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Volumn 11, Issue 4, 2009, Pages 777-790

Regulation of autophagy by reactive oxygen species (ROS): Implications for cancer progression and treatment

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; HYDROGEN PEROXIDE; HYDROXYL GROUP; MEMBRANE PROTEIN; NITRIC OXIDE; NITROGEN DIOXIDE; PEROXYNITRITE; PROTEIN ATG4; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

EID: 60749108379     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2008.2270     Document Type: Review
Times cited : (663)

References (120)
  • 1
    • 33847026354 scopus 로고    scopus 로고
    • Autophagy delays apoptotic death in breast cancer cells following DNA damage
    • Abedin MJ, Wang D, McDonnell MA, Lehmann U, and Kelekar A. Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ 14: 500-510, 2007.
    • (2007) Cell Death Differ , vol.14 , pp. 500-510
    • Abedin, M.J.1    Wang, D.2    McDonnell, M.A.3    Lehmann, U.4    Kelekar, A.5
  • 2
    • 33751072935 scopus 로고    scopus 로고
    • Bioenergetics and the formation of mitochondrial reactive oxygen species
    • Adam-Vizi V and Chinopoulos C. Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol Sci 27: 639-645, 2006.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 639-645
    • Adam-Vizi, V.1    Chinopoulos, C.2
  • 3
    • 33749543605 scopus 로고    scopus 로고
    • Non-irradiation-derived reactive oxygen species (ROS) and cancer: Therapeutic implications
    • Agostinelli E and Seiler N. Non-irradiation-derived reactive oxygen species (ROS) and cancer: therapeutic implications. Amino Acids 31: 341-355, 2006.
    • (2006) Amino Acids , vol.31 , pp. 341-355
    • Agostinelli, E.1    Seiler, N.2
  • 5
    • 0027171266 scopus 로고
    • Oxidants, antioxidants, and the degenerative diseases of aging
    • Ames BN, Shigenaga MK, and Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A 90: 7915-7922, 1993.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2    Hagen, T.M.3
  • 6
    • 0035929650 scopus 로고    scopus 로고
    • The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
    • Arico S, Petiot A, Bauvy C, Dubbelhuis PF, Meijer AJ, Codogno P, and Ogier-Denis E. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 276: 35243-35246, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 35243-35246
    • Arico, S.1    Petiot, A.2    Bauvy, C.3    Dubbelhuis, P.F.4    Meijer, A.J.5    Codogno, P.6    Ogier-Denis, E.7
  • 7
    • 0035929650 scopus 로고    scopus 로고
    • The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
    • Arico S, Petiot A, Bauvy C, Dubbelhuis PF, Meijer AJ, Codogno P, and Ogier-Denis E. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 276: 35243-35246, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 35243-35246
    • Arico, S.1    Petiot, A.2    Bauvy, C.3    Dubbelhuis, P.F.4    Meijer, A.J.5    Codogno, P.6    Ogier-Denis, E.7
  • 8
    • 33750805015 scopus 로고    scopus 로고
    • Thinking globally and acting locally with TOR
    • Arsham AM and Neufeld TP. Thinking globally and acting locally with TOR. Curr Opin Cell Biol 18: 589-597, 2006.
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 589-597
    • Arsham, A.M.1    Neufeld, T.P.2
  • 9
    • 38949119423 scopus 로고    scopus 로고
    • Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3
    • Azad MB, Chen Y, Henson ES, Cizeau J, McMillan-Ward E, Israels SJ, and Gibson SB. Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3. Autophagy 4: 195-204, 2008.
    • (2008) Autophagy , vol.4 , pp. 195-204
    • Azad, M.B.1    Chen, Y.2    Henson, E.S.3    Cizeau, J.4    McMillan-Ward, E.5    Israels, S.J.6    Gibson, S.B.7
  • 10
    • 15144343374 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF)-induced generation of hydrogen peroxide: Role in EGF receptor-mediated tyrosine phosphorylation
    • Bae YS, Kang SW, Seo MS, Baines IC, Tekle E, Chock PB, and Rhee SG. Epidermal growth factor (EGF)-induced generation of hydrogen peroxide: role in EGF receptor-mediated tyrosine phosphorylation. J Biol Chem 272: 217-221, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 217-221
    • Bae, Y.S.1    Kang, S.W.2    Seo, M.S.3    Baines, I.C.4    Tekle, E.5    Chock, P.B.6    Rhee, S.G.7
  • 11
    • 0028812631 scopus 로고
    • Increased antioxidant enzyme activities in the colorectal adenoma and carcinoma
    • Beno I, Staruchova M, Volkovova K, and Batovsky M. Increased antioxidant enzyme activities in the colorectal adenoma and carcinoma. Neoplasma 42: 265-269, 1995.
    • (1995) Neoplasma , vol.42 , pp. 265-269
    • Beno, I.1    Staruchova, M.2    Volkovova, K.3    Batovsky, M.4
  • 12
    • 0043204997 scopus 로고    scopus 로고
    • The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically
    • Bergamini E, Cavallini G, Donati A, and Gori Z. The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically. Biomed Pharmacother 57: 203-208, 2003.
    • (2003) Biomed Pharmacother , vol.57 , pp. 203-208
    • Bergamini, E.1    Cavallini, G.2    Donati, A.3    Gori, Z.4
  • 14
    • 17144403458 scopus 로고    scopus 로고
    • Programmed cell death via mitochondria: Different modes of dying
    • Bras M, Queenan B, and Susin SA. Programmed cell death via mitochondria: different modes of dying. Biochemistry (Mosc) 70: 231-239, 2005.
    • (2005) Biochemistry (Mosc) , vol.70 , pp. 231-239
    • Bras, M.1    Queenan, B.2    Susin, S.A.3
  • 15
    • 2942531063 scopus 로고    scopus 로고
    • Mitochondrial defects in cancer
    • Carew JS and Huang P. Mitochondrial defects in cancer. Mol Cancer 1: 9, 2002.
    • (2002) Mol Cancer , vol.1 , pp. 9
    • Carew, J.S.1    Huang, P.2
  • 16
    • 34347394714 scopus 로고    scopus 로고
    • Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance
    • Carew JS, Nawrocki ST, Kahue CN, Zhang H, Yang C, Chung L, Houghton JA, Huang P, Giles FJ, and Cleveland JL. Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood 110: 313-322, 2007.
    • (2007) Blood , vol.110 , pp. 313-322
    • Carew, J.S.1    Nawrocki, S.T.2    Kahue, C.N.3    Zhang, H.4    Yang, C.5    Chung, L.6    Houghton, J.A.7    Huang, P.8    Giles, F.J.9    Cleveland, J.L.10
  • 17
    • 0038127194 scopus 로고    scopus 로고
    • Endostatin induces autophagic cell death in EAhy926 human endothelial cells
    • Chau YP, Lin SY, Chen JH, and Tai MH. Endostatin induces autophagic cell death in EAhy926 human endothelial cells. Histol Histopathol 18: 715-726, 2003.
    • (2003) Histol Histopathol , vol.18 , pp. 715-726
    • Chau, Y.P.1    Lin, S.Y.2    Chen, J.H.3    Tai, M.H.4
  • 18
    • 38949203787 scopus 로고    scopus 로고
    • Is mitochondrial generation of reactive oxygen species a trigger for autophagy?
    • Chen Y and Gibson SB. Is mitochondrial generation of reactive oxygen species a trigger for autophagy? Autophagy 4: 246-248, 2008.
    • (2008) Autophagy , vol.4 , pp. 246-248
    • Chen, Y.1    Gibson, S.B.2
  • 19
    • 37349067228 scopus 로고    scopus 로고
    • Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells
    • Chen Y, McMillan-Ward E, Kong J, Israels SJ, and Gibson SB. Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ 15: 171-182, 2008.
    • (2008) Cell Death Differ , vol.15 , pp. 171-182
    • Chen, Y.1    McMillan-Ward, E.2    Kong, J.3    Israels, S.J.4    Gibson, S.B.5
  • 20
    • 38349043984 scopus 로고    scopus 로고
    • Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species
    • Chen Y, McMillan-Ward E, Kong J, Israels SJ, and Gibson SB. Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. J Cell Sci 120: 4155-4166, 2007.
    • (2007) J Cell Sci , vol.120 , pp. 4155-4166
    • Chen, Y.1    McMillan-Ward, E.2    Kong, J.3    Israels, S.J.4    Gibson, S.B.5
  • 21
    • 18144383207 scopus 로고    scopus 로고
    • Chiarugi P. PTPs versus PTKs: the redox side of the coin. Free Radic Res 39: 353-364, 2005.
    • Chiarugi P. PTPs versus PTKs: the redox side of the coin. Free Radic Res 39: 353-364, 2005.
  • 22
    • 38349105900 scopus 로고    scopus 로고
    • Complex I is the major site of mitochondrial superoxide production by paraquat
    • Cocheme HM and Murphy MP. Complex I is the major site of mitochondrial superoxide production by paraquat. J Biol Chem 283: 1786-1798, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 1786-1798
    • Cocheme, H.M.1    Murphy, M.P.2
  • 23
    • 0034642510 scopus 로고    scopus 로고
    • Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis
    • Costantini P, Belzacq AS, Vieira HL, Larochette N, de Pablo MA, Zamzami N, Susin SA, Brenner C, and Kroemer G. Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis. Oncogene 19: 307-314, 2000.
    • (2000) Oncogene , vol.19 , pp. 307-314
    • Costantini, P.1    Belzacq, A.S.2    Vieira, H.L.3    Larochette, N.4    de Pablo, M.A.5    Zamzami, N.6    Susin, S.A.7    Brenner, C.8    Kroemer, G.9
  • 24
    • 34248158083 scopus 로고    scopus 로고
    • Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells
    • Cui Q, Tashiro S, Onodera S, Minami M, and Ikejima T. Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells. Biol Pharm Bull 30: 859-864, 2007.
    • (2007) Biol Pharm Bull , vol.30 , pp. 859-864
    • Cui, Q.1    Tashiro, S.2    Onodera, S.3    Minami, M.4    Ikejima, T.5
  • 26
    • 33845192397 scopus 로고    scopus 로고
    • Potentiation of radiation sensitivity in breast tumor cells by the vitamin D3 analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery
    • Demasters G, Di X, Newsham I, Shiu R, and Gewirtz DA. Potentiation of radiation sensitivity in breast tumor cells by the vitamin D3 analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery. Mol Cancer Ther 5: 2786-2797, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2786-2797
    • Demasters, G.1    Di, X.2    Newsham, I.3    Shiu, R.4    Gewirtz, D.A.5
  • 27
    • 0033813282 scopus 로고    scopus 로고
    • Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: Dual regulation by reactive oxygen species
    • Deshpande SS, Angkeow P, Huang J, Ozaki M, and Irani K. Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species. FASEB J 14: 1705-1714, 2000.
    • (2000) FASEB J , vol.14 , pp. 1705-1714
    • Deshpande, S.S.1    Angkeow, P.2    Huang, J.3    Ozaki, M.4    Irani, K.5
  • 29
    • 0037031843 scopus 로고    scopus 로고
    • The APG8/12-activating enzyme APG7 is required for proper nutrient recycling and senescence in Arabidopsis thaliana
    • Doelling JH, Walker JM, Friedman EM, Thompson AR, and Vierstra RD. The APG8/12-activating enzyme APG7 is required for proper nutrient recycling and senescence in Arabidopsis thaliana. J Biol Chem 277: 33105-33114, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 33105-33114
    • Doelling, J.H.1    Walker, J.M.2    Friedman, E.M.3    Thompson, A.R.4    Vierstra, R.D.5
  • 30
    • 33750072949 scopus 로고    scopus 로고
    • mTOR and cancer therapy
    • Easton JB and Houghton PJ. mTOR and cancer therapy. Oncogene 25: 6436-6446, 2006.
    • (2006) Oncogene , vol.25 , pp. 6436-6446
    • Easton, J.B.1    Houghton, P.J.2
  • 31
    • 7744235672 scopus 로고    scopus 로고
    • Death by design: Apoptosis, necrosis and autophagy
    • Edinger AL and Thompson CB. Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol 16: 663-669, 2004.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 663-669
    • Edinger, A.L.1    Thompson, C.B.2
  • 32
    • 27744557065 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis: A new treatment paradigm in cancer
    • Engel RH and Evens AM. Oxidative stress and apoptosis: a new treatment paradigm in cancer. Front Biosci 11: 300-312, 2006.
    • (2006) Front Biosci , vol.11 , pp. 300-312
    • Engel, R.H.1    Evens, A.M.2
  • 34
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng Z, Zhang H, Levine AJ, and Jin S. The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci U S A 102: 8204-8209, 2005.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 35
    • 0031932169 scopus 로고    scopus 로고
    • Protein aggregation: Folding aggregates, inclusion bodies and amyloid
    • Fink AL. Protein aggregation: folding aggregates, inclusion bodies and amyloid. Fold Des 3: R9-R23, 1998.
    • (1998) Fold Des , vol.3
    • Fink, A.L.1
  • 36
    • 0030977793 scopus 로고    scopus 로고
    • Inhibition of the multicatalytic proteinase (proteasome) by 4-hydroxy-2-nonenal cross-linked protein
    • Friguet B and Szweda LI. Inhibition of the multicatalytic proteinase (proteasome) by 4-hydroxy-2-nonenal cross-linked protein. FEBS Lett 405: 21-25, 1997.
    • (1997) FEBS Lett , vol.405 , pp. 21-25
    • Friguet, B.1    Szweda, L.I.2
  • 37
    • 33847349283 scopus 로고    scopus 로고
    • Reactive oxygen species: A breath of life or death?
    • Fruehauf JP and Meyskens FL Jr. Reactive oxygen species: a breath of life or death? Clin Cancer Res 13: 789-794, 2007.
    • (2007) Clin Cancer Res , vol.13 , pp. 789-794
    • Fruehauf, J.P.1    Meyskens Jr., F.L.2
  • 39
    • 2342517643 scopus 로고    scopus 로고
    • Arsenic trioxide induces apoptosis in peripheral blood T lymphocyte subsets by inducing oxidative stress: A role of Bcl-2
    • Gupta S, Yel L, Kim D, Kim C, Chiplunkar S, and Gollapudi S. Arsenic trioxide induces apoptosis in peripheral blood T lymphocyte subsets by inducing oxidative stress: a role of Bcl-2. Mol Cancer Ther 2: 711-719, 2003.
    • (2003) Mol Cancer Ther , vol.2 , pp. 711-719
    • Gupta, S.1    Yel, L.2    Kim, D.3    Kim, C.4    Chiplunkar, S.5    Gollapudi, S.6
  • 41
    • 33749570745 scopus 로고    scopus 로고
    • Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes
    • Hamacher-Brady A, Brady NR, and Gottlieb RA. Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem 281: 29776-29787, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 29776-29787
    • Hamacher-Brady, A.1    Brady, N.R.2    Gottlieb, R.A.3
  • 42
    • 0030865646 scopus 로고    scopus 로고
    • Dual regulation of caspase activity by hydrogen peroxide: Implications for apoptosis
    • Hampton MB and Orrenius S. Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis. FEBS Lett 414: 552-556, 1997.
    • (1997) FEBS Lett , vol.414 , pp. 552-556
    • Hampton, M.B.1    Orrenius, S.2
  • 43
    • 33646701679 scopus 로고    scopus 로고
    • Antioxidant protective mechanisms against reactive oxygen species (ROS) generated by mitochondrial P450 systems in steroidogenic cells
    • Hanukoglu I. Antioxidant protective mechanisms against reactive oxygen species (ROS) generated by mitochondrial P450 systems in steroidogenic cells. Drug Metab Rev 38: 171-196, 2006.
    • (2006) Drug Metab Rev , vol.38 , pp. 171-196
    • Hanukoglu, I.1
  • 44
    • 33750284176 scopus 로고    scopus 로고
    • Autophagy in cancer: Good, bad, or both?
    • Hippert MM, O'Toole PS, and Thorburn A. Autophagy in cancer: good, bad, or both? Cancer Res 66: 9349-9351, 2006.
    • (2006) Cancer Res , vol.66 , pp. 9349-9351
    • Hippert, M.M.1    O'Toole, P.S.2    Thorburn, A.3
  • 45
    • 0034699513 scopus 로고    scopus 로고
    • Superoxide dismutase as a target for the selective killing of cancer cells
    • Huang P, Feng L, Oldham EA, Keating MJ, and Plunkett W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature 407: 390-395, 2000.
    • (2000) Nature , vol.407 , pp. 390-395
    • Huang, P.1    Feng, L.2    Oldham, E.A.3    Keating, M.J.4    Plunkett, W.5
  • 46
    • 34548833829 scopus 로고    scopus 로고
    • Role of oxidative stress from mitochondria on aging and cancer
    • 26(9 suppl)1
    • Ishii N. Role of oxidative stress from mitochondria on aging and cancer. Cornea 26(9 suppl)1: S3-S9, 2007.
    • (2007) Cornea
    • Ishii, N.1
  • 47
    • 33750483598 scopus 로고    scopus 로고
    • Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer
    • James J, Murry DJ, Treston AM, Storniolo AM, Sledge GW, Sidor C, and Miller KD. Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer. Invest New Drugs 25: 41-48, 2007.
    • (2007) Invest New Drugs , vol.25 , pp. 41-48
    • James, J.1    Murry, D.J.2    Treston, A.M.3    Storniolo, A.M.4    Sledge, G.W.5    Sidor, C.6    Miller, K.D.7
  • 48
    • 33846244269 scopus 로고    scopus 로고
    • Role of autophagy in cancer: Management of metabolic stress
    • Jin S and White E. Role of autophagy in cancer: management of metabolic stress. Autophagy 3: 28-31, 2007.
    • (2007) Autophagy , vol.3 , pp. 28-31
    • Jin, S.1    White, E.2
  • 49
    • 0033140347 scopus 로고    scopus 로고
    • Activation of NF-kappa B by reactive oxygen intermediates in the nervous system
    • Kaltschmidt B, Sparna T, and Kaltschmidt C. Activation of NF-kappa B by reactive oxygen intermediates in the nervous system. Antioxid Redox Signal 1: 129-144, 1999.
    • (1999) Antioxid Redox Signal , vol.1 , pp. 129-144
    • Kaltschmidt, B.1    Sparna, T.2    Kaltschmidt, C.3
  • 50
    • 13944256602 scopus 로고    scopus 로고
    • Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3
    • Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, and Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene 24: 980-991, 2005.
    • (2005) Oncogene , vol.24 , pp. 980-991
    • Kanzawa, T.1    Zhang, L.2    Xiao, L.3    Germano, I.M.4    Kondo, Y.5    Kondo, S.6
  • 51
    • 33846829572 scopus 로고    scopus 로고
    • The role of autophagy in the death of L1210 leukemia cells initiated by the new antitumor agents, XK469 and SH80
    • Kessel D, Reiners JJ Jr, Hazeldine ST, Polin L, and Horwitz JP. The role of autophagy in the death of L1210 leukemia cells initiated by the new antitumor agents, XK469 and SH80. Mol .Cancer Ther 6: 370-379, 2007.
    • (2007) Mol .Cancer Ther , vol.6 , pp. 370-379
    • Kessel, D.1    Reiners Jr, J.J.2    Hazeldine, S.T.3    Polin, L.4    Horwitz, J.P.5
  • 53
    • 6344275803 scopus 로고    scopus 로고
    • Activation of chaperone-mediated autophagy during oxidative stress
    • Kiffin R, Christian C, Knecht E, and Cuervo AM. Activation of chaperone-mediated autophagy during oxidative stress. Mol Biol Cell 15: 4829-4840, 2004.
    • (2004) Mol Biol Cell , vol.15 , pp. 4829-4840
    • Kiffin, R.1    Christian, C.2    Knecht, E.3    Cuervo, A.M.4
  • 54
    • 34447132925 scopus 로고    scopus 로고
    • Sodium selenite induces superoxide-mediated mitochondrialdamageandsubsequent autophagic cell death in malignant glioma cells
    • Kim EH, Sohn S, Kwon HJ, Kim SU, Kim MJ, Lee SJ, and Choi KS. Sodium selenite induces superoxide-mediated mitochondrialdamageandsubsequent autophagic cell death in malignant glioma cells. Cancer Res 67: 6314-6324, 2007.
    • (2007) Cancer Res , vol.67 , pp. 6314-6324
    • Kim, E.H.1    Sohn, S.2    Kwon, H.J.3    Kim, S.U.4    Kim, M.J.5    Lee, S.J.6    Choi, K.S.7
  • 57
    • 33845974091 scopus 로고    scopus 로고
    • Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of rapamycin signaling
    • Kim KW, Mutter RW, Cao C, Albert JM, Freeman M, Hallahan DE, and Lu B. Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of rapamycin signaling. J Biol Chem 281: 36883-36890, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 36883-36890
    • Kim, K.W.1    Mutter, R.W.2    Cao, C.3    Albert, J.M.4    Freeman, M.5    Hallahan, D.E.6    Lu, B.7
  • 58
    • 0037146679 scopus 로고    scopus 로고
    • Loss of cardiolipin and mitochondria during programmed neuronal death: Evidence of a role for lipid peroxidation and autophagy
    • Kirkland RA, Adibhatla RM, Hatcher JF, and Franklin JL. Loss of cardiolipin and mitochondria during programmed neuronal death: evidence of a role for lipid peroxidation and autophagy. Neuroscience 115: 587-602, 2002.
    • (2002) Neuroscience , vol.115 , pp. 587-602
    • Kirkland, R.A.1    Adibhatla, R.M.2    Hatcher, J.F.3    Franklin, J.L.4
  • 60
    • 40949126440 scopus 로고    scopus 로고
    • Mitochondrial complex III regulates hypoxic activation of HIF
    • Klimova T and Chandel NS. Mitochondrial complex III regulates hypoxic activation of HIF. Cell Death Differ 15: 660-666, 2008.
    • (2008) Cell Death Differ , vol.15 , pp. 660-666
    • Klimova, T.1    Chandel, N.S.2
  • 63
    • 33645944960 scopus 로고    scopus 로고
    • Autophagy and cancer therapy
    • Kondo Y and Kondo S. Autophagy and cancer therapy. Autophagy 2: 85-90, 2006.
    • (2006) Autophagy , vol.2 , pp. 85-90
    • Kondo, Y.1    Kondo, S.2
  • 65
    • 34347257042 scopus 로고    scopus 로고
    • Nox enzymes, ROS, and chronic disease: An example of antagonistic pleiotropy
    • Lambeth JD. Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. Free Radic Biol Med 43: 332-347, 2007.
    • (2007) Free Radic Biol Med , vol.43 , pp. 332-347
    • Lambeth, J.D.1
  • 66
    • 38049027838 scopus 로고    scopus 로고
    • Proautophagic drugs: A novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas
    • Lefranc F, Facchini V, and Kiss R. Proautophagic drugs: a novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas. Oncologist 12: 1395-1403, 2007.
    • (2007) Oncologist , vol.12 , pp. 1395-1403
    • Lefranc, F.1    Facchini, V.2    Kiss, R.3
  • 67
    • 12944308330 scopus 로고    scopus 로고
    • Eating oneself and uninvited guests: Autophagy-related pathways in cellular defense
    • Levine B. Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. Cell 120: 159-162, 2005.
    • (2005) Cell , vol.120 , pp. 159-162
    • Levine, B.1
  • 68
    • 33644990327 scopus 로고    scopus 로고
    • Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase
    • Li Q and Engelhardt JF. Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase. J Biol Chem 281: 1495-1505, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 1495-1505
    • Li, Q.1    Engelhardt, J.F.2
  • 70
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, and Thompson CB. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120: 237-248, 2005.
    • (2005) Cell , vol.120 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3    Harris, M.H.4    Li, C.5    Lindsten, T.6    Thompson, C.B.7
  • 71
    • 34548444513 scopus 로고    scopus 로고
    • Free radical oxidation of proteins and its relationship with functional state of organisms
    • Lushchak VI. Free radical oxidation of proteins and its relationship with functional state of organisms. Biochemistry (Mosc) 72: 809-827, 2007.
    • (2007) Biochemistry (Mosc) , vol.72 , pp. 809-827
    • Lushchak, V.I.1
  • 72
    • 0035842896 scopus 로고    scopus 로고
    • VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release
    • Madesh M and Hajnoczky G. VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J Cell Biol 155: 1003-1015, 2001.
    • (2001) J Cell Biol , vol.155 , pp. 1003-1015
    • Madesh, M.1    Hajnoczky, G.2
  • 74
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between autophagy and apoptosis
    • Maiuri MC, Zalckvar E, Kimchi A, and Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8: 741-752, 2007.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 75
    • 34047195222 scopus 로고    scopus 로고
    • PTEN, the Achilles' heel of myocardial ischaemia/reperfusion injury?
    • Mocanu MM and Yellon DM. PTEN, the Achilles' heel of myocardial ischaemia/reperfusion injury? Br J Pharmacol 150: 833-838, 2007.
    • (2007) Br J Pharmacol , vol.150 , pp. 833-838
    • Mocanu, M.M.1    Yellon, D.M.2
  • 76
    • 0031577534 scopus 로고    scopus 로고
    • Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric oxide
    • Mohr S, Zech B, Lapetina EG, and Brune B. Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric oxide. Biochem Biophys Res Commun 238: 387-391, 1997.
    • (1997) Biochem Biophys Res Commun , vol.238 , pp. 387-391
    • Mohr, S.1    Zech, B.2    Lapetina, E.G.3    Brune, B.4
  • 77
    • 34548019210 scopus 로고    scopus 로고
    • Hypoxia activates c-Jun N-terminal kinase via Rac1-dependent reactive oxygen species production in hepatocytes
    • Mollen KP, McCloskey CA, Tanaka H, Prince JM, Levy RM, Zuckerbraun BS, and Billiar TR. Hypoxia activates c-Jun N-terminal kinase via Rac1-dependent reactive oxygen species production in hepatocytes. Shock 28: 270-277, 2007.
    • (2007) Shock , vol.28 , pp. 270-277
    • Mollen, K.P.1    McCloskey, C.A.2    Tanaka, H.3    Prince, J.M.4    Levy, R.M.5    Zuckerbraun, B.S.6    Billiar, T.R.7
  • 78
    • 32644483702 scopus 로고    scopus 로고
    • Autophagy: Role in surviving environmental stress
    • Moore MN, Allen JI, and Somerfield PJ. Autophagy: role in surviving environmental stress. Mar Environ Res 62(suppl): S420-S425, 2006.
    • (2006) Mar Environ Res , vol.62 , Issue.SUPPL.
    • Moore, M.N.1    Allen, J.I.2    Somerfield, P.J.3
  • 79
    • 3042702881 scopus 로고    scopus 로고
    • Inflammatory cytokines and postmyocardial infarction remodeling
    • Nian M, Lee P, Khaper N, and Liu P. Inflammatory cytokines and postmyocardial infarction remodeling. Circ Res 94: 1543-1553, 2004.
    • (2004) Circ Res , vol.94 , pp. 1543-1553
    • Nian, M.1    Lee, P.2    Khaper, N.3    Liu, P.4
  • 80
    • 2342465589 scopus 로고    scopus 로고
    • Regulation of the apoptosis-necrosis switch
    • Nicotera P and Melino G. Regulation of the apoptosis-necrosis switch. Oncogene 23: 2757-2765, 2004.
    • (2004) Oncogene , vol.23 , pp. 2757-2765
    • Nicotera, P.1    Melino, G.2
  • 81
    • 18044364791 scopus 로고    scopus 로고
    • Mechanism of the tumor suppressive effect of MnSOD overexpression
    • Oberley LW. Mechanism of the tumor suppressive effect of MnSOD overexpression. Biomed Pharmacother 59: 143-148, 2005.
    • (2005) Biomed Pharmacother , vol.59 , pp. 143-148
    • Oberley, L.W.1
  • 82
    • 0035286734 scopus 로고    scopus 로고
    • Molecular dissection of autophagy: Two ubiquitin-like systems
    • Ohsumi Y. Molecular dissection of autophagy: two ubiquitin-like systems. Nat Rev Mol Cell Biol 2: 211-216, 2001.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 211-216
    • Ohsumi, Y.1
  • 83
    • 0034634674 scopus 로고    scopus 로고
    • Rac1 regulates stress-induced, redox-dependent heat shock factor activation
    • Ozaki M, Deshpande SS, Angkeow P, Suzuki S, and Irani K. Rac1 regulates stress-induced, redox-dependent heat shock factor activation. J Biol Chem 275: 35377-35383, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 35377-35383
    • Ozaki, M.1    Deshpande, S.S.2    Angkeow, P.3    Suzuki, S.4    Irani, K.5
  • 84
    • 34748858784 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis: Impact on cancer therapy
    • Ozben T. Oxidative stress and apoptosis: impact on cancer therapy. J Pharm Sci 96: 2181-2196, 2007.
    • (2007) J Pharm Sci , vol.96 , pp. 2181-2196
    • Ozben, T.1
  • 85
  • 87
    • 2942593991 scopus 로고    scopus 로고
    • ROS stress in cancer cells and therapeutic implications
    • Pelicano H, Carney D, and Huang P. ROS stress in cancer cells and therapeutic implications. Drug Resist Update 7: 97-110, 2004.
    • (2004) Drug Resist Update , vol.7 , pp. 97-110
    • Pelicano, H.1    Carney, D.2    Huang, P.3
  • 89
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • Pouyssegur J, Dayan F, and Mazure NM. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441: 437-443, 2006.
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouyssegur, J.1    Dayan, F.2    Mazure, N.M.3
  • 91
    • 33646523798 scopus 로고    scopus 로고
    • A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death
    • Reef S, Zalckvar E, Shifman O, Bialik S, Sabanay H, Oren M, and Kimchi A. A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. Mol Cell 22: 463-475, 2006.
    • (2006) Mol Cell , vol.22 , pp. 463-475
    • Reef, S.1    Zalckvar, E.2    Shifman, O.3    Bialik, S.4    Sabanay, H.5    Oren, M.6    Kimchi, A.7
  • 92
    • 0027954494 scopus 로고
    • Free radicals in biology: Oxidative stress and the effects of ionizing radiation
    • Riley PA. Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol 65: 27-33, 1994.
    • (1994) Int J Radiat Biol , vol.65 , pp. 27-33
    • Riley, P.A.1
  • 93
    • 17644392450 scopus 로고    scopus 로고
    • Redox regulation of the Cdc25 phosphatases
    • Rudolph J. Redox regulation of the Cdc25 phosphatases. Antioxid Redox Signal 7: 761-767, 2005.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 761-767
    • Rudolph, J.1
  • 94
    • 44449162944 scopus 로고    scopus 로고
    • The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation
    • Rygiel TP, Mertens AE, Strumane K, van der Kammen R, and Collard JG. The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation. J Cell Sci 121: 1183-1192, 2008.
    • (2008) J Cell Sci , vol.121 , pp. 1183-1192
    • Rygiel, T.P.1    Mertens, A.E.2    Strumane, K.3    van der Kammen, R.4    Collard, J.G.5
  • 95
    • 0033103523 scopus 로고    scopus 로고
    • Caspase-8 is required for cell death induced by expanded polyglutamine repeats
    • Sanchez I, Xu CJ, Juo P, Kakizaka A, Blenis J, and Yuan J. Caspase-8 is required for cell death induced by expanded polyglutamine repeats. Neuron 22: 623-633, 1999.
    • (1999) Neuron , vol.22 , pp. 623-633
    • Sanchez, I.1    Xu, C.J.2    Juo, P.3    Kakizaka, A.4    Blenis, J.5    Yuan, J.6
  • 97
    • 38449108124 scopus 로고    scopus 로고
    • NF-kappaB: A potential target for cancer chemoprevention and therapy
    • Sarkar FH and Li Y. NF-kappaB: a potential target for cancer chemoprevention and therapy. Front Biosci 13: 2950-2959, 2008.
    • (2008) Front Biosci , vol.13 , pp. 2950-2959
    • Sarkar, F.H.1    Li, Y.2
  • 98
    • 34848920863 scopus 로고    scopus 로고
    • ROS, mitochondria and the regulation of autophagy
    • Scherz-Shouval R, and Elazar Z. ROS, mitochondria and the regulation of autophagy. Trends Cell Biol 17: 422-427, 2007.
    • (2007) Trends Cell Biol , vol.17 , pp. 422-427
    • Scherz-Shouval, R.1    Elazar, Z.2
  • 99
    • 34247186472 scopus 로고    scopus 로고
    • Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
    • Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, and Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 26: 1749-1760, 2007.
    • (2007) EMBO J , vol.26 , pp. 1749-1760
    • Scherz-Shouval, R.1    Shvets, E.2    Fass, E.3    Shorer, H.4    Gil, L.5    Elazar, Z.6
  • 100
    • 33845292901 scopus 로고    scopus 로고
    • Peroxisomes and oxidative stress
    • Schrader M and Fahimi HD. Peroxisomes and oxidative stress. Biochim Biophys Acta 1763: 1755-1766, 2006.
    • (2006) Biochim Biophys Acta , vol.1763 , pp. 1755-1766
    • Schrader, M.1    Fahimi, H.D.2
  • 101
    • 0034468736 scopus 로고    scopus 로고
    • Role of reactive oxygen species (ROS) in apoptosis induction
    • Simon HU, Haj-Yehia A, and Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5: 415-418, 2000.
    • (2000) Apoptosis , vol.5 , pp. 415-418
    • Simon, H.U.1    Haj-Yehia, A.2    Levi-Schaffer, F.3
  • 102
  • 103
    • 49549123183 scopus 로고    scopus 로고
    • Inhibition of ERK attenuates autophagy and potentiates tumor necrosis factor-alpha-induced cell death in MCF-7 cells
    • Sivaprasad U and Basu A. Inhibition of ERK attenuates autophagy and potentiates tumor necrosis factor-alpha-induced cell death in MCF-7 cells. J Cell Mol Med 12: 1265-1271, 2008.
    • (2008) J Cell Mol Med , vol.12 , pp. 1265-1271
    • Sivaprasad, U.1    Basu, A.2
  • 104
    • 0029682522 scopus 로고    scopus 로고
    • Transcriptional regulators of oxidative stress-inducible genes in prokaryotes and eukaryotes
    • Storz G and Polla BS. Transcriptional regulators of oxidative stress-inducible genes in prokaryotes and eukaryotes. EXS 77: 239-254, 1996.
    • (1996) EXS , vol.77 , pp. 239-254
    • Storz, G.1    Polla, B.S.2
  • 106
    • 34248139628 scopus 로고    scopus 로고
    • Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae
    • Suzuki K and Ohsumi Y. Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae. FEBS Lett 581: 2156-2161, 2007.
    • (2007) FEBS Lett , vol.581 , pp. 2156-2161
    • Suzuki, K.1    Ohsumi, Y.2
  • 108
    • 25144452785 scopus 로고    scopus 로고
    • A phase II multicenter, randomized, doubleblind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer
    • Sweeney C, Liu G, Yiannoutsos C, Kolesar J, Horvath D, Staab MJ, Fife K, Armstrong V, Treston A, Sidor C, and Wilding G. A phase II multicenter, randomized, doubleblind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer. Clin Cancer Res 11: 6625-6633, 2005.
    • (2005) Clin Cancer Res , vol.11 , pp. 6625-6633
    • Sweeney, C.1    Liu, G.2    Yiannoutsos, C.3    Kolesar, J.4    Horvath, D.5    Staab, M.J.6    Fife, K.7    Armstrong, V.8    Treston, A.9    Sidor, C.10    Wilding, G.11
  • 109
    • 0037591401 scopus 로고    scopus 로고
    • Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: Evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase
    • Takada Y, Mukhopadhyay A, Kundu GC, Mahabeleshwar GH, Singh S, and Aggarwal BB. Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase. J Biol Chem 278: 24233-24241, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 24233-24241
    • Takada, Y.1    Mukhopadhyay, A.2    Kundu, G.C.3    Mahabeleshwar, G.H.4    Singh, S.5    Aggarwal, B.B.6
  • 110
    • 2342487990 scopus 로고    scopus 로고
    • Cells have distinct mechanisms to maintain protection against different reactive oxygen species: Oxidative-stress-response genes
    • Thorpe GW, Fong CS, Alic N, Higgins VJ, and Dawes IW. Cells have distinct mechanisms to maintain protection against different reactive oxygen species: oxidative-stress-response genes. Proc Natl Acad Sci U S A 101: 6564-6569, 2004.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 6564-6569
    • Thorpe, G.W.1    Fong, C.S.2    Alic, N.3    Higgins, V.J.4    Dawes, I.W.5
  • 111
    • 0034029318 scopus 로고    scopus 로고
    • Tobacco-related diseases: Is there a role for antioxidant micronutrient supplementation?
    • Traber MG, van der Vliet A, Reznick AZ, and Cross CE. Tobacco-related diseases: is there a role for antioxidant micronutrient supplementation? Clin Chest Med 21: 173-187, 2000.
    • (2000) Clin Chest Med , vol.21 , pp. 173-187
    • Traber, M.G.1    van der Vliet, A.2    Reznick, A.Z.3    Cross, C.E.4
  • 112
    • 0027424777 scopus 로고
    • Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae
    • Tsukada M and Ohsumi Y. Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333: 169-174, 1993.
    • (1993) FEBS Lett , vol.333 , pp. 169-174
    • Tsukada, M.1    Ohsumi, Y.2
  • 114
    • 33847679043 scopus 로고    scopus 로고
    • A possible role of oxidative stress in the switch mechanism of the cell death mode from apoptosis to necrosis: Studies on rho0 cells
    • Wochna A, Niemczyk E, Kurono C, Masaoka M, Kedzior J, Slominska E, Lipinski M, and Wakabayashi T. A possible role of oxidative stress in the switch mechanism of the cell death mode from apoptosis to necrosis: studies on rho0 cells. Mitochondrion 7: 119-124, 2007.
    • (2007) Mitochondrion , vol.7 , pp. 119-124
    • Wochna, A.1    Niemczyk, E.2    Kurono, C.3    Masaoka, M.4    Kedzior, J.5    Slominska, E.6    Lipinski, M.7    Wakabayashi, T.8
  • 115
    • 0034123691 scopus 로고    scopus 로고
    • Mechanisms of neurodegenerative disorders: Pt. 1: protein aggregates
    • Wolozin B and Behl C. Mechanisms of neurodegenerative disorders: Pt. 1: protein aggregates. Arch Neurol 57: 793-796, 2000.
    • (2000) Arch Neurol , vol.57 , pp. 793-796
    • Wolozin, B.1    Behl, C.2
  • 116
    • 33846117134 scopus 로고    scopus 로고
    • The signaling mechanism of ROS in tumor progression
    • Wu WS. The signaling mechanism of ROS in tumor progression. Cancer Metastasis Rev 25: 695-705, 2006.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 695-705
    • Wu, W.S.1
  • 117
    • 33745845126 scopus 로고    scopus 로고
    • Autophagy contributes to caspase-independent macrophage cell death
    • Xu Y, Kim SO, Li Y, and Han J. Autophagy contributes to caspase-independent macrophage cell death. J Biol Chem 281: 19179-19187, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 19179-19187
    • Xu, Y.1    Kim, S.O.2    Li, Y.3    Han, J.4
  • 118
    • 44949102384 scopus 로고    scopus 로고
    • Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells
    • Yang C, Kaushal V, Shah SV, and Kaushal GP. Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells. Am J Physiol Renal Physiol 294: F777-F787, 2008.
    • (2008) Am J Physiol Renal Physiol , vol.294
    • Yang, C.1    Kaushal, V.2    Shah, S.V.3    Kaushal, G.P.4
  • 120
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Yue Z, Jin S, Yang C, Levine AJ, and Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A 100: 15077-15082, 2003.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5


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