Rho Kinase Inhibition Initiates Apoptosis in Human Airway Epithelial Cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 30, Issue 3, 2004, Pages 379-387

  Moore, Michael ^a   Marroquin, Bertha A ^a   Gugliotta, Wendy ^a   Tse, Roberta ^a   White, Steven R ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ACTIN; FASUDIL; PHOSPHOTRANSFERASE INHIBITOR; RHO KINASE;

ACTIN FILAMENT; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MEMBRANE; CELL STRUCTURE; CONTROLLED STUDY; CYTOSKELETON; EMBRYO; ENZYME INHIBITION; EPITHELIUM CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RESPIRATORY EPITHELIUM;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; 3T3 CELLS; ACTINS; AMIDES; ANIMALS; APOPTOSIS; CASPASES; CELL MEMBRANE; CELLS, CULTURED; CYTOCHALASIN D; CYTOSKELETON; ENZYME INHIBITORS; EPITHELIAL CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RESPIRATORY MUCOSA; STRESS FIBERS;

ANIMALIA;

EID: 1542374720     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2003-0019OC     Document Type: Article

References (35)

1. Wyllie, A. H., J. F. R. Kerr, and A. R. Currie. 1980. Cell death: the significance of apoptosis. Int. Rev. Cytol. 68:251-306.
2. Steller, H. 1995. Mechanisms and genes of cellular suicide. Science 267:1445-1449.
3. Mills, J. C., N. L. Stone, and R. N. Pittman. 1999. Extranuclear apoptosis: the role of the cytoplasm in the execution phase. J. Cell Biol. 146:703-707.
4. Frisch, S. M., and R. A. Screaton. 2001. Anoikis mechanisms. Curr. Opin. Cell Biol. 13:555-562.
5. White, S. R., P. Williams, K. R. Wojcik, S. Sun, P. S. Hiemstra, K. F. Rabe, and D. R. Dorscheid. 2001. Initiation of apoptosis by actin cytoskeletal derangement with cytochalasin D and jasplakinolide in human airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 24:282-294.
6. Rao, J. Y., Y. S. Jin, Q. Zheng, J. Cheng, J. Tai, and G. P. Hemstreet, III. 1999. Alterations of the actin polymerization status as an apoptotic morphological effector in HL-60 cells. J. Cell. Biochem. 75:686-697.
7. Li, X., L. Liu, J. C. Tupper, D. D. Bannerman, R. K. Winn, S. M. Sebti, A. D. Hamilton, and J. M. Harlan. 2002. Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells. J. Biol. Chem. 277:15309-15316.
8. Korichneva, I., and U. Hammerling. 1999. F-actin as a functional target for retro-retinoids: a potential role in anhydroretinol-triggered cell death. J. Cell Sci. 112:2521-2528.
9. Sun, H. Q., M. Yamamoto, M. Mejillano, and H. L. Yin. 1999. Gelsolin, a multifunctional actin regulatory protein. J. Biol. Chem. 274:33179-33182.
10. Mackay, D. J. G., and A. Hall. 1998. Rho GTPases. J. Biol. Chem. 273:20685-20688.
11. Ridley, A. 2000. Rho GTPases: integrating integrin signaling. J. Cell Biol. 150:F107-F109.
12. Ridley, A. J., and A. Hall. 1992. The small GTP-binding protein regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389-399.
13. Nobes, C. D., and A. Hall. 1995. Rho, Rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81:53-62.
14. Amano, M., Y. Fukata, and K. Kaibuchi. 2000. Regulation and functions of Rho-associated kinase. Exp. Cell Res. 261:44-51.
15. ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions. FEBS Lett. 404:118-124.
16. Leung, T., X. Chen, E. Manser, and L. Lim. 1996. The p160 RhoA-binding kinase ROKα is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol. Cell. Biol. 16:5313-5327.
17. Bazenet, C. E., M. A. Mota, and L. L. Rubin. 1998. The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death. Proc. Natl. Acad. Sci. USA 95:3984-3989.
18. Chuang, T. H., K. M. Hahn, J. D. Lee, D. E. Danley, and G. M. Bokoch. 1997. The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes. Mol. Biol. Cell 8:1687-1698.
19. Esteve, P., N. Embade, R. Perona, B. Jimenez, L. del Peso, J. Leon, M. Arends, T. Miki, and J. C. Lacal. 1998. Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway. Oncogene 17:1855-1869.
20. Agarwal, B., B. Halmos, A. Feoktistov, P. Protiva, W. G. Ramey, M. Chen, C. Pothoulakis, J. T. Lamont, and P. R. Holt. 2002. Mechanism of lovastatin-induced apoptosis in intestinal epithelial cells. Carcinogenesis 23:521-528.
21. Subauste, M. C., M. Von Herrath, V. Benard, C. E. Chamberlain, T.-H. Chuan, K. Chu, G. M. Bokoch, and K. M. Hahn. 2000. Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. J. Biol. Chem. 275:9725-9733.
22. Dorscheid, D. R., A. E. Conforti, K. J. Hamann, K. F. Rabe, and S. R. White. 1999. Characterization of lectin-binding patterns of human airway epithelium. Histochem. J. 31:145-151.
23. Cain, K., D. G. Brown, C. Langlais, and G. M. Cohen. 1999. Caspase activation involves the formation of the aposome, a large (∼700 kDa) caspase-activating complex. J. Biol. Chem. 274:22686-22692.
24. Uehata, M., T. Ishizaki, H. Satoh, T. Ono, T. Kawahara, T. Morishita, H. Tamakawa, K. Yamagami, J. Inui, M. Maekawa, and S. Narumiya. 1997. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389:990-994.
25. Ishizaki, T., M. Uehata, I. Tamechika, J. Keel, K. Nonomura, M. Maekawa, and S. Narumiya. 2000. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol. Pharmacol. 57:976-983.
26. Ikegaki, I., T. Hattori, T. Yamaguchi, Y. Sasaki, S. Satoh, T. Asano, and H. Shimokawa. 2001. Involvement of Rho-kinase in vascular remodeling caused by long-term inhibition of nitric oxide synthesis in rats. Eur. J. Pharmacol. 427:69-75.
27. Tang, D., H. Okada, J. Ruland, L. Liu, V. Stambolic, T. W. Mak, and A. J. Ingram. 2001. Akt is activated in response to an apoptotic signal. J. Biol. Chem. 276:30461-30466.
28. Bubb, M. R., A. M. J. Senderowicz, E. A. Sausville, K. L. K. Duncan, and E. D. Korn. 1994. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J. Biol. Chem. 269:14869-14871.
29. Coleman, M. L., E. A. Sahai, M. Yeo, M. Bosch, A. Dewar, and M. F. Olson. 2001. Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat. Cell Biol. 3:339-345.
30. Donovan, F. M., and D. D. Cunningham. 1998. Signaling pathways involved in thrombin-induced cell protection. J. Biol. Chem. 273:12746-12752.
31. Asano, T., T. Suzuki, M. Tsuchiya, S. Satoh, I. Ikegaki, M. Shibuya, Y. Suzuki, and H. Hidaka. 1989. Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase. Br. J. Pharmacol. 98:1091-1100.
32. Amano, M., K. Chihara, N. Nakamura, T. Kaneko, Y. Matsuura, and K. Kaibuchi. 1999. The COOH terminus of Rho-kinase negatively regulates rho-kinase activity. J. Biol. Chem. 274:32418-32424.
33. Henning, S. W., R. Galandrini, A. Hall, and D. A. Cantrell. 1997. The GTPase Rho has a critical regulatory role in thymus development. EMBO J. 16:2397-2407.
34. Shibata, R., H. Kai, Y. Seki, S. Kato, M. Morimatsu, K. Kaibuchi, and T. Imaizumi. 2001. Role of Rho-associated kinase in neointima formation after vascular injury. Circulation 103:284-289.
35. Sebbagh, M., C. Renvoize, J. Hamelin, N. Riche, J. Bertoglio, and J. Breard. 2001. Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nat. Cell Biol. 3:346-352.