Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide

Science

Volumn 299, Issue 5608, 2003, Pages 896-899

  Nisoli, Enzo ^a,b   Clementi, Emilio ^c,d   Paolucci, Clara ^c   Cozzi, Valeria ^a   Tonello, Cristina ^a   Sciorati, Clara ^c   Bracale, Renata ^a   Valerio, Alessandra ^e   Francolini, Maura ^f   Moncada, Salvador ^g   Carruba, Michele O ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^c SAN RAFFAELE HOSPITAL   (Italy)

^d UNIVERSITY OF CALABRIA   (Italy)

^e UNIVERSITY OF BRESCIA   (Italy)

^f CNR   (Italy)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NITROGEN OXIDES; TISSUE;

MITOCHONDRIAL BIOGENESIS;

CELLS;

CYCLIC GMP; CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; N ACETYL S NITROSOPENICILLAMINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PENICILLAMINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; UNCLASSIFIED DRUG;

MAMMAL; MITOCHONDRIAL DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BROWN ADIPOSE TISSUE; COLD EXPOSURE; CONTROLLED STUDY; DNA CONTENT; ENERGY BALANCE; ENERGY EXPENDITURE; HELA CELL; MAMMAL; METABOLIC RATE; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THERMOGENESIS; WEIGHT GAIN;

3T3 CELLS; 8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ADIPOCYTES; ADIPOSE TISSUE, BROWN; ANIMALS; COLD; CYCLIC GMP; DNA, MITOCHONDRIAL; DNA-BINDING PROTEINS; EATING; ENERGY METABOLISM; FEMALE; HELA CELLS; HIGH MOBILITY GROUP PROTEINS; HUMANS; MALE; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOTOR ACTIVITY; NF-E2-RELATED FACTOR 1; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; NUCLEAR PROTEINS; NUCLEAR RESPIRATORY FACTORS; OLIGONUCLEOTIDES, ANTISENSE; OXADIAZOLES; OXYGEN CONSUMPTION; PENICILLAMINE; QUINOXALINES; RATS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; U937 CELLS; WEIGHT GAIN;

ANIMALIA; MAMMALIA;

EID: 0347579845     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1079368     Document Type: Article

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22. We thank A. Higgs for her help with preparation of the manuscript; L. Vizzotto for assistance with light microscopy; F. Gennari for help with figure preparation; R. Scurati for help with food intake and body weight measurements; and E. Ferrannini, J. Meldolesi, and P. Mantegazza for critical support and revision of the manuscript. Supported by grants from the Ministero dell'Istruzione, dell'Università e della Ricerca cofinanziamento 2001 to E.N. and E.C., the Italian Association for Cancer Research to E.C., the Medical Research Council to S.M., and the University of Milan and the Italian Ministry of Health to M.O.C. and E.N.