Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo

Journal of Controlled Release

Volumn 159, Issue 3, 2012, Pages 393-402

  Biswas, Swati ^a   Dodwadkar, Namita S ^a   Deshpande, Pranali P ^a   Torchilin, Vladimir P ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Amphiphilic polymer; Cancer; Liposomes; Mitochondrial targeting; PEG PE; TPP

Indexed keywords

AMPHIPHILIC POLYMERS; CANCER; MITOCHONDRIAL TARGETING; PEG-PE; TPP;

CELL CULTURE; CONFOCAL MICROSCOPY; CYTOTOXICITY; DRUG DELIVERY; EXPERIMENTS; LIPID BILAYERS; LIPOSOMES; MITOCHONDRIA; POLYETHYLENE OXIDES; TOXICITY;

POLYETHYLENE GLYCOLS;

LIPOSOME; MACROGOL; METHYLTRIPHENYLPHOSPHONIUM; PACLITAXEL; PHOSPHATIDYLETHANOLAMINE;

ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONFOCAL MICROSCOPY; CONJUGATE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPID BILAYER; MITOCHONDRIAL TARGETING SIGNAL; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL SURVIVAL; DRUG CARRIERS; DRUG COMPOUNDING; ENDOCYTOSIS; FEMALE; FLOW CYTOMETRY; HELA CELLS; HUMANS; LIPID BILAYERS; LIPOSOMES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICROSCOPY, CONFOCAL; MITOCHONDRIA; MOLECULAR STRUCTURE; NEOPLASM TRANSPLANTATION; PACLITAXEL; PARTICLE SIZE; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; SURFACE PROPERTIES;

EID: 84860662855     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.01.009     Document Type: Article

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