Mitochondrial targeting of quinones: Therapeutic implications

Mitochondrion

Volumn 7, Issue SUPPL., 2007, Pages

  Cochemé, Helena M ^a   Kelso, Geoffrey F ^b   James, Andrew M ^a   Ross, Meredith F ^a   Trnka, Jan ^a   Mahendiran, Thabo ^a   Asin Cayuela, Jordi ^a   Blaikie, Frances H ^b   Manas, Abdul Rahman B ^b   Porteous, Carolyn M ^b   Adlam, Victoria J ^b   Smith, Robin A J ^b   Murphy, Michael P ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Antioxidants; Mitochondria; MitoQ

Indexed keywords

CATION; DRUG METABOLITE; MITOQ; REACTIVE OXYGEN METABOLITE; UBIQUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL DAMAGE; CELL INTERACTION; CELL ISOLATION; CELL PROTECTION; CLINICAL TRIAL; CONCENTRATION RESPONSE; CYTOTOXICITY; DEGENERATIVE DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; DRUG MECHANISM; DRUG METABOLISM; DRUG RESEARCH; DRUG SAFETY; DRUG TARGETING; DRUG TISSUE LEVEL; DRUG TOLERABILITY; DRUG TRANSPORT; DRUG UPTAKE; FRIEDREICH ATAXIA; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; LIPOPHILICITY; MAXIMUM PLASMA CONCENTRATION; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MEMBRANE TRANSPORT; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PARKINSON DISEASE; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; TREATMENT DURATION;

ADMINISTRATION, ORAL; ANIMALS; CATIONS; CELL MEMBRANE; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEMBRANE POTENTIALS; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MODELS, BIOLOGICAL; MODELS, CHEMICAL; ORGANOPHOSPHORUS COMPOUNDS; OXYGEN; QUINONES; UBIQUINONE;

EID: 34248159898     PISSN: 15677249     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mito.2007.02.007     Document Type: Article

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