Targeting antioxidants to mitochondria by conjugation to lipophilic cations

Annual Review of Pharmacology and Toxicology

Volumn 47, Issue , 2007, Pages 629-656

  Murphy, Michael P ^a   Smith, Robin A J ^b  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

MitoQ; Oxidative damage; Reactive oxygen species; Triphenylphosphonium; Ubiquinol

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; CATION; DICHLOROFLUORESCEIN; GLYCOPROTEIN P; HYDROETHIDINE; IDEBENONE; MULTIDRUG RESISTANCE PROTEIN 1; PHOSPHONIUM DERIVATIVE; TRIPHENYLPHOSPHONIUM; UBIQUINOL CYTOCHROME C REDUCTASE; UBIQUINONE; UNCLASSIFIED DRUG;

BIOACCUMULATION; BLOOD BRAIN BARRIER; CELL PROTECTION; CONJUGATION; ENTHALPY; HYDROPHOBICITY; LIPID PEROXIDATION; LIPOPHILICITY; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MEMBRANE TRANSPORT; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MUSCLE CELL; NONHUMAN; OXIDATIVE STRESS; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW;

ANTIOXIDANTS; CATIONS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; MEMBRANE POTENTIALS; MITOCHONDRIA; MITOCHONDRIAL DISEASES; REACTIVE OXYGEN SPECIES; TISSUE DISTRIBUTION;

EID: 33847071146     PISSN: 03621642     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.pharmtox.47.120505.105110     Document Type: Review

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