Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation

Journal of Immunology

Volumn 169, Issue 4, 2002, Pages 2134-2140

  Shibata, Youichi ^a   Kamata, Tohru ^a   Kimura, Motoko ^a   Yamashita, Masakatsu ^a   Wang, Chrong Reen ^a   Murata, Kaoru ^a   Miyazaki, Masaru ^a   Taniguchi, Masaru ^a   Watanabe, Naohiro ^a   Nakayama, Toshinori ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; METHACHOLINE; MITOGEN ACTIVATED PROTEIN KINASE; OVALBUMIN; RAS PROTEIN;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHIL; HELIGMOSOMOIDES POLYGYRUS; HISTOPATHOLOGY; LUNG LAVAGE; MOUSE; NEMATODIASIS; NIPPOSTRONGYLUS BRASILIENSIS; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; T LYMPHOCYTE ACTIVATION; TH2 CELL; TRANSGENIC MOUSE;

EID: 0037103264     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.4.2134     Document Type: Article

References (41)

1. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
2. Lymphokine production by human T cells in disease states
3. The regulation of immunity to Leishmania major
4. Functional diversity of helper T lymphocytes
5. + T cell responses: The alternative approaches
6. Cytokines induce the development of functionally heterogeneous T helper cell subsets
7. Defective T cell differentiation in the absence of Jnk1
8. Interferon-g expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway
9. + T cells to Th1 cells requires MAP kinase JNK2
10. lck tyrosine kinase activation in Th subset differentiation
11. T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex
12. T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation
13. Asthma
14. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
15. Mouse models of allergic airway disease
16. Immunologic basis of antigen-induced airway hyperresponsiveness
17. Sorting out the cytokines of asthma
18. The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells
19. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity
20. Requirement for IL-13 independently of IL-4 in experimental asthma
21. Interleukin-13: Central mediator of allergic asthma
22. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity
23. + T-lymphocytes and interleukin-5 mediate antigeninduced eosinophil infiltration into the mouse trachea
24. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
25. Anti-interleukin 5 but not anti-IgE prevents airway inflammation and airway hyperresponsiveness
26. ras distinguishes positive and negative selection in thymocytes
27. Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Val4 natural killer T cells
28. Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene
29. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation
30. Peptides bind to eosinophils in the rat stomach
31. + T cells regulate the IgE response and protective immunity in mice
32. Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice
33. The importance of Th2 cytokines in protective immunity to nematodes
34. Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors
35. Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma
36. A critical role for NF-κB in GATA3 expression and Th2 differentiation in allergic airway inflammation
37. Th2 cells and GATA-3 in asthma: New insights into the regulation of airway inflammation
38. Cytokine-directed therapies for asthma
39. Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells
40. ras in IL-3-dependent hematopoietic cells
41. The effect of dexamethasone, cyclosporine, and rapamycin on T-lymphocyte proliferation in vitro: Comparison of cells from patients with glucocorticoid-sensitive and glucocorticoid-resistant chronic asthma