The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin- dependent kinase inhibitors: A potential mechanism for GGTI-298 antitumor activity

Journal of Biological Chemistry

Volumn 274, Issue 11, 1999, Pages 6930-6934

  Sun, Jiazhi ^a   Qian, Yimin ^b   Chen, Zhi ^a   Marfurt, Judith ^b   Hamilton, Andrew D ^b   Sebti, Saïd M ^a,c  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b YALE UNIVERSITY   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E; ENZYME INHIBITOR; GERANYLGERANYLTRANSFERASE I INHIBITOR; GGTI 298; PROTEIN P15; PROTEIN P21; PROTEIN P27; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; HUMAN CELL; LUNG CARCINOMA; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; TUMOR CELL LINE;

ALKYL AND ARYL TRANSFERASES; ANTINEOPLASTIC AGENTS; BENZAMIDES; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; HUMANS; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; TUMOR CELLS, CULTURED;

ANIMALIA; MUS MUSCULUS;

EID: 0033548675     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.11.6930     Document Type: Article

References (29)

1. Zhang, F. L., and Casey, P. J. (1996) Annu. Rev. Biochem. 65, 241-269
2. Katz, M. E., and McCormick, F. (1997) Curr. Opin. Genet. Dev. 7, 75-79
3. Barbacid, M. (1987) Annu. Rev. Biochem. 56, 779-827
4. Jackson, J. H., Cochrane, C. G., Bourne, J. R. Solski, P. A., Buss, J. E., and Der, C. J. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 3042-3046
5. Olson, M. F., Ashworth, A., and Hall, A. (1995) Science 269, 1270-1272
6. Khosravi-Far, R., Solski, P. A., Clark, G. J., Kinch, M. S., and Der, C. J. (1995) Mol. Cell. Biol. 15, 6443-6453
7. Qiu, R. G., Chen, J., McCormick, F., and Symons, M. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 11781-11785
8. Sebti, S. M., and Hamilton, A. D. (1997) Pharmacol. Ther. 74, 103-114
9. Lerner, E., Qian, Y., Blaskovich, M. A., Fossum, R., Vogt, A., Sun, J., Cox, A., Der, C., Hamilton, A. D., and Sebti, S. M. (1995) J. Biol. Chem. 270, 26802-26806
10. Vogt, A., Qian, Y., Hamilton, A. D., and Sebti, S. M. (1996) Oncogene 13, 1991-1999
11. Sun, J., Qian, Y., Hamilton, A. D., and Sebti, S. M. (1995) Cancer Res. 55, 4243-4247
12. Sun, J., Qian, Y. Hamilton, A. D., and Sebti, S. M. (1998) Oncogene 16, 1467-1473
13. Zujewski, J., Horak, I. D., Woestenborghs, R., Chiao, J. Cusack, G., Kohler, D., Kremer, A. B., and Cowan, K. H. (1998) Proc. Am. Assoc. Cancer Res. 39, 270 (abstr.)
14. McGuire, T., Qian, Y., Vogt, A., Hamilton, A. D., and Sebti, S. M. (1996) J. Biol. Chem. 271, 27402-27407
15. Miguel, K., Pradines, A., Sun, J., Hamilton, A. D., Sebti, S. M., and Favre, G. (1997) Cancer Res. 57, 1846-1850
16. Stark, W. W., Blaskovich, M. A., Johnson, B. A., Vasudevan, A., Hamilton, A. D., Sebti, S. M., and Davies, P. (1999) Am. J. Physiol., in press
17. Finder, J. D., Litz, J. L., Blaskovich, M. A., McGuire, T. F., Qian, Y., Hamilton, A. D., Davies, P., and Sebti, S. M. (1997) J. Biol. Chem. 272, 13484-13488
18. Boota, A., Johnson, B., Lee, K., Blaskovich, M. A., Hamilton, A. D., Pitt, B., Sebti, S. M., and Davies, P. (1998) Am. J. Physiol. 275, L55-L63
19. Vogt, A., Sun, J., Qian, Y., Hamilton, A. D., and Sebti, S. M. (1997) J. Biol. Chem. 272, 27224-27229
20. Sherr, C. J. (1996) Science 274, 1672-1677
21. Elledge, S. J. (1996) Science 274, 1664-1671
22. Musunuru, K., and Hinds, P. W. (1997) Cell Cycle Regulators in Cancer, Karger Landes Systems, Basel, Switzerland
23. Weber, J. D., Hu, W., Jefcoat, S. C., Jr., Raben, D. M., and Baldassare J. J. (1997) J Biol. Chem. 272, 32966-32971
24. Irani, K., Xia, Y., Zweier, J. L., Sollot, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., and Goldschmidt-Clermont, P. J. (1997) Science 275, 1649-1652
25. LaBaer, J., Garrett, M. D., Stevenson, L. F., Slingerland, J. M., Sandhu, C., Chou, H. S., Fattaey, A., and Harlow, E. (1997) Genes Dev. 11, 847-862
26. Blain, S. W., Montalvo, E., and Massague, J. (1997) J Biol. Chem. 272, 25863-25872
27. Reynisdottir, I., Polyak, K., Iavarone, A., and Massague, J. (1995) Genes Dev. 9, 1831-1845
28. Tapon, N., Nagata, K., Lamarche, N., and Hall, A. (1998) EMBO J. 17, 1395-1404
29. Adnane, J., Bizouarn, F., Qian, Y., Hamilton, A. D., and Sebti, S. M. (1998) Mol. Cell. Biol. 18, 6962-6970