Mitochondrial reactive oxygen species enhance amp-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes

Clinical Science

Volumn 124, Issue 6, 2013, Pages 403-411

  Mackenzie, Ruth M ^a   Salt, Ian P ^a   Miller, William H ^a   Logan, Angela ^b   Ibrahim, Hagar A ^a   Degasperi, Andrea ^a   Dymott, Jane A ^a   Hamilton, Carlene A ^a   Murphy, Michael P ^b   Delles, Christian ^a   Dominiczak, Anna F ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

AMP activated protein kinase (AMPK); Coronary artery disease (CAD); Diabetes; Endothelium; Mitochondrion; Oxidative stress

Indexed keywords

HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROGEN PEROXIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; REACTIVE OXYGEN METABOLITE;

ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; PRIORITY JOURNAL; SAPHENOUS VEIN; VASODILATATION;

AGED; AMP-ACTIVATED PROTEIN KINASES; CORONARY ARTERY DISEASE; DIABETES MELLITUS, TYPE 2; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; VASODILATION;

EID: 84872241559     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20120239     Document Type: Article

References (3)

1. Corton, J. M., Gillespie, J. G., Hawley, S. A. and Hardie, D. G. (1995) 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur. J. Biochem. 229, 558-565
2. Hardie, D. G., Haystead, T. A. J., Salt, I. P. and Davies, S. P. (1999) Assay and purification of protein: serine/threonine kinases. Protein Phosphorylation: A Practical Approach 2nd edn, (Hardie, D. G., ed.), pp. 201-209, Oxford University Press, Oxford
3. Quintero, M., Colombo, S. L., Godfrey, A. and Moncada, S. (2006) Mitochondria as signaling organelles in the vascular endothelium. Proc. Natl. Acad. Sci. U.S.A. 103, 5379-5384