Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 40, 2012, Pages 16288-16293

  Marrache, Sean ^a   Dhar, Shanta ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Drug trafficking; Nanocarrier; Nanomedicine; Organelle

Indexed keywords

2,4 DINITROPHENOL; ALPHA TOCOPHEROL SUCCINATE; AMYLOID BETA PROTEIN; CURCUMIN; INTERLEUKIN 6; LONIDAMINE; MACROGOL; METHYLTRIPHENYLPHOSPHONIUM; NANOPARTICLE; POLYGLYCOLIC ACID; QUANTUM DOT; TUMOR NECROSIS FACTOR ALPHA;

ACIDIFICATION; ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CANCER CHEMOTHERAPY; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOSOL; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SELECTIVITY; DRUG STRUCTURE; ENDOSOME; ENERGY METABOLISM; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INTERNALIZATION; LYSOSOME; MITOCHONDRION; MOUSE; NEUROPROTECTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXIDATIVE STRESS; PARTICLE SIZE; PHOTODEGRADATION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SURFACE CHARGE; ZETA POTENTIAL;

2,4-DINITROPHENOL; ADIPOGENESIS; ALPHA-TOCOPHEROL; ANALYSIS OF VARIANCE; BIOENGINEERING; CURCUMIN; DRUG DELIVERY SYSTEMS; HUMANS; INDAZOLES; MITOCHONDRIAL DISEASES; NANOPARTICLES; POLYETHYLENE GLYCOLS; POLYGLACTIN 910; POLYMERS;

EID: 84867089289     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1210096109     Document Type: Article

References (31)

1. Duchen MR (2004) Mitochondria in health and disease: Perspectives on a new mitochondrial biology. Mol Aspects Med 25:365-451.
2. Fulda S, Galluzzi L, Kroemer G (2010) Targeting mitochondria for cancer therapy. Nat Rev Drug Discov 9:447-464.
3. Galluzzi L, et al. (2010) Mitochondrial gateways to cancer. Mol Aspects Med 31: 1-20.
4. Peer D, et al. (2007) Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2:751-760. (Pubitemid 350223348)
5. Dhar S, Gu FX, Langer R, Farokhzad OC, Lippard SJ (2008) Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Proc Natl Acad Sci USA 105:17356-17361.
6. Hrkach J, et al. (2012) Preclinical development and clinical translation of a PSMA-argeted docetaxel nanoparticle with a differentiated pharmacological profile. Sci Transl Med 4:128ra139.
7. Agemy L, et al. (2011) Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma. Proc Natl Acad Sci USA 108: 17450-17455.
8. Weissig V, D'Souza GGM (2010) Mitochondria-targeted drug delivery. Targeted Delivery of Small and Macromolecular Drugs, eds Narang AS, Mahato RI (CRC Press, Boca Raton, FL), pp 255-273.
9. Boddapati SV, D 'Souza GGM, Erdogan S, Torchilin VP, Weissig V (2008) Organelle-targeted nanocarriers: specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo. Nano Lett 8:2559-2563.
10. Patel NR, et al. (2010) Mitochondria-targeted liposomes improve the apoptotic and cytotoxic action of sclareol. J Liposome Res 20:244-249.
11. Esumi K, Takei N, Yoshimura T (2003) Antioxidant potentiality of gold-chitosan nanocomposites. Colloids Surface B 32:117-123.
12. Esumi K, Houdatsu H, Yoshimura T (2004) Antioxidant action by gold-PAMAM dendrimer nanocomposites. Langmuir 20:2536-2538.
13. Wang LM, et al. (2011) Selective targeting of gold nanorods at the mitochondria of cancer cells: Implications for cancer therapy. Nano Lett 11:772-780.
14. Paunesku T, et al. (2007) Intracellular distribution of TiO2-DNA oligonucleotide nanoconjugates directed to nucleolus and mitochondria indicates sequence specificity. Nano Lett 7:596-601. (Pubitemid 46516032)
15. Hikosaka K, Kim J, Kajita M, Kanayama A, Miyamoto Y (2008) Platinum nanoparticles have an activity similar to mitochondrial NADH:ubiquinone oxidoreductase. Colloids Surf B Biointerfaces 66:195-200.
16. Kajita M, et al. (2007) Platinum nanoparticle is a useful scavenger of superoxide anion and hydrogen peroxide. Free Radic Res 41:615-626. (Pubitemid 46845581)
17. Sharma A, et al. (2012) Design and evaluation of multifunctional nanocarriers for selective delivery of coenzyme Q10 to mitochondria. Biomacromolecules 13:239-252.
18. Kolishetti N, et al. (2010) Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy. Proc Natl Acad Sci USA 107: 17939-17944.
19. Beletsi A, Panagi Z, Avgoustakis K (2005) Biodistribution properties of nanoparticles based on mixtures of PLGA with PLGA-PEG diblock copolymers. Int J Pharm 298: 233-241. (Pubitemid 40828344)
20. Smith RA, Porteous CM, Gane AM, Murphy MP (2003) Delivery of bioactive molecules to mitochondria in vivo. Proc Natl Acad Sci USA 100:5407-5412. (Pubitemid 36542718)
21. Blaikie FH, et al. (2006) Targeting dinitrophenol to mitochondria: Limitations to the development of a self-limiting mitochondrial protonophore. Biosci Rep 26:231-243. (Pubitemid 44259491)
22. Liu JK, et al. (2009) Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity: Hope from natural mitochondrial nutrients. Adv Drug Deliv Rev 61:1343-1352.
23. Wang F, Ogasawara MA, Huang P (2010) Small mitochondria-targeting molecules as anti-cancer agents. Mol Aspects Med 31:75-92.
24. Mulik RS, Mönkkönen J, Juvonen RO, Mahadik KR, Paradkar AR (2010) ApoE3-mediated poly(butyl) cyanoacrylate nanoparticles containing curcumin: Study of enhanced activity of curcumin against beta amyloid-induced cytotoxicity using in vitro cell culture model. Mol Pharm 7:815-825.
25. Ono K, Hasegawa K, Naiki H, Yamada M (2004) Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. J Neurosci Res 75: 742-750. (Pubitemid 38296087)
26. Floridi A, et al. (1981) Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells. J Natl Cancer Inst 66:497-499. (Pubitemid 11098551)
27. Neuzil J, et al. (2007) Mitocans as anti-cancer agents targeting mitochondria: Lessons from studies with vitamin E analogues, inhibitors of complex II. J Bioenerg Biomembr 39:65-72. (Pubitemid 46877173)
28. Dhar S, Kolishetti N, Lippard SJ, Farokhzad OC (2011) Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo. Proc Natl Acad Sci USA 108:1850-1855.
29. Sonawane ND, Szoka FC, Jr., Verkman AS (2003) Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J Biol Chem 278: 44826-44831. (Pubitemid 37377241)
30. Chalmers S, et al. (2012) Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore. J Am Chem Soc 134:758-761.
31. Deroose FD, Clercq PJD (1995) Novel enantioselective syntheses of (+)-biotin. J Org Chem 60:321-330.