-
1
-
-
13944278132
-
Mitochondria, oxidants, and aging
-
Balaban RS, Nemoto S, Finkel T (2005) Mitochondria, oxidants, and aging. Cell 120:483-495.
-
(2005)
Cell
, vol.120
, pp. 483-495
-
-
Balaban, R.S.1
Nemoto, S.2
Finkel, T.3
-
2
-
-
0030008052
-
Superoxide production in rat hippocampal neurons: Selective imaging with hydroethidine
-
Bindokas VP, Jordan J, Lee CC, Miller RJ (1996) Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. J Neuro-sci 16:1324-1336.
-
(1996)
J Neuro-sci
, vol.16
, pp. 1324-1336
-
-
Bindokas, V.P.1
Jordan, J.2
Lee, C.C.3
Miller, R.J.4
-
3
-
-
68849110235
-
Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease
-
Dumont M, Wille E, Stack C, Calingasan NY, Beal MF, Lin MT (2009) Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease. FASEB J 23:2459-2466.
-
(2009)
FASEB J
, vol.23
, pp. 2459-2466
-
-
Dumont, M.1
Wille, E.2
Stack, C.3
Calingasan, N.Y.4
Beal, M.F.5
Lin, M.T.6
-
4
-
-
33646922865
-
Reduction in mitochon-drial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice
-
Esposito L, Raber J, Kekonius L, Yan F, Yu GQ, Bien-Ly N, Puolivali J, Scearce-Levie K, Masliah E, Mucke L (2006) Reduction in mitochon-drial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice. J Neurosci 26:5167-5179.
-
(2006)
J Neurosci
, vol.26
, pp. 5167-5179
-
-
Esposito, L.1
Raber, J.2
Kekonius, L.3
Yan, F.4
Yu, G.Q.5
Bien-Ly, N.6
Puolivali, J.7
Scearce-Levie, K.8
Masliah, E.9
Mucke, L.10
-
5
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid beta-peptide
-
Haass C, Selkoe DJ (2007) Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 8:101-112.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
6
-
-
0032036316
-
Transgenic models for the study of lung antioxidant defense: Enhanced manganese-containing superoxide dismutase activity gives partial protection to B6C3 hybrid mice exposed to hyperoxia
-
Ho YS, Vincent R, Dey MS, Slot JW, Crapo JD (1998) Transgenic models for the study of lung antioxidant defense: enhanced manganese-containing superoxide dismutase activity gives partial protection to B6C3 hybrid mice exposed to hyperoxia. Am J Respir Cell Mol Biol 18:538-547.
-
(1998)
Am J Respir Cell Mol Biol
, vol.18
, pp. 538-547
-
-
Ho, Y.S.1
Vincent, R.2
Dey, M.S.3
Slot, J.W.4
Crapo, J.D.5
-
7
-
-
33646101468
-
Aging-dependent alterations in synaptic plasticity and memory in mice that overexpress extracellular superoxide dismutase
-
Hu D, Serrano F, Oury TD, Klann E (2006) Aging-dependent alterations in synaptic plasticity and memory in mice that overexpress extracellular superoxide dismutase. J Neurosci 26:3933-3941.
-
(2006)
J Neurosci
, vol.26
, pp. 3933-3941
-
-
Hu, D.1
Serrano, F.2
Oury, T.D.3
Klann, E.4
-
8
-
-
33846345418
-
Hip-pocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase
-
Hu D, Cao P, Thiels E, Chu CT, Wu GY, Oury TD, Klann E (2007) Hip-pocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase. Neurobiol Learn Mem 87:372-384.
-
(2007)
Neurobiol Learn Mem
, vol.87
, pp. 372-384
-
-
Hu, D.1
Cao, P.2
Thiels, E.3
Chu, C.T.4
Wu, G.Y.5
Oury, T.D.6
Klann, E.7
-
9
-
-
40949119810
-
Superoxide-induced potentiation in the hippocampus requires activation of ryanodine receptor type 3 and ERK
-
Huddleston AT, Tang W, Takeshima H, Hamilton SL, Klann E (2008) Superoxide-induced potentiation in the hippocampus requires activation of ryanodine receptor type 3 and ERK. J Neurophysiol 99:1565-1571.
-
(2008)
J Neurophysiol
, vol.99
, pp. 1565-1571
-
-
Huddleston, A.T.1
Tang, W.2
Takeshima, H.3
Hamilton, S.L.4
Klann, E.5
-
10
-
-
33645520634
-
Earlyonset behavioral and synaptic deficits in a mouse model of Alzheimer's disease
-
Jacobsen JS, Wu CC, Redwine JM, Comery TA, Arias R, Bowlby M, Martone R, Morrison JH, Pangalos MN, Reinhart PH, Bloom FE (2006) Earlyonset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 103:5161-5166.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 5161-5166
-
-
Jacobsen, J.S.1
Wu, C.C.2
Redwine, J.M.3
Comery, T.A.4
Arias, R.5
Bowlby, M.6
Martone, R.7
Morrison, J.H.8
Pangalos, M.N.9
Reinhart, P.H.10
Bloom, F.E.11
-
11
-
-
0035049961
-
Co-expression of multiple transgenes in mouse CNS: A comparison of strategies
-
Jankowsky JL, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, Borchelt DR (2001) Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng 17:157-165.
-
(2001)
Biomol Eng
, vol.17
, pp. 157-165
-
-
Jankowsky, J.L.1
Slunt, H.H.2
Ratovitski, T.3
Jenkins, N.A.4
Copeland, N.G.5
Borchelt, D.R.6
-
12
-
-
0344393017
-
Paradoxical actions of hydrogen peroxide on long-term potentiation in transgenic superoxide dismutase-1 mice
-
Kamsler A, Segal M (2003) Paradoxical actions of hydrogen peroxide on long-term potentiation in transgenic superoxide dismutase-1 mice. J Neurosci 23:10359-10367.
-
(2003)
J Neurosci
, vol.23
, pp. 10359-10367
-
-
Kamsler, A.1
Segal, M.2
-
13
-
-
33846241298
-
Sources and targets of reactive oxygen species in synaptic plasticity and memory
-
Kishida KT, Klann E (2007) Sources and targets of reactive oxygen species in synaptic plasticity and memory. Antioxid Redox Signal 9:233-244.
-
(2007)
Antioxid Redox Signal
, vol.9
, pp. 233-244
-
-
Kishida, K.T.1
Klann, E.2
-
14
-
-
22244487284
-
NADPH oxidase is required for NMDA receptor-dependent activation of ERK in hippocampal area CA1
-
Kishida KT, Pao M, Holland SM, Klann E (2005) NADPH oxidase is required for NMDA receptor-dependent activation of ERK in hippocampal area CA1. J Neurochem 94:299-306.
-
(2005)
J Neurochem
, vol.94
, pp. 299-306
-
-
Kishida, K.T.1
Pao, M.2
Holland, S.M.3
Klann, E.4
-
15
-
-
33746483283
-
Synaptic plasticity deficits and mild memory impairments in mouse models of chronic granulomatous disease
-
Kishida KT, Hoeffer CA, Hu D, Pao M, Holland SM, Klann E (2006) Synaptic plasticity deficits and mild memory impairments in mouse models of chronic granulomatous disease. Mol Cell Biol 26:5908-5920.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 5908-5920
-
-
Kishida, K.T.1
Hoeffer, C.A.2
Hu, D.3
Pao, M.4
Holland, S.M.5
Klann, E.6
-
16
-
-
0031840847
-
Cell-permeable scavengers of superoxide prevent long-term potentiation in hippocampal area CA1
-
Klann E (1998) Cell-permeable scavengers of superoxide prevent long-term potentiation in hippocampal area CA1. J Neurophysiol 80:452-457.
-
(1998)
J Neurophysiol
, vol.80
, pp. 452-457
-
-
Klann, E.1
-
17
-
-
0032548843
-
A role for superoxide in protein kinase C activation and induction of long-term potentiation
-
Klann E, Roberson ED, Knapp LT, Sweatt JD (1998) A role for superoxide in protein kinase C activation and induction of long-term potentiation. J Biol Chem 273:4516-4522
-
(1998)
J Biol Chem
, vol.273
, pp. 4516-4522
-
-
Klann, E.1
Roberson, E.D.2
Knapp, L.T.3
Sweatt, J.D.4
-
18
-
-
0036470423
-
Potentiation of hippocampal synaptic transmission by superoxide requires the oxidative activation of protein kinase C
-
Knapp LT, Klann E (2002) Potentiation of hippocampal synaptic transmission by superoxide requires the oxidative activation of protein kinase C. J Neurosci 22:674-683.
-
(2002)
J Neurosci
, vol.22
, pp. 674-683
-
-
Knapp, L.T.1
Klann, E.2
-
19
-
-
58549090329
-
The molecular and cellular biology of enhanced cognition
-
Lee YS, Silva AJ (2009) The molecular and cellular biology of enhanced cognition. Nat Rev Neurosci 10:126-140.
-
(2009)
Nat Rev Neurosci
, vol.10
, pp. 126-140
-
-
Lee, Y.S.1
Silva, A.J.2
-
20
-
-
2642544767
-
Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice
-
Li F, Calingasan NY, Yu F, Mauck WM, Toidze M, Almeida CG, Takahashi RH, Carlson GA, Flint Beal M, Lin MT, Gouras GK (2004) Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice. J Neurochem 89:1308-1312.
-
(2004)
J Neurochem
, vol.89
, pp. 1308-1312
-
-
Li, F.1
Calingasan, N.Y.2
Yu, F.3
Mauck, W.M.4
Toidze, M.5
Almeida, C.G.6
Takahashi, R.H.7
Carlson, G.A.8
Flint Beal, M.9
Lin, M.T.10
Gouras, G.K.11
-
21
-
-
33750347347
-
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
-
Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443:787-795.
-
(2006)
Nature
, vol.443
, pp. 787-795
-
-
Lin, M.T.1
Beal, M.F.2
-
22
-
-
77958465822
-
Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease
-
Ma T, Hoeffer CA, Capetillo-Zarate E, Yu F, Wong H, Lin MT, Tampellini D, Klann E, Blitzer RD, Gouras GK (2010) Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease. PLoS One 5:e12845.
-
(2010)
PLoS One
, vol.5
-
-
Ma, T.1
Hoeffer, C.A.2
Capetillo-Zarate, E.3
Yu, F.4
Wong, H.5
Lin, M.T.6
Tampellini, D.7
Klann, E.8
Blitzer, R.D.9
Gouras, G.K.10
-
23
-
-
0242363254
-
The long-term potential of LTP
-
Malenka RC (2003) The long-term potential of LTP. Nat Rev Neurosci 4:923-926.
-
(2003)
Nat Rev Neurosci
, vol.4
, pp. 923-926
-
-
Malenka, R.C.1
-
24
-
-
0033578855
-
Long-term potentiation: A decade of progress?
-
Malenka RC, Nicoll RA (1999) Long-term potentiation: a decade of progress? Science 285:1870-1874.
-
(1999)
Science
, vol.285
, pp. 1870-1874
-
-
Malenka, R.C.1
Nicoll, R.A.2
-
25
-
-
69449096141
-
Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease
-
Massaad CA, Washington TM, Pautler RG, Klann E (2009) Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 106:13576-13581.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 13576-13581
-
-
Massaad, C.A.1
Washington, T.M.2
Pautler, R.G.3
Klann, E.4
-
26
-
-
58249093939
-
How mitochondria produce reactive oxygen species
-
Murphy MP (2009) How mitochondria produce reactive oxygen species. Biochem J 417:1-13.
-
(2009)
Biochem J
, vol.417
, pp. 1-13
-
-
Murphy, M.P.1
-
27
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
-
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Mether-ate R, Mattson MP, Akbari Y, LaFerla FM (2003) Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39:409-421.
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
Mether-Ate, R.7
Mattson, M.P.8
Akbari, Y.9
Laferla, F.M.10
-
28
-
-
0028893203
-
Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production
-
Pollock JD, Williams DA, Gifford MA, Li LL, Du X, Fisherman J, Orkin SH, Doerschuk CM, Dinauer MC (1995) Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat Genet 9:202-209.
-
(1995)
Nat Genet
, vol.9
, pp. 202-209
-
-
Pollock, J.D.1
Williams, D.A.2
Gifford, M.A.3
Li, L.L.4
Du, X.5
Fisherman, J.6
Orkin, S.H.7
Doerschuk, C.M.8
Dinauer, M.C.9
-
29
-
-
56349145099
-
Oxidative stress hypothesis in Alzheimer's disease: A reappraisal
-
Pratico D (2008) Oxidative stress hypothesis in Alzheimer's disease: a reappraisal. Trends Pharmacol Sci 29:609-615.
-
(2008)
Trends Pharmacol Sci
, vol.29
, pp. 609-615
-
-
Pratico, D.1
-
30
-
-
38949146389
-
NADPH oxidase inhibitor DPI is neuroprotective at femtomolar concentrations through inhibition of microglia over-activation
-
Qian L, Gao X, Pei Z, Wu X, Block M, Wilson B, Hong JS, Flood PM (2007) NADPH oxidase inhibitor DPI is neuroprotective at femtomolar concentrations through inhibition of microglia over-activation. Parkinsonism Relat Disord 13:S316-S320.
-
(2007)
Parkinsonism Relat Disord
, vol.13
-
-
Qian, L.1
Gao, X.2
Pei, Z.3
Wu, X.4
Block, M.5
Wilson, B.6
Hong, J.S.7
Flood, P.M.8
-
32
-
-
33846153236
-
Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease
-
Reiserer RS, Harrison FE, Syverud DC, McDonald MP (2007) Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. Genes Brain Behav 6:54-65.
-
(2007)
Genes Brain Behav
, vol.6
, pp. 54-65
-
-
Reiserer, R.S.1
Harrison, F.E.2
Syverud, D.C.3
McDonald, M.P.4
-
33
-
-
0033578309
-
EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology
-
Rong Y, Doctrow SR, Tocco G, Baudry M (1999) EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proc Natl Acad Sci USA 96:9897-9902.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 9897-9902
-
-
Rong, Y.1
Doctrow, S.R.2
Tocco, G.3
Baudry, M.4
-
34
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
Selkoe DJ (2002) Alzheimer's disease is a synaptic failure. Science 298:789-791.
-
(2002)
Science
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
35
-
-
5644239087
-
Alzheimer disease: Mechanistic understanding predicts novel therapies
-
Selkoe DJ (2004) Alzheimer disease: mechanistic understanding predicts novel therapies. Ann Intern Med 140:627-638.
-
(2004)
Ann Intern Med
, vol.140
, pp. 627-638
-
-
Selkoe, D.J.1
-
36
-
-
49149124343
-
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ (2008) Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 14:837- 842.
-
(2008)
Nat Med
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
Garcia-Munoz, A.4
Shepardson, N.E.5
Smith, I.6
Brett, F.M.7
Farrell, M.A.8
Rowan, M.J.9
Lemere, C.A.10
Regan, C.M.11
Walsh, D.M.12
Sabatini, B.L.13
Selkoe, D.J.14
-
37
-
-
77955283395
-
Animal and human studies with the mitochondria-targeted antioxidant MitoQ
-
Smith RA, Murphy MP (2010) Animal and human studies with the mitochondria-targeted antioxidant MitoQ. Ann N Y Acad Sci 1201:96-103.
-
(2010)
Ann N Y Acad Sci
, vol.1201
, pp. 96-103
-
-
Smith, R.A.1
Murphy, M.P.2
-
38
-
-
23044468691
-
The synaptic Abeta hypothesis of Alzheimer disease
-
Tanzi RE (2005) The synaptic Abeta hypothesis of Alzheimer disease. Nat Neurosci 8:977-979.
-
(2005)
Nat Neurosci
, vol.8
, pp. 977-979
-
-
Tanzi, R.E.1
-
39
-
-
0034667713
-
Impairment of long-term potentiation and associative memory in mice that overexpress extracellular super-oxide dismutas
-
Thiels E, Urban NN, Gonzalez-Burgos GR, Kanterewicz BI, Barrionuevo G, Chu CT, Oury TD, Klann E (2000) Impairment of long-term potentiation and associative memory in mice that overexpress extracellular super-oxide dismutas. J Neurosci 20:7631-7639.
-
(2000)
J Neurosci
, vol.20
, pp. 7631-7639
-
-
Thiels, E.1
Urban, N.N.2
Gonzalez-Burgos, G.R.3
Kanterewicz, B.I.4
Barrionuevo, G.5
Chu, C.T.6
Oury, T.D.7
Klann, E.8
-
40
-
-
77950617631
-
A mouse model of amyloid beta oligomers: Their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo
-
Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, Ishi-bashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, Ito K, Shimada H, Lambert MP, Klein WL, Mori H (2010) A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J Neurosci 30:4845-4856.
-
(2010)
J Neurosci
, vol.30
, pp. 4845-4856
-
-
Tomiyama, T.1
Matsuyama, S.2
Iso, H.3
Umeda, T.4
Takuma, H.5
Ohnishi, K.6
Ishi-Bashi, K.7
Teraoka, R.8
Sakama, N.9
Yamashita, T.10
Nishitsuji, K.11
Ito, K.12
Shimada, H.13
Lambert, M.P.14
Klein, W.L.15
Mori, H.16
-
41
-
-
34249829585
-
Mitogen-activated protein kinase upregulates the dendritic translation machinery in long-term potentiation by controlling the mammalian target of rapa-mycin pathway
-
Tsokas P, Ma T, Iyengar R, Landau EM, Blitzer RD (2007) Mitogen-activated protein kinase upregulates the dendritic translation machinery in long-term potentiation by controlling the mammalian target of rapa-mycin pathway. J Neurosci 27:5885-5894.
-
(2007)
J Neurosci
, vol.27
, pp. 5885-5894
-
-
Tsokas, P.1
Ma, T.2
Iyengar, R.3
Landau, E.M.4
Blitzer, R.D.5
|