The inhibition of mevalonate pathway induces upregulation of NALP3 expression: New insight in the pathogenesis of mevalonate kinase deficiency

European Journal of Human Genetics

Volumn 18, Issue 7, 2010, Pages 844-847

  Pontillo, Alessandra ^a   Paoluzzi, Elisa ^a   Crovella, Sergio ^a,b  

^a INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

Caspase 1; Inflammasome; Mevalonate kinase deficiency; NALP3

Indexed keywords

ALENDRONIC ACID; BACTERIUM LIPOPOLYSACCHARIDE; CRYOPYRIN; GERANYLGERANYL PYROPHOSPHATE; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; MEVALONATE KINASE;

ADULT; ARTICLE; CASE REPORT; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GENE IDENTIFICATION; HUMAN; HUMAN CELL; MALE; MEVALONATE KINASE DEFICIENCY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SCHOOL CHILD; UPREGULATION;

ALENDRONATE; CARRIER PROTEINS; CHILD; FEMALE; HUMANS; INFLAMMATION; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MALE; METABOLIC NETWORKS AND PATHWAYS; MEVALONATE KINASE DEFICIENCY; MEVALONIC ACID; UP-REGULATION; YOUNG ADULT;

BACTERIA (MICROORGANISMS);

EID: 77953806728     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2010.9     Document Type: Article

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