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Volumn 25, Issue 5, 2011, Pages 299-308

Competitive metabolism of L -arginine: Arginase as a therapeutic target in asthma

Author keywords

Arginase; L arginine; Nitric oxide; Nitric oxide synthase; Nitrosation; Nor NOHA

Indexed keywords

2 AMINO 5 (2 AMINOIMIDAZOL 1 YL)PENTAENOIC ACID; 2 AMINO 6 BORONOHEXONIC ACID; ANTIASTHMATIC AGENT; ARGINASE; ARGINASE 1; ARGINASE INHIBITOR; ARGININE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; S (2 BORONOETHYL)CYSTEINE; S 2 AMINO 6 IODOACETAMIDOHEXANOIC ACID; UNCLASSIFIED DRUG;

EID: 80054864540     PISSN: 16748301     EISSN: 16748301     Source Type: Journal    
DOI: 10.1016/S1674-8301(11)60041-9     Document Type: Review
Times cited : (32)

References (116)
  • 1
    • 58149265524 scopus 로고    scopus 로고
    • Structural aspects of airway re-modeling in asthma
    • Siddiqui S, Martin JG Structural aspects of airway re-modeling in asthma. Curr Allergy Asthma Rep 2008, 8:540-547.
    • (2008) Curr Allergy Asthma Rep , vol.8 , pp. 540-547
    • Siddiqui, S.1    Martin, J.G.2
  • 2
    • 37849000903 scopus 로고    scopus 로고
    • Airway smooth muscle growth in asthma: proliferation, hypertrophy, and mi-gration
    • Bentley JK, Hershenson MB Airway smooth muscle growth in asthma: proliferation, hypertrophy, and mi-gration. Proc Am Thorac Soc 2008, 5:89-96.
    • (2008) Proc Am Thorac Soc , vol.5 , pp. 89-96
    • Bentley, J.K.1    Hershenson, M.B.2
  • 3
    • 0030895523 scopus 로고    scopus 로고
    • The measurement of reticular base-ment membrane and submucosal collagen in the asth-matic airway
    • Wilson JW, Li X The measurement of reticular base-ment membrane and submucosal collagen in the asth-matic airway. Clin Exp Allergy 1997, 27:363-371.
    • (1997) Clin Exp Allergy , vol.27 , pp. 363-371
    • Wilson, J.W.1    Li, X.2
  • 4
    • 17644363081 scopus 로고    scopus 로고
    • ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide
    • ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide. Am J Respir Crit Care Med 2005, 171:912-930.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 912-930
  • 6
    • 77649275723 scopus 로고    scopus 로고
    • Beneficial effects of high dose of L-arginine on airway hyperresponsiveness and airway inflammation in a murine model of asthma
    • Mabalirajan U, Ahmad T, Leishangthem GD, Joseph DA, Dinda AK, Agrawal A, et al. Beneficial effects of high dose of L-arginine on airway hyperresponsiveness and airway inflammation in a murine model of asthma. J Allergy Clin Immunol 2010, 125:626-635.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 626-635
    • Mabalirajan, U.1    Ahmad, T.2    Leishangthem, G.D.3    Joseph, D.A.4    Dinda, A.K.5    Agrawal, A.6
  • 8
  • 10
    • 0033844950 scopus 로고    scopus 로고
    • Regulation of ciliary beat frequency by the nitric oxide-cyclic gua-nosine monophosphate signaling pathway in rat airway epithelial cells
    • Li D, Shirakami G, Zhan X, Johns RA Regulation of ciliary beat frequency by the nitric oxide-cyclic gua-nosine monophosphate signaling pathway in rat airway epithelial cells. Am J Respir Cell Mol Biol 2000, 23:175-181.
    • (2000) Am J Respir Cell Mol Biol , vol.23 , pp. 175-181
    • Li, D.1    Shirakami, G.2    Zhan, X.3    Johns, R.A.4
  • 11
    • 0032958338 scopus 로고    scopus 로고
    • Role of nitric oxide released from iNANC neurons in airway responsiveness in cats
    • Aizawa H, Takata S, Inoue H, Matsumoto K, Koto H, Hara N Role of nitric oxide released from iNANC neurons in airway responsiveness in cats. Eur Respir J 1999, 3:775-780.
    • (1999) Eur Respir J , vol.3 , pp. 775-780
    • Aizawa, H.1    Takata, S.2    Inoue, H.3    Matsumoto, K.4    Koto, H.5    Hara, N.6
  • 12
    • 0025194522 scopus 로고
    • L-NG-nitroarginine inhibits non-adrenergic, non-cholinergic relaxations of guinea-pig isolated tracheal smooth muscle
    • Tucker JF, Brave SR, Charalambous L, Hobbs AJ, Gib-son A L-NG-nitroarginine inhibits non-adrenergic, non-cholinergic relaxations of guinea-pig isolated tracheal smooth muscle. Br J Pharmacol 1990, 100:663-664.
    • (1990) Br J Pharmacol , vol.100 , pp. 663-664
    • Tucker, J.F.1    Brave, S.R.2    Charalambous, L.3    Hobbs, A.J.4    Gib-son, A.5
  • 13
    • 0037083737 scopus 로고    scopus 로고
    • Nitric Oxide-de-pendent Modulation of Smooth-Muscle Tone by Airway Parasympathetic Nerves
    • Kesler BS, Mazzone SB, Canning BJ Nitric Oxide-de-pendent Modulation of Smooth-Muscle Tone by Airway Parasympathetic Nerves. Am J Respir Crit Care Med 2002, 165:481-488.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 481-488
    • Kesler, B.S.1    Mazzone, S.B.2    Canning, B.J.3
  • 14
    • 0025731835 scopus 로고
    • Nitric oxide: an en-dogenous modulator of leukocyte adhesion
    • Kubes P, Suzuki M, Granger DN Nitric oxide: an en-dogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991, 88:4651-4655.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4651-4655
    • Kubes, P.1    Suzuki, M.2    Granger, D.N.3
  • 15
    • 0029159779 scopus 로고
    • Nitric oxide de-creases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of ad-hesion molecules and proinflammatory cytokines
    • De Caterina R, Libby P, Peng HB, Thannickal VJ, Ra-javashisth TB, Gimbrone MA, et al. Nitric oxide de-creases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of ad-hesion molecules and proinflammatory cytokines. J Clin Invest 1995, 96:60-68.
    • (1995) J Clin Invest , vol.96 , pp. 60-68
    • De Caterina, R.1    Libby, P.2    Peng, H.B.3    Thannickal, V.J.4    Ra-javashisth, T.B.5    Gimbrone, M.A.6
  • 18
    • 0028999596 scopus 로고
    • Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
    • MacMicking JD, Nathan C, Hom G, Chartrain N, Fletcher DS, Trumbauer M, et al. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 1995, 81:641-650.
    • (1995) Cell , vol.81 , pp. 641-650
    • MacMicking, J.D.1    Nathan, C.2    Hom, G.3    Chartrain, N.4    Fletcher, D.S.5    Trumbauer, M.6
  • 20
    • 35348890158 scopus 로고    scopus 로고
    • Mouse models of asthma: can they give us mechanistic insights into the role of nitric oxide?
    • Mathrani VC, Kenyon NJ, Zeki A, Last JA Mouse models of asthma: can they give us mechanistic insights into the role of nitric oxide?. Curr Med Chem 2007, 14:2204-2213.
    • (2007) Curr Med Chem , vol.14 , pp. 2204-2213
    • Mathrani, V.C.1    Kenyon, N.J.2    Zeki, A.3    Last, J.A.4
  • 21
    • 85047693239 scopus 로고    scopus 로고
    • Arginase: marker, effector, or candidate gene for asthma?
    • Vercelli D Arginase: marker, effector, or candidate gene for asthma?. J Clin Invest 2003, 111:1815-1817.
    • (2003) J Clin Invest , vol.111 , pp. 1815-1817
    • Vercelli, D.1
  • 22
    • 33846349963 scopus 로고    scopus 로고
    • ENOS phosphorylation: a pivotal molecular switch in vasodilation and cardioprotection?
    • Kukreja RC, Xi L eNOS phosphorylation: a pivotal molecular switch in vasodilation and cardioprotection?. J Mol Cell Cardiol 2007, 42:280-282.
    • (2007) J Mol Cell Cardiol , vol.42 , pp. 280-282
    • Kukreja, R.C.1    Xi, L.2
  • 23
    • 33846849033 scopus 로고    scopus 로고
    • Identification of a classic cytokine-induced enhancer upstream in the human iNOS promoter
    • Guo Z, Shao L, Du Q, Park KS, Geller DA Identification of a classic cytokine-induced enhancer upstream in the human iNOS promoter. FASEB J 2007, 21:535-542.
    • (2007) FASEB J , vol.21 , pp. 535-542
    • Guo, Z.1    Shao, L.2    Du, Q.3    Park, K.S.4    Geller, D.A.5
  • 24
    • 0032575626 scopus 로고    scopus 로고
    • Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor kappaB-binding sites
    • Marks-Konczalik J, Chu SC, Moss J Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor kappaB-binding sites. J Biol Chem 1998, 273:22201-22208.
    • (1998) J Biol Chem , vol.273 , pp. 22201-22208
    • Marks-Konczalik, J.1    Chu, S.C.2    Moss, J.3
  • 25
    • 0032581389 scopus 로고    scopus 로고
    • Analysis of the cytokine-stimulated human inducible nitric oxide synthase (iNOS) gene: characterization of differences between human and mouse iNOS promoters
    • Chu SC, Marks-Konczalik J, Wu HP, Banks TC, Moss J Analysis of the cytokine-stimulated human inducible nitric oxide synthase (iNOS) gene: characterization of differences between human and mouse iNOS promoters. Biochem Biophys Res Commun 1998, 248:871-878.
    • (1998) Biochem Biophys Res Commun , vol.248 , pp. 871-878
    • Chu, S.C.1    Marks-Konczalik, J.2    Wu, H.P.3    Banks, T.C.4    Moss, J.5
  • 27
    • 0028102802 scopus 로고
    • Constitutive and inducible nitric ox-ide synthase gene expression, regulation, and activity in human lung epithelial cells
    • Asano K, Chee CB, Gaston B, Lilly CM, Gerard C, Drazen JM, et al. Constitutive and inducible nitric ox-ide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc Natl Acad Sci U S A 1994, 91:10089-10093.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10089-10093
    • Asano, K.1    Chee, C.B.2    Gaston, B.3    Lilly, C.M.4    Gerard, C.5    Drazen, J.M.6
  • 28
    • 78349258229 scopus 로고    scopus 로고
    • Nitric oxide synthase enzymes in the airways of mice exposed to ovalbumin: NOS2 ex-pression is NOS3 dependent
    • PMID:20953358
    • Bratt JM, Williams K, Rabowsky MF, Last MS, Franzi LM, Last JA, et al. Nitric oxide synthase enzymes in the airways of mice exposed to ovalbumin: NOS2 ex-pression is NOS3 dependent. Mediators Inflamm 2010, PMID:20953358.
    • (2010) Mediators Inflamm
    • Bratt, J.M.1    Williams, K.2    Rabowsky, M.F.3    Last, M.S.4    Franzi, L.M.5    Last, J.A.6
  • 29
    • 0032478104 scopus 로고    scopus 로고
    • Accelerated reaction of nitric oxide with O2 with in hydrophobic interior of biological membranes
    • Liu X, Miller MJ, Joshi MS, Thomas DD, Lancaster JR Accelerated reaction of nitric oxide with O2 with in hydrophobic interior of biological membranes. Proc Natl Acad Sci U S A 1998, 95:2175-2179.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 2175-2179
    • Liu, X.1    Miller, M.J.2    Joshi, M.S.3    Thomas, D.D.4    Lancaster, J.R.5
  • 30
    • 74549201021 scopus 로고    scopus 로고
    • Nitrite potently inhibits hy-poxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidore-ductase-dependent nitric oxide generation
    • Zuckerbraun BS, Shiva S, Ifedigbo E, Mathier MA, Mollen KP, Rao J, et al. Nitrite potently inhibits hy-poxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidore-ductase-dependent nitric oxide generation. Circulation 2010, 121:98-109.
    • (2010) Circulation , vol.121 , pp. 98-109
    • Zuckerbraun, B.S.1    Shiva, S.2    Ifedigbo, E.3    Mathier, M.A.4    Mollen, K.P.5    Rao, J.6
  • 31
    • 33947728687 scopus 로고    scopus 로고
    • Deoxymyoglobin is a nitrite re-ductase that generates nitric oxide and regulates mito-chondrial respiration
    • Shiva S, Huang Z, Grubina R, Sun J, Ringwood LA, MacArthur PH, et al. Deoxymyoglobin is a nitrite re-ductase that generates nitric oxide and regulates mito-chondrial respiration. Circ Res 2007, 100:654-661.
    • (2007) Circ Res , vol.100 , pp. 654-661
    • Shiva, S.1    Huang, Z.2    Grubina, R.3    Sun, J.4    Ringwood, L.A.5    MacArthur, P.H.6
  • 32
    • 53449085187 scopus 로고    scopus 로고
    • The functional nitrite reductase activity of the heme-globins
    • Gladwin MT, Kim-Shapiro DB The functional nitrite reductase activity of the heme-globins. Blood 2008, 112:2636-2647.
    • (2008) Blood , vol.112 , pp. 2636-2647
    • Gladwin, M.T.1    Kim-Shapiro, D.B.2
  • 33
    • 34249804168 scopus 로고    scopus 로고
    • Pharmacokinetics of arginine and related amino acids
    • Cynober L Pharmacokinetics of arginine and related amino acids. J Nutr 2007, 137:1646S-1649S.
    • (2007) J Nutr , vol.137
    • Cynober, L.1
  • 34
    • 0028942273 scopus 로고
    • Structural specificity of substrate for S-adenosylmethionine:protein arginine N-methyltrans-ferases
    • Rawal N, Rajpurohit R, Lischwe MA, Williams KR, Paik WK, Kim S Structural specificity of substrate for S-adenosylmethionine:protein arginine N-methyltrans-ferases. Biochim Biophys Acta 1995, 1248:11-18.
    • (1995) Biochim Biophys Acta , vol.1248 , pp. 11-18
    • Rawal, N.1    Rajpurohit, R.2    Lischwe, M.A.3    Williams, K.R.4    Paik, W.K.5    Kim, S.6
  • 35
    • 0016421339 scopus 로고
    • Biological methylation: Selected aspects
    • Cantoni GL Biological methylation: Selected aspects. Annu Rev Biochem 1975, 44:435-451.
    • (1975) Annu Rev Biochem , vol.44 , pp. 435-451
    • Cantoni, G.L.1
  • 36
    • 0028335392 scopus 로고
    • Metabolism of methylarginines by human vasculature; implications for the regulation of nitric oxide synthesis
    • MacAllister RJ, Fickling SA, Whitley GS, Vallance P Metabolism of methylarginines by human vasculature; implications for the regulation of nitric oxide synthesis. Br J Pharmacol 1994, 112:43-48.
    • (1994) Br J Pharmacol , vol.112 , pp. 43-48
    • MacAllister, R.J.1    Fickling, S.A.2    Whitley, G.S.3    Vallance, P.4
  • 38
    • 0029941131 scopus 로고    scopus 로고
    • Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by de-carboxylation of arginine
    • Galea E, Regunathan S, Eliopoulos V, Feinstein DL, Reis DJ Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by de-carboxylation of arginine. Biochem J 1996, 316:247-249.
    • (1996) Biochem J , vol.316 , pp. 247-249
    • Galea, E.1    Regunathan, S.2    Eliopoulos, V.3    Feinstein, D.L.4    Reis, D.J.5
  • 39
    • 34447116242 scopus 로고    scopus 로고
    • A GABAergic system in airway epithelium is es-sential for mucus overproduction in asthma
    • Xiang YY, Wang S, Liu M, Hirota JA, Li J, Ju W, et al. A GABAergic system in airway epithelium is es-sential for mucus overproduction in asthma. Nat Med 2007, 13:862-867.
    • (2007) Nat Med , vol.13 , pp. 862-867
    • Xiang, Y.Y.1    Wang, S.2    Liu, M.3    Hirota, J.A.4    Li, J.5    Ju, W.6
  • 40
    • 46049093188 scopus 로고    scopus 로고
    • A comprehensive evaluation of the en-zymatic and nonenzymatic antioxidant systems in child-hood asthma
    • Sackesen C, Ercan H, Dizdar E, Soyer O, Gumus P, Tosun BN, et al. A comprehensive evaluation of the en-zymatic and nonenzymatic antioxidant systems in child-hood asthma. J Allergy Clin Immunol 2008, 122:78-85.
    • (2008) J Allergy Clin Immunol , vol.122 , pp. 78-85
    • Sackesen, C.1    Ercan, H.2    Dizdar, E.3    Soyer, O.4    Gumus, P.5    Tosun, B.N.6
  • 44
    • 12944250997 scopus 로고    scopus 로고
    • Arginine, citrulline, and nitric oxide metabolism in end-stage renal disease patients
    • Lau T, Owen W, Yu YM, Noviski N, Lyons J, Zura-kowski D, et al. Arginine, citrulline, and nitric oxide metabolism in end-stage renal disease patients. J Clin Invest 2000, 105:1217-1225.
    • (2000) J Clin Invest , vol.105 , pp. 1217-1225
    • Lau, T.1    Owen, W.2    Yu, Y.M.3    Noviski, N.4    Lyons, J.5    Zura-kowski, D.6
  • 47
    • 9944259578 scopus 로고    scopus 로고
    • Accessibility of endothelial and inducible nitric oxide synthase to the intracellular citrulline-arginine regeneration pathway. Biochem
    • Shen LJ, Beloussow K, Shen WC Accessibility of endothelial and inducible nitric oxide synthase to the intracellular citrulline-arginine regeneration pathway. Biochem. Pharmacol 2005, 69:97-104.
    • (2005) Pharmacol , vol.69 , pp. 97-104
    • Shen, L.J.1    Beloussow, K.2    Shen, W.C.3
  • 48
    • 33747586994 scopus 로고    scopus 로고
    • Mitochondrial arginase II modulates nitric-oxide synthesis through nonfreely exchangeable L-arginine pools in human endothelial cells
    • Topal G, Brunet A, Walch L, Boucher JL, David-Dufil-ho M Mitochondrial arginase II modulates nitric-oxide synthesis through nonfreely exchangeable L-arginine pools in human endothelial cells. J Pharmacol Exp Ther 2006, 318:1368-1374.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 1368-1374
    • Topal, G.1    Brunet, A.2    Walch, L.3    Boucher, J.L.4    David-Dufil-ho, M.5
  • 49
    • 0033986606 scopus 로고    scopus 로고
    • Sub-strate supply for nitric oxide synthase in macrophages and endothelial cells: role of cationic amino acid trans-porters
    • Closs EI, Scheld JS, Sharafi M, Förstermann U Sub-strate supply for nitric oxide synthase in macrophages and endothelial cells: role of cationic amino acid trans-porters. Mol Pharmacol 2000, 57:68-74.
    • (2000) Mol Pharmacol , vol.57 , pp. 68-74
    • Closs, E.I.1    Scheld, J.S.2    Sharafi, M.3    Förstermann, U.4
  • 50
    • 46949111065 scopus 로고    scopus 로고
    • Arginases I and II in lungs of ovalbumin-sensitized mice exposed to ovalbumin: sources and consequences
    • Kenyon NJ, Bratt JM, Linderholm AL, Last MS, Last JA Arginases I and II in lungs of ovalbumin-sensitized mice exposed to ovalbumin: sources and consequences. Toxicol Appl Pharmacol 2008, 230:269-275.
    • (2008) Toxicol Appl Pharmacol , vol.230 , pp. 269-275
    • Kenyon, N.J.1    Bratt, J.M.2    Linderholm, A.L.3    Last, M.S.4    Last, J.A.5
  • 54
    • 0042243556 scopus 로고    scopus 로고
    • Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis
    • Zimmermann N, King NE, Laporte J, Yang M, Mishra A, Pope SM, et al. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest 2003, 111:1863-1874.
    • (2003) J Clin Invest , vol.111 , pp. 1863-1874
    • Zimmermann, N.1    King, N.E.2    Laporte, J.3    Yang, M.4    Mishra, A.5    Pope, S.M.6
  • 55
    • 4444378175 scopus 로고    scopus 로고
    • Increased lev-els of hypoxia sensitive proteins in allergic airway in-flammation
    • Fajardo I, Svensson L, Bucht A, Pejler G Increased lev-els of hypoxia sensitive proteins in allergic airway in-flammation. Am J Respir Crit Care Med 2004, 170:477-484.
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 477-484
    • Fajardo, I.1    Svensson, L.2    Bucht, A.3    Pejler, G.4
  • 56
    • 58649121269 scopus 로고    scopus 로고
    • Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice ex-posed to ovalbumin
    • Bratt JM, Franzi LM, Linderholm AL, Last MS, Kenyon NJ, Last JA Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice ex-posed to ovalbumin. Toxicol Appl Pharmacol 2009, 234:273-280.
    • (2009) Toxicol Appl Pharmacol , vol.234 , pp. 273-280
    • Bratt, J.M.1    Franzi, L.M.2    Linderholm, A.L.3    Last, M.S.4    Kenyon, N.J.5    Last, J.A.6
  • 57
    • 77953522851 scopus 로고    scopus 로고
    • Direct inhibition of ar-ginase attenuated airway allergic reactions and inflam-mation in a Dermatophagoides farinae-induced NC/Nga mouse model
    • PMID: 20382750
    • Takahashi N, Ogino K, Takemoto K, Hamanishi S, Wang DH, Takigawa T, et al. Direct inhibition of ar-ginase attenuated airway allergic reactions and inflam-mation in a Dermatophagoides farinae-induced NC/Nga mouse model. Am J Physiol Lung Cell Mol Physiol 2010, PMID: 20382750.
    • (2010) Am J Physiol Lung Cell Mol Physiol
    • Takahashi, N.1    Ogino, K.2    Takemoto, K.3    Hamanishi, S.4    Wang, D.H.5    Takigawa, T.6
  • 58
    • 0029900905 scopus 로고    scopus 로고
    • Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury
    • Xia Y, Dawson VL, Dawson TM, Snyder SH, Zweier JL Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proc Natl Acad Sci U S A 1996, 93:6770-6774.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 6770-6774
    • Xia, Y.1    Dawson, V.L.2    Dawson, T.M.3    Snyder, S.H.4    Zweier, J.L.5
  • 59
    • 0032475865 scopus 로고    scopus 로고
    • Superoxide gen-eration from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regula-tory process
    • Xia Y, Tsai AL, Berka V, Zweier JL Superoxide gen-eration from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regula-tory process. J Biol Chem 1998, 273:25804-25808.
    • (1998) J Biol Chem , vol.273 , pp. 25804-25808
    • Xia, Y.1    Tsai, A.L.2    Berka, V.3    Zweier, J.L.4
  • 60
    • 33645744625 scopus 로고    scopus 로고
    • Coupled and Uncoupled NOS: Separate But Equal? Uncoupled NOS in Endothelial Cells Is a Critical Pathway for Intracellular Signaling
    • Sullivan JC, Pollock JS Coupled and Uncoupled NOS: Separate But Equal? Uncoupled NOS in Endothelial Cells Is a Critical Pathway for Intracellular Signaling. Circ Res 2006, 98:717.
    • (2006) Circ Res , vol.98 , pp. 717
    • Sullivan, J.C.1    Pollock, J.S.2
  • 61
    • 0035890621 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase generates superoxide from the oxygenase domain
    • Yoneyama H, Yamamoto A, Kosaka H Neuronal nitric oxide synthase generates superoxide from the oxygenase domain. Biochem J 2001, 360:247-253.
    • (2001) Biochem J , vol.360 , pp. 247-253
    • Yoneyama, H.1    Yamamoto, A.2    Kosaka, H.3
  • 62
    • 0031002421 scopus 로고    scopus 로고
    • Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophag-es
    • Xia Y, Zweier JL Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophag-es. Proc Natl Acad Sci U S A 1997, 94:6954-6958.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 6954-6958
    • Xia, Y.1    Zweier, J.L.2
  • 63
    • 0032575598 scopus 로고    scopus 로고
    • Inducible nitric-oxide synthase generates superoxide from the re-ductase domain
    • Xia Y, Roman LJ, Masters BS, Zweier JL Inducible nitric-oxide synthase generates superoxide from the re-ductase domain. J Biol Chem 1998, 273:22635-22639.
    • (1998) J Biol Chem , vol.273 , pp. 22635-22639
    • Xia, Y.1    Roman, L.J.2    Masters, B.S.3    Zweier, J.L.4
  • 64
    • 67649604532 scopus 로고    scopus 로고
    • Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice
    • Niese KA, Collier AR, Hajek AR, Cederbaum SD, O'Brien WE, Wills-Karp M, et al. Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice. BMC Immunol 2009, 10:33.
    • (2009) BMC Immunol , vol.10 , pp. 33
    • Niese, K.A.1    Collier, A.R.2    Hajek, A.R.3    Cederbaum, S.D.4    O'Brien, W.E.5    Wills-Karp, M.6
  • 65
    • 0035085582 scopus 로고    scopus 로고
    • Glucocorticoids inhibit li-popolysaccharideinduced up-regulation of arginase in rat alveolar macrophages
    • Klasen S, Hammermann R, Fuhrmann M, Lindemann D, Beck KF, Pfeilschifter J, et al. Glucocorticoids inhibit li-popolysaccharideinduced up-regulation of arginase in rat alveolar macrophages. Br J Pharmacol 2001, 132:1349-1357.
    • (2001) Br J Pharmacol , vol.132 , pp. 1349-1357
    • Klasen, S.1    Hammermann, R.2    Fuhrmann, M.3    Lindemann, D.4    Beck, K.F.5    Pfeilschifter, J.6
  • 66
    • 0347991779 scopus 로고    scopus 로고
    • Glucocorticoid inhibition of interleukin-4 (IL-4) and interleukin-13 (IL-13) induced up-regulation of arginase in rat airway fibroblasts
    • Lindemann D, Racké K Glucocorticoid inhibition of interleukin-4 (IL-4) and interleukin-13 (IL-13) induced up-regulation of arginase in rat airway fibroblasts. Naunyn Schmiedebergs Arch Pharmacol 2003, 368:546-550.
    • (2003) Naunyn Schmiedebergs Arch Pharmacol , vol.368 , pp. 546-550
    • Lindemann, D.1    Racké, K.2
  • 67
    • 37149036630 scopus 로고    scopus 로고
    • Transiently, paralleled upregulation of arginase and nitric oxide synthase and the ef-fect of both enzymes on the pathology of asthma
    • Takemoto K, Ogino K, Shibamori M, Gondo T, Hitomi Y, Takigawa T, et al. Transiently, paralleled upregulation of arginase and nitric oxide synthase and the ef-fect of both enzymes on the pathology of asthma. Am J Physiol Lung Cell Mol Physiol 2007, 293:L1419-L1426.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.293
    • Takemoto, K.1    Ogino, K.2    Shibamori, M.3    Gondo, T.4    Hitomi, Y.5    Takigawa, T.6
  • 68
    • 0028085936 scopus 로고
    • Rat liver arginase: kinetic mechanism, alternate substrates, and inhibitors
    • Reczkowski RS, Ash DE Rat liver arginase: kinetic mechanism, alternate substrates, and inhibitors. Arch Biochem Biophys 1994, 312:31-37.
    • (1994) Arch Biochem Biophys , vol.312 , pp. 31-37
    • Reczkowski, R.S.1    Ash, D.E.2
  • 69
    • 9944259578 scopus 로고    scopus 로고
    • Accessibility of endothelial and inducible nitric oxide synthase to the intracellular citrulline-arginine regeneration pathway
    • Shen LJ, Beloussow K, Shen WC Accessibility of endothelial and inducible nitric oxide synthase to the intracellular citrulline-arginine regeneration pathway. Biochem Pharmacol 2005, 69:97-104.
    • (2005) Biochem Pharmacol , vol.69 , pp. 97-104
    • Shen, L.J.1    Beloussow, K.2    Shen, W.C.3
  • 70
    • 33747586994 scopus 로고    scopus 로고
    • Mitochondrial arginase II modulates nitric-oxide synthesis through nonfreely exchangeable L-arginine pools in human endothelial cells
    • Topal G, Brunet A, Walch L, Boucher JL, David-Dufil-ho M Mitochondrial arginase II modulates nitric-oxide synthesis through nonfreely exchangeable L-arginine pools in human endothelial cells. J Pharmacol Exp Ther 2006, 318:1368-1374.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 1368-1374
    • Topal, G.1    Brunet, A.2    Walch, L.3    Boucher, J.L.4    David-Dufil-ho, M.5
  • 71
    • 0033986606 scopus 로고    scopus 로고
    • Sub-strate supply for nitric oxide synthase in macrophages and endothelial cells: role of cationic amino acid trans-porters
    • Closs EI, Scheld JS, Sharafi M, Förstermann U Sub-strate supply for nitric oxide synthase in macrophages and endothelial cells: role of cationic amino acid trans-porters. Mol Pharmacol 2000, 57:68-74.
    • (2000) Mol Pharmacol , vol.57 , pp. 68-74
    • Closs, E.I.1    Scheld, J.S.2    Sharafi, M.3    Förstermann, U.4
  • 72
    • 80053926448 scopus 로고    scopus 로고
    • Modeling gas phase nitric ox-ide release in lung epithelial cells
    • Jiang J, George SC Modeling gas phase nitric ox-ide release in lung epithelial cells. Nitric Oxide 2011, 10.1016/j.niox.2011.04.010.
    • (2011) Nitric Oxide
    • Jiang, J.1    George, S.C.2
  • 73
    • 0031452440 scopus 로고    scopus 로고
    • A caveolar complex between the cationic amino acid transporter 1 and endothelial nitric-oxide synthase may explain the arginine paradox
    • McDonald KK, Zharikov S, Block ER, Kilberg MS A caveolar complex between the cationic amino acid transporter 1 and endothelial nitric-oxide synthase may explain the arginine paradox. J Biol Chem 1997, 272:31213-31216.
    • (1997) J Biol Chem , vol.272 , pp. 31213-31216
    • McDonald, K.K.1    Zharikov, S.2    Block, E.R.3    Kilberg, M.S.4
  • 74
    • 0027309122 scopus 로고
    • Characterization of L-arginine transport by pulmonary artery endothelial cells
    • Greene B, Pacitti AJ, Souba WW Characterization of L-arginine transport by pulmonary artery endothelial cells. Am J Physiol 1993, 264:L351-L356.
    • (1993) Am J Physiol , vol.264
    • Greene, B.1    Pacitti, A.J.2    Souba, W.W.3
  • 75
    • 0029949609 scopus 로고    scopus 로고
    • Deficiency of nitric oxide in allergen-induced airway hyperreactivity to contractile agonists after the early asthmatic reaction: an ex vivo study
    • de Boer J, Meurs H, Coers W, Koopal M, Bottone AE, Visser AC, et al. Deficiency of nitric oxide in allergen-induced airway hyperreactivity to contractile agonists after the early asthmatic reaction: an ex vivo study. Br J Pharmacol 1996, 119:1109-1116.
    • (1996) Br J Pharmacol , vol.119 , pp. 1109-1116
    • de Boer, J.1    Meurs, H.2    Coers, W.3    Koopal, M.4    Bottone, A.E.5    Visser, A.C.6
  • 77
    • 0032755339 scopus 로고    scopus 로고
    • Role of L-arginine in the defi-ciency of nitric oxide and airway hyperreactivity after the allergen-induced early asthmatic reaction in guinea-pigs
    • de Boer J, Duyvendak M, Schuurman FE, Pouw FM, Zaagsma J, Meurs H Role of L-arginine in the defi-ciency of nitric oxide and airway hyperreactivity after the allergen-induced early asthmatic reaction in guinea-pigs. Br J Pharmacol 1999, 128:1114-1120.
    • (1999) Br J Pharmacol , vol.128 , pp. 1114-1120
    • de Boer, J.1    Duyvendak, M.2    Schuurman, F.E.3    Pouw, F.M.4    Zaagsma, J.5    Meurs, H.6
  • 78
    • 0033845785 scopus 로고    scopus 로고
    • Modulation of cholinergic air-way reactivity and nitric oxide production by endog-enous arginase activity
    • Meurs H, Hamer MA, Pethe S, Vadon-Le Goff S, Boucher JL, Zaagsma J Modulation of cholinergic air-way reactivity and nitric oxide production by endog-enous arginase activity. Br J Pharmacol 2000, 130:1793-1798.
    • (2000) Br J Pharmacol , vol.130 , pp. 1793-1798
    • Meurs, H.1    Hamer, M.A.2    Pethe, S.3    Vadon-Le Goff, S.4    Boucher, J.L.5    Zaagsma, J.6
  • 79
    • 25444448497 scopus 로고    scopus 로고
    • Argin-ase attenuates inhibitory nonadrenergic noncholinergic nerve-induced nitric oxide generation and airway smooth muscle relaxation
    • Maarsingh H, Tio MA, Zaagsma J, Meurs H Argin-ase attenuates inhibitory nonadrenergic noncholinergic nerve-induced nitric oxide generation and airway smooth muscle relaxation. Respir Res 2005, 6:23.
    • (2005) Respir Res , vol.6 , pp. 23
    • Maarsingh, H.1    Tio, M.A.2    Zaagsma, J.3    Meurs, H.4
  • 80
    • 32844458380 scopus 로고    scopus 로고
    • Arginase strongly impairs neuronal nitric oxide-mediat-ed airway smooth muscle relaxation in allergic asthma
    • Maarsingh H, Leusink J, Bos IS, Zaagsma J, Meurs H Arginase strongly impairs neuronal nitric oxide-mediat-ed airway smooth muscle relaxation in allergic asthma. Respir Res 2006, 7:6.
    • (2006) Respir Res , vol.7 , pp. 6
    • Maarsingh, H.1    Leusink, J.2    Bos, I.S.3    Zaagsma, J.4    Meurs, H.5
  • 81
    • 33748325836 scopus 로고    scopus 로고
    • Role of the L-citrulline/L-arginine cycle in iNANC nerve-me-diated nitric oxide production and airway smooth muscle relaxation in allergic asthma
    • Maarsingh H, Leusink J, Zaagsma J, Meurs H Role of the L-citrulline/L-arginine cycle in iNANC nerve-me-diated nitric oxide production and airway smooth muscle relaxation in allergic asthma. Eur J Pharmacol 2006, 546:171-176.
    • (2006) Eur J Pharmacol , vol.546 , pp. 171-176
    • Maarsingh, H.1    Leusink, J.2    Zaagsma, J.3    Meurs, H.4
  • 82
    • 0026496811 scopus 로고
    • Inverse relation in the de novo arginase synthesis and nitric oxide production in murine and rat peritoneal macrophages in long-term cultures in vitro
    • Hrabák A, Temesi A, Csuka I, Antoni F Inverse relation in the de novo arginase synthesis and nitric oxide production in murine and rat peritoneal macrophages in long-term cultures in vitro. Comp Biochem Physiol B 1992, 103:839-845.
    • (1992) Comp Biochem Physiol B , vol.103 , pp. 839-845
    • Hrabák, A.1    Temesi, A.2    Csuka, I.3    Antoni, F.4
  • 83
    • 0033535039 scopus 로고    scopus 로고
    • Arginase II downregulates nitric oxide (NO) production and prevents NO-mediated apoptosis in murine macrophage-derived RAW 264.7 cells
    • Gotoh T, Mori M Arginase II downregulates nitric oxide (NO) production and prevents NO-mediated apoptosis in murine macrophage-derived RAW 264.7 cells. J Cell Biol 1999, 144:427-434.
    • (1999) J Cell Biol , vol.144 , pp. 427-434
    • Gotoh, T.1    Mori, M.2
  • 84
    • 2942741190 scopus 로고    scopus 로고
    • Argin-ase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells
    • Chicoine LG, Paffett ML, Young TL, Nelin LD Argin-ase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells. Am J Physiol Lung Cell Mol Physiol 2004, 287:L60-L68.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Chicoine, L.G.1    Paffett, M.L.2    Young, T.L.3    Nelin, L.D.4
  • 87
    • 64549106465 scopus 로고    scopus 로고
    • Asthma management: reinventing the wheel in sickle cell disease
    • Morris CR Asthma management: reinventing the wheel in sickle cell disease. Am J Hematol 2009, 84:234-241.
    • (2009) Am J Hematol , vol.84 , pp. 234-241
    • Morris, C.R.1
  • 88
    • 70350303578 scopus 로고    scopus 로고
    • Recent advances in arginine metabolism: Roles and regulation of the arginases
    • Morris SM Recent advances in arginine metabolism: Roles and regulation of the arginases. Br J Pharmacol 2009, 157:922-930.
    • (2009) Br J Pharmacol , vol.157 , pp. 922-930
    • Morris, S.M.1
  • 89
    • 0142245584 scopus 로고    scopus 로고
    • Design of Amino Acid Sulfonamides as Transition-State Analogue Inhibi-tors of Arginase
    • Cama E, Shin H, Christianson DW Design of Amino Acid Sulfonamides as Transition-State Analogue Inhibi-tors of Arginase. J Am Chem Soc 2003, 125:13052-13057.
    • (2003) J Am Chem Soc , vol.125 , pp. 13052-13057
    • Cama, E.1    Shin, H.2    Christianson, D.W.3
  • 90
    • 77952685306 scopus 로고    scopus 로고
    • 2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear Manganese Metalloenzyme Human Ar-ginase I
    • Ilies M, Di Costanzo L, North ML, Scott JA, Christian-son DW 2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear Manganese Metalloenzyme Human Ar-ginase I. J Med Chem 2010, 53:4266-4276.
    • (2010) J Med Chem , vol.53 , pp. 4266-4276
    • Ilies, M.1    Di Costanzo, L.2    North, M.L.3    Scott, J.A.4    Christian-son, D.W.5
  • 91
    • 0035822618 scopus 로고    scopus 로고
    • Classical and Slow-Binding Inhibitors of Human Type II Arginase
    • Colleluori DM, Ash DE Classical and Slow-Binding Inhibitors of Human Type II Arginase. Biochemistry 2001, 40:9356-9362.
    • (2001) Biochemistry , vol.40 , pp. 9356-9362
    • Colleluori, D.M.1    Ash, D.E.2
  • 92
    • 0035814879 scopus 로고    scopus 로고
    • Probing erectile function: S-(2-boronoethyl)-l-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum
    • Kim NN, Cox JD, Baggio RF, Emig FA, Mistry SK, Harper SL, et al. Probing erectile function: S-(2-boronoethyl)-l-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry 2001, 40:2678-2688.
    • (2001) Biochemistry , vol.40 , pp. 2678-2688
    • Kim, N.N.1    Cox, J.D.2    Baggio, R.F.3    Emig, F.A.4    Mistry, S.K.5    Harper, S.L.6
  • 93
    • 51849107399 scopus 로고    scopus 로고
    • Arginase inhibition protects against allergen-induced airway obstruction, hyperre-sponsiveness, and inflammation
    • Maarsingh H, Zuidhof AB, Bos IS, van Duin M, Bouch-er JL, Zaagsma J, et al. Arginase inhibition protects against allergen-induced airway obstruction, hyperre-sponsiveness, and inflammation. Am J Respir Crit Care Med 2008, 178:565-573.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 565-573
    • Maarsingh, H.1    Zuidhof, A.B.2    Bos, I.S.3    van Duin, M.4    Bouch-er, J.L.5    Zaagsma, J.6
  • 96
    • 0027086907 scopus 로고
    • Antitumor effect and toxicity of two new active-site-directed irreversible ornithine decarboxylase and extrahepatic arginase inhibitors
    • Trujillo-Ferrara J, Koizumia G, Munoz O, Joseph-Nath-an P, Yañez R Antitumor effect and toxicity of two new active-site-directed irreversible ornithine decarboxylase and extrahepatic arginase inhibitors. Cancer Letters 1992, 67:193-197.
    • (1992) Cancer Letters , vol.67 , pp. 193-197
    • Trujillo-Ferrara, J.1    Koizumia, G.2    Munoz, O.3    Joseph-Nath-an, P.4    Yañez, R.5
  • 97
    • 77958606868 scopus 로고    scopus 로고
    • Diclofenac inhibits tumor growth in a murine model of pancreatic cancer by modulation of VEGF levels and arginase ac-tivity
    • Mayorek N, Naftali-Shani N, Grunewald M Diclofenac inhibits tumor growth in a murine model of pancreatic cancer by modulation of VEGF levels and arginase ac-tivity. PLoS One 2010, 5:e12715.
    • (2010) PLoS One , vol.5
    • Mayorek, N.1    Naftali-Shani, N.2    Grunewald, M.3
  • 98
    • 78649245378 scopus 로고    scopus 로고
    • Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?
    • Zeki AA, Bratt JM, Rabowsky M, Last JA, Kenyon NJ Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?. Transl Res 2010, 156:335-349.
    • (2010) Transl Res , vol.156 , pp. 335-349
    • Zeki, A.A.1    Bratt, J.M.2    Rabowsky, M.3    Last, J.A.4    Kenyon, N.J.5
  • 99
    • 33749531372 scopus 로고    scopus 로고
    • Inhibition of argi-nase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness
    • Yang M, Rangasamy D, Matthaei KI, Frew AJ, Zim-mmermann N, Mahalingam S, et al. Inhibition of argi-nase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness. J Immunol 2006, 177:5595-5603.
    • (2006) J Immunol , vol.177 , pp. 5595-5603
    • Yang, M.1    Rangasamy, D.2    Matthaei, K.I.3    Frew, A.J.4    Zim-mmermann, N.5    Mahalingam, S.6
  • 100
    • 56149107742 scopus 로고    scopus 로고
    • Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration
    • Ckless K, Lampert A, Reiss J, Kasahara D, Poynter ME, Irvin CG, et al. Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration. J Immunol 2008, 181:4255-4264.
    • (2008) J Immunol , vol.181 , pp. 4255-4264
    • Ckless, K.1    Lampert, A.2    Reiss, J.3    Kasahara, D.4    Poynter, M.E.5    Irvin, C.G.6
  • 101
    • 77649275723 scopus 로고    scopus 로고
    • Beneficial effects of high dose of L-arginine on airway hyperresponsiveness and airway inflammation in a murine model of asthma
    • Mabalirajan U, Ahmad T, Leishangthem GD, Joseph DA, Dinda AK, Agrawal A, et al. Beneficial effects of high dose of L-arginine on airway hyperresponsiveness and airway inflammation in a murine model of asthma. J Allergy Clin Immunol 2010, 125:626-635.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 626-635
    • Mabalirajan, U.1    Ahmad, T.2    Leishangthem, G.D.3    Joseph, D.A.4    Dinda, A.K.5    Agrawal, A.6
  • 102
    • 78349258229 scopus 로고    scopus 로고
    • Nitric oxide synthase enzymes in the airways of mice exposed to ovalbumin: NOS2 ex-pression is NOS3 dependent
    • PMID:20953358
    • Bratt JM, Williams K, Rabowsky MF, Last MS, Franzi LM, Last JA, et al. Nitric oxide synthase enzymes in the airways of mice exposed to ovalbumin: NOS2 ex-pression is NOS3 dependent. Mediators Inflamm 2010, PMID:20953358.
    • (2010) Mediators Inflamm
    • Bratt, J.M.1    Williams, K.2    Rabowsky, M.F.3    Last, M.S.4    Franzi, L.M.5    Last, J.A.6
  • 103
  • 104
    • 33646597220 scopus 로고    scopus 로고
    • The effect of overexpression of endothe-lial nitric oxide synthase on eosinophilic lung inflam-mation in a murine model
    • Kobayashi K, Nishimura Y, Yamashita T, Sataouchi M, Yokoyama M The effect of overexpression of endothe-lial nitric oxide synthase on eosinophilic lung inflam-mation in a murine model. Int Immunopharmacol 2006, 6:1040-1052.
    • (2006) Int Immunopharmacol , vol.6 , pp. 1040-1052
    • Kobayashi, K.1    Nishimura, Y.2    Yamashita, T.3    Sataouchi, M.4    Yokoyama, M.5
  • 106
    • 0030872552 scopus 로고    scopus 로고
    • L-arginine treatment alters the ki-netics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle
    • Huk I, Nanobashvili J, Neumayer C, Punz A, Mueller M, Afkhampour K, et al. L-arginine treatment alters the ki-netics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle. Circulation 1997, 96:667-675.
    • (1997) Circulation , vol.96 , pp. 667-675
    • Huk, I.1    Nanobashvili, J.2    Neumayer, C.3    Punz, A.4    Mueller, M.5    Afkhampour, K.6
  • 107
    • 45949105789 scopus 로고    scopus 로고
    • Arginase blockade protects against he-patic damage in warm ischemia-reperfusion
    • Jeyabalan G, Klune JR, Nakao A, Martik N, Wu G, Tsung A, et al. Arginase blockade protects against he-patic damage in warm ischemia-reperfusion. Nitric Oxide 2008, 19:29-35.
    • (2008) Nitric Oxide , vol.19 , pp. 29-35
    • Jeyabalan, G.1    Klune, J.R.2    Nakao, A.3    Martik, N.4    Wu, G.5    Tsung, A.6
  • 109
    • 0028849916 scopus 로고
    • L-arginine reduces en-dothelial inflammation and myocardial stunning during ischemia/reperfusion
    • Engelman DT, Watanabe M, Maulik N, Cordis GA, Engelman RM, Rousou, et al. L-arginine reduces en-dothelial inflammation and myocardial stunning during ischemia/reperfusion. Ann Thorac Surg 1995, 60:1275-1281.
    • (1995) Ann Thorac Surg , vol.60 , pp. 1275-1281
    • Engelman, D.T.1    Watanabe, M.2    Maulik, N.3    Cordis, G.A.4    Engelman, R.M.5    Rousou6
  • 110
    • 70350117109 scopus 로고    scopus 로고
    • Arginase inhibition restores NOS cou-pling and reverses endothelial dysfunction and vascular stiffness in old rats
    • Kim JH, Bugaj LJ, Oh YJ, Bivalacqua TJ, Ryoo S, Soucy KG, et al. Arginase inhibition restores NOS cou-pling and reverses endothelial dysfunction and vascular stiffness in old rats. J Appl Physiol 2009, 107:1249-1257.
    • (2009) J Appl Physiol , vol.107 , pp. 1249-1257
    • Kim, J.H.1    Bugaj, L.J.2    Oh, Y.J.3    Bivalacqua, T.J.4    Ryoo, S.5    Soucy, K.G.6
  • 111
    • 43449084960 scopus 로고    scopus 로고
    • Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat
    • Bagnost T, Berthelot A, Bouhaddi M, Laurant P, An-dré C, Guillaume Y, et al. Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat. J Hypertens 2008, 26:1110-1118.
    • (2008) J Hypertens , vol.26 , pp. 1110-1118
    • Bagnost, T.1    Berthelot, A.2    Bouhaddi, M.3    Laurant, P.4    An-dré, C.5    Guillaume, Y.6
  • 112
    • 0142023863 scopus 로고    scopus 로고
    • Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels
    • Berkowitz DE, White R, Li D, Minhas KM, Cernetich A, Kim S, et al. Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. Circulation 2003, 108:2000-2006.
    • (2003) Circulation , vol.108 , pp. 2000-2006
    • Berkowitz, D.E.1    White, R.2    Li, D.3    Minhas, K.M.4    Cernetich, A.5    Kim, S.6
  • 113
    • 0035911231 scopus 로고    scopus 로고
    • The inhibition of arginase by N-(omega)-hydroxy-L-arginine controls the growth of Leishmania inside macrophages
    • Iniesta V, Gómez-Nieto LC, Corraliza I The inhibition of arginase by N-(omega)-hydroxy-L-arginine controls the growth of Leishmania inside macrophages. J Exp Med 2001, 193:777-784.
    • (2001) J Exp Med , vol.193 , pp. 777-784
    • Iniesta, V.1    Gómez-Nieto, L.C.2    Corraliza, I.3
  • 114
    • 0036243589 scopus 로고    scopus 로고
    • Arginase I induction in mac-rophages, triggered by Th2-type cytokines, supports the growth of intracellular Leishmania parasites
    • Iniesta V, Gómez-Nieto LC, Molano I, Mohedano A, Carcelén J, Mirón C, et al. Arginase I induction in mac-rophages, triggered by Th2-type cytokines, supports the growth of intracellular Leishmania parasites. Parasite Immunol 2002, 24:113-118.
    • (2002) Parasite Immunol , vol.24 , pp. 113-118
    • Iniesta, V.1    Gómez-Nieto, L.C.2    Molano, I.3    Mohedano, A.4    Carcelén, J.5    Mirón, C.6
  • 115
    • 33847700110 scopus 로고    scopus 로고
    • Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of anti-arginase
    • Bivalacqua TJ, Burnett AL, Hellstrom WJ, Champion HC Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of anti-arginase. Am J Physiol Heart Circ Physiol 2007, 292:H1340-H1351.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Bivalacqua, T.J.1    Burnett, A.L.2    Hellstrom, W.J.3    Champion, H.C.4


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