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Volumn 13, Issue , 2012, Pages

Statins as potential therapeutic drug for asthma?

Author keywords

Anti inflammatory; Asthma; Lung function; Statins

Indexed keywords

ATORVASTATIN; SIMVASTATIN; ANTIASTHMATIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

EID: 84869884061     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-13-108     Document Type: Review
Times cited : (44)

References (46)
  • 1
    • 34547657273 scopus 로고    scopus 로고
    • Antileukotriene drugs: clinical application, effectiveness and safety
    • 10.2174/092986707781368522, 17691939
    • Riccioni G. Antileukotriene drugs: clinical application, effectiveness and safety. Curr Med Chem 2007, 14(18):1966-1977. 10.2174/092986707781368522, 17691939.
    • (2007) Curr Med Chem , vol.14 , Issue.18 , pp. 1966-1977
    • Riccioni, G.1
  • 2
    • 33745227751 scopus 로고    scopus 로고
    • Omalizumab for Asthma
    • 10.1056/NEJMct055184, 16790701
    • Strunk RC. Omalizumab for Asthma. N Engl J Med 2006, 354(25):2689-2695. 10.1056/NEJMct055184, 16790701.
    • (2006) N Engl J Med , vol.354 , Issue.25 , pp. 2689-2695
    • Strunk, R.C.1
  • 3
    • 58149214006 scopus 로고    scopus 로고
    • Asthma in smokers: challenges and opportunities
    • 10.1097/MCP.0b013e32831da894, 19077704
    • Thomson NC, Chaudhuri R. Asthma in smokers: challenges and opportunities. Curr Opin Pulm Med 2009, 15(1):39-45. 10.1097/MCP.0b013e32831da894, 19077704.
    • (2009) Curr Opin Pulm Med , vol.15 , Issue.1 , pp. 39-45
    • Thomson, N.C.1    Chaudhuri, R.2
  • 4
    • 33644865225 scopus 로고    scopus 로고
    • Influence of body mass index on the response to asthma controller agents
    • 10.1183/09031936.06.00077205, 16507848
    • Peters-Golden M, Swern A, Bird SS, et al. Influence of body mass index on the response to asthma controller agents. Eur Respir J 2006, 27:495-503. 10.1183/09031936.06.00077205, 16507848.
    • (2006) Eur Respir J , vol.27 , pp. 495-503
    • Peters-Golden, M.1    Swern, A.2    Bird, S.S.3
  • 6
    • 69249150516 scopus 로고    scopus 로고
    • T-helper Type 2-driven Inflammation Defines Major Subphenotypes of Asthma
    • 10.1164/rccm.200903-0392OC, 2742757, 19483109
    • Prescott G, Woodruff BM. T-helper Type 2-driven Inflammation Defines Major Subphenotypes of Asthma. Am J Respir Crit Care Med 2009, 180:388-395. 10.1164/rccm.200903-0392OC, 2742757, 19483109.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 388-395
    • Prescott, G.1    Woodruff, B.M.2
  • 7
    • 79551636378 scopus 로고    scopus 로고
    • Statin drugs, metabolic pathways, and asthma: a therapeutic opportunity needing further research
    • 10.2174/187231211794455217, 21198438
    • Zeki AA, Kenyon NJ, Goldkorn T. Statin drugs, metabolic pathways, and asthma: a therapeutic opportunity needing further research. Drug Metab Lett 2011, 5(1):40-44. 10.2174/187231211794455217, 21198438.
    • (2011) Drug Metab Lett , vol.5 , Issue.1 , pp. 40-44
    • Zeki, A.A.1    Kenyon, N.J.2    Goldkorn, T.3
  • 8
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • 10.1038/343425a0, 1967820
    • Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature 1990, 343(6257):425-430. 10.1038/343425a0, 1967820.
    • (1990) Nature , vol.343 , Issue.6257 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 9
    • 58149384692 scopus 로고    scopus 로고
    • RhoA/Rho-kinase as a therapeutic target in asthma
    • 10.2174/092986708786242831, 18991642
    • Kume H. RhoA/Rho-kinase as a therapeutic target in asthma. Curr Med Chem 2008, 15(27):2876-2885. 10.2174/092986708786242831, 18991642.
    • (2008) Curr Med Chem , vol.15 , Issue.27 , pp. 2876-2885
    • Kume, H.1
  • 10
    • 78649424607 scopus 로고    scopus 로고
    • RhoA, a possible target for treatment of airway hyperresponsiveness in bronchial asthma
    • 10.1254/jphs.10R03CR, 20948164
    • Chiba Y, Matsusue K, Misawa M. RhoA, a possible target for treatment of airway hyperresponsiveness in bronchial asthma. J Pharmacol Sci 2010, 114(3):239-247. 10.1254/jphs.10R03CR, 20948164.
    • (2010) J Pharmacol Sci , vol.114 , Issue.3 , pp. 239-247
    • Chiba, Y.1    Matsusue, K.2    Misawa, M.3
  • 11
    • 1342282244 scopus 로고    scopus 로고
    • A Novel Anti-Inflammatory Role of Simvastatin in a Murine Model of Allergic Asthma
    • McKay A, Leung BP, McInnes IB, Thomson NC, Liew FY. A Novel Anti-Inflammatory Role of Simvastatin in a Murine Model of Allergic Asthma. J Immunol 2004, 172(5):2903-2908.
    • (2004) J Immunol , vol.172 , Issue.5 , pp. 2903-2908
    • McKay, A.1    Leung, B.P.2    McInnes, I.B.3    Thomson, N.C.4    Liew, F.Y.5
  • 12
    • 33750468907 scopus 로고    scopus 로고
    • Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin
    • Takeda N, Kondo M, Ito S, Ito Y, Shimokata K, Kume H. Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin. AmJ Respir Cell Mol Biol 2006, 35(6):722-729.
    • (2006) AmJ Respir Cell Mol Biol , vol.35 , Issue.6 , pp. 722-729
    • Takeda, N.1    Kondo, M.2    Ito, S.3    Ito, Y.4    Shimokata, K.5    Kume, H.6
  • 15
    • 77957788255 scopus 로고    scopus 로고
    • Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase
    • e751., 10.1016/j.jaci.2010.08.005, 20920765
    • Maneechotesuwan K, Ekjiratrakul W, Kasetsinsombat K, Wongkajornsilp A, Barnes PJ. Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase. J Allergy Clin Immunol 2010, 126:754-762. e751., 10.1016/j.jaci.2010.08.005, 20920765.
    • (2010) J Allergy Clin Immunol , vol.126 , pp. 754-762
    • Maneechotesuwan, K.1    Ekjiratrakul, W.2    Kasetsinsombat, K.3    Wongkajornsilp, A.4    Barnes, P.J.5
  • 18
    • 74749089013 scopus 로고    scopus 로고
    • The effect of statin therapy on allergic patients with asthma
    • 10.1016/S1081-1206(10)60261-X, 20084838
    • Ostroukhova M, Kouides RW, Friedman E. The effect of statin therapy on allergic patients with asthma. Ann Allergy Asthma Immunol 2009, 103(6):463-468. 10.1016/S1081-1206(10)60261-X, 20084838.
    • (2009) Ann Allergy Asthma Immunol , vol.103 , Issue.6 , pp. 463-468
    • Ostroukhova, M.1    Kouides, R.W.2    Friedman, E.3
  • 20
    • 0029914622 scopus 로고    scopus 로고
    • Assessing the Quality of Reports of Randomized Clinical Trials: Is Blinding Necessary?
    • 10.1016/0197-2456(95)00134-4, 8721797
    • Jadad AR. Assessing the Quality of Reports of Randomized Clinical Trials: Is Blinding Necessary?. Controlled Clin Trials 1996, 17:1-12. 10.1016/0197-2456(95)00134-4, 8721797.
    • (1996) Controlled Clin Trials , vol.17 , pp. 1-12
    • Jadad, A.R.1
  • 21
    • 33846804393 scopus 로고    scopus 로고
    • Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma
    • 10.1016/j.jaci.2006.10.014, 17141851
    • Menzies D, Nair A, Meldrum KT, Fleming D, Barnes M, Lipworth BJ. Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma. J Allergy Clin Immunol 2007, 119:328-335. 10.1016/j.jaci.2006.10.014, 17141851.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 328-335
    • Menzies, D.1    Nair, A.2    Meldrum, K.T.3    Fleming, D.4    Barnes, M.5    Lipworth, B.J.6
  • 23
    • 84872413663 scopus 로고    scopus 로고
    • Does atorvastatin have effect on lung function and morbidity as add on therapy in asthmatic patients? [Abstract]
    • Fahimi F, Jamaati H, Taheri ZM, Fakharian A, Salamzadeh J. Does atorvastatin have effect on lung function and morbidity as add on therapy in asthmatic patients? [Abstract]. Eur Respir J 2007, 490s:2960.
    • (2007) Eur Respir J , vol.490 s , pp. 2960
    • Fahimi, F.1    Jamaati, H.2    Taheri, Z.M.3    Fakharian, A.4    Salamzadeh, J.5
  • 24
    • 84869789379 scopus 로고    scopus 로고
    • Evaluation of atorvastatin for the treatment of patients with asthma: a double-blind randomized clinical trial
    • 10.4168/aair.2012.4.5.290, 3423603, 22950035
    • Moini A, Azimi G, Farivar A. Evaluation of atorvastatin for the treatment of patients with asthma: a double-blind randomized clinical trial. Allergy Asthma Immunol Res 2012, 4(5):290-294. 10.4168/aair.2012.4.5.290, 3423603, 22950035.
    • (2012) Allergy Asthma Immunol Res , vol.4 , Issue.5 , pp. 290-294
    • Moini, A.1    Azimi, G.2    Farivar, A.3
  • 25
    • 77957204710 scopus 로고    scopus 로고
    • Simvastatin in the treatment of asthma: lack of steroid-sparing effect
    • 10.1136/thx.2010.138990, 20861293
    • Cowan DC, Cowan JO, Palmay R, Williamson A, Taylor DR. Simvastatin in the treatment of asthma: lack of steroid-sparing effect. Thorax 2010, 65:891-896. 10.1136/thx.2010.138990, 20861293.
    • (2010) Thorax , vol.65 , pp. 891-896
    • Cowan, D.C.1    Cowan, J.O.2    Palmay, R.3    Williamson, A.4    Taylor, D.R.5
  • 27
    • 84872382203 scopus 로고    scopus 로고
    • Effects of lipid lowering therapy in a representative asthma population
    • Adams R, Appleton S, Wilson D, Ruffin R. Effects of lipid lowering therapy in a representative asthma population. Respirology 2010, 15:A46.
    • (2010) Respirology , vol.15
    • Adams, R.1    Appleton, S.2    Wilson, D.3    Ruffin, R.4
  • 28
    • 84872395031 scopus 로고    scopus 로고
    • Effect on lung function and morbidity in asthmatic patients who use atorvastatin
    • Moskovljevic J, Zivkovic M. Effect on lung function and morbidity in asthmatic patients who use atorvastatin. Allergy: Eur J Allergy Clin Immunol 2010, 65:526.
    • (2010) Allergy: Eur J Allergy Clin Immunol , vol.65 , pp. 526
    • Moskovljevic, J.1    Zivkovic, M.2
  • 29
    • 55049142175 scopus 로고    scopus 로고
    • Evaluation anti-inflammatory and anti-oxidant activity of simvastatin in asthma
    • Al Obaidi AHA, Al Samarai AGM. Evaluation anti-inflammatory and anti-oxidant activity of simvastatin in asthma. J Bahrain Med Soc 2008, 20(2):55-59.
    • (2008) J Bahrain Med Soc , vol.20 , Issue.2 , pp. 55-59
    • Al Obaidi, A.H.A.1    Al Samarai, A.G.M.2
  • 30
    • 79953746639 scopus 로고    scopus 로고
    • Statin use in patients with asthma - a nationwide population-based study
    • 10.1111/j.1365-2362.2010.02434.x, 21128938
    • Huang CC, Chan WL, Chen YC, Chen TJ, Chou KT, Lin SJ, Chen JW, Leu HB. Statin use in patients with asthma - a nationwide population-based study. Eur J Clin Invest 2011, 41(5):507-512. 10.1111/j.1365-2362.2010.02434.x, 21128938.
    • (2011) Eur J Clin Invest , vol.41 , Issue.5 , pp. 507-512
    • Huang, C.C.1    Chan, W.L.2    Chen, Y.C.3    Chen, T.J.4    Chou, K.T.5    Lin, S.J.6    Chen, J.W.7    Leu, H.B.8
  • 31
    • 84863645652 scopus 로고    scopus 로고
    • Do statins improve outcomes in patients with asthma on inhaled corticosteroid therapy? A retrospective cohort analysis
    • Lokhandwala T, West-Strum D, Banahan BF, Bentley JP, Yang Y. Do statins improve outcomes in patients with asthma on inhaled corticosteroid therapy? A retrospective cohort analysis. BMJ Open 2012, 2(3).
    • (2012) BMJ Open , vol.2 , Issue.3
    • Lokhandwala, T.1    West-Strum, D.2    Banahan, B.F.3    Bentley, J.P.4    Yang, Y.5
  • 33
    • 0031955156 scopus 로고    scopus 로고
    • Asthma in the elderly: underperceived, underdiagnosed and undertreated; a community survey
    • 10.1016/S0954-6111(98)90311-0, 9692125
    • Parameswaran K. Asthma in the elderly: underperceived, underdiagnosed and undertreated; a community survey. Respir Med 1998, 92:573-577. 10.1016/S0954-6111(98)90311-0, 9692125.
    • (1998) Respir Med , vol.92 , pp. 573-577
    • Parameswaran, K.1
  • 34
    • 0034045299 scopus 로고    scopus 로고
    • Underutilization of controller and rescue medications among older adults with asthma requiring hospital care
    • Hartert TV. Underutilization of controller and rescue medications among older adults with asthma requiring hospital care. J Am Geriatr Soc 2000, 48:651-657.
    • (2000) J Am Geriatr Soc , vol.48 , pp. 651-657
    • Hartert, T.V.1
  • 35
    • 35348972883 scopus 로고    scopus 로고
    • Statin Use Reduces Decline in Lung Function: VA Normative Aging Study
    • 10.1164/rccm.200705-656OC, 2020828, 17673694
    • Alexeeff SE. Statin Use Reduces Decline in Lung Function: VA Normative Aging Study. Am J Respir Crit Care Med 2007, 176:742-747. 10.1164/rccm.200705-656OC, 2020828, 17673694.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 742-747
    • Alexeeff, S.E.1
  • 36
    • 37549021118 scopus 로고    scopus 로고
    • The Use of Statins and Lung Function in Current and Former Smokers
    • 10.1378/chest.07-0298, 17908708
    • Keddissi JI. The Use of Statins and Lung Function in Current and Former Smokers. Chest 2007, 132(6):1764-1771. 10.1378/chest.07-0298, 17908708.
    • (2007) Chest , vol.132 , Issue.6 , pp. 1764-1771
    • Keddissi, J.I.1
  • 37
    • 34748878277 scopus 로고    scopus 로고
    • Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma
    • 10.1016/j.rmed.2007.06.031, 17686624
    • Boulet LP, Franssen E. Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma. Respir Med 2007, 101:2240-2247. 10.1016/j.rmed.2007.06.031, 17686624.
    • (2007) Respir Med , vol.101 , pp. 2240-2247
    • Boulet, L.P.1    Franssen, E.2
  • 38
    • 33344462192 scopus 로고    scopus 로고
    • Higher BMI is associated with worse asthma control and quality of life but not asthma severity
    • 10.1016/j.rmed.2005.08.001, 16159709
    • Lavoie KL, Bacon SL, Labrecque M, et al. Higher BMI is associated with worse asthma control and quality of life but not asthma severity. Respir Med 2006, 100:648-657. 10.1016/j.rmed.2005.08.001, 16159709.
    • (2006) Respir Med , vol.100 , pp. 648-657
    • Lavoie, K.L.1    Bacon, S.L.2    Labrecque, M.3
  • 39
    • 79952301495 scopus 로고    scopus 로고
    • Decreased response to inhaled steroids in overweight and obese asthmatic children
    • 10.1016/j.jaci.2010.12.010, 3056233, 21377042
    • Forno E, Lescher R. Decreased response to inhaled steroids in overweight and obese asthmatic children. J Allergy Clin Immunol 2011, 127(3):741-749. 10.1016/j.jaci.2010.12.010, 3056233, 21377042.
    • (2011) J Allergy Clin Immunol , vol.127 , Issue.3 , pp. 741-749
    • Forno, E.1    Lescher, R.2
  • 40
    • 26144481287 scopus 로고    scopus 로고
    • Rho and vascular disease
    • 10.1016/j.atherosclerosis.2005.04.023, 15982657
    • Rolfe BE, Worth NF. Rho and vascular disease. Atherosclerosis 2005, 183(1):1-16. 10.1016/j.atherosclerosis.2005.04.023, 15982657.
    • (2005) Atherosclerosis , vol.183 , Issue.1 , pp. 1-16
    • Rolfe, B.E.1    Worth, N.F.2
  • 41
    • 0037180449 scopus 로고    scopus 로고
    • Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA
    • 10.1073/pnas.232551499, 137719, 12424339
    • Neese RA, Misell LM, Turner S, Chu A, Kim J, Cesar D, et al. Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA. Proc Nat Acad Sci USA 2002, 99(24):15345-15350. 10.1073/pnas.232551499, 137719, 12424339.
    • (2002) Proc Nat Acad Sci USA , vol.99 , Issue.24 , pp. 15345-15350
    • Neese, R.A.1    Misell, L.M.2    Turner, S.3    Chu, A.4    Kim, J.5    Cesar, D.6
  • 42
    • 33750291943 scopus 로고    scopus 로고
    • Measurement of mouse vascular smooth muscle and atheroma cell proliferation by 2H2O incorporation into DNA
    • 10.1152/ajpcell.00191.2006, 16774990
    • Chu A, Ordonez ET, Hellerstein MK. Measurement of mouse vascular smooth muscle and atheroma cell proliferation by 2H2O incorporation into DNA. Am J Physiol Cell Physiol 2006, 291(5):C1014-C1021. 10.1152/ajpcell.00191.2006, 16774990.
    • (2006) Am J Physiol Cell Physiol , vol.291 , Issue.5
    • Chu, A.1    Ordonez, E.T.2    Hellerstein, M.K.3
  • 43
    • 0034283536 scopus 로고    scopus 로고
    • Inhibitors of HMG-CoA reductase sensitize human smooth muscle cells to Fas-ligand and cytokine-induced cell death
    • 10.1016/S0021-9150(99)00462-1, 10996358
    • Knapp AC, Huang J, Starling G. Inhibitors of HMG-CoA reductase sensitize human smooth muscle cells to Fas-ligand and cytokine-induced cell death. Atherosclerosis 2000, 152:217-227. 10.1016/S0021-9150(99)00462-1, 10996358.
    • (2000) Atherosclerosis , vol.152 , pp. 217-227
    • Knapp, A.C.1    Huang, J.2    Starling, G.3
  • 44
    • 0141566768 scopus 로고    scopus 로고
    • Statins differ in their ability to block NFkB activation in human blood monocytes
    • Hilgendorff A, Muth H, Parviz B. Statins differ in their ability to block NFkB activation in human blood monocytes. Int J Clin Pharmacol Ther 2003, 41:397-401.
    • (2003) Int J Clin Pharmacol Ther , vol.41 , pp. 397-401
    • Hilgendorff, A.1    Muth, H.2    Parviz, B.3
  • 45
    • 0035129882 scopus 로고    scopus 로고
    • Stimulation of inflammatory responses in vitro and in vivo by lipophilic HMG-CoA reductase inhibitors
    • 10.1016/S0162-3109(00)00272-1, 11367508
    • Kiener PA, Davis PM, Murray JL. Stimulation of inflammatory responses in vitro and in vivo by lipophilic HMG-CoA reductase inhibitors. Int Immunopharmacol 2001, 1:105-118. 10.1016/S0162-3109(00)00272-1, 11367508.
    • (2001) Int Immunopharmacol , vol.1 , pp. 105-118
    • Kiener, P.A.1    Davis, P.M.2    Murray, J.L.3
  • 46
    • 78649245378 scopus 로고    scopus 로고
    • Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?
    • 10.1016/j.trsl.2010.09.003, 2990975, 21078495
    • Amir A, Zeki JMB. Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?. Transl Res 2010, 156:335-349. 10.1016/j.trsl.2010.09.003, 2990975, 21078495.
    • (2010) Transl Res , vol.156 , pp. 335-349
    • Amir, A.1    Zeki, J.M.B.2


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