Potent mitochondria-targeted peptides reduce myocardial infarction in rats

Coronary Artery Disease

Volumn 18, Issue 3, 2007, Pages 215-220

  Cho, Janghyun ^a   Won, Kyungheon ^b   Wu, DunLi ^c   Soong, Yi ^c   Liu, Shaoyi ^c   Szeto, Hazel H ^c   Hong, Mun K ^d  

^a Saint Carollo Hospital   (South Korea)

^b Seoul Medical Center   (South Korea)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

Author keywords

Antioxidant; Lipid peroxidation; Myocardial infarction; Reperfusion

Indexed keywords

DEXTO ARGININE 2',6' DIMETHYLTYROSYLLYSYLPHENYLALANINAMIDE; OPIATE; PEPTIDE DERIVATIVE; PHENYLALANYL DEXTRO ARGINYLPHENYLALANYLLYSINAMIDE; SS 20; SS 31; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTERY LIGATION; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; HEART ARRHYTHMIA; HEART INFARCTION; HEART INFARCTION SIZE; HEART PROTECTION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LIPID PEROXIDATION; MALE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION;

ANIMALS; ANTIOXIDANTS; LIPID PEROXIDATION; MALE; MITOCHONDRIA; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION; OLIGOPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 34247209532     PISSN: 09546928     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mca.0000236285.71683.b6     Document Type: Article

References (18)

1. Wu D, Soong Y, Zhao GM, Szeto HH. A highly potent peptide analgesic that protects against ischemia - reperfusion-induced myocardial stunning. Am J Physiol Heart Circ Physiol 2002; 283:H783-H791.
2. Song WH, Shin JH, Lee JU, Kim HJ, Oh DJ, Edelberg JM, et al. A potent opiate agonist protects against myocardial stunning during myocardial ischemia and reperfusion in rats. Coron Artery Dis 2005; 16:407-410.
3. Schultz JE, Gross GJ. Opioids and cardioprotection. Pharmacol Ther 1995; 268: H2157-H2161.
4. Meine TJ, Roe MT, Chen AY, Patel MR, Washam JB, Ohman EM, et al. Association of intravenous morphine use and outcomes in acute coronary syndromes: results from the CRUSADE quality improvement initiative. Am Heart J 2005; 149:1043-1049.
5. Goldhaber JI, Weis JN. Oxygen free radicals and cardiac reperfusion abnormalities. Hypertension 1992; 20:118-127.
6. Petrosillo G, Venosa ND, Pistolese M, Casanova G, Tiravanti E, Colantuono G, et al. Protective effect of melatonin against mitochondrial dysfunction associated with cardiac ischemia-reperfusion: role of cardiolipin. FASEB J 2006; 20:269-276.
7. Chen Z, Chua CC, Gao J, Hamdy RC, Cuua BHL. Protective effect of melatonin on myocardial infarction. Am J Physiol 2003; 284:H1618-H1624.
8. Zhao K, Zhao GM, Wu D, Soong Y, Birk AV, Schiller PW, et al. Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury. J Biol Chem 2004; 279:34682-34690.
9. Zhao K, Luo G, Giannelli S, Szeto HH. Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines. Biochem Pharmacol 2005; 70:1796-1806.
10. Schiller PW, Nguyen TM, Berezowska I, Dupuis S, Weltrowska G, Chung NN, et al. Synthesis and in vitro opioid activity profiles of DALDA analogues. Eur J Med Chem 2000; 35:895-901.
11. Schwarz ER, Somoano Y, Hale SL, Kloner RA. What is the required reperfusion period of assessment of myocardial infarct size using triphenyltetrazolum chloride staining in the rat? J Thromb Thrombolys 2000; 10:181-187.
12. Walker MJ, Curtis MJ, Hearse DJ, Campbell RW, Janse MJ, Yellon DM, et al. The Lambeth Conventions: guidelines for the study of arrhythmias in ischemia infarction, and reperfusion. Cardiovasc Res 1988; 22:447-455.
13. Curtis MJ, Walker MJ. Quantification of arrhythmias using scoring systems: an examination of seven scores in an in vivo model of regional myocardial ischemia. Cardiovasc Res 1988; 22:656-665.
14. Galvani M, Ottani F, Ferrini D, Sorbello R, Rusticali F. Patency of the infarctrelated artery and left ventricular function as the major determinants of survival after Q-wave acute myocardial infarction. Am J Cardiol 1993; 71:1-7.
15. Yellon DM, Baxter GF. Protecting the ischaemic and reperfused myocardium in acute myocardial infarction: distant dream or near reality? Heart 2000; 83:381-387.
16. Stone GW, Webb J, Cox DA, Brodie BR, Qureshi M, Kalynch A, et al. Distal microcirculatory protection during percutaneous coronary intervention in acute ST-segment elevation myocardial infarction: a randomized controlled trial. JAMA 2005; 293:1063-1072.
17. Ali A. AngioJet rheolytic thrombectomy in patients undergoing primary angioplasty for acute myocardial infarction. Washington, District of Columbia: TCT; 2004.
18. Chen TY, Lee MY, Chen HY, Kuo YL, Lin SC, Wu TS, et al. Melatonin attenuates the postischemic increase in blood-brain barrier permeability and decreases hemorrhagic transformation of tissue-plasminogen activator therapy following ischemic stroke in mice. Am J Physiol Heart Circ Physiol 2006; 40:242-250.