Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease

Pharmacology and Therapeutics

Volumn 143, Issue 1, 2014, Pages 87-110

  Yeganeh, Behzad ^a   Wiechec, Emilia ^b   Ande, Sudharsana R ^c   Sharma, Pawan ^d   Moghadam, Adel Rezaei ^e,f   Post, Martin ^a   Freed, Darren H ^c   Hashemi, Mohammad ^g   Shojaei, Shahla ^h   Zeki, Amir A ⁱ   Ghavami, Saeid ^c  

^a UNIVERSITY OF TORONTO   (Canada)

^b LINKÖPING UNIVERSITY   (Sweden)

^c UNIVERSITY OF MANITOBA   (Canada)

^d UNIVERSITY OF CALGARY   (Canada)

^e ISLAMIC AZAD UNIVERSITY   (Iran)

^f ISLAMIC AZAD UNIVERSITY   (Iran)

^g ZAHEDAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^h SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Asthma; Farnesyl transferase inhibitors; Fibrosis; Geranylgeranyl transferase inhibitors; Rho GTPase; Statins

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ATORVASTATIN; BMS 186511; CERIVASTATIN; CHOLESTEROL; COMPACTIN; CORTICOSTEROID; ENZYME; FLUINDOSTATIN; GERANYLGERANYLTRANSFERASE; GGTI 2154; GGTI 2418; GGTI 297; GGTI 298; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; LAPAQUISTAT; LONAFARNIB; MANUMYCIN; MANUMYCIN A; MEVALONIC ACID; MEVINOLIN; PLACEBO; PRAVASTATIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; ROSUVASTATIN; SIMVASTATIN; TIPIFARNIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; FARNESYL TRANS TRANSFERASE; GERANYLGERANYLTRANSFERASE TYPE-I; RHO KINASE; TRANSFERASE;

ACUTE CORONARY SYNDROME; ACUTE LYMPHOBLASTIC LEUKEMIA; ALLERGIC ASTHMA; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASTHMA; ATHEROSCLEROSIS; BLOOD; BREAST CANCER; CANCER THERAPY; CARDIOVASCULAR DISEASE; CATALYSIS; CELL CYCLE; CELL FATE; CELL MEMBRANE; CELL MEMBRANE FLUIDITY; CELL PROLIFERATION; CHOLESTEROL SYNTHESIS; CHRONIC MYELOID LEUKEMIA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; CORONARY ARTERY DISEASE; CYTOSKELETON; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; DRUG TARGETING; ENZYME INHIBITION; FEEDBACK SYSTEM; HEART ATRIUM FIBRILLATION; HEART DISEASE; HEART FAILURE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; IMMUNOMODULATION; INFLAMMATION; ISCHEMIC HEART DISEASE; LIVER TOXICITY; LOW DRUG DOSE; LUNG DISEASE; LUNG FIBROSIS; LUNG INJURY; MALIGNANT NEOPLASTIC DISEASE; MEMBRANE STRUCTURE; METABOLISM; MITOCHONDRION; MOLECULAR BIOLOGY; MULTIPLE MYELOMA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SIGNAL TRANSDUCTION; SYSTOLIC HEART FAILURE; ANIMAL; ANTAGONISTS AND INHIBITORS; CARDIOVASCULAR DISEASES; LUNG DISEASES; NEOPLASMS; PHYSIOLOGY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

ALKYL AND ARYL TRANSFERASES; ANIMALS; CARDIOVASCULAR DISEASES; FARNESYLTRANSTRANSFERASE; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LUNG DISEASES; MEVALONIC ACID; NEOPLASMS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES;

EID: 84898922652     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2014.02.007     Document Type: Review

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