Fibrin clot properties are altered in patients with chronic obstructive pulmonary disease: Beneficial effects of simvastatin treatment

Thrombosis and Haemostasis

Volumn 102, Issue 6, 2009, Pages 1176-1182

  Undas, Anetta ^a   Kaczmarek, Przemyslaw ^a   Sladek, Krzysztof ^a   Stepien, Ewa ^b   Skucha, Wojciech ^c   Rzeszutko, Marcin ^a   Gorkiewicz Kot, Izabela ^b   Tracz, Wieslawa ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b Krakowski Szpital Specjalistyczny Im Jana Pawła II   (Poland)

^c District Hospital Proszowice   (Poland)

Author keywords

Coagulation; Fibrin; Fibrinolysis; Inflammation; Statins

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; FIBRIN; FIBRINOGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; SIMVASTATIN;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; FIBRIN CLOT; FORCED EXPIRATORY VOLUME; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY;

AGED; BLOOD COAGULATION; CASE-CONTROL STUDIES; FEMALE; FIBRIN; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MICROSCOPY, ELECTRON, SCANNING; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SIMVASTATIN; THROMBOSIS;

EID: 72949119341     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH09-02-0118     Document Type: Article

References (33)

1. Sin DD, Anthonisen NR, Soriano JB, et al. Mortality in COPD: role of comorbidities. Eur Respir J 2006; 28: 1245-1257.
2. Anthonisen NR, Connett JE, Enright PL, et al. Lung Health Study Research Group. Hospitalizations and mortality in the Lung Health Study. Am J Respir Crit Care Med 2002; 166: 333-339.
3. Huiart L, Ernst P, Suissa S. Cardiovascular morbidity and mortality in COPD. Chest 2005; 128: 2640-2646.
4. Sin DD, Man SF. Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease. Circulation 2003; 107: 1514-1519.
5. Undas A, Celinska-Lowenhoff M, Lowenhoff T, et al. Statins, fenofibrate, and quinapril increase clot permeability and enhance fibrinolysis in patients with coronary artery disease. J Thromb Haemost 2006; 4: 1029-1036.
6. Undas A, Plicner D, Stepien E, et al. Altered fibrin clot structure in patients with advanced coronary artery disease: a role of C-reactive protein, lipoprotein(a), and homocysteine. J Thromb Haemost 2007; 5: 1988-1990.
7. Bini A, Fenoglio J, Mesa-Tejada E, et al. Identification and distribution of fibrinogen, fibrin, and fibrin( ogen) degradation products in atherosclerosis. Atherosclerosis 1989; 69: 1038-1045.
8. Thompson W, Smith E. Atherosclerosis and the coagulation system. J Pathol 1989; 159: 97-106.
9. Mosesson MW, Siebenlist KR, Meh DA. The structure and biological features of fibrinogen and fibrin. Ann NY Acad Sci 2001; 936: 11-30.
10. Blombäck B, Carlsson K, Fatah K, et al. Fibrin in human plasma: gel architecture governed by rate and nature of fibrinogen activation. Thromb Res 1994; 5: 521-538.
11. Collet JP, Lesty C, Montalescot G,. Dynamic changes of fibrin architecture during fibrin formation and intrinsic fibrinolysis of fibrin-rich clots. J Biol Chem 2003; 278: 21331-21335.
12. Scott EM, Ariëns RAS, Grant PJ. Genetic and environmental determinants of fibrin structure and function. Relevance to clinical disease. Arterioscler Thromb Vasc Biol 2004; 24: 1558-1566.
13. Undas A, Zeglin M. Fibrin clot structure and cardiovascular disease. Vasc Dis Prevention 2006; 3: 99-106.
14. Undas A, Brozek J, Jankowski M, et al. Plasma homocysteine affects fibrin clot permeability and resistance to lysis in human subjects. Arterioscler Thromb Vasc Biol 2006; 26: 1397-1404.
15. Undas A, Stepien E, Tracz W, et al. Lipoprotein(a) as a modifier of fibrin clot permeability and susceptibility to lysis. J Thromb Haemost 2006; 4: 973-975.
16. Salonen EM, Vartio T, Hedman K. Binding of fibronectin by the acute phase C-reactive protein. J Biol Chem 1984; 259: 1496-1501.
17. Shacter E, Williams JA, Lim M, et al. Differential susceptibility of plasma proteins to oxidative modification: examination by western blot immunoassay. Free Radic Biol Med 1994; 17: 429-437.
18. Dunn EJ, Ariëns RA, Grant PJ. The influence of type 2 diabetes on fibrin structure and function. Diabetologica 2005; 48: 1198-1206.
19. Williams S, Fatah K, Ivert T, et al. The effect of acetyl salicylic acid on fibrin gel lysis by tissue plasminogen activator. Blood Coagul Fibrinolysis 1995; 6: 718-725.
20. Mancini GB, Etminan M, Zhang B, et al. Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary disease. J Am Coll Cardiol. 2006; 47: 2554-2560.
21. Mills JD, Ariens RA, Mansfield MW, et al. Altered fibrin clot structure in the healthy relatives of patients with premature coronary artery disease. Circulation. 2002; 106: 1938-1942.
22. Collet J-P, Mishal Z, Lesty C, et al. Abnormal fibrin clot architecture in nephritic patients is related to hypofibrinolysis: influence of plasma biochemical modifications. Thromb Haemost 1999; 82: 1482-1489.
23. Collet J-P, Allali Y, Lesty C, et al. Altered fibrin architecture is associated with hypofibrinolysis and premature coronary atherothrombosis. Arterioscler Thromb Vasc Biol 2006; 26: 2567-2573.
24. Undas A, Topor-Madry R, Tracz W. Simvastatin increases clot permeability and susceptibility to lysis in patients with LDL cholesterol below 3.4 mmol/l. Pol Arch Med Wewn. 2009; 119: 354-359.
25. Gonbert S, Malinsky S, Sposito AC, et al. Atorvastatin lowers lipoprotein(a) but not apolipoprotein(a) fragment levels in hypercholesterolemic subjects at high cardiovascular risk. Atherosclerosis 2002; 164: 305-311.
26. Lee TM, Chen CC, Shan HN, et al. Effects of pravastatin on functional capacity in patients with chronic obstructive pulmonary disease and pulmonary hypertension. Clin Sci (Lond) 2009; 116: 497-505.
27. Maclay JD, McAlister DA, MacNee W. Cardiovascular risk in chronic obstructive pulmonary disease. Respirology 2007; 12: 634-641.
28. Lahera V, Goicoechea M, de Vinuesa SG, et al. Endothelial dysfunction, oxidative stress and inflammation in atherosclerosis: beneficial effects of statins. Curr Med Chem 2007; 14: 243-248.
29. Undas A, Szuldrzynski K, Stepien E, et al. Reduced clot permeability and susceptibility to lysis in patients with acute coronary syndrome: effects of inflammation and oxidative stress. Atherosclerosis 2007; 196:551-558.
30. Ashitani J, Mukae H, Arimura Y, et al. Elevated plasma procoagulant and fibrinolytic markers in patients with chronic obstructive pulmonary disease. Int Medicine 2002; 41: 181-185.
31. Joppa P, Petrasova D, Stancak B, et al. Systemic inflammation in patients with COPD and pulmonary hypertension. Chest 2006; 130: 326-333.
32. Brenner O, Birm MD, Long M. Sclerosis of pulmonary artery with thrombosis. Lancet 1931; 1: 911-914.
33. Singh U, Deveraj S, Jialal I. C-reactive protein decreases tissue plasminogen activator activity in human aortic endothelial cells: evidence that CRP is prothrombotic. Arterioscler Thromb Vasc Biol 2005; 25: 2216-2221.