Mitochondrial-associated nitric oxide synthase activity inhibits cytochrome c oxidase: Implications for breast Cancer

Free Radical Biology and Medicine

Volumn 57, Issue , 2013, Pages 210-220

  Sen, Suvajit ^a   Kawahara, Brian ^a   Chaudhuri, Gautam ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Breast cancer; Cytochrome c oxidase; Free radicals; Hydrogen peroxide; Nitric oxide; Proliferation

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; CATALASE; CYCLIC GMP; CYTOCHROME C OXIDASE; GLUTATHIONE PEROXIDASE 1; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE;

ARTICLE; BREAST CANCER; BREAST DISEASE; BREAST EPITHELIUM; CANCER CELL; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM CELL; GENE SILENCING; HUMAN; HUMAN CELL; MITOCHONDRION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; TUMOR CELL;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; ELECTRON TRANSPORT COMPLEX IV; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GUANYLATE CYCLASE; HUMANS; HYDROGEN PEROXIDE; MITOCHONDRIA; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXADIAZOLES; OXYGEN CONSUMPTION; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; PROTO-ONCOGENE PROTEINS C-AKT; QUINOXALINES;

EID: 84874645124     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.10.545     Document Type: Article

References (31)

1. L.L. Thomsen, D.W. Miles, L. Happerfield, L.G. Bobrow, R.G. Knowles, and S. Moncada Nitric oxide synthase activity in human breast cancer Br. J. Cancer 72 1995 41 44
2. S.A. Glynn, B.J. Boersma, T.H. Dorsey, M. Yi, H.G. Yfantis, L.A. Ridnour, D.N. Martin, C.H. Switzer, R.S. Hudson, D.A. Wink, D.H. Lee, R.M. Stephens, and S. Ambs Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients J. Clin. Invest. 120 2010 3843 3854
3. M. Vakkala, K. Kahlos, E. Lakari, P. Paakko, V. Kinnula, and Y. Soini Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas Clin. Cancer Res. 6 2000 2408 2416 (Pubitemid 30399209)
4. G.M. Tse, F.C. Wong, A.K. Tsang, C.S. Lee, P.C. Lui, A.W. Lo, B.K. Law, R.A. Scolyer, R.Z. Karim, and T.C. Putti Stromal nitric oxide synthase (NOS) expression correlates with the grade of mammary phyllodes tumour J. Clin. Pathol. 58 2005 600 604 (Pubitemid 40814019)
5. R. Singh, S. Pervin, A. Karimi, S. Cederbaum, and G. Chaudhuri Arginase activity in human breast cancer cell lines: N(omega)-hydroxy-L-arginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB-468 cells Cancer Res 60 2000 3305 3312 (Pubitemid 30407931)
6. S. Pervin, R. Singh, and G. Chaudhuri Nitric oxide, N omega-hydroxy-L-arginine and breast cancer Nitric Oxide 19 2008 103 106
7. S. Pervin, R. Singh, E. Hernandez, G. Wu, and G. Chaudhuri Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of rapamycin/eIF4E pathway Cancer Res 67 2007 289 299 (Pubitemid 46142787)
8. R. Zeillinger, E. Tantscher, C. Schneeberger, W. Tschugguel, S. Eder, G. Sliutz, and J.C. Huber Simultaneous expression of nitric oxide synthase and estrogen receptor in human breast cancer cell lines Breast Cancer Res. Treat. 40 1996 205 207
9. X. Zhang Real time and in vivo monitoring of nitric oxide by electrochemical sensors - from dream to reality Front. Biosci 9 2004 3434 3446
10. Y.T. Shen, C. Depre, L. Yan, J.Y. Park, B. Tian, K. Jain, L. Chen, Y. Zhang, R.K. Kudej, X. Zhao, J. Sadoshima, D.E. Vatner, and S.F. Vatner Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning Circulation 118 2008 1961 1969
11. Q. Zhang, M. Raoof, Y. Chen, Y. Sumi, T. Sursal, W. Junger, K. Brohi, K. Itagaki, and C.J. Hauser Circulating mitochondrial DAMPs cause inflammatory responses to injury Nature 464 2010 104 107
12. M.R. Lemberg Cytochrome oxidase Physiol. Rev. 49 1969 48 121
13. E. Eruslanov, and S. Kusmartsev Identification of ROS using oxidized DCFDA and flow-cytometry Methods Mol. Biol. 594 2010 57 72
14. P. Mukhopadhyay, M. Rajesh, G. Hasko, B.J. Hawkins, M. Madesh, and P. Pacher Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy Nat. Protoc. 2 2007 2295 2301 (Pubitemid 351565867)
15. P. Ghafourifar, and C. Richter Mitochondrial nitric oxide synthase regulates mitochondrial matrix pH Biol. Chem. 380 1999 1025 1028 (Pubitemid 29412764)
16. R.R. Nazarewicz, W.J. Zenebe, A. Parihar, S.K. Larson, E. Alidema, J. Choi, and P. Ghafourifar Tamoxifen induces oxidative stress and mitochondrial apoptosis via stimulating mitochondrial nitric oxide synthase Cancer Res. 67 2007 1282 1290
17. C.T. Taylor, and S. Moncada Nitric oxide, cytochrome C oxidase, and the cellular response to hypoxia Arterioscler. Thromb. Vasc. Biol. 30 2010 643 647
18. M.W. Cleeter, J.M. Cooper, V.M. Darley-Usmar, S. Moncada, and A.H. Schapira Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide: implications for neurodegenerative diseases FEBS Lett 345 1994 50 54
19. M. Schweizer, and C. Richter Nitric oxide potently and reversibly deenergizes mitochondria at low oxygen tension Biochem. Biophys. Res. Commun. 204 1994 169 175 (Pubitemid 24335277)
20. E. Clementi, G.C. Brown, N. Foxwell, and S. Moncada On the mechanism by which vascular endothelial cells regulate their oxygen consumption Proc. Natl. Acad. Sci. USA 96 1999 1559 1562 (Pubitemid 29098490)
21. P.R. Miles, L. Bowman, and L. Huffman Nitric oxide alters metabolism in isolated alveolar type II cells Am. J. Physiol. 271 1 Pt 1 1996 L23 30
22. W. Shen, T.H. Hintze, and M.S. Wolin Nitric oxide: an important signaling mechanism between vascular endothelium and parenchymal cells in the regulation of oxygen consumption Circulation 92 1995 3505 3512
23. A. Boveris, and B. Chance The mitochondrial generation of hydrogen peroxide: general properties and effect of hyperbaric oxygen Biochem. J. 134 1973 707 716
24. G. Loschen, A. Azzi, C. Richter, and L. Flohe Superoxide radicals as precursors of mitochondrial hydrogen peroxide FEBS Lett 42 1974 68 72
25. J.J. Poderoso, M.C. Carreras, C. Lisdero, N. Riobo, F. Schopfer, and A. Boveris Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles Arch. Biochem. Biophys. 328 1996 85 92 (Pubitemid 26108173)
26. D.M. Sullivan, N.B. Wehr, M.M. Fergusson, R.L. Levine, and T. Finkel Identification of oxidant-sensitive proteins: TNF-alpha induces protein glutathiolation Biochemistry 39 2000 11121 11128
27. C.H. Switzer, R.Y. Cheng, T.M. Vitek, D.J. Christensen, D.A. Wink, and M.P. Vitek Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy Oncogene 30 2011 2504 2513
28. C.H. Switzer, S.A. Glynn, L.A. Ridnour, R.Y. Cheng, M.P. Vitek, S. Ambs, and D.A. Wink Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer Trends Pharmacol. Sci. 32 2011 644 651
29. F. Diaz, C. Thomas, S. Garcia, D. Hernandez, and T.C. Mores Mice lacking COX10 skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency Hum. Mol. Genet. 14 2005 2737 2748 (Pubitemid 41300646)
30. 2 levels, and its mechanism of action to induce growth in breast cancer cells: important roles of bioactive catalase and PP2A. Free Radic. Biol. Med. 53 2012 1541 1551
31. B.P. Dranka, B.G. Hill, and V.M. Darley-Usmar Mitochondrial reserve capacity in endothelial cells: the impact of nitric oxide and reactive oxygen species Free Radic. Biol. Med. 48 2010 905-114