-
1
-
-
1542344000
-
Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice
-
Alp NJ, McAteer MA, Khoo J, Choudhury RP, and Channon KM (2004) Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice. Arterioscler Thromb Vasc Biol 24:445-450.
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. 445-450
-
-
Alp, N.J.1
McAteer, M.A.2
Khoo, J.3
Choudhury, R.P.4
Channon, K.M.5
-
2
-
-
33745962138
-
Therapeutic potential of resveratrol: The in vivo evidence
-
Baur JA and Sinclair DA (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5:493-506.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 493-506
-
-
Baur, J.A.1
Sinclair, D.A.2
-
4
-
-
11144338749
-
Vascular NADPH oxidases: Molecular mechanisms of activation
-
Brandes RP and Kreuzer J (2005) Vascular NADPH oxidases: molecular mechanisms of activation. Cardiovasc Res 65:16-27.
-
(2005)
Cardiovasc Res
, vol.65
, pp. 16-27
-
-
Brandes, R.P.1
Kreuzer, J.2
-
5
-
-
1942484416
-
Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: Protection against oxidative and electrophilic injury
-
Cao Z and Li Y (2004) Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injury. Eur J Pharmacol 489:39-48.
-
(2004)
Eur J Pharmacol
, vol.489
, pp. 39-48
-
-
Cao, Z.1
Li, Y.2
-
6
-
-
1942438521
-
Asymmetrical dimethylarginine: The Uber marker?
-
Cooke JP (2004) Asymmetrical dimethylarginine: the Uber marker? Circulation 109:1813-1818.
-
(2004)
Circulation
, vol.109
, pp. 1813-1818
-
-
Cooke, J.P.1
-
7
-
-
59449086328
-
Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: Insights from cells with tet-regulated GTP cyclohydrolase I expression
-
Crabtree MJ, Tatham AL, Al-Wakeel Y, Warrick N, Hale AB, Cai S, Channon KM, and Alp NJ (2009) Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression. J Biol Chem 284:1136-1144.
-
(2009)
J Biol Chem
, vol.284
, pp. 1136-1144
-
-
Crabtree, M.J.1
Tatham, A.L.2
Al-Wakeel, Y.3
Warrick, N.4
Hale, A.B.5
Cai, S.6
Channon, K.M.7
Alp, N.J.8
-
8
-
-
67650091375
-
Resveratrol induces mitochondrial biogenesis in endothelial cells
-
Csiszar A, Labinskyy N, Pinto JT, Ballabh P, Zhang H, Losonczy G, Pearson K, de Cabo R, Pacher P, Zhang C, et al. (2009) Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol 297:H13-H20.
-
(2009)
Am J Physiol Heart Circ Physiol
, vol.297
-
-
Csiszar, A.1
Labinskyy, N.2
Pinto, J.T.3
Ballabh, P.4
Zhang, H.5
Losonczy, G.6
Pearson, K.7
De Cabo, R.8
Pacher, P.9
Zhang, C.10
-
9
-
-
23944478990
-
A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress
-
Del Rio D, Stewart AJ, and Pellegrini N (2005) A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-328.
-
(2005)
Nutr Metab Cardiovasc Dis
, vol.15
, pp. 316-328
-
-
Del Rio, D.1
Stewart, A.J.2
Pellegrini, N.3
-
10
-
-
0033559692
-
Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase
-
Feron O, Dessy C, Moniotte S, Desager JP, and Balligand JL (1999) Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase. J Clin Invest 103:897-905.
-
(1999)
J Clin Invest
, vol.103
, pp. 897-905
-
-
Feron, O.1
Dessy, C.2
Moniotte, S.3
Desager, J.P.4
Balligand, J.L.5
-
11
-
-
44449162751
-
Oxidative stress in vascular disease: Causes, defense mechanisms and potential therapies
-
Förstermann U (2008) Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat Clin Pract Cardiovasc Med 5:338-349.
-
(2008)
Nat Clin Pract Cardiovasc Med
, vol.5
, pp. 338-349
-
-
Förstermann, U.1
-
12
-
-
33645780634
-
Endothelial nitric oxide synthase in vascular disease: From marvel to menace
-
DOI 10.1161/CIRCULATIONAHA.105.602532, PII 0000301720060404000013
-
Förstermann U and Münzel T (2006) Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 113:1708-1714. (Pubitemid 43754233)
-
(2006)
Circulation
, vol.113
, Issue.13
, pp. 1708-1714
-
-
Forstermann, U.1
Munzel, T.2
-
13
-
-
1942468123
-
Novel NAD(P)H oxidases in the cardiovascular system
-
Griendling KK (2004) Novel NAD(P)H oxidases in the cardiovascular system. Heart 90:491-493.
-
(2004)
Heart
, vol.90
, pp. 491-493
-
-
Griendling, K.K.1
-
14
-
-
14844295766
-
Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors α and β in endothelial cells
-
Klinge CM, Blankenship KA, Risinger KE, Bhatnagar S, Noisin EL, Sumanasekera WK, Zhao L, Brey DM, and Keynton RS (2005) Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors α and β in endothelial cells. J Biol Chem 280:7460-7468.
-
(2005)
J Biol Chem
, vol.280
, pp. 7460-7468
-
-
Klinge, C.M.1
Blankenship, K.A.2
Risinger, K.E.3
Bhatnagar, S.4
Noisin, E.L.5
Sumanasekera, W.K.6
Zhao, L.7
Brey, D.M.8
Keynton, R.S.9
-
15
-
-
46749116365
-
Resveratrol stimulates nitric oxide production by increasing estrogen receptor α-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells
-
Klinge CM, Wickramasinghe NS, Ivanova MM, and Dougherty SM (2008) Resveratrol stimulates nitric oxide production by increasing estrogen receptor α-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells. FASEB J 22:2185-2197.
-
(2008)
FASEB J
, vol.22
, pp. 2185-2197
-
-
Klinge, C.M.1
Wickramasinghe, N.S.2
Ivanova, M.M.3
Dougherty, S.M.4
-
16
-
-
0037399439
-
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
-
Landmesser U, Dikalov S, Price SR, McCann L, Fukai T, Holland SM, Mitch WE, and Harrison DG (2003) Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest 111:1201-1209.
-
(2003)
J Clin Invest
, vol.111
, pp. 1201-1209
-
-
Landmesser, U.1
Dikalov, S.2
Price, S.R.3
McCann, L.4
Fukai, T.5
Holland, S.M.6
Mitch, W.E.7
Harrison, D.G.8
-
17
-
-
0035814951
-
Endothelial regulation of vasomotion in apoE-deficient mice: Implications for interactions between peroxynitrite and tetrahydrobiopterin
-
Laursen JB, Somers M, Kurz S, McCann L, Warnholtz A, Freeman BA, Tarpey M, Fukai T, and Harrison DG (2001) Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation 103:1282-1288.
-
(2001)
Circulation
, vol.103
, pp. 1282-1288
-
-
Laursen, J.B.1
Somers, M.2
Kurz, S.3
McCann, L.4
Warnholtz, A.5
Freeman, B.A.6
Tarpey, M.7
Fukai, T.8
Harrison, D.G.9
-
18
-
-
0342723791
-
Nitric oxide in the pathogenesis of vascular disease
-
DOI 10.1002/(SICI)1096-9896(200002)190:3<244::AID-PATH575>3.0.CO;2- 8
-
Li H and Förstermann U (2000) Nitric oxide in the pathogenesis of vascular disease. J Pathol 190:244-254. (Pubitemid 30141371)
-
(2000)
Journal of Pathology
, vol.190
, Issue.3
, pp. 244-254
-
-
Li, H.1
Forstermann, U.2
-
19
-
-
70449431340
-
Prevention of atherosclerosis by interference with the vascular nitric oxide system
-
Li H and Förstermann U (2009a) Prevention of atherosclerosis by interference with the vascular nitric oxide system. Curr Pharm Des 15:3133-3145.
-
(2009)
Curr Pharm des
, vol.15
, pp. 3133-3145
-
-
Li, H.1
Förstermann, U.2
-
20
-
-
77649198149
-
Resveratrol: A multifunctional compound improving endothelial function
-
Editorial to: "Resveratrol supplementation gender independently improves endothelial reactivity and suppresses superoxide production in healthy rats" by S. Soylemez et al.
-
Li H and Förstermann U (2009b) Resveratrol: a multifunctional compound improving endothelial function. Editorial to: "Resveratrol supplementation gender independently improves endothelial reactivity and suppresses superoxide production in healthy rats" by S. Soylemez et al. Cardiovasc Drugs Ther 23:425-429.
-
(2009)
Cardiovasc Drugs Ther
, vol.23
, pp. 425-429
-
-
Li, H.1
Förstermann, U.2
-
21
-
-
0036430356
-
Regulation of endothelial-type NO synthase expression in pathophysiology and in response to drugs
-
Li H, Wallerath T, Münzel T, and Förstermann U (2002) Regulation of endothelial-type NO synthase expression in pathophysiology and in response to drugs. Nitric Oxide 7:149-164.
-
(2002)
Nitric Oxide
, vol.7
, pp. 149-164
-
-
Li, H.1
Wallerath, T.2
Münzel, T.3
Förstermann, U.4
-
22
-
-
33745009958
-
Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats
-
Li H, Witte K, August M, Brausch I, Gödtel-Armbrust U, Habermeier A, Closs EI, Oelze M, Münzel T, and Förstermann U (2006a) Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats. J Am Coll Cardiol 47:2536-2544.
-
(2006)
J Am Coll Cardiol
, vol.47
, pp. 2536-2544
-
-
Li, H.1
Witte, K.2
August, M.3
Brausch, I.4
Gödtel-Armbrust, U.5
Habermeier, A.6
Closs, E.I.7
Oelze, M.8
Münzel, T.9
Förstermann, U.10
-
23
-
-
27744488160
-
Up-regulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress
-
Li Y, Cao Z, and Zhu H (2006b) Up-regulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress. Pharmacol Res 53:6-15.
-
(2006)
Pharmacol Res
, vol.53
, pp. 6-15
-
-
Li, Y.1
Cao, Z.2
Zhu, H.3
-
24
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method
-
Livak KJ and Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method. Methods 25:402-408.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
25
-
-
35549008884
-
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
-
DOI 10.1073/pnas.0704329104
-
Mattagajasingh I, Kim CS, Naqvi A, Yamamori T, Hoffman TA, Jung SB, DeRicco J, Kasuno K, and Irani K (2007) SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc Natl Acad Sci USA 104:14855-14860. (Pubitemid 350003232)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.37
, pp. 14855-14860
-
-
Mattagajasingh, I.1
Kim, C.-S.2
Naqvi, A.3
Yamamori, T.4
Hoffman, T.A.5
Jung, S.-B.6
DeRicco, J.7
Kasuno, K.8
Irani, K.9
-
26
-
-
34249083199
-
Sirtuins in mammals: Insights into their biological function
-
Michan S and Sinclair D (2007) Sirtuins in mammals: insights into their biological function. Biochem J 404:1-13.
-
(2007)
Biochem J
, vol.404
, pp. 1-13
-
-
Michan, S.1
Sinclair, D.2
-
27
-
-
40849135481
-
The Sirtuin family: Therapeutic targets to treat diseases of aging
-
Milne JC and Denu JM (2008) The Sirtuin family: therapeutic targets to treat diseases of aging. Curr Opin Chem Biol 12:11-17.
-
(2008)
Curr Opin Chem Biol
, vol.12
, pp. 11-17
-
-
Milne, J.C.1
Denu, J.M.2
-
28
-
-
36749087548
-
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
-
Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, et al. (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450:712-716.
-
(2007)
Nature
, vol.450
, pp. 712-716
-
-
Milne, J.C.1
Lambert, P.D.2
Schenk, S.3
Carney, D.P.4
Smith, J.J.5
Gagne, D.J.6
Jin, L.7
Boss, O.8
Perni, R.B.9
Vu, C.B.10
-
29
-
-
41149150716
-
NADPH oxidases, reactive oxygen species, and hypertension: Clinical implications and therapeutic possibilities
-
Paravicini TM and Touyz RM (2008) NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Diabetes Care 31 (Suppl 2):S170-S180.
-
(2008)
Diabetes Care
, vol.31
, Issue.SUPPL. 2
-
-
Paravicini, T.M.1
Touyz, R.M.2
-
30
-
-
34447536457
-
Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease
-
Schmidt TS and Alp NJ (2007) Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease. Clin Sci (London) 113:47-63.
-
(2007)
Clin Sci (London)
, vol.113
, pp. 47-63
-
-
Schmidt, T.S.1
Alp, N.J.2
-
31
-
-
77950469163
-
Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4)
-
Spanier G, Xu H, Xia N, Tobias S, Deng S, Wojnowski L, Forstermann U, and Li H (2009) Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4). J Physiol Pharmacol 60 (Suppl 4):111-116.
-
(2009)
J Physiol Pharmacol
, vol.60
, Issue.SUPPL. 4
, pp. 111-116
-
-
Spanier, G.1
Xu, H.2
Xia, N.3
Tobias, S.4
Deng, S.5
Wojnowski, L.6
Forstermann, U.7
Li, H.8
-
32
-
-
77950901103
-
Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure
-
Tanno M, Kuno A, Yano T, Miura T, Hisahara S, Ishikawa S, Shimamoto K, and Horio Y (2010) Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. J Biol Chem 285:8375-8382.
-
(2010)
J Biol Chem
, vol.285
, pp. 8375-8382
-
-
Tanno, M.1
Kuno, A.2
Yano, T.3
Miura, T.4
Hisahara, S.5
Ishikawa, S.6
Shimamoto, K.7
Horio, Y.8
-
33
-
-
33847346061
-
Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes
-
Thum T, Fraccarollo D, Schultheiss M, Froese S, Galuppo P, Widder JD, Tsikas D, Ertl G, and Bauersachs J (2007) Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes. Diabetes 56:666-674.
-
(2007)
Diabetes
, vol.56
, pp. 666-674
-
-
Thum, T.1
Fraccarollo, D.2
Schultheiss, M.3
Froese, S.4
Galuppo, P.5
Widder, J.D.6
Tsikas, D.7
Ertl, G.8
Bauersachs, J.9
-
34
-
-
34250842528
-
Resveratrol increases vascular oxidative stress resistance
-
Ungvari Z, Orosz Z, Rivera A, Labinskyy N, Xiangmin Z, Olson S, Podlutsky A, and Csiszar A (2007) Resveratrol increases vascular oxidative stress resistance. Am J Physiol Heart Circ Physiol 292:H2417-H2424.
-
(2007)
Am J Physiol Heart Circ Physiol
, vol.292
-
-
Ungvari, Z.1
Orosz, Z.2
Rivera, A.3
Labinskyy, N.4
Xiangmin, Z.5
Olson, S.6
Podlutsky, A.7
Csiszar, A.8
-
35
-
-
33744912221
-
Detection of specific nitrotyrosine-modified proteins as a marker of oxidative stress in cardiovascular disease
-
Viappiani S and Schulz R (2006) Detection of specific nitrotyrosine-modified proteins as a marker of oxidative stress in cardiovascular disease. Am J Physiol Heart Circ Physiol 290:H2167-H2168.
-
(2006)
Am J Physiol Heart Circ Physiol
, vol.290
-
-
Viappiani, S.1
Schulz, R.2
-
36
-
-
0037167677
-
Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase
-
Wallerath T, Deckert G, Ternes T, Anderson H, Li H, Witte K, and Förstermann U (2002) Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-1658.
-
(2002)
Circulation
, vol.106
, pp. 1652-1658
-
-
Wallerath, T.1
Deckert, G.2
Ternes, T.3
Anderson, H.4
Li, H.5
Witte, K.6
Förstermann, U.7
-
37
-
-
45549085992
-
Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase
-
Wei CC, Wang ZQ, Tejero J, Yang YP, Hemann C, Hille R, and Stuehr DJ (2008) Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase. J Biol Chem 283:11734-11742.
-
(2008)
J Biol Chem
, vol.283
, pp. 11734-11742
-
-
Wei, C.C.1
Wang, Z.Q.2
Tejero, J.3
Yang, Y.P.4
Hemann, C.5
Hille, R.6
Stuehr, D.J.7
-
38
-
-
48449093231
-
AT1-receptor blockade by telmisartan up-regulates GTP-cyclohydrolase I and protects eNOS in diabetic rats
-
Wenzel P, Schulz E, Oelze M, Müller J, Schuhmacher S, Alhamdani MS, Debrezion J, Hortmann M, Reifenberg K, Fleming I, et al. (2008) AT1-receptor blockade by telmisartan up-regulates GTP-cyclohydrolase I and protects eNOS in diabetic rats. Free Radic Biol Med 45:619-626.
-
(2008)
Free Radic Biol Med
, vol.45
, pp. 619-626
-
-
Wenzel, P.1
Schulz, E.2
Oelze, M.3
Müller, J.4
Schuhmacher, S.5
Alhamdani, M.S.6
Debrezion, J.7
Hortmann, M.8
Reifenberg, K.9
Fleming, I.10
-
39
-
-
42449083767
-
Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial nitric-oxide synthase (eNOS) expression and preventing eNOS uncoupling
-
Wohlfart P, Xu H, Endlich A, Habermeier A, Closs EI, Hübschle T, Mang C, Strobel H, Suzuki T, Kleinert H, et al. (2008) Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial nitric-oxide synthase (eNOS) expression and preventing eNOS uncoupling. J Pharmacol Exp Ther 325:370-379.
-
(2008)
J Pharmacol Exp Ther
, vol.325
, pp. 370-379
-
-
Wohlfart, P.1
Xu, H.2
Endlich, A.3
Habermeier, A.4
Closs, E.I.5
Hübschle, T.6
Mang, C.7
Strobel, H.8
Suzuki, T.9
Kleinert, H.10
-
40
-
-
41149140205
-
Differential roles of PKCα and PKCε in controlling the gene expression of Nox4 in human endothelial cells
-
Xu H, Goettsch C, Xia N, Horke S, Morawietz H, Förstermann U, and Li H (2008) Differential roles of PKCα and PKCε in controlling the gene expression of Nox4 in human endothelial cells. Free Radic Biol Med 44:1656-1667.
-
(2008)
Free Radic Biol Med
, vol.44
, pp. 1656-1667
-
-
Xu, H.1
Goettsch, C.2
Xia, N.3
Horke, S.4
Morawietz, H.5
Förstermann, U.6
Li, H.7
|