Simvastatin decreases IL-6 and IL-8 production in epithelial cells

Journal of Dental Research

Volumn 85, Issue 6, 2006, Pages 520-523

  Sakoda, K ^a   Yamamoto, M ^b   Negishi, Y ^c   Liao, J K ^d   Node, K ^e   Izumi, Y ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b SHOWA UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

^c TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^d HARVARD MEDICAL SCHOOL   (United States)

^e SAGA UNIVERSITY   (Japan)

Author keywords

Human oral epithelial cell; Inflammatory cytokines; Periodontitis; Pleiotropic effects; Simvastatin (3 hydroxy 3 methylglutaryl co enzyme A reductase inhibitor)

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTILIPEMIC AGENT; FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; ISOPRENOID PHOSPHATE; MEVALONIC ACID; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SIMVASTATIN; TRANSCRIPTION FACTOR AP 1;

ARTICLE; CELL STRAIN KB; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; EPITHELIUM CELL; GINGIVA; HUMAN;

ANTI-INFLAMMATORY AGENTS; ANTILIPEMIC AGENTS; EPITHELIAL CELLS; GINGIVA; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTERLEUKIN-1; INTERLEUKIN-6; INTERLEUKIN-8; KB CELLS; MEVALONIC ACID; NF-KAPPA B; POLYISOPRENYL PHOSPHATES; RHO GTP-BINDING PROTEINS; SIMVASTATIN; TRANSCRIPTION FACTOR AP-1;

EID: 33745373880     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910608500608     Document Type: Article

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