Mitochondrial biotransformation of ω-(phenoxy)alkanoic acids, 3-(phenoxy)acrylic acids, and ω-(1-methyl-1H-imidazol-2-ylthio)alkanoic acids: A prodrug strategy for targeting cytoprotective antioxidants to mitochondria

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 4, 2010, Pages 1441-1448

  Roser, Kurt S ^a   Brookes, Paul S ^a   Wojtovich, Andrew P ^b   Olson, Leif P ^a   Shojaie, Jalil ^a   Parton, Richard L ^a   Anders, M W ^a,b  

^a Department of Anesthesiology   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Antioxidants; Hypoxia reoxygenation injury; Mitochondrial oxidation; Mitochondrial prodrug targeting

Indexed keywords

3 (1 METHYL 1H IMIDAZOL 2 YL THIO)PROPANOIC ACID; 3 (2 METHYLPHENOXY)PROPANOIC ACID; 3 (2 NAPHTHOXY)PROPANOIC ACID; 3 (2,6 DIISOPROPYLPHENOXY)ACRYLIC ACID; 3 (2,6 DIMETHYLPHENOXY)ACRYLIC ACID; 3 (2,6 DIMETHYLPHENOXY)PROPANOIC ACID; 3 (3,5 DIMETHYLPHENOXY)PROPANOIC ACID; 3 (PHENOXY)ACRYLIC ACID DERIVATIVE; 3 (PHENOXY)PROPANOIC ACID; 3 [(2,6 DIMETHYLPHENOXY)METHYLTHIO]PROPANOIC ACID; 5 (1 METHYL 1H IMIDAZOL 2 YL THIO)PENTANOIC ACID; 5 (2 METHYLPHENOXY)PENTANOIC ACID; 5 (2,6 DIMETHYLPHENOXY)PENTANOIC ACID; 5 (3,5 DIMETHYLPHENOXY)PENTANOIC ACID; 5 (PHENOXY)PENTANOIC ACID; ALKANOIC ACID; ANTIOXIDANT; METHYL GROUP; OCTANOIC ACID; OMEGA (1 METHYL 1H IMIDAZOL 2 YL THIO)ALKANOIC ACID DERIVATIVE; OMEGA (PHENOXY)ALKANOIC ACID DERIVATIVE; PHENOL DERIVATIVE; PRODRUG; THIAMAZOLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BIOTRANSFORMATION; CELL HYPOXIA; CELL PROTECTION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; DRUG TARGETING; FATTY ACID OXIDATION; HEART MUSCLE CELL; MALE; MITOCHONDRION; NONHUMAN; RAT; REOXYGENATION; SUBSTITUTION REACTION;

ACRYLATES; ALKANES; BIOTRANSFORMATION; CYTOPROTECTION; MAGNETIC RESONANCE SPECTROSCOPY; MITOCHONDRIA; PRODRUGS; REACTIVE OXYGEN SPECIES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 75849164405     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.019     Document Type: Article

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