Genomic analysis of metastasis reveals an essential role for RhoC

Nature

Volumn 406, Issue 6795, 2000, Pages 532-535

  Clark, Edwin A ^a,e   Golub, Todd R ^b,d   Lander, Eric S ^b,c   Hynes, Richard O ^a,c  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e Millenium Predictive Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRONECTIN; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE RHOC; PROTEIN; RHO FACTOR; SCLEROPROTEIN; THYMOSIN BETA4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INVASION; GENE EXPRESSION; HUMAN; HUMAN CELL; LUNG METASTASIS; MELANOMA; MELANOMA B16; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALS; FIBRONECTINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE TRANSFER TECHNIQUES; HUMANS; LUNG NEOPLASMS; MELANOMA; MICE; MICE, INBRED C57BL; MICE, NUDE; MUTATION; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RAS PROTEINS; RHO GTP-BINDING PROTEINS; RHOA GTP-BINDING PROTEIN; THYMOSIN; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0034601487     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35020106     Document Type: Article

References (29)

1. Van Noorden, C. J. F., Meade-Tollin, L. C. & Bosman, F. T. Metastasis. Am. Sci. 86, 130-141 (1998).
2. Fidlet, I. J. & Radinsky, R. Search for genes that suppress cancer metastasis. J. Natl Cancer Inst. 88, 1700-1703 (1996).
3. Roberts, D. D. Regulation of tumor growth and metastasis by thrombospondin-1. FASEB J. 10, 1183-1191 (1996).
4. Bao, L. et al. Thymosin β15: a novel regulator of tumor cell motility upregulaled in metastatic prostate cancer. Nature Med 2, 1322-1328 (1996).
5. Habets, G. G. M. et al. Identification of an invasion-inducing gene. Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for rho-like proteins. Cell 77, 537-549 (1994).
6. Fidler, I. J. Selection of successive tumour lines for metastasis. Nature 242, 148-149 (1973).
7. Kozlowski, J. M., Hart, I. R., Fidler, I. J. & Hanna, N. A human melanoma cell line heterogeneous with respect to metastatic capacity in athymic nude mice J. Natl Cancer Inst. 72, 913-917 (1984).
8. Welch, D. K. et al. Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicity. Oncogene 9, 255-262 (1994).
9. Zhang, L. et al. Gene expression profiles in normal and cancer cells. Science 276, 1268-1272 (1997).
10. Maniotis, A. J. et al. Vascular channel formation by human melanoma cells in vivo and in vitro: visculogenic mimicry. Am. J. Pathol. 155, 739-752 (1999).
11. Humphries, M. J., Olden, K. & Yamada, K. M. A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells. Science 233, 467-469 (1986).
12. Van Aelst, L. & D'Souza-Schorey, C. Rho GTPases and signaling networks. Genes Dev. 11, 2295-2322 (1997).
13. Suwa, H. et al. Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas. Br. J. Cancer 77, 147-352 (1998).
14. Hall, A. K. Differential expression of thymosin genes in human tumors and in the developing human kidney. Int. J. Cancer 48, 672-677 (1991).
15. Weterman, M. A. J., van Muijen, G. N. P., Ruiter, D. J. & Bloemers, H. P. J. Thymosin β-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma. Int. J. Cancer 53, 278-284 (1993).
16. Chen, L., O'Bryan, J. P., Smith, H. S. & Liu, E. Overexpression of matrix Gla protein mRNA in malignant human breast cells: isolation by differential cDNA hybridization. Oncogene 5, 1391-1395 (1990).
17. Schonherr, E. et al. Interaction of biglycan with type 1 collagen. J. Biol. Chem. 270, 2776-2783 (1995).
18. Svensson, L. et al. Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon. J. Biol. Chem. 274, 9636-9647 (1999).
19. Ruoslahti, E. Fibronectin and its integrin receptors in cancer. Adv. Cancer Res. 76, 1-20 (1999).
20. Jeffers, M., Rong, S. & Vande Woude, G. F. Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-Met signalling human cells concomitant with induction of the urokinase proteolysis network. Mol. Cell. Biol. 16, 1115-1125 (1996).
21. Chambers, A. F. & Matrisian, L. M. Changing views of the role of matrix metalloproteinases in metastasis. J. Natl Cancer Inst. 89, 1260-1270 (1997).
22. Albelda, S. M. et al. Integrin distribution in malignant melanoma: association of the β3 subunit with tumor progression. Cancer Res. 50, 6757-6764 (1990).
23. Quilliam, L. A., Khosravi-Far, R., Huff, S. Y. & Der, C. J. Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins. BioEssays 17, 395-404 (1995).
24. Feig, L. A. & Cooper, G. M. Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Cell. Biol. 8, 3235-3243 (1988).
25. Lauffenburger, D. A. & Horwitz, A. F. Cell migration: a physically integrated molecular process. Cell 84, 359-369 (1496).
26. Fambrough, D., McClure, K., Kazlauskas, A. & Lander, E. S. Diverse signaling pathways activited by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell 97, 727-741 (1999).
27. Liu, X. et al. Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc. Natl Acad. Sci. USA 94, 10669-10674 (1997).
28. Yebra, M. et al. Requirement of receptor-bound urokinase-type plasminogen activator for integrin αvβ5-directed cell migration. J. Biol. Chem. 271, 29393-29399 (1996).
29. Clark, E. A., King, W. G., Brugge, J. S., Symons, M. & Hynes, R. O. Integrin-mediated signals regulated by members of the rho family of GTPases. J. Cell Biol. 142, 573-586 (1998).