Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic: Insights into the interaction of ebselen with mitochondria

Journal of Biological Chemistry

Volumn 280, Issue 25, 2005, Pages 24113-24126

  Filipovska, Aleksandra ^a   Kelso, Geoffrey F ^b   Brown, Stephanie E ^a   Beer, Samantha M ^a   Smith, Robin A J ^b   Murphy, Michael P ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; BIOMIMETIC MATERIALS; ENZYMES; OXIDATION; PEROXIDES; POSITIVE IONS; REDOX REACTIONS; SIGNALING; SPECTROMETRY; STRESSES;

EBSELEN; SELECTIVE DEGRADATION; THIOLS; TRIPHENYLPHOSPHONIUM-CONJUGATED PEROXIDASE;

BIOSYNTHESIS;

GLUTATHIONE; PEROXIDASE; PHOSPHONIUM DERIVATIVE; PROTEIN 2[4(4 TRIPHENYLPHOPHONIOBUTOXY)PHENYL]1,2 BENZISOSELENAZOL) 3(2H) ONE IODIDE; PROTEIN EBSELEN; SELENAZOLE DERIVATIVE; THIOREDOXIN; TRIPHENYLPHOSPHONIUM; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; LIPID PEROXIDATION; MASS SPECTROMETRY; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN SYNTHESIS;

ANIMALS; AZOLES; GLUTATHIONE; MAGNETIC RESONANCE SPECTROSCOPY; MITOCHONDRIA, LIVER; MOLECULAR MIMICRY; ORGANOSELENIUM COMPOUNDS; OXIDATION-REDUCTION; PEROXIDASE; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; THIOREDOXIN;

EID: 21244448078     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501148200     Document Type: Article

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