Mitochondrial α-ketoglutarate dehydrogenase complex generates reactive oxygen species

Journal of Neuroscience

Volumn 24, Issue 36, 2004, Pages 7779-7788

  Starkov, Anatoly A ^a   Fiskum, Gary ^b   Chinopoulos, Christos ^b   Lorenzo, Beverly J ^a   Browne, Susan E ^a   Patel, Mulchand S ^c   Beal, M Flint ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Alzheimer; Ketoglutarate dehydrogenase; Lipoamide dehydrogenase; Mitochondria; Parkinson; Reactive oxygen species

Indexed keywords

2 OXOGLUTARIC ACID; ADENOSINE DIPHOSPHATE; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; DIHYDROLIPOAMIDE DEHYDROGENASE; HYDROGEN PEROXIDE; MITOCHONDRIAL ENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXOGLUTARATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; ROTENONE; SUPEROXIDE; UBIQUINOL CYTOCHROME C REDUCTASE;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CELL DEATH; CONTROLLED STUDY; ENZYME DEFICIENCY; ENZYME SUBSTRATE; KNOCKOUT MOUSE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; REDUCTION; RESPIRATORY CHAIN;

ADENOSINE DIPHOSPHATE; ANIMALS; ANTIMYCIN A; DIHYDROLIPOAMIDE DEHYDROGENASE; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX I; HYDROGEN PEROXIDE; INTRACELLULAR MEMBRANES; KETOGLUTARATE DEHYDROGENASE COMPLEX; KETOGLUTARIC ACIDS; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; NAD; NADP; NERVE TISSUE PROTEINS; OLIGOMYCINS; OXIDATION-REDUCTION; PROSENCEPHALON; PYRUVATE DEHYDROGENASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; ROTENONE; SUCCINIC ACID; SUPEROXIDE DISMUTASE; SUPEROXIDES; UBIQUINONE;

EID: 4544359913     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1899-04.2004     Document Type: Article

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