Structural basis of mitochondrial tethering by mitofusin complexes

Science

Volumn 305, Issue 5685, 2004, Pages 858-862

  Koshiba, Takumi ^a   Detmer, Scott A ^a   Kaiser, Jens T ^a,b   Chen, Hsiuchen ^a   McCaffery, J Michael ^c   Chan, David C ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; POLYMERIZATION; PROTEINS;

HEPTAD REPEAT REGION (HR2); MITOCHONDRIA; OLIGOMERIZATION; VESICLE FUSION;

BIOCHEMISTRY;

MITOCHONDRIAL PROTEIN; MITOFUSIN; SNARE PROTEIN; UNCLASSIFIED DRUG;

BIOLOGY;

ARTICLE; CELL ORGANELLE; CRYSTAL STRUCTURE; MEMBRANE TRANSPORT; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; GTP PHOSPHOHYDROLASES; HUMANS; HYBRID CELLS; HYDROPHOBICITY; INTRACELLULAR MEMBRANES; MEMBRANE FUSION; MICE; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 3843075121     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1099793     Document Type: Article

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25. We are grateful to D. Rees, J. Nunnari, and R. Dashaies for helpful discussions. We thank the staff of the Advanced Light Source at Berkeley Lab. We thank P. Huang for advice on structural analysis. T.K. was supported by a Gosney Foundation postdoctoral fellowship; J.T.K. is an HHMI Research Associate. This work was supported by the National Institute of Health (R01 GM62967). D.C.C. is a Bren Scholar, Rita Allen Scholar, and Beckman Young Investigator. Atomic coordinates and structure factors have been deposited in the Protein Data Bank, accession code 1T3J.