RhoA signaling modulates cyclin D1 expression in human lung fibroblasts; implications for idiopathic pulmonary fibrosis

Respiratory Research

Volumn 7, Issue , 2006, Pages

  Watts, Keira L ^a   Cottrell, Elizabeth ^a   Hoban, P R ^a   Spiteri, Monica A ^a  

^a UNIVERSITY HOSPITAL OF NORTH STAFFORDSHIRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CONNECTIVE TISSUE GROWTH FACTOR; CYCLIN D1; EXOTOXIN; MESSENGER RNA; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIMVASTATIN; TRANSFORMING GROWTH FACTOR BETA1; BOTULINUM TOXIN; CTGF PROTEIN, HUMAN; EXOENZYME C3, CLOSTRIDIUM BOTULINUM; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMEDIATE EARLY PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SIGNAL PEPTIDE; TGFB1 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REGULATION; EXTRACELLULAR MATRIX; FLUORESCENCE ACTIVATED CELL SORTING; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOTHESIS; INHIBITION KINETICS; LUNG FIBROBLAST; LUNG FIBROSIS; MYOBLAST; PATHOGENESIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL DIVISION; CELL LINE; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION; GENETICS; LUNG; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ADP RIBOSE TRANSFERASES; BOTULINUM TOXINS; CELL DIVISION; CELL LINE; CONNECTIVE TISSUE GROWTH FACTOR; CYCLIN D1; FIBROBLASTS; G1 PHASE; GENE EXPRESSION; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; PULMONARY FIBROSIS; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SIMVASTATIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 34247550969     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-7-88     Document Type: Article

References (29)

1. Selman M King TE Pardo A Idiopathic pulmonary fibrosis: Prevailing and evolving hypotheses about its pathogenesis and implications for therapy Ann Intern Med 2001 134 2 136-151 11177318
2. Nicholson AG Colby TV du Bois RM Hansell DM Wells AU The prognostic significance of the histologic pattern of interstitial pneumonia in patients presenting with the clinical entity of cryptogenic fibrosing alveolitis Am J Respir Crit Care Med 2000 162 2213-2217 11112140
3. Phan SH The myofibroblast in pulmonary fibrosis Chest 2002 122 6 Suppl 286S-289S 10.1378/chest.122.6_suppl.286S 12475801
4. Allen JT Knight RA Bloor CA Spiteri MA Enhanced insulin-like growth factor binding protein-related protein 2 (Connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis Am J Respir Cell Mol Biol 1999 21 6 693-700 10572066
5. Grotendorst GR Okochi H Hayashi N A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene Cell Growth Differ 1996 7 4 469-80 9052988
6. Watts KL Spiteri MA Connective tissue growth factor expression and induction by transforming growth factor-beta is abrogated by simvastatin via a Rho signaling mechanism Am J Physiol Lung Cell Mol Physiol 2004 287 6 L1323-32 10.1152/ajplung.00447.2003 15298857
7. Watts KL Sampson EM Schultz GS Spiteri MA Simvastatin inhibits growth factor expression and modulates profibrogenic markers in lung fibroblasts Am J Respir Cell Mol Biol 2005 32 4 290-300 10.1165/ rcmb.2004-0127OC 15677772
8. Welsh CF Roovers K Villanueva J Liu Y Schwartz MA Assoian RK Timing of cyclin D1 expression within G1 phase is controlled by Rho Nat Cell Biol 2001 3 11 950-7 10.1038/ncb1101-950 11715015
9. Fu M Nang C Li Z Sakamaki T Pestell RG Minireview: Cyclin D1: normal and abnormal functions Endocrinology 2004 145 12 5439-47 10.1210/ en.2004-0959 15331580
10. Caldon CE Daly RJ Sutherland RL Musgrove EA Cell cycle control in breast cancer cells J Cell Biochem 2005
11. Holley SL Parkes G Matthias C Bockmuhl U Jahnke V Leder K Strange RC Fryer AA Hoban PR Cyclin D1 polymorphism and expression in patients with squamous cell carcinoma of the head and neck Am J Pathol 2001 159 5 1917-24 11696452
12. Ratschiller D Heighway J Gugger M Kappeler A Pirnia F Schmid RA Borner MM Betticher DC Cyclin D1 overexpression in bronchial epithelia of patients with lung cancer is associated with smoking and predicts survival J Clin Oncol 2003 21 11 2085-93 10.1200/JCO.2003.03.103 12775733
13. Sherr CJ Roberts JM CDK inhibitors: Positive and negative regulators of G1-phase progression Genes Dev 1999 13 12 1501-12 10385618
14. Qin XQ Livingston DM Kaelin WG Jr Adams PD Deregulated trasnscription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis Proc Natl Acad Sci 1994 91 10918-19022 45137 7971984 10.1073/ pnas.91.23.10918
15. He S Cook BL Deverman BE Weihe U Zhang F Prachand V Zheng J Weintraub SJ E2F is required to prevent inappropriate S-phase entry of mammalian cells Mol Cell Biol 2000 20 1 363-71 85091 10594038
16. Bartkova J Lukas J Bartek J Aberrations of the G1- and G1/S-regulating genes in human cancer Prog Cell Cycle Res 1997 3 211-20 9552416
17. Quelle DE Ashmun RA Shurtleff SA Kato JY Bar-Sagi D Roussel MF Sherr CJ Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts Genes Dev 1993 7 8 1559-71 8339933
18. Schwartz MA Assoian RK Integrins and cell proliferation: Regulation of cyclin-dependent kinases via cytoplasmic signaling pathways J Cell Sci 2001 114 Pt 14 2553-60 11683383.
19. Welsh CF Rho GTPases as key transducers of proliferative signals in g1 cell cycle regulation Breast Cancer Res Treat 2004 84 1 33-42 10.1023/ B:BREA.0000018425.31633.07 14999152
20. Lamprecht J Wojcik C Jakobisiak M Stoehr M Schrorter D Paweletz N Lovastatin induces mitotic abnormalities in various cell lines Cell Biol Int 1999 23 1 51-60 10.1006/cbir.1998.0322 10527548
21. Kurzrock R Ku S Talpaz M Abnormalities in the PARD1 (CYCLIN D1/BCL-1) oncogene are frequent in the cervical and vulval squamous cell carcinoma cell lines Cancer 1995 75 584-590 7812927
22. Diehl JA Cycling to cancer with cyclin D1 Cancer Biol Ther 2002 1 3 226-31 12432268
23. Keely PJ Rho GTPases as early markers for tumour progression Lancet 2001 358 9295 1744-5 10.1016/S0140-6736(01)06840-4 11734226
24. Hishikawa K Nakaki T Fujii T Connective tissue growth factor induces apoptosis via caspase 3 in cultured human aortic smooth muscle cells Eur J Pharmacol 2000 392 1-2 19-22 10.1016/S0014-2999(00)00115-1 10748267
25. Holinstat M Knezevic N Broman M Samarel AM Malik AB Mehta D Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: Role of regulation of endothelial permeability JBC 2005
26. Goppelt-Struebe M Hahn A Iwanciw D Rehm M Banas B Regulation of connective tissue growth factor (ccn2; ctgf) gene expression in human mesangial cells: Modulation by HMG CoA reductase inhibitors (statins) Mol Pathol 2001 54 3 176-9 1187058 11376131 10.1136/mp.54.3.176
27. Porter KE Turner NA O'Regan DJ Balmforth AJ Ball SG Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA Cardiovasc Res 2004 61 4 745-55 10.1016/ j.cardiores.2003.11.032 14985071
28. Matallanas D Sanz-Moreno V Arozarena I Calvo F Agudo-Ibanez L Santos E Berciano MT Crespo P Distinct utilization of effectors and biological outcomes resulting from site specific Ras activation: Ras functions in lipid rafts and golgi complex are dispensable for proliferation and transformation Molecular and Cellular Biology 2006 26 1 100-116 10.1128/ MCB.26.1.100-116.2006
29. Ogata H Chinen T Yoshida T Kinjyo I Takaesu G Shiraishi H Iida M Kobayashi T Yoshimura A Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production Oncogene 25 17 2520-2530 10.1038/sj.onc.1209281 16474852