The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SD11) in a p53-independent manner

Journal of Biological Chemistry

Volumn 272, Issue 43, 1997, Pages 27224-27229

  Vogt, Andreas ^b   Sun, Jiazhi ^a   Qian, Yimin ^c   Hamilton, Andrew D ^c,d   Sebti, Saïd M ^a,b  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GERANYLTRANSFERASE; PROTEIN P21; PROTEIN P53;

ARTICLE; CELL CYCLE; CELL CYCLE G0 PHASE; CELL DIVISION; CELL GROWTH; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

ALKYL AND ARYL TRANSFERASES; BENZAMIDES; BREAST NEOPLASMS; CELL CYCLE; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; ENZYME INHIBITORS; FEMALE; FIBROSARCOMA; G0 PHASE; G1 PHASE; HEAD AND NECK NEOPLASMS; HUMANS; LOVASTATIN; METHIONINE; OLIGOPEPTIDES; PANCREATIC NEOPLASMS; PROTEIN ISOPRENYLATION; TUMOR SUPPRESSOR PROTEIN P53; URINARY BLADDER NEOPLASMS;

EID: 0030774573     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.43.27224     Document Type: Article

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