(R)-α-Lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate

FASEB Journal

Volumn 13, Issue 2, 1999, Pages 411-418

  Hagen, Tory M ^a,c   Ingersoll, Russell T ^a   Lykkesfeldt, Jens ^a,d   Liu, Jiankang ^a   Wehr, Carol M ^a   Vinarsky, Vladimir ^a   Bartholomew, James C ^b   Ames, Bruce N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c OREGON STATE UNIVERSITY   (United States)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Aging; Ambulatory activity; Antioxidants; Liver; MDA

Indexed keywords

THIOCTIC ACID;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; LIPID PEROXIDATION; LIVER CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT;

ANIMALIA; TRIXIS;

EID: 0033042929     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.13.2.411     Document Type: Article

References (43)

1. Shigenaga, M. K., Hagen, T. M., and Ames, B. N. (1994) Oxidative damage and mitochondrial decay in aging. Proc. Natl. Acad. Sci. USA 91, 10771-10778
2. Sastre, J., Pallardo, F. V., Pla, R., Pellin, A., Juan, G., O'Conner, J. E., Estrela, J. M., Miquel, J., and Vina, J. (1996) Aging of the liver: age-associated mitochondrial damage in intact hepatocytes. Hepatology 24, 1199-1205
3. Sohal, R. S., and Weindruch, R. (1996) Oxidative stress, caloric restriction and aging. Science 273, 59-63
4. Hagen, T. M., Yowe, D. L., Bartholomew, J. C., Wehr, C. M., Do, K. L., Park, J.-Y., and Ames, B. N. (1997) Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc. Natl. Acad. Sci. USA 94, 3064-3069
5. Erdincler, D. S., Seven, A., Inci, F., Beager, T., and Candan, G. (1997) Lipid peroxidation and antioxidant status in experimental animals: effects of aging and hypercholesterolemic diet. Clin. Chem. Acta 265, 77-84
6. Sanz, N., Diez-Fernandez, C., Alvarez, A., and Cascales, M. (1997) Age-dependent modifications in rat hepatocyte antioxidant defense systems. J. Hepatol. 27, 524-534
7. Jacob, S., Henriksen, E. J., Tritschler, H. J., Augustin, H. J., and Dietz, G. J. (1996) Improvement of insulin-stimulated glucose disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Endocrinol. Diabetes 104, 284-288
8. Sachse, G., and Willms, B. (1980) Efficacy of thioctic acid in the therapy of peripheral diabetic neuropathy. Horm. Metab. Res. Suppl. 9, 105-107
9. Ziegler, D., Hanefeld, M., Ruhnau, K. J., Meissner, H. P., Lobisch, M., Schutte, K., and Gries, F. A. (1995) Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant α-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN study). Diabetologia 38, 1425-1433
10. Suzuki, Y. T., Tsuchia, M., and Packer, L. (1991) Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Rad. Res. Commun. 15, 255-263
11. Scott, B. C., Aruoma, O. I., Evans, P. J., O'Neill, C., Van Der Vliet, A., Cross, C. E., Tritschler, H. J., and Halliwell, B. (1994) Lipoic acid and dihydrolipoic acids as antioxidants. A critical evaluation. Free Rad. Res. Commun. 20, 119-133
12. Han, D., Handelman, G., Marcocci, L., Sen, C. K., Roy, S., Kobuchi, H., Tritschler, H. J., Flohe, L., and Packer, L. (1997) Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization. Biofactors 6, 321-338
13. Xu, D. P., and Wells, W. W. (1996) alpha-Lipoic acid dependent regeneration of ascorbic acid from dehydroascorbic acid in rat liver mitochondria. J. Bioenerg. Biomembr. 28, 77-85
14. Lykkesfeldt, J., Hagen, T. M., Vinarsky, V., and Ames, B. N. (1998) Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes - reversal with (R)-α-lipoic acid supplementation. FASEB J. 12, 1183-1189
15. Kagen, V. E., Serbinova, E. A., Forte, T., Sata, G., and Packer, L. (1992) Recycling of vitamin E on human low density lipoproteins. J. Lipid Res. 33, 385-397
16. Zimmer, G., Mainka, L., and Kruger, E. (1991) Dihydrolipoic acid activates oligomycin-sensitive thiol groups and increases ATP synthesis in mitochondria. Arch. Biochem. Biophys. 288, 609-613
17. Moldèus, P., Hogberg, J., and Orrenius, S. (1978) Isolation and use of liver cells. Methods Enzymol. 52, 60-71
18. Steinkamp, J. A., Fulwyler, M. J., Coulter, J. R., Hiebert, R. D., Homey, J. L., and Mullancy, P. F. (1973) A new multiparameter separator for microscope particles and biological cells. Rev. Sci. Instrum. 44, 1301-1310
19. LeBel, C. P., Ischiropoulos, H., and Bondy, S. C. (1992) Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem. Res. Toxicol. 5, 227-231
20. Reed, D. J., Babson, J. R., Beatty, P. W., Brodie, A. E., Ellis, W. W., and Potter, D. W. (1982) High performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides. Anal. Biochem. 106, 55-62
21. Lykkesfeldt, J., Loft, S., and Poulsen, H. E. (1995) Determination of ascorbic acid and dehydroascorbic acid in plasma by high-performance liquid chromatography with coulometric detection - are they reliable biomarkers of oxidative stress? Anal. Biochem. 229, 329-335
22. Yeo, H. C., Helbock, H. J., Chyu, D. W., and Ames, B. N. (1994) Assay of malondialdehyde in biological fluids by gas chromatography-mass spectrometry. Anal. Biochem. 220, 391-396
23. Liu, J., Yeo, H. C., Doniger, S. J., and Ames, B. N. (1997) Assay of aldehydes from lipid peroxidation: gas chromatography-mass spectrometry compared to thiobarbituric acid. Anal. Biochem. 245, 161-166
24. Bustamante, J., Lodge, J. K., Marcocci, L., Tritschler, H. J., Packer, L., and Rihn, B. H. (1998) α-Lipoic acid in liver metabolism and disease. Free Rad. Biol. Med. 24, 1023-1039
25. Zimmer, G., Beikler, T. K., Schneider, M., Ibel, J., Tritschler, H., and Ulrich, H. (1995) Dose/response curves of lipoic acid R-and S-forms in the working rat heart during reoxygenation: superiority of the R-enantiomer in enhancement of aortic flow. J. Mol. Cell Cardiol. 27, 1895-1903
26. Maitra, I., Serbinova, E., Tritschler, H. J., and Packer, L. (1996) Stereospecific effects of R-lipoic acid on buthionine-S,R-sulfoximine-induced cataract formation in newborn rats. Biochem. Biophys. Res. Commun. 221, 422-429
27. Estrada, D. E., Ewart, H. S., Tsakiridis, T., Volchuk, A., Ramlal, T., Tritschler, H. J., and Klip, A. (1996) Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin-signaling pathway. Diabetes 45, 1798-1804
28. Ou, P., Tritschler, H. J., and Wolff, P. (1995) Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant? Biochem. Pharmacol. 50, 123-126
29. 14C]rac-α-lipoic acid from in situ ligated segments of the gastrointestinal tract of the rat. Arzneim. Forsch. Drug Res. 45, 293-299
30. Teichart, J., and Preiss, R. (1995) Determination of lipoic acid in human plasma by high-performance liquid chromatography with electrochemical detection. J. Chromatogr. B. 672, 277-281
31. 14C] lipoic acid in the rat. Arch. Biochem. Biophys. 160, 514-522
32. Peindado, J., Sies, H., and Akerboom, T. P. M. (1989) Hepatic lipoate uptake. Arch. Biochem. Biophys. 273, 389-395
33. Streeper, R. S., Henriksen, E. J., Jacob, S., Hokama, J. Y., Fogt, D. L., and Tritschler, H. J. (1997) Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Am. J. Physiol. 273, E185-E191
34. Gregus, Z., Stein, A. F., Varga, F., and Klaassen, C. D. (1992) Effect of lipoic acid on biliary excretion of glutathione and metals. Toxicol. Appl. Pharmacol. 114, 88-96
35. Jacob, S., Augustin, H. J., and Dietze, G. J. (1995) Thioctic acid: a potential modulator of insulin sensitivity and glucose metabolism in patients with Type II diabetes. In: Lipoic Acid in Health and Disease (Fuchs, J., Packer, L., and Zimmer, G., eds) pp. 373-392, Marcel Dekker, New York
36. Steyn, D. G. (1966) The treatment of cases of amanita phalloides and amanita capensis poisoning. S. Afr. Med. J. 40, 405-406
37. Korkina, L. G., Afanas'ef, I. B., and Diplock, A. T. (1993) Antioxidant therapy in children affected by irradiation from the Chernobyl nuclear accident. Biochem. Soc. Trans. 21, 314S
38. Paradies, G., Ruggiero, F. M., Petrosillo, G., Gadaleta, M. N., and Quagliariello, E. (1995) Carnitine-acylcarnitine translocase activity in cardiac mitochondria from aged rats: the effect of acetyl-L-carnitine. Mech. Ageing Dev. 84, 103-112
39. Paradies, G., and Ruggiero, F. M. (1990) Age-related changes in the activity of the pyruvate carrier and in the lipid composition in rat-heart mitochondria. Biochim. Biophys. Acta. 1016, 207-212
40. Villa, R. F., Turpeenoja, L., Benzi, G., and Giuffrida Stella, A. M. (1998) Action of L-acetylcarnitine on age-dependent modifications of mitochondrial membrane proteins from rat cerebellum. Neurochem. Res. 10, 909-916
41. Paradies, G., Ruggiero, F. M., Petrosillo, G., Gadaleta, M. N., and Quagliariello, E. (1994) Effect of aging and acetyl-L-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in heart mitochondria. FEBS Lett. 350, 213-215
42. Carta, A., Calvani, M., Bravi, D., and Bhuachalla, S. N. (1993) Acetyl-L-carnitine and Alzheimer's disease: pharmacological considerations beyond the cholinergic sphere, In: Alzheimer's Disease: Amyloid Precursor Proteins, Signal Transduction and Neuronal Transplantation (Wurtman, R. J., Corkin, S., Growdon, J. H., and Nitsch, R. M., eds) Vol. 695, pp. 324-326, New York Academy of Sciences, New York
43. Hagen, T. M., Ingersoll, R. T., Wehr, C. M., Lykkesfeldt, J., Vinarsky, V., Bartholomew, J. C., Song, M.-H., and Ames, B. N. (1998) Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proc. Natl. Acad. Sci. USA 95, 9562-9566