Design, mechanism of action, bioavailability and therapeutic effects of Mn porphyrin-based redox modulators

Medical Principles and Practice

Volumn 22, Issue 2, 2013, Pages 103-130

  Tovmasyan, Artak ^a   Sheng, Huaxin ^a   Weitner, Tin ^a   Arulpragasam, Amanda ^a   Lu, Miaomiao ^a,b   Warner, David S ^a   Vujaskovic, Zeljko ^a   Spasojevic, Ivan ^a   Batinic Haberle, Ines ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b ZHENGZHOU UNIVERSITY   (China)

Author keywords

Bioavailability; Cancer; Cationic Mn porphyrins; Central nervous system injuries; Mechanism of action; Radioprotection

Indexed keywords

4 CARBOXYTEMPO; ANTIDIABETIC AGENT; ANTINEOPLASTIC AGENT; CARBONIC ACID; CENTRAL NERVOUS SYSTEM AGENTS; COPPER ZINC SUPEROXIDE DISMUTASE; CURCUMIN; DIAGNOSTIC AGENT; EUK 189; EUK 207; EUK 418; GADOLINIUM TEXAPHYRIN; HONOKIOL; HYPOCHLORITE; IMISOPASEM MANGANESE; LIPID PEROXIDE; MANGANESE DERIVATIVE; MANGANESE N,N' ETHYLENEBIS(3 METHOXYSALICYLIDENEAMINE); MANGANESE SALEN CHLORIDE; NITRIC OXIDE; PEROXYNITRITE; POLYAMINE; POLYPHENOL; PORPHYRIN DERIVATIVE; RADICAL; RADIOPROTECTIVE AGENT; SUPEROXIDE; TEMPOL; TEMPONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; MANGANESE PORPHYRIN; METAL COMPLEX; RADIOSENSITIZING AGENT;

BRAIN CANCER; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG EFFECT; DRUG MECHANISM; DRUG PURITY; DRUG STRUCTURE; ESCHERICHIA COLI; HUMAN; IMMUNE RESPONSE; INFLAMMATION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; REVIEW; SACCHAROMYCES CEREVISIAE; STRUCTURE ACTIVITY RELATION; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; BRAIN CORTEX; CELL NUCLEUS; CENTRAL NERVOUS SYSTEM DISEASE; CEREBRAL PALSY; CEREBROVASCULAR ACCIDENT; DIABETES MELLITUS; EPILEPSY; HEMATOPOIETIC STEM CELL; HIPPOCAMPUS; HYPERTHERMIA; IN VIVO STUDY; MITOCHONDRION; MORPHINE TOLERANCE; NEUROPATHIC PAIN; PARKINSON DISEASE; RADIATION PROTECTION; SPINAL CORD INJURY; SUBARACHNOID HEMORRHAGE;

ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CENTRAL NERVOUS SYSTEM DISEASES; CONTRAST MEDIA; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; FREE RADICAL SCAVENGERS; MANGANESE; NEOPLASMS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PORPHYRINS; SUPEROXIDE DISMUTASE;

EID: 84873638808     PISSN: 10117571     EISSN: 14230151     Source Type: Journal    
DOI: 10.1159/000341715     Document Type: Review

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