Prevention of diabetic nephropathy in Ins2+/-AkitaJ mice by the mitochondria-targeted therapy MitoQ

Biochemical Journal

Volumn 432, Issue 1, 2010, Pages 9-19

  Chacko, Balu K ^a   Reily, Colin ^a   Srivastava, Anup ^a   Johnson, Michelle S ^a   Ye, Yaozu ^a   Ulasova, Elena ^a   Agarwal, Anupam ^b,c   Zinn, Kurt R ^d   Murphy, Michael P ^e   Kalyanaraman, Balaraman ^f   Darley Usmar, Victor ^a,b  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c University of Alabama at Birmingham   (United States)

^d University of Alabama   (United States)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Diabetes; Ins2+ AkitaJ mice (Akita mice); Interstitial fibrosis; Mitochondrial function; MitoQ; Renal clearance

Indexed keywords

DIABETES; INS2+/-AKITAJ MICE (AKITA MICE); INTERSTITIAL FIBROSIS; MITOCHONDRIAL FUNCTION; MITOQ; RENAL CLEARANCE;

ANIMALS; GLUCOSE; OXYGEN; TRANSCRIPTION FACTORS;

MITOCHONDRIA;

ALBUMIN; BETA CATENIN; CITRATE SYNTHASE; COPPER ZINC SUPEROXIDE DISMUTASE; CREATININE; EXTRACELLULAR SUPEROXIDE DISMUTASE; HEMOGLOBIN A1C; INSULIN; MANGANESE SUPEROXIDE DISMUTASE; PENTETATE TECHNETIUM TC 99M; REACTIVE OXYGEN METABOLITE; SMAD2 PROTEIN; SMAD3 PROTEIN; UBIQUINONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETIC NEPHROPATHY; DRUG CLEARANCE; ENZYME ACTIVITY; FUNCTIONAL ASSESSMENT; GLOMERULAR DYSFUNCTION; GLOMERULUS; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; KIDNEY; KIDNEY FIBROSIS; KIDNEY TUBULE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN URINE LEVEL; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; BETA CATENIN; BLOOD GLUCOSE; CELL NUCLEUS; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; FIBROSIS; GLOMERULAR MESANGIUM; IMMUNOHISTOCHEMISTRY; INSULIN; KIDNEY; KIDNEY TUBULES; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICROSCOPY, ELECTRON; MITOCHONDRIA; PHOSPHORYLATION; SMAD2 PROTEIN; SMAD3 PROTEIN; UBIQUINONE;

ANIMALIA; MUS;

EID: 78649755150     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100308     Document Type: Article

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