Selective inhibition by simvastatin of IRF3 phosphorylation and TSLP production in dsRNAchallenged bronchial epithelial cells from COPD donors

British Journal of Pharmacology

Volumn 168, Issue 2, 2013, Pages 363-374

  Brandelius, Angelica ^a   Mahmutovic Persson, Irma ^a   Calvén, Jenny ^a   Bjermer, Leif ^b   Persson, Carl Ga ^c   Andersson, Morgan ^b   Uller, Lena ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

bronchial brushing epithelium; COPD; dsRNA; IFN ; IRF3 phosphorylation; mevalonate independent; simvastatin; TSLP

Indexed keywords

BETA INTERFERON; BX 795; DEXAMETHASONE; DOUBLE STRANDED RNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 8; MEVALONIC ACID; PROTEIN INHIBITOR; SIMVASTATIN; THYMIC STROMAL LYMPHOPOIETIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; AMINO ACID SEQUENCE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRONCHUS MUCOSA; CELL CULTURE; CELL VIABILITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG ACTIVITY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; FIBEROPTIC BRONCHOSCOPY; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN CELL; LIMIT OF DETECTION; MALE; MICROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA EXTRACTION; SIGNAL TRANSDUCTION; VIRUS INFECTION;

ADULT; AGED; ANTI-INFLAMMATORY AGENTS; BRONCHI; CELLS, CULTURED; CYTOKINES; DEXAMETHASONE; EPITHELIAL CELLS; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTERFERON REGULATORY FACTOR-3; MALE; MIDDLE AGED; NF-KAPPA B; PHOSPHORYLATION; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RNA, DOUBLE-STRANDED; SIMVASTATIN;

EID: 84871585883     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.02131.x     Document Type: Article

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