Structural requirements for optimized delivery, inhibition of oxidative stress, and antiapoptotic activity of targeted nitroxides

Journal of Pharmacology and Experimental Therapeutics

Volumn 320, Issue 3, 2007, Pages 1050-1060

  Jiang, Jianfei ^a   Kurnikov, Igor ^a   Belikova, Natalia A ^a   Xiao, Jingbo ^a   Zhao, Qing ^a   Amoscato, Andrew A ^b   Braslau, Rebecca ^c   Studer, Armido ^d   Fink, Mitchell P ^b   Greenberger, Joel S ^b   Wipf, Peter ^a   Kagan, Valerian E ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; DACTINOMYCIN; GRAMICIDIN S; NITROXIDE DERIVATIVE; SUPEROXIDE; TEMPOL;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CHEMICAL COMPOSITION; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; ELECTRON SPIN RESONANCE; ELECTROSPRAY MASS SPECTROMETRY; EMBRYO; HYDROPHOBICITY; IN VIVO STUDY; LIPID MEMBRANE; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOLECULAR DYNAMICS; MONTE CARLO METHOD; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OXIDATIVE STRESS; PRIORITY JOURNAL; SIMULATION; STRUCTURE ACTIVITY RELATION; THREE DIMENSIONAL IMAGING;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL MEMBRANE; CELLS, CULTURED; CIRCULAR DICHROISM; CYCLIC N-OXIDES; DACTINOMYCIN; GRAMICIDIN; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MITOCHONDRIA; MODELS, MOLECULAR; OXIDATIVE STRESS; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33847130168     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.114769     Document Type: Article

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