bamstable C. and Horvath T. (2003) Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning. Endocrinology. 144, 5014-5021.
    • (2003) Endocrinology , vol.144 , pp. 5014-5021
    • Diano, S.1    Matthews, R.2    Patrylo, P.3    Yang, L.4    Beal, M.5    Bamstable, C.6    Horvath, T.7
  • 10
    • 0034735799 scopus 로고    scopus 로고
    • Coenzyme Q is an obligatory cofactor for uncoupling protein function
    • Echtay K. S., Wiakler E. and Klingenberg M. (2000) Coenzyme Q is an obligatory cofactor for uncoupling protein function. Nature. 408, 609-613.
    • (2000) Nature , vol.408 , pp. 609-613
    • Echtay, K.S.1    Wiakler, E.2    Klingenberg, M.3
  • 11
    • 0037033039 scopus 로고    scopus 로고
    • Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants
    • Echtay K. S., Murphy M. P., Smith R. A., Talbot D. A. and Brand M. D. (2002) Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J. Biol. Chem. 277, 47 129-47 135.
    • (2002) J. Biol. Chem. , vol.277 , pp. 47129-47135
    • Echtay, K.S.1    Murphy, M.P.2    Smith, R.A.3    Talbot, D.A.4    Brand, M.D.5
  • 12
    • 0031019249 scopus 로고    scopus 로고
    • Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
    • Fleury C., Neverova M., Collins S. et al. (1997) Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat. Genet. 15, 269-272.
    • (1997) Nat. Genet. , vol.15 , pp. 269-272
    • Fleury, C.1    Neverova, M.2    Collins, S.3
  • 14
    • 0026619292 scopus 로고
    • Stereology: The fast lane between neuroanatomy and brain function - Or still only a tightrope?
    • Gundersen H. J. (1992) Stereology: the fast lane between neuroanatomy and brain function - or still only a tightrope? Acta Neurol. Scand. Suppl. 137, 8-13.
    • (1992) Acta Neurol. Scand. Suppl. , vol.137 , pp. 8-13
    • Gundersen, H.J.1
  • 15
    • 0022394280 scopus 로고
    • The importance of free radicals and catalytic metal ions in human diseases
    • Halliwell B. and Gutteridge J. M. (1985) The importance of free radicals and catalytic metal ions in human diseases. Mol. Aspects Med. 8, 89-193.
    • (1985) Mol. Aspects Med. , vol.8 , pp. 89-193
    • Halliwell, B.1    Gutteridge, J.M.2
  • 16
    • 0344223263 scopus 로고    scopus 로고
    • Inhibition of protein phosphatase 2A (PP2A) mimics suckling-induced sensitization of mammotropes: Involvement of a pertussis toxin (PTX) sensitive G-protein and the adenylate cyclase (AC)
    • Horvath K. M., Radnai B., Bela T. E., Fekete M. I. and Nagy G. M. (1999a) Inhibition of protein phosphatase 2A (PP2A) mimics suckling-induced sensitization of mammotropes: involvement of a pertussis toxin (PTX) sensitive G-protein and the adenylate cyclase (AC). Mol. Cell Endocrinol. 149, 1-7.
    • (1999) Mol. Cell Endocrinol. , vol.149 , pp. 1-7
    • Horvath, K.M.1    Radnai, B.2    Bela, T.E.3    Fekete, M.I.4    Nagy, G.M.5
  • 17
    • 0033492873 scopus 로고    scopus 로고
    • Brain uncoupling protein 2: Uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers
    • Horvath T. L., Warden C. H., Hajos M., Lombardi A., Goglia F. and Diano S. (1999b) Brain uncoupling protein 2: uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers. J. Neurosci. 19, 10 417-10 427.
    • (1999) J. Neurosci. , vol.19 , pp. 10417-10427
    • Horvath, T.L.1    Warden, C.H.2    Hajos, M.3    Lombardi, A.4    Goglia, F.5    Diano, S.6
  • 18
    • 0038336912 scopus 로고    scopus 로고
    • Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease
    • Horvath T. L., Diano S., Leranth C. et al. (2003) Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease. Endocrinology. 144, 27 57-27 60.
    • (2003) Endocrinology , vol.144 , pp. 2757-2760
    • Horvath, T.L.1    Diano, S.2    Leranth, C.3
  • 19
    • 0029751104 scopus 로고    scopus 로고
    • Oxidative stress and the pathogenesis of Parkinson's disease
    • Jenner P. and Olanow C. W. (1996) Oxidative stress and the pathogenesis of Parkinson's disease. Neurology. 47, S161-S170.
    • (1996) Neurology , vol.47
    • Jenner, P.1    Olanow, C.W.2
  • 20
    • 0242684415 scopus 로고    scopus 로고
    • Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: A novel therapy for Parkinson's disease
    • Kaur D., Yantiri F., Rajagopalan S. et al. (2003) Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. Neuron. 37, 899-909.
    • (2003) Neuron , vol.37 , pp. 899-909
    • Kaur, D.1    Yantiri, F.2    Rajagopalan, S.3
  • 21
    • 17344371804 scopus 로고    scopus 로고
    • Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: Suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction
    • Keller J. N., Kindy M. S., Holtsberg F. W., St Clair D. K., Yen H. C., Germeyer A., Steiner S. M., Bruce-Keller A. J., Hutchins J. B. and Mattson M. P. (1998) Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J. Neurosci. 18, 687-697.
    • (1998) J. Neurosci. , vol.18 , pp. 687-697
    • Keller, J.N.1    Kindy, M.S.2    Holtsberg, F.W.3    St Clair, D.K.4    Yen, H.C.5    Germeyer, A.6    Steiner, S.M.7    Bruce-Keller, A.J.8    Hutchins, J.B.9    Mattson, M.P.10
  • 22
    • 0034764681 scopus 로고    scopus 로고
    • BMCP1: A mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production
    • Kim-Han J. S., Reichert S. A., Quick K. L. and Dugan L. L. (2001) BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production, J. Neurochem. 79, 658-668.
    • (2001) J. Neurochem. , vol.79 , pp. 658-668
    • Kim-Han, J.S.1    Reichert, S.A.2    Quick, K.L.3    Dugan, L.L.4
  • 25
    • 0344528794 scopus 로고    scopus 로고
    • The inflammatory reaction following 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine intoxication in mouse
    • Kurkowska-Jastrzebska I., Wronska A., Kohutnicka M., Czlonkowski A. and Czlonkowska A. (1999) The inflammatory reaction following 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine intoxication in mouse. Exp. Neurol. 156, 50-61.
    • (1999) Exp. Neurol. , vol.156 , pp. 50-61
    • Kurkowska-Jastrzebska, I.1    Wronska, A.2    Kohutnicka, M.3    Czlonkowski, A.4    Czlonkowska, A.5
  • 26
    • 0034624017 scopus 로고    scopus 로고
    • The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity
    • Lotharius J. and O'Malley K. L. (2000) The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity. J. Biol. Chem. 275, 38 581-38 588.
    • (2000) J. Biol. Chem. , vol.275 , pp. 38581-38588
    • Lotharius, J.1    O'Malley, K.L.2
  • 27
    • 0034611678 scopus 로고    scopus 로고
    • Towards a molecular understanding of adaptive thermogenesis
    • Lowell B. B. and Spiegelman B. M. (2000) Towards a molecular understanding of adaptive thermogenesis. Nature. 404, 652-660.
    • (2000) Nature , vol.404 , pp. 652-660
    • Lowell, B.B.1    Spiegelman, B.M.2
  • 28
    • 0032998265 scopus 로고    scopus 로고
    • UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells
    • Erratum FEBS Lett. 449, 293
    • Mao W., YuX. X., Zhong A., Li W., Brush J., Sherwood S. W., Adams S. H. and Pan G. (1999) UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Lett. 443, 326-330 [Erratum FEBS Lett. 449, 293].
    • (1999) FEBS Lett. , vol.443 , pp. 326-330
    • Mao, W.1    Yu, X.X.2    Zhong, A.3    Li, W.4    Brush, J.5    Sherwood, S.W.6    Adams, S.H.7    Pan, G.8
  • 30
    • 0041464712 scopus 로고    scopus 로고
    • Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma
    • Mattiasson G., Shamloo M., Gido G. et al. (2003) Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nat. Med. 9, 1062-1068.
    • (2003) Nat. Med. , vol.9 , pp. 1062-1068
    • Mattiasson, G.1    Shamloo, M.2    Gido, G.3
  • 31
    • 0029888641 scopus 로고    scopus 로고
    • A transgenic mouse model to study transsynaptic regulation of tyrosine hydroxylase gene expression
    • Min N., Joh T. H., Corp E. S., Baker H., Cubells J. F. and Son J. H. (1996) A transgenic mouse model to study transsynaptic regulation of tyrosine hydroxylase gene expression. J. Neurochem. 67, 11-18.
    • (1996) J. Neurochem. , vol.67 , pp. 11-18
    • Min, N.1    Joh, T.H.2    Corp, E.S.3    Baker, H.4    Cubells, J.F.5    Son, J.H.6
  • 32
    • 0033934847 scopus 로고    scopus 로고
    • The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: The role of mitochondrial complex I and reactive oxygen species revisited
    • Nakamura K., Bindokas V. P., Marks J. D., Wright D. A., Frim D. M., Miller R. J. and Kang U. J. (2000) The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: the role of mitochondrial complex I and reactive oxygen species revisited. Mol. Pharmacol. 58, 271-278.
    • (2000) Mol. Pharmacol. , vol.58 , pp. 271-278
    • Nakamura, K.1    Bindokas, V.P.2    Marks, J.D.3    Wright, D.A.4    Frim, D.M.5    Miller, R.J.6    Kang, U.J.7
  • 33
    • 0034643340 scopus 로고    scopus 로고
    • Normalizing mitochondrial Superoxide production blocks three pathways of hyperglycaemic damage
    • Nishikawa T., Du Edelstein D. X. L., Yamagishi S. et al. (2000) Normalizing mitochondrial Superoxide production blocks three pathways of hyperglycaemic damage. Nature. 404, 787-790.
    • (2000) Nature , vol.404 , pp. 787-790
    • Nishikawa, T.1    Du Edelstein, D.X.L.2    Yamagishi, S.3
  • 34
    • 0025242960 scopus 로고
    • Oxidation reactions in Parkinson's disease
    • Olanow C. W. (1990) Oxidation reactions in Parkinson's disease. Neurology. 40, 37-39.
    • (1990) Neurology , vol.40 , pp. 37-39
    • Olanow, C.W.1
  • 35
    • 0027496238 scopus 로고
    • A radical hypothesis for neurodegeneration
    • Olanow C. W. (1993) A radical hypothesis for neurodegeneration. Trends Neurosci. 16, 439-444.
    • (1993) Trends Neurosci. , vol.16 , pp. 439-444
    • Olanow, C.W.1
  • 36
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos M. H., Lavedan C., Leroy E. et al. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science. 276, 2045-2047.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3
  • 37
    • 10244222286 scopus 로고    scopus 로고
    • MPTP as a mitochondrial neurotoxic model of Parkinson's disease
    • Przedborski S., Tieu K., Perier C. and Vila M. (2004) MPTP as a mitochondrial neurotoxic model of Parkinson's disease. J. Bioenerg. Biomembr. 36, 375-379.
    • (2004) J. Bioenerg. Biomembr. , vol.36 , pp. 375-379
    • Przedborski, S.1    Tieu, K.2    Perier, C.3    Vila, M.4
  • 39
    • 0027269914 scopus 로고
    • Increased striatal lipid peroxidation after intracerebroventricular MPP+ administration to mice
    • Rojas P. and Rios C. (1993) Increased striatal lipid peroxidation after intracerebroventricular MPP+ administration to mice. Pharmacol. Toxicol. 72, 364-368.
    • (1993) Pharmacol. Toxicol. , vol.72 , pp. 364-368
    • Rojas, P.1    Rios, C.2
  • 40
    • 0030249277 scopus 로고    scopus 로고
    • Prevention of transneuronal degeneration of neurons in the substantia nigra reticulata by ablation of the subthalamic nucleus
    • Saji M., Blau A. D. and Volpe B. T. (1996) Prevention of transneuronal degeneration of neurons in the substantia nigra reticulata by ablation of the subthalamic nucleus. Exp. Neurol. 141, 120-129.
    • (1996) Exp. Neurol. , vol.141 , pp. 120-129
    • Saji, M.1    Blau, A.D.2    Volpe, B.T.3
  • 41
    • 0032545458 scopus 로고    scopus 로고
    • BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast
    • Sanchis D., Fleury C., Chomiki N. et al. (1998) BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. J. Biol. Chem. 273, 34 611-34 615.
    • (1998) J. Biol. Chem. , vol.273 , pp. 34611-34615
    • Sanchis, D.1    Fleury, C.2    Chomiki, N.3
  • 42
    • 0035829368 scopus 로고    scopus 로고
    • Behavioral phenotyping of the MPTP mouse model of Parkinson's disease
    • Sedelis M., Schwarring R. K. and Huston J. P. (2001) Behavioral phenotyping of the MPTP mouse model of Parkinson's disease. Behav. Brain Res. 125, 109-125.
    • (2001) Behav. Brain Res. , vol.125 , pp. 109-125
    • Sedelis, M.1    Schwarring, R.K.2    Huston, J.P.3
  • 45
    • 0037146907 scopus 로고    scopus 로고
    • Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS
    • Sugama S., Cho B. P., Baker H., Joh T. H., Lucero J. and Conti B. (2002) Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS. Brain Res. 958, 1-9.
    • (2002) Brain Res. , vol.958 , pp. 1-9
    • Sugama, S.1    Cho, B.P.2    Baker, H.3    Joh, T.H.4    Lucero, J.5    Conti, B.6
  • 46
    • 0037469952 scopus 로고    scopus 로고
    • Age-related microglial activation in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL/6 mice
    • Sugama S., Yang L., Cho B. P., DeGiorgio L. A., Lorenzl S., Albers D. S., Beal M. F., Volpe B. T. and Joh T. H. (2003) Age-related microglial activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL/6 mice. Brain Res. 964, 288-294.
    • (2003) Brain Res. , vol.964 , pp. 288-294
    • Sugama, S.1    Yang, L.2    Cho, B.P.3    DeGiorgio, L.A.4    Lorenzl, S.5    Albers, D.S.6    Beal, M.F.7    Volpe, B.T.8    Joh, T.H.9
  • 47
    • 0038443821 scopus 로고    scopus 로고
    • Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death
    • Sullivan P. G., Dube C., Dorenbos K., Steward O. and Baram T. Z. (2003) Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death. Ann. Neurol. 53, 711-717.
    • (2003) Ann. Neurol. , vol.53 , pp. 711-717
    • Sullivan, P.G.1    Dube, C.2    Dorenbos, K.3    Steward, O.4    Baram, T.Z.5
  • 48
    • 0032526940 scopus 로고    scopus 로고
    • The regulation of reactive oxygen species production during programmed cell death
    • Tan S., Sagara Y., Liu Y., Maher P. and Schubert D. (1998) The regulation of reactive oxygen species production during programmed cell death. J. Cell Biol. 141, 1423-1432.
    • (1998) J. Cell Biol. , vol.141 , pp. 1423-1432
    • Tan, S.1    Sagara, Y.2    Liu, Y.3    Maher, P.4    Schubert, D.5
  • 49
    • 0027504297 scopus 로고
    • Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds
    • Tipton K. F. and Singer T. P. (1993) Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J. Neurochem. 61, 1191-1206.
    • (1993) J. Neurochem. , vol.61 , pp. 1191-1206
    • Tipton, K.F.1    Singer, T.P.2
  • 50
    • 0033672624 scopus 로고    scopus 로고
    • Uncoupling expectations
    • Vidal-Puig A. J. (2000) Uncoupling expectations. Nat. Genet. 26, 387-388.
    • (2000) Nat. Genet. , vol.26 , pp. 387-388
    • Vidal-Puig, A.J.1
  • 51
    • 0034717015 scopus 로고    scopus 로고
    • Energy metabolism in uncoupling protein 3 gene knockout mice
    • Vidal-Puig A. J., Grujic D., Zhang C. Y. et al. (2000) Energy metabolism in uncoupling protein 3 gene knockout mice. J. Biol. Chem. 275, 16 258-16 266.
    • (2000) J. Biol. Chem. , vol.275 , pp. 16258-16266
    • Vidal-Puig, A.J.1    Grujic, D.2    Zhang, C.Y.3
  • 52
    • 0032484557 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor prevents the loss of nigral neurons induced by excitotoxic striatal-pallidal lesions
    • Volpe B. T., Wildmann J. and Altar C. A. (1998) Brain-derived neurotrophic factor prevents the loss of nigral neurons induced by excitotoxic striatal-pallidal lesions. Neuroscience. 83, 741-748.
    • (1998) Neuroscience , vol.83 , pp. 741-748
    • Volpe, B.T.1    Wildmann, J.2    Altar, C.A.3
  • 53
    • 0033993476 scopus 로고    scopus 로고
    • Pramipexole inhibits lipid peroxidation and reduces injury in the substantia nigra induced by the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine C57BL/6 mice
    • Zou L., Xu J., Jankovic J., He Y., Appel S. H. and Le W. (2000) Pramipexole inhibits lipid peroxidation and reduces injury in the substantia nigra induced by the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine C57BL/6 mice. Neurosci. Lett. 281, 167-170.
    • (2000) Neurosci. Lett. , vol.281 , pp. 167-170
    • Zou, L.1    Xu, J.2    Jankovic, J.3    He, Y.4    Appel, S.H.5    Le, W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.