Paraoxonase 1 (PON1) attenuates macrophage oxidative status: Studies in PON1 transfected cells and in PON1 transgenic mice

Atherosclerosis

Volumn 181, Issue 1, 2005, Pages 9-18

  Rozenberg, Orit ^a   Shih, Diana M ^a,b   Aviram, Michael ^a  

^a RAMBAM MEDICAL CENTER   (Israel)

^b Department of Medicine ^*  (United States)

Author keywords

Atherosclerotic lesion; Lipoprotein; Macrophages; Paraoxonase 1; Transgenic mice

Indexed keywords

ANTIOXIDANT; APOLIPOPROTEIN E; ARYLDIALKYLPHOSPHATASE; GLUTATHIONE; LIPID PEROXIDE; MESSENGER RNA; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXIDE; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SYNTHESIS; EXPERIMENTAL MODEL; GENE EXPRESSION; GENETIC TRANSFECTION; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ANIMALS; AORTA; AORTIC DISEASES; ARTERIOSCLEROSIS; ARYLDIALKYLPHOSPHATASE; CELLS, CULTURED; HUMANS; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OXIDATION-REDUCTION; OXIDATIVE STRESS; TRANSFECTION;

EID: 20444419056     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2004.12.030     Document Type: Article

References (44)

1. M.I. Mackness, B. Mackness, and P.N. Durrington Paraoxonase and coronary heart disease Atheroscler Suppl 3 2002 49 55
2. B.N. La Du, M. Aviram, and S. Billecke On the physiological role(s) of the paraoxonases Chem Biol Interact 119/120 1999 379 388
3. M. Aviram Does paraoxonase play a role in susceptibility to cardiovascular disease? Mol Med Today 5 1999 381 386
4. M. Aviram Review of human studies on oxidative damage and antioxidant protection related to cardiovascular diseases Free Radic Res 33 Suppl 2000 S85 S97
5. G.S. Getz, and C.A. Reardon Paraoxonase, a cardioprotective enzyme: continuing issues Curr Opin Lipidol 15 2004 261 267
6. A. Tward, Y.R. Xia, and X.P. Wang Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice Circulation 106 2002 484 490
7. D.I. Draganov, and B.N. La Du Pharmacogenetics of paraoxonases: a brief review Naunyn Schmiedebergs Arch Pharmacol 369 2004 78 88
8. M. Navab, J.A. Berliner, and A.D. Watson The Yin and Yang of oxidation in the development of the fatty streak Arterioscler Thromb Vasc Biol 16 1996 831 842
9. M.I. Mackness, S. Arrol, and P.N. Durrington Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein FEBS Lett 286 1991 152 154
10. G.M. Chisolm, and D. Steinberg The oxidative modification hypothesis of atherogenesis: an overview Free Radic Biol Med 28 2000 1815 1826
11. M. Aviram, and B. Fuhrman Effects of flavonoids on the oxidation of LDL and atherosclerosis C.A. Rice-Evans L. Packer Flavonoids in Health and Disease 2nd ed. 2003 Marcel Dekker NY 165 203
12. B. Fuhrman, and M. Aviram Flavonoids protect LDL from oxidation and attenuate atherosclerosis Curr Opin Lipidol 12 2001 41 48
13. A.J. Lusis Atherosclerosis Nature 407 2000 233 241
14. D.M. Shih, L. Gu, and Y.R. Xia Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis Nature 394 1998 284 287
15. D.M. Shih, Y.R. Xia, and X.P. Wang Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis J Biol Chem 275 2000 17527 17535
16. O. Rozenberg, M. Rosenblat, R. Coleman, D.M. Shih, and M. Aviram Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice Free Radic Biol Med 34 2003 774 784
17. O. Rozenberg, D.M. Shih, and M. Aviram Human serum paraoxonase 1 decreases macrophage cholesterol biosynthesis: possible role for its phospholipase-A2-like activity and lysophosphatidylcholine formation Arterioscler Thromb Vasc Biol 23 2003 461 467
18. D.M. Shih, L. Gu, and S. Hama Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model J Clin Invest 97 1996 1630 1639
19. B. Fuhrman, N. Volkova, and M. Aviram Oxidative stress increases the expression of the CD36 scavenger receptor and the cellular uptake of oxidized low-density lipoprotein in macrophages from atherosclerotic mice: protective role of antioxidants and of paraoxonase Atherosclerosis 161 2002 307 316
20. G. Schmitz, H. Robenek, U. Lohmann, and G. Assmann Interaction of high density lipoproteins with cholesteryl ester-laden macrophages: biochemical and morphological characterization of cell surface receptor binding, endocytosis and resecretion of high density lipoproteins by macrophages EMBO J 4 1985 613 622
21. B. Mackness, R. Hunt, P.N. Durrington, and M.I. Mackness Increased immunolocalization of paraoxonase, clusterin, and apolipoprotein A-I in the human artery wall with the progression of atherosclerosis Arterioscler Thromb Vasc Biol 17 1997 1233 1238
22. K.N. Gan, A. Smolen, H.W. Eckerson, and B.N. La Du Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities Drug Metab Dispos 19 1991 100 106
23. C.P. LeBel, H. Ischiropoulos, and S.C. Bondy Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress Chem Res Toxicol 5 1992 227 231
24. J.J. Zulueta, R. Sawhney, F.S. Yu, C.C. Cote, and P.M. Hassoun Intracellular generation of reactive oxygen species in endothelial cells exposed to anoxia-reoxygenation Am J Physiol 272 1997 897 902
25. H. Wang, and J.A. Joseph Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader Free Radic Biol Med 27 1999 612 616
26. M. El Saadani, H. Esterbauer, and M. El Sayed A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent J Lipid Res 30 1989 627 630
27. O.H. Lowry, N.J. Rosebrough, L. Farr, and R.J. Randall Protein measurement with the folin phenol reagent J Biol Chem 193 1951 265 275
28. J.A. Buege, and S.D. Aust Microsomal lipid peroxidation Meth Enzymol 52 1978 302 310
29. H.Y. Sohn, M. Keller, and T. Gloe The small G-protein Rac mediates depolarization-induced superoxide formation in human endothelial cells J Biol Chem 275 2000 18745 18750
30. Y. Li, H. Zhu, and P. Kuppusamy Validation of lucigenin (bis-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems J Biol Chem 273 1998 2015 2023
31. M. Rosenblat, R. Coleman, and M. Aviram Increased macrophage glutathione content reduces cell-mediated oxidation of LDL and atherosclerosis in apolipoprotein E-deficient mice Atherosclerosis 163 2002 17 28
32. M. Rosenblat, and M. Aviram Macrophage glutathione content and glutathione peroxidase activity are inversely related to cell-mediated oxidation of LDL: in vitro and in vivo studies Free Radic Biol Med 24 1998 305 317
33. A.S. Plump, J.D. Smith, and T. Hayek Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells Cell 71 1992 343 353
34. M. Rosenblat, and M. Aviram Oxysterol-induced activation of macrophage NADPH-oxidase enhances cell-mediated oxidation of LDL in the atherosclerotic apolipoprotein E deficient mouse: inhibitory role for vitamin E Atherosclerosis 160 2002 69 80
35. M. Rosenblat, D. Draganov, and C.E. Watson Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress Arterioscler Thromb Vasc Biol 1 23 2003 468 474
36. R.C. Sorenson, C.L. Bisgaier, and M. Aviram Human serum paraoxonase/arylesterase's retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids: apolipoprotein A-I stabilizes activity Arterioscler Thromb Vasc Biol 19 1999 2214 2225
37. G.K. Marathe, G.A. Zimmerman, and T.M. McIntyre Platelet-activating factor acetylhydrolase, and not paraoxonase-1, is the oxidized phospholipid hydrolase of high density lipoprotein particles J Biol Chem 278 6 2003 3937 3947
38. S. Deakin, I. Leviev, M. Gomaraschi, L. Calabresi, G. Franceschini, and R.W. James Enzymatically active paraoxonase-1 is located at the external membrane of producing cells and released by a high affinity, saturable, desorption mechanism J Biol Chem 277 2002 4301 4308
39. M. Aviram, M. Rosenblat, and C.L. Bisgaier Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase J Clin Invest 101 1998 1581 1590
40. M. Aviram, E. Hardak, and J. Vaya Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities Circulation 101 2000 2510 2517
41. B. Fuhrman, M. Shiner, N. Volkova, and M. Aviram Cell-induced copper ion-mediated low density lipoprotein oxidation increases during in vivo monocyte-to-macrophage differentiation Free Radic Biol Med 37 2004 259 271
42. M. Rosenblat, T. Hayek, K. Hussein, and M. Aviram Decreased macrophage paraoxonase 2 expression in patients with hypercholesterolemia is the result of their increased cellular cholesterol content: effect of atorvastatin therapy Arterioscler Thromb Vasc Biol 24 2004 175 180
43. M. Rosenblat, and M. Aviram Macrophage glutathione content and glutathione peroxidase activity are inversely related to cell-mediated oxidation of LDL Free Radic Biol Med 24 1998 305 317
44. G. Keller-Weibel, P.G. Yancey, and W.G. Jerome Crystallization of free cholesterol in model macrophage foam cells Arterioscler Thromb Vasc Biol 19 1999 1891 1898