Molecular mechanism of the anti-cancer activity of cerivastatin, an inhibitor of HMG-CoA reductase, on aggressive human breast cancer cells

Cellular Signalling

Volumn 15, Issue 3, 2003, Pages 327-338

  Denoyelle, Christophe ^a   Albanese, Patricia ^b   Uzan, Georges ^b   Hong, Li ^a   Vannier, Jean Pierre ^a   Soria, Jeannette ^c   Soria, Claudine ^a,d  

^a UNIVERSITÉ DE ROUEN   (France)

^b HÔPITAL PAUL BROUSSE   (France)

^c HÔTEL DIEU   (France)

^d SAINT LOUIS HOSPITAL   (France)

Author keywords

AKT; Cancer cell signalling; FAK; HMG CoA reductase inhibitor; Microarray; RhoA; ROCK

Indexed keywords

ACTIN; CERIVASTATIN; CYCLIN D1; CYCLINE; ENZYME INHIBITOR; EXOENZYME C3; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTEGRIN; INTEGRIN BETA8; MYC PROTEIN; PROTEIN P19; PROTEIN P21; RHO KINASE; THROMBOSPONDIN 2; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL INVASION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; GENE ACTIVATION; GENE ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOLECULAR MECHANICS; PRENYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRESS FIBER;

ADP RIBOSE TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; BOTULINUM TOXINS; BREAST NEOPLASMS; CELL DIVISION; CELL MEMBRANE; CYTOSOL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN ISOPRENYLATION; PYRIDINES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

RICKETTSIA SP. PAR;

EID: 0346826281     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0898-6568(02)00124-9     Document Type: Article

References (62)

1. Takemoto M., Liao J.K. Arterioscler. Thromb. Vasc. Biol. 21:2001;1712-1719.
2. Sparrow C.P., Burton C.A., Hernandez M., Mundt S., Hassing H., Patel S.et al. Arterioscler. Thromb. Vasc. Biol. 21:2001;115-121.
3. Mundy G.R. Bone. 29:2001;495-497.
4. Denoyelle C., Vasse M., Körner M., Mishal Z., Ganné F., Vannier J.P.et al. Carcinogenesis. 22:2001;1139-1148.
5. Bellosta S., Ferri N., Bernini F., Paoletti R., Corsini A. Ann. Med. 32:2000;164-176.
6. Matar P., Rozados V.R., Roggero E.A., Scharovsky O.G. Cancer Biother. Radiopharm. 13:1998;87-93.
7. Kawata S., Yamasaki E., Nagase T., Inui Y., Ito N., Matsuda Y.et al. Br. J. Cancer. 84:2001;886-891.
8. Pedersen T.R., Wilhelmsen L., Faergeman O., Strandberg T.E., Thorgeirsson G., Troedson L.et al. Am. J. Cardiol. 86:2000;257-262.
9. Goldstein J.L., Brown M.S. Nature. 343:1990;425-430.
10. Casey P.J. Science. 268:1995;221-225.
11. Malaney S. J. Mammary Gland. Biol. Neoplasia. 6:2001;101-113.
12. Sahai E., Marshall C.J. Nat. Rev., Cancer. 2:2002;133-142.
13. Matar P., Rozados V.R., Binda M.M., Roggero E.A., Bonfil R.D., Scharovsky O.G. Clin. Exp. Metastasis. 17:1999;19-25.
14. Mehta N., Hordies J., Sykes D., Doerr R.J., Cohen S.A. Clin. Exp. Metastasis. 17:1998;587-594.
15. Dignam J.D., Lebovitz R.M., Roeder R.G. Nucleic Acids Res. 11:1983;1475-1489.
16. Bradford M.M. Anal. Biochem. 72:1976;248-254.
17. Laemmli U.K. Nature. 227:1970;680-685.
18. Weidner N., Semple J.P., Welch W.R., Folkman J. N. Engl. J. Med. 324:1991;1-8.
19. Blasi F. Thromb. Haemost. 82:2001;298-304.
20. Streit M., Riccardi L., Velasco P., Brown L.F., Hawighorst T., Bornstein P.et al. Proc. Natl. Acad. Sci. 96:1999;14888-14893.
21. Vogt A., Qian Y., McGuire T.F., Hamilton A.D., Sebti S.M. Oncogene. 13:1996;1991-1999.
22. Lerner E.C., Qian Y., Blaskovich M.A., Fossum R.D., Vogt A., Sun J.et al. J. Biol. Chem. 270:1995;26802-26806.
23. Sekine A., Fujiwara M., Narumiya S. J. Biol. Chem. 264:1989;8602-8605.
24. Matsui T., Amano M., Yamamoto T., Chihara K., Nakafuku M., Ito M.et al. EMBO J. 15:1996;2208-2216.
25. Uehata M., Ishizaki T., Satoh H., Ono T., Kawahara T., Morishita T.et al. Nature. 389:1997;990-994.
26. Khosravi-Far R., White M.A., Westwick J.K., Solski P.A., Chrzanowska-Wodnicka M., Van Aelst L.et al. Mol. Cell Biol. 16:1996;3923-3933.
27. Patel R., Nagueh S.F., Tsybouleva N., Abdellatif M., Lutucuta S., Kopelen H.A.et al. Circulation. 104:2001;317-324.
28. Yoshioka K., Nakamori S., Itok K. Cancer Res. 59:1999;2004-2010.
29. Clark E.A., King W.G., Brugge J.S., Symons M., Hynes R.O. J. Cell Biol. 142:1998;573-586.
30. Chen H.C., Guan J.L. Proc. Natl. Acad. Sci. 91:1994;10148-10152.
31. Coffer P., Jin J., Woodgett J.R. J. Biochem. 335:1998;1-13.
32. Nakatani K., Thompson D.A., Barthel A., Sakaue H., Liu W., Weigel R.J.et al. J. Biol. Chem. 274:1999;21528-21532.
33. Hutchinson J., Jin J., Cardiff R.D., Woodgett J.R., Muller W.J. Mol. Cell Biol. 21:2001;2203-2212.
34. Cross D.A., Alessi D.R., Cohen P., Andjelkovich M., Hemmings B.A. Nature. 378:1995;785-789.
35. Novak A., Dedhar S. Cell Mol. Life Sci. 56:1999;523-537.
36. El-Deiry W.S., Tokino T., Velcu lescu V.E., Levy D.B., Parsons R., Trent J.M.et al. Cell. 75:1993;817-825.
37. Hirai H., Roussel M.F., Kato J.Y., Ashmun R.A., Sherr C.J. Mol. Cell Biol. 15:1995;2672-2681.
38. Baldin V., Lukas J., Marcote M.J., Pagano M., Draetta G. Genes Dev. 7:1993;812-821.
39. Kreipe H., Feist H., Fischer L., Felgner J., Heidorn K., Mettler L.et al. Cancer Res. 53:1993;1956-1961.
40. Heimann R., Ferguson D., Recant W.M., Hellman S. Cancer J. Sci. 3:1997;224-229.
41. Gray-Bablin J., Rao S., Keyomarsi K. Cancer Res. 54:1997;604-609.
42. Cambier S., Mu D.Z., O'Connell D., Boylen K., Travis W., Liu W.H.et al. Cancer Res. 60:2000;7084-7093.
43. Andreasen P.A., Egelund R., Petersen H.H. Cell Mol. Life Sci. 57:2000;25-40.
44. Egeblad M., Werb Z. Nat. Rev. Cancer. 2:2002;161-174.
45. Irigoyen J.P., Munoz-Canoves P., Montero L., Koziczak M., Nagamine Y. Cell Mol. Life Sci. 56:1999;104-132.
46. Bajou K., Noel A., Gerard R.D., Masson V., Brunner N., Holst-Hansen C.et al. Nat. Med. 4:1998;923-928.
47. Olson D.J., Gibo D.M., Saggers G., Debinski W., Kumar R. Cell Growth Differ. 8:1997;417-423.
48. Toyooka K.O., Toyooka S., Virmani A.K., Sathyanarayana U.G., Euhus D.M., Gilcrease M.et al. Cancer Res. 61:2001;4556-4560.
49. Vincent L., Chen W., Hong L., Mirshahi F., Mishal Z., Mirshahi-Khorassani T.et al. FEBS Lett. 495:2001;159-166.
50. Amano M., Fukata Y., Kaibuchi K. Exp. Cell Res. 261:2001;44-51.
51. Itoh K., Yoshioka K., Akedo H., Uehata M., Ishizaki T., Narumiya S. Nat. Med. 5:1999;221-225.
52. Somlyo A.V., Bradshaw D., Ramos S., Murphy C., Myers C.E., Somlyo A.P. Biochem. Biophys. Res. Commun. 269:2000;652-659.
53. Danen E.H., Sonneveld P., Sonnenberg A., Yamada K.M. J. Cell Biol. 151:2000;1413-1422.
54. Adnane J., Bizouarn F.A., Qian Y., Hamilton A.D., Sebti S.M. Mol. Cell Biol. 18:1998;6962-6970.
55. Wong B., Lumma W.C., Smith A.M., Sisko J.T., Wright S.D., Cai T.Q. J. Leukoc. Biol. 69:2001;959-962.
56. Essig M., Nguyen G., Prie D., Escoubet B., Sraer J.D., Friedlander G. Circ. Res. 83:1998;683-690.
57. Muller S.M., Okan E., Jones P. Biochem. Biophys. Res. Commun. 21:2000;892-898.
58. Eto M., Kozai T., Cosentino F., Joch H., Luscher T.F. Circulation. 105:2002;1756-1759.
59. Duyao M.P., Buckler A.J., Sonenshein G.E. Proc. Natl. Acad. Sci. 27:1990;4727-4731.
60. Hansen S.K., Nerlov C., Zabel U., Verde P., Johnsen P.A., Baeuerle P.A.et al. EMBO J. 11:1992;205-213.
61. Nerlov C., Rorth P., Blasi F., Johnsen M. Oncogene. 6:1991;583-1592.
62. He T.C., Sparks A.B., Rago C., Hermeking H., Zawel L., da Costa L.T.et al. Science. 281:1998;1509-1512.