Simvastatin inhibits cancer cell growth by inducing apoptosis correlated to activation of Bax and down-regulation of BCL-2 gene expression

International Journal of Oncology

Volumn 40, Issue 4, 2012, Pages 935-941

  Spampanato, Carmine ^a   De Maria, Salvatore ^a   Sarnataro, Maddalena ^a   Giordano, Elisabetta ^a   Zanfardino, Mario ^a   Baiano, Salvatore ^a   Cartenì, Maridela ^a   Morelli, Franco ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Apoptosis; Bax gene; BCL 2 gene; Cancer cell growth; Simvastatin

Indexed keywords

ANTINEOPLASTIC AGENT; PROTEIN BAX; PROTEIN BCL 2; SIMVASTATIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CELL LINE, TUMOR; DNA FRAGMENTATION; DOWN-REGULATION; GENE EXPRESSION; GENES, BCL-2; HEP G2 CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IN SITU NICK-END LABELING; NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; REAL-TIME POLYMERASE CHAIN REACTION; SIMVASTATIN;

EID: 84858661389     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.1273     Document Type: Article

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