Complex I dysfunction and tolerance to nitroglycerin: An approach based on mitochondrial-targeted antioxidants

Circulation Research

Volumn 99, Issue 10, 2006, Pages 1067-1075

  Esplugues, Juan V ^a   Rocha, Milagros ^a   Nuñez, Cristina ^b   Bosca, Irene ^b   Ibiza, Sales ^b   Herance, Jose R ^c   Ortega, Angel ^b   Serrador, Juan M ^b   D'Ocon, Pilar ^a   Victor, Victor M ^b,d  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c Instituto de Alta Tecnologia   (Spain)

^d Unidad Mixta CNIC Valencia   (Spain)

Author keywords

Antioxidant; Endothelium; Mitochondria; Nitroglycerin; Oxidative stress

Indexed keywords

ALDEHYDE DEHYDROGENASE; ANTIOXIDANT; GLUTATHIONE; GLYCERYL TRINITRATE; MITOQUINONE; OXYGEN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); SUCCINIC ACID; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOTRANSFORMATION; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG TARGETING; DRUG TOLERANCE; ENZYME ACTIVITY; HEART MITOCHONDRION; HEART MUSCLE OXYGEN CONSUMPTION; HUMAN; HUMAN CELL; INCUBATION TIME; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ALDEHYDE DEHYDROGENASE; ANIMALS; ANTIOXIDANTS; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; ELECTRON TRANSPORT COMPLEX I; ENDOTHELIAL CELLS; GLUTATHIONE; HUMANS; MALE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NITROGLYCERIN; ORGANOPHOSPHORUS COMPOUNDS; OXIDATIVE STRESS; OXYGEN CONSUMPTION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; UBIQUINONE; VASODILATOR AGENTS;

EID: 33750930318     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000250430.62775.99     Document Type: Article

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