Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model

Neuroscience Letters

Volumn 304, Issue 3, 2001, Pages 157-160

  Jung, Cheolwha ^a   Rong, Yongqi ^b   Doctrow, Susan ^c   Baudry, Michel ^b   Malfroy, Bernard ^c   Xu, Zuoshang ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c Eukarion Inc   (United States)

Author keywords

Antioxidant; Motor neuron; Neurodegeneration; Neurodegenerative disease; Spinal cord

Indexed keywords

ANTIOXIDANT; CATALASE; COPPER; MANGANESE N,N' ETHYLENEBIS(3 METHOXYSALICYLIDENEAMINE); MANGANESE SALEN CHLORIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; ZINC;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEATH; DISEASE COURSE; GENE EXPRESSION; GENE MUTATION; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PARALYSIS; PRIORITY JOURNAL; SURVIVAL TIME;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CATALASE; MANGANESE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; ORGANOMETALLIC COMPOUNDS; OXIDATIVE STRESS; SUPEROXIDE DISMUTASE; SURVIVAL ANALYSIS;

EID: 0035947221     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)01784-0     Document Type: Article

References (20)

1. Andrus P.K., Fleck T.J., Gurney M.E., Hall E.D. Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis. J. Neurochem. 71:1998;2041-2048.
2. Baker K., Marcus C.B., Huffman K., Kruk H., Malfroy B., Doctrow S.R. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury. J. Pharmacol. Exp. Therap. 284:1998;215-221.
3. Bogdanov M.B., Ramos L.E., Xu Z., Beal M.F. Elevated hydroxyl radical generation in vivo in an animal model of amyotrophic lateral sclerosis. J. Neurochem. 71:1998;1321-1324.
4. Bruijn L.I., Houseweart M.K., Kato S., Anderson K.L., Anderson S.D., Ohama E., Reaume A.G., Scott R.W., Cleveland D.W. Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild type SOD1. Science. 281:1998;1851-1854.
5. Doctrow S.R., Huffman K., Marcus C.B., Musleh W., Bruce A., Baudry M., Malfroy B. 'Salen manganese complexes: combined superoxide dismutase/catalase mimics with broad pharmacological efficacy'. Sies H. Antioxidants in Disease Mechanisms and Therapeutic Strategies. Advances in Pharmacology. 1997;247-269 Academic Press, New York.
6. Dugan L.L., Turetsky D.M., Du C., Lobner D., Wheeler M., Almli C.R., Shen C.K.-F., Luh T.-Y., Choi D.W., Lin T.-S. Carboxyfullerenes as neuroprotective agents. Proc. Natl. Acad. Sci. USA. 94:1997;9434-9439.
7. Ferrante R.J., Browne S.E., Shinobu L.A., Bowling A.C., Baik M.J., MacGarvey U., Kowall N.W., Brown J.R.H., Beal M.F. Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. J. Neurochem. 69:1997;2064-2074.
8. Ghadge G.D., Lee J.P., Bindokas V.P., Jordan J., Ma L., Miller R.J., Roos R.P. Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection. J. Neurosci. 17:1997;8756-8766.
9. Gurney M.E., Cutting F.B., Zhai P., Doble A., Taylor C.P., Andrus P.K., Hall E.D. Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis [see comments]. Ann. Neurol. 39:1996;147-157.
10. Gurney M.E., Pu H., Chiu A.Y. Dal Canto. M.C., Polchow, C.Y., Alexander, D.D., Caliendo, J., Hentati, A., Kwon, Y.W., Deng, H.-X., Chen, W., Zhai, P., Sufit, R.L. and Siddique, T., Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase, Science. 264:1994;1772-1775.
11. Hall E.D., Andrus P.K., Oostveen J.A., Fleck T.J., Gurney M.E. Relationship of oxygen radical-induced lipid peroxidative damage to disease onset and progression in a transgenic model of familial ALS. J. Neurosci. Res. 53:1998;66-77.
12. Kong J., Xu Z. Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1. J. Neurosci. 18:1998;3241-3250.
13. Kruman I.I., Pedersen W.A., Springer J.E., Mattson M.P. ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis. Exp. Neurol. 160:1999;28-39.
14. Levine R.L., Garland D., Oliver C.N., Amici A., Climent I., Lenz A.-G., Ahn B.-W., Shaltiel S., Stadtman E.R. Determination of carbonyl content in oxidatively modified proteins. Meth. Enzymol. 186:1990;464-478.
15. Liu R., Althaus J.S., Ellerbrock B.R., Becker D.A., Gurney M.E. Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis. Ann. Neurol. 44:1998;763-770.
16. Malfroy B., Doctrow S.R., Orr P.L., Tocco G., Fedoseyeva E.V., Benichou G. Prevention and suppression of autoimmune encephalomyelitis by EUK-8, a synthetic catalytic scavenger of oxygen-reactive metabolites, Cell. Immunol. 177:1997;62-68.
17. Poduslo J.F., Whelan S.L., Curran G.L., Wengenack T.M. Therapeutic benefit of polyamine-modified catalase as a scavenger of hydrogen peroxide and nitric oxide in familial amyotrophic lateral sclerosis transgenics. Ann Neurol. 48:2000;943-947.
18. Rong Y., Doctrow S.R., Tocco G., Baudry M. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology, Proc. Natl. Acad. Sci. USA. 96:1999;9897-9902.
19. Rong Y., Geng Z., Lau B.H. Ginkgo biloba attenuates oxidative stress in macrophages and endothelial cells. Free Rad. Biol. Med. 20:1996;12112-12117.
20. Xu Z. Mechanism and treatment of motoneuron degeneration in ALS: what have SOD1 mutants told us? ALS Neuromuscular Disord. 1:2000;225-234.