메뉴 건너뛰기




Volumn 80, Issue 10, 2002, Pages 629-638

Rho/Rho-kinase mediated signaling in physiology and pathophysiology

Author keywords

Fasudil; Myosin light chain phosphorylation; Rho; Rho kinase; Y 27632

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CPI 17; ENZYME INHIBITOR; FASUDIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NUCLEOTIDE; PHOSPHATASE INHIBITOR; RHO FACTOR; RHO KINASE; STATIN; UNCLASSIFIED DRUG; MYOSIN; PROTEIN SERINE THREONINE KINASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO-ASSOCIATED KINASE; SIGNAL PEPTIDE;

EID: 0036460051     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-002-0370-2     Document Type: Review
Times cited : (314)

References (136)
  • 1
    • 0028043535 scopus 로고
    • Signal transduction and regulation in smooth muscle
    • Somlyo AP, Somlyo AV (1994) Signal transduction and regulation in smooth muscle. Nature 372:231-236
    • (1994) Nature , vol.372 , pp. 231-236
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 2
    • 0034650714 scopus 로고    scopus 로고
    • Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
    • Somlyo AP, Somlyo AV (2000) Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol (Lond) 522:177-185
    • (2000) J Physiol (Lond) , vol.522 , pp. 177-185
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 3
    • 0027310995 scopus 로고
    • Effects of calyculin A on tension and myosin phosphorylation in skinned smooth muscle of the rabbit mesenteric artery
    • Suzuki A, Itoh T (1993) Effects of calyculin A on tension and myosin phosphorylation in skinned smooth muscle of the rabbit mesenteric artery. Br J Pharmacol 109:703-712
    • (1993) Br J Pharmacol , vol.109 , pp. 703-712
    • Suzuki, A.1    Itoh, T.2
  • 4
    • 0033134836 scopus 로고    scopus 로고
    • 2+-independent phosphorylation of myosin in rat caudal artery and chicken gizzard myofilaments
    • 2+-independent phosphorylation of myosin in rat caudal artery and chicken gizzard myofilaments. J Physiol (Lond) 516:805-824
    • (1999) J Physiol (Lond) , vol.516 , pp. 805-824
    • Weber, L.P.1    Van Lierop, J.E.2    Walsh, M.P.3
  • 5
    • 0035844257 scopus 로고    scopus 로고
    • 2+-independent smooth muscle contraction. A novel function for integrin-linked kinase
    • 2+-independent smooth muscle contraction. A novel function for integrin-linked kinase. J Biol Chem 276:16365-16373
    • (2001) J Biol Chem , vol.276 , pp. 16365-16373
    • Deng, J.T.1    Van Lierop, J.E.2    Sutherland, C.3    Walsh, M.P.4
  • 6
    • 0023162273 scopus 로고
    • Alterations in cytoplasmic calcium sensitivity during porcine coronary artery contractions as detected by aequorin
    • Bradley AB, Morgan KG (1987) Alterations in cytoplasmic calcium sensitivity during porcine coronary artery contractions as detected by aequorin. J Physiol (Lond) 385:437-448
    • (1987) J Physiol (Lond) , vol.385 , pp. 437-448
    • Bradley, A.B.1    Morgan, K.G.2
  • 8
    • 0025197314 scopus 로고
    • 2+] sensitivity of myosin phosphorylation in intact swine arterial smooth muscle
    • 2+] sensitivity of myosin phosphorylation in intact swine arterial smooth muscle. J Physiol (Lond) 429:77-94
    • (1990) J Physiol (Lond) , vol.429 , pp. 77-94
    • Rembold, C.M.1
  • 11
    • 0029831696 scopus 로고    scopus 로고
    • Role of Rho proteins in carbachol-induced contractions in intact and permeabilized guinea-pig intestinal smooth muscle
    • Otto B, Steusloff A, Just I, Aktories K, Pfitzer G (1996) Role of Rho proteins in carbachol-induced contractions in intact and permeabilized guinea-pig intestinal smooth muscle. J Physiol (Lond) 496:317-329
    • (1996) J Physiol (Lond) , vol.496 , pp. 317-329
    • Otto, B.1    Steusloff, A.2    Just, I.3    Aktories, K.4    Pfitzer, G.5
  • 12
    • 0030721443 scopus 로고    scopus 로고
    • Inhibition of rhoA translocation and calcium sensitization by in vivo ADP-ribosylation with the chimeric toxin DC3B
    • Fujihara H, Walker LA, Gong MC, Lemichez E, Boquet P, Somlyo AV, Somlyo AP (1997) Inhibition of rhoA translocation and calcium sensitization by in vivo ADP-ribosylation with the chimeric toxin DC3B. Mol Biol Cell 8:2437-2447
    • (1997) Mol Biol Cell , vol.8 , pp. 2437-2447
    • Fujihara, H.1    Walker, L.A.2    Gong, M.C.3    Lemichez, E.4    Boquet, P.5    Somlyo, A.V.6    Somlyo, A.P.7
  • 15
    • 0030977123 scopus 로고    scopus 로고
    • Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation
    • Kureishi Y, Kobayashi S, Amano M, Kimura K, Kanaide H, Nakano T, Kaibuchi K, Ito M (1997) Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem 272:12257-12260
    • (1997) J Biol Chem , vol.272 , pp. 12257-12260
    • Kureishi, Y.1    Kobayashi, S.2    Amano, M.3    Kimura, K.4    Kanaide, H.5    Nakano, T.6    Kaibuchi, K.7    Ito, M.8
  • 16
    • 0021830154 scopus 로고
    • A novel ras-related gene family
    • Madaule P, Axel R (1985) A novel ras-related gene family. Cell 41:31-40
    • (1985) Cell , vol.41 , pp. 31-40
    • Madaule, P.1    Axel, R.2
  • 17
    • 0035575585 scopus 로고    scopus 로고
    • Rho family proteins: Coordinating cell responses
    • Ridley AJ (2001) Rho family proteins: Coordinating cell responses. Trends Cell Biol 11:471-477
    • (2001) Trends Cell Biol , vol.11 , pp. 471-477
    • Ridley, A.J.1
  • 18
    • 0034213327 scopus 로고    scopus 로고
    • Rho GTPases and their effector proteins
    • Bishop AL, Hall A (2000) Rho GTPases and their effector proteins. Biochem J 348:241-255
    • (2000) Biochem J , vol.348 , pp. 241-255
    • Bishop, A.L.1    Hall, A.2
  • 19
    • 0028863142 scopus 로고
    • A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes
    • Leung T, Manser E, Tan L, Lim L (1995) A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes. J Biol Chem 270:29051-29054
    • (1995) J Biol Chem , vol.270 , pp. 29051-29054
    • Leung, T.1    Manser, E.2    Tan, L.3    Lim, L.4
  • 22
    • 0029008006 scopus 로고
    • Arachidonic acid and diacylglycerol release associated with inhibition of myosin light chain dephosphorylation in rabbit smooth muscle
    • Gong MC, Kinter MT, Somlyo AV, Somlyo AP (1995) Arachidonic acid and diacylglycerol release associated with inhibition of myosin light chain dephosphorylation in rabbit smooth muscle. J Physiol (Lond) 486:113-122
    • (1995) J Physiol (Lond) , vol.486 , pp. 113-122
    • Gong, M.C.1    Kinter, M.T.2    Somlyo, A.V.3    Somlyo, A.P.4
  • 23
    • 0033772834 scopus 로고    scopus 로고
    • Use and properties of ROCK-specific inhibitor Y-27632
    • Narumiya S, Ishizaki T, Uehata M (2000) Use and properties of ROCK-specific inhibitor Y-27632. Methods Enzymol 325:273-284
    • (2000) Methods Enzymol , vol.325 , pp. 273-284
    • Narumiya, S.1    Ishizaki, T.2    Uehata, M.3
  • 25
    • 0026061774 scopus 로고
    • Effects of HA1077, a protein kinase inhibitor, on myosin-phosphorylation and tension in smooth muscle
    • Seto M, Sasaki Y, Hidaka H, Sasaki Y (1991) Effects of HA1077, a protein kinase inhibitor, on myosin-phosphorylation and tension in smooth muscle. Eur J Pharmacol 195:267-272
    • (1991) Eur J Pharmacol , vol.195 , pp. 267-272
    • Seto, M.1    Sasaki, Y.2    Hidaka, H.3    Sasaki, Y.4
  • 26
    • 0032988987 scopus 로고    scopus 로고
    • H-series protein kinase inhibitors and potential clinical applications
    • Ono-Saito N, Niki I, Hidaka H (1999) H-series protein kinase inhibitors and potential clinical applications. Pharmacol Ther 82:123-131
    • (1999) Pharmacol Ther , vol.82 , pp. 123-131
    • Ono-Saito, N.1    Niki, I.2    Hidaka, H.3
  • 28
    • 0029583638 scopus 로고
    • A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization
    • Eto M, Ohmori T, Suzuki M, Furuya K, Morita F (1995) A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization. J Biochem (Tokyo) 118:1104-1107
    • (1995) J Biochem (Tokyo) , vol.118 , pp. 1104-1107
    • Eto, M.1    Ohmori, T.2    Suzuki, M.3    Furuya, K.4    Morita, F.5
  • 29
    • 0034616292 scopus 로고    scopus 로고
    • Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility
    • Kitazawa T, Eto M, Woodsome TP, Brautigan DL (2000) Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility. J Biol Chem 275:9897-9900
    • (2000) J Biol Chem , vol.275 , pp. 9897-9900
    • Kitazawa, T.1    Eto, M.2    Woodsome, T.P.3    Brautigan, D.L.4
  • 30
    • 0032993518 scopus 로고    scopus 로고
    • Identification of trimeric myosin phosphatase (PP1 M) as a target for a novel PKC-potentiated protein phosphatase-1 inhibitory protein (CPI17) in porcine aorta smooth muscle
    • Senba S, Eto M, Yazawa M (1999) Identification of trimeric myosin phosphatase (PP1 M) as a target for a novel PKC-potentiated protein phosphatase-1 inhibitory protein (CPI17) in porcine aorta smooth muscle. J Biochem (Tokyo) 125:354-362
    • (1999) J Biochem (Tokyo) , vol.125 , pp. 354-362
    • Senba, S.1    Eto, M.2    Yazawa, M.3
  • 32
    • 0034705765 scopus 로고    scopus 로고
    • Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase
    • Koyama M, Ito M, Feng J, Seko T, Shiraki K, Takase K, Hartshorne DJ, Nakano T (2000) Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase. FEBS Lett 475:197-200
    • (2000) FEBS Lett , vol.475 , pp. 197-200
    • Koyama, M.1    Ito, M.2    Feng, J.3    Seko, T.4    Shiraki, K.5    Takase, K.6    Hartshorne, D.J.7    Nakano, T.8
  • 34
    • 0033607682 scopus 로고    scopus 로고
    • Control of actin dynamics in cell motility. Role of ADF/cofilin
    • Carlier MF, Ressad F, Pantaloni D (1999) Control of actin dynamics in cell motility. Role of ADF/cofilin. J Biol Chem 274:33827-33380
    • (1999) J Biol Chem , vol.274 , pp. 33827-33380
    • Carlier, M.F.1    Ressad, F.2    Pantaloni, D.3
  • 35
    • 0033058184 scopus 로고    scopus 로고
    • Rho guanine dissociation inhibitors: Pivotal molecules in cellular signalling
    • Olofsson B (1999) Rho guanine dissociation inhibitors: Pivotal molecules in cellular signalling. Cell Signal 11:545-554
    • (1999) Cell Signal , vol.11 , pp. 545-554
    • Olofsson, B.1
  • 36
    • 0035668525 scopus 로고    scopus 로고
    • Dbl family guanine nucleotide exchange factors
    • Zheng Y (2001) Dbl family guanine nucleotide exchange factors. Trends Biochem Sci 26:724-732
    • (2001) Trends Biochem Sci , vol.26 , pp. 724-732
    • Zheng, Y.1
  • 38
    • 0028973505 scopus 로고
    • Galpha12 and Galpha13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly
    • Buhl AM, Johnson NL, Dhanasekaran N, Johnson GL (1995) Galpha12 and Galpha13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly. J Biol Chem 270:-24631-24634
    • (1995) J Biol Chem , vol.270 , pp. 24631-24634
    • Buhl, A.M.1    Johnson, N.L.2    Dhanasekaran, N.3    Johnson, G.L.4
  • 39
    • 0030886445 scopus 로고    scopus 로고
    • The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation
    • Fromm C, Coso OA, Montaner S, Xu N, Gutkind JS (1997) The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation. Proc Natl Acad Sci USA 94:10098-11103
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10098-11103
    • Fromm, C.1    Coso, O.A.2    Montaner, S.3    Xu, N.4    Gutkind, J.S.5
  • 41
    • 0033605294 scopus 로고    scopus 로고
    • A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho
    • Fukuhara S, Murga C, Zohar M, Igishi T, Gutkind JS (1999) A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J Biol Chem 274:5868-5879
    • (1999) J Biol Chem , vol.274 , pp. 5868-5879
    • Fukuhara, S.1    Murga, C.2    Zohar, M.3    Igishi, T.4    Gutkind, J.S.5
  • 43
    • 0035952680 scopus 로고    scopus 로고
    • RGS-containing RhoGEFs: The missing link between transforming G proteins and Rho?
    • Fukuhara S, Chikumi H, Gutkind JS (2001) RGS-containing RhoGEFs: The missing link between transforming G proteins and Rho? Oncogene 20:1661-1668
    • (2001) Oncogene , vol.20 , pp. 1661-1668
    • Fukuhara, S.1    Chikumi, H.2    Gutkind, J.S.3
  • 46
    • 0032582343 scopus 로고    scopus 로고
    • Constitutively active Galpha12, Galpha13, and Galphaq induce Rho-dependent neurite retraction through different signaling pathways
    • Katoh H, Aoki J, Yamaguchi Y, Kitano Y, Ichikawa A, Negishi M (1998) Constitutively active Galpha12, Galpha13, and Galphaq induce Rho-dependent neurite retraction through different signaling pathways. J Biol Chem 273:28700-707
    • (1998) J Biol Chem , vol.273 , pp. 28700-28707
    • Katoh, H.1    Aoki, J.2    Yamaguchi, Y.3    Kitano, Y.4    Ichikawa, A.5    Negishi, M.6
  • 47
    • 0032538570 scopus 로고    scopus 로고
    • Specific involvement of G proteins in regulation of serum response factor-mediated gene transcription by different receptors
    • Mao J, Yuan H, Xie W, Simon MI, Wu D (1998) Specific involvement of G proteins in regulation of serum response factor-mediated gene transcription by different receptors. J Biol Chem 273:27118-27123
    • (1998) J Biol Chem , vol.273 , pp. 27118-27123
    • Mao, J.1    Yuan, H.2    Xie, W.3    Simon, M.I.4    Wu, D.5
  • 48
    • 0019445517 scopus 로고
    • The relationship between calmodulin binding and phosphorylation of smooth muscle myosin kinase by the catalytic subunit of 3′:5′cAMP-dependent protein kinase
    • Conti MA, Adelstein RS (1981) The relationship between calmodulin binding and phosphorylation of smooth muscle myosin kinase by the catalytic subunit of 3′:5′cAMP-dependent protein kinase. J Biol Chem 256:3178-181
    • (1981) J Biol Chem , vol.256 , pp. 3178-3181
    • Conti, M.A.1    Adelstein, R.S.2
  • 49
    • 0020617315 scopus 로고
    • The role of myosin light chain kinase phosphorylation in beta-adrenergic relaxation of tracheal smooth muscle
    • Miller JR, Silver PJ, Stull JT (1983) The role of myosin light chain kinase phosphorylation in beta-adrenergic relaxation of tracheal smooth muscle. Mol Pharmacol 24:235-242
    • (1983) Mol Pharmacol , vol.24 , pp. 235-242
    • Miller, J.R.1    Silver, P.J.2    Stull, J.T.3
  • 50
    • 0025123347 scopus 로고
    • Myosin light chain kinase phosphorylation in tracheal smooth muscle
    • Stull JT, Hsu LC, Tansey MG, Kamm KE (1990) Myosin light chain kinase phosphorylation in tracheal smooth muscle. J Biol Chem 265:16683-166890
    • (1990) J Biol Chem , vol.265 , pp. 16683-166890
    • Stull, J.T.1    Hsu, L.C.2    Tansey, M.G.3    Kamm, K.E.4
  • 51
    • 0034991244 scopus 로고    scopus 로고
    • Cross talk between cyclic nucleotides and polyphosphoinositide hydrolysis, protein kinases, and contraction in smooth muscle
    • Abdel-Latif AA (2001) Cross talk between cyclic nucleotides and polyphosphoinositide hydrolysis, protein kinases, and contraction in smooth muscle. Exp Biol Med (Maywood) 226:153-163
    • (2001) Exp Biol Med (Maywood) , vol.226 , pp. 153-163
    • Abdel-Latif, A.A.1
  • 52
    • 0030813029 scopus 로고    scopus 로고
    • Elevation of intracellular cAMP inhibits RhoA activation and integrin-dependent leukocyte adhesion induced by chemoattractants
    • Laudanna C, Campbell JJ, Butcher EC (1997) Elevation of intracellular cAMP inhibits RhoA activation and integrin-dependent leukocyte adhesion induced by chemoattractants. J Biol Chem 272:24141-24144
    • (1997) J Biol Chem , vol.272 , pp. 24141-24144
    • Laudanna, C.1    Campbell, J.J.2    Butcher, E.C.3
  • 53
    • 0032575667 scopus 로고    scopus 로고
    • cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalpha
    • Dong JM, Leung T, Manser E, Lim L (1998) cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalpha. J Biol Chem 273:22554-22562
    • (1998) J Biol Chem , vol.273 , pp. 22554-22562
    • Dong, J.M.1    Leung, T.2    Manser, E.3    Lim, L.4
  • 55
    • 0033624157 scopus 로고    scopus 로고
    • Role for G (12)/G (13) in agonist-induced vascular smooth muscle cell contraction
    • Gohla A, Schultz G, Offermanns S (2000) Role for G (12)/G (13) in agonist-induced vascular smooth muscle cell contraction. Circ Res 87:221-227
    • (2000) Circ Res , vol.87 , pp. 221-227
    • Gohla, A.1    Schultz, G.2    Offermanns, S.3
  • 56
    • 0035930528 scopus 로고    scopus 로고
    • Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides
    • Gratacap MP, Payrastre B, Nieswandt B, Offermanns S (2001) Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. J Biol Chem 276:47906-47913
    • (2001) J Biol Chem , vol.276 , pp. 47906-47913
    • Gratacap, M.P.1    Payrastre, B.2    Nieswandt, B.3    Offermanns, S.4
  • 57
    • 0034033975 scopus 로고    scopus 로고
    • Rising behind NO: cGMP-dependent protein kinases
    • Hofmann F, Ammendola A, Schlossmann J (2000) Rising behind NO: cGMP-dependent protein kinases. J Cell Sci 113:1671-1676
    • (2000) J Cell Sci , vol.113 , pp. 1671-1676
    • Hofmann, F.1    Ammendola, A.2    Schlossmann, J.3
  • 62
    • 0027969286 scopus 로고
    • Augmented agonist-induced Ca (2+)-sensitization of coronary artery contraction in genetically hypertensive rats. Evidence for altered signal transduction in the coronary smooth muscle cells
    • Satoh S, Kreutz R, Wilm C, Ganten D, Pfitzer G (1994) Augmented agonist-induced Ca (2+)-sensitization of coronary artery contraction in genetically hypertensive rats. Evidence for altered signal transduction in the coronary smooth muscle cells. J Clin Invest 94:1397-1403
    • (1994) J Clin Invest , vol.94 , pp. 1397-1403
    • Satoh, S.1    Kreutz, R.2    Wilm, C.3    Ganten, D.4    Pfitzer, G.5
  • 67
    • 0026534605 scopus 로고
    • Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial
    • Shibuya M, Suzuki Y, Sugita K, Saito I, Sasaki T, Takakura K, Nagata I, Kikuchi H, Takemae T, Hidaka H, et al (1992) Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial. J Neurosurg 76:571-577
    • (1992) J Neurosurg , vol.76 , pp. 571-577
    • Shibuya, M.1    Suzuki, Y.2    Sugita, K.3    Saito, I.4    Sasaki, T.5    Takakura, K.6    Nagata, I.7    Kikuchi, H.8    Takemae, T.9    Hidaka, H.10
  • 68
    • 0033879562 scopus 로고    scopus 로고
    • Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm
    • Sato M, Tani E, Fujikawa H, Kaibuchi K (2000) Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm. Circ Res 87:195-200
    • (2000) Circ Res , vol.87 , pp. 195-200
    • Sato, M.1    Tani, E.2    Fujikawa, H.3    Kaibuchi, K.4
  • 69
    • 0033850422 scopus 로고    scopus 로고
    • Upregulation of rho A and rho kinase messenger RNAs in the basilar artery of a rat model of subarachnoid hemorrhage
    • Miyagi Y, Carpenter RC, Meguro T, Parent AD, Zhang JH (2000) Upregulation of rho A and rho kinase messenger RNAs in the basilar artery of a rat model of subarachnoid hemorrhage. J Neurosurg 93:471-476
    • (2000) J Neurosurg , vol.93 , pp. 471-476
    • Miyagi, Y.1    Carpenter, R.C.2    Meguro, T.3    Parent, A.D.4    Zhang, J.H.5
  • 71
    • 0026541706 scopus 로고
    • The pathogenesis of coronary artery disease and the acute coronary syndromes (2)
    • Fuster V, Badimon L, Badimon JJ, Chesebro JH (1992) The pathogenesis of coronary artery disease and the acute coronary syndromes (2). N Engl J Med 326:310-318
    • (1992) N Engl J Med , vol.326 , pp. 310-318
    • Fuster, V.1    Badimon, L.2    Badimon, J.J.3    Chesebro, J.H.4
  • 72
    • 0033979414 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of coronary artery spasm: Lessons from animal models
    • Shimokawa H (2000) Cellular and molecular mechanisms of coronary artery spasm: Lessons from animal models. Jpn Circ J 64:1-12
    • (2000) Jpn Circ J , vol.64 , pp. 1-12
    • Shimokawa, H.1
  • 76
    • 0035678906 scopus 로고    scopus 로고
    • Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina
    • Utsunomiya T, Satoh S, Ikegaki I, Toshima Y, Asano T, Shimokawa H (2001) Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina. Br J Pharmacol 134:1724-1730
    • (2001) Br J Pharmacol , vol.134 , pp. 1724-1730
    • Utsunomiya, T.1    Satoh, S.2    Ikegaki, I.3    Toshima, Y.4    Asano, T.5    Shimokawa, H.6
  • 77
    • 0037007054 scopus 로고    scopus 로고
    • Suppression of coronary artery spasm by the rho-kinase inhibitor fasudil in patients with vasospastic angina
    • Masumoto A, Mohri M, Shimokawa H, Urakami L, Usui M, Takeshita A (2002) Suppression of coronary artery spasm by the rho-kinase inhibitor fasudil in patients with vasospastic angina. Circulation 105:1545-1547
    • (2002) Circulation , vol.105 , pp. 1545-1547
    • Masumoto, A.1    Mohri, M.2    Shimokawa, H.3    Urakami, L.4    Usui, M.5    Takeshita, A.6
  • 78
    • 0003194666 scopus 로고    scopus 로고
    • Antianginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: A multicenter study
    • Shimokawa H, Iinuma H, Kishida H, et al (2001) Antianginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: A multicenter study (abstract). Circulation 104 [Suppl II]:II691
    • (2001) Circulation , vol.104 , Issue.SUPPL. II
    • Shimokawa, H.1    Iinuma, H.2    Kishida, H.3
  • 79
    • 0021124760 scopus 로고
    • Comparison of in vivo airway responsiveness and in vitro smooth muscle sensitivity to methacholine in man
    • Roberts JA, Raeburn D, Rodger IW, Thomson NC (1984) Comparison of in vivo airway responsiveness and in vitro smooth muscle sensitivity to methacholine in man. Thorax 39:837-843
    • (1984) Thorax , vol.39 , pp. 837-843
    • Roberts, J.A.1    Raeburn, D.2    Rodger, I.W.3    Thomson, N.C.4
  • 80
    • 0028832404 scopus 로고
    • Characteristics of muscarinic cholinoceptors in airways of antigen-induced airway hyperresponsive rats
    • Chiba Y, Misawa M (1995) Characteristics of muscarinic cholinoceptors in airways of antigen-induced airway hyperresponsive rats. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 111:351-357
    • (1995) Comp Biochem Physiol C Pharmacol Toxicol Endocrinol , vol.111 , pp. 351-357
    • Chiba, Y.1    Misawa, M.2
  • 81
    • 0033024335 scopus 로고    scopus 로고
    • Augmented acetylcholine-induced, Rho-mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats
    • Chiba Y, Takada Y, Miyamoto S, MitsuiSaito M, Karaki H, Misawa M (1999) Augmented acetylcholine-induced, Rho-mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats. Br J Pharmacol 127:597-600
    • (1999) Br J Pharmacol , vol.127 , pp. 597-600
    • Chiba, Y.1    Takada, Y.2    Miyamoto, S.3    MitsuiSaito, M.4    Karaki, H.5    Misawa, M.6
  • 82
    • 0034892133 scopus 로고    scopus 로고
    • Augmented acetylcholine-induced translocation of RhoA in bronchial smooth muscle from antigen-induced airway hyperresponsive rats
    • Chiba Y, Sakai H, Misawa M (2001) Augmented acetylcholine-induced translocation of RhoA in bronchial smooth muscle from antigen-induced airway hyperresponsive rats. Br J Pharmacol 133:886-890
    • (2001) Br J Pharmacol , vol.133 , pp. 886-890
    • Chiba, Y.1    Sakai, H.2    Misawa, M.3
  • 86
    • 0035170363 scopus 로고    scopus 로고
    • The effects of inhibiting Rho-associated kinase with Y-27632 on force and intracellular calcium in human myometrium
    • Kupittayanant S, Burdyga T, Wray S (2001) The effects of inhibiting Rho-associated kinase with Y-27632 on force and intracellular calcium in human myometrium. Pflugers Arch 443:112-114
    • (2001) Pflugers Arch , vol.443 , pp. 112-114
    • Kupittayanant, S.1    Burdyga, T.2    Wray, S.3
  • 88
    • 0034863248 scopus 로고    scopus 로고
    • Effect of Rho-kinase inhibition on vasoconstriction in the penile circulation
    • Mills TM, Chitaley K, Wingard CJ, Lewis RW, Webb RC (2001) Effect of Rho-kinase inhibition on vasoconstriction in the penile circulation. J Appl Physiol 91:1269-1273
    • (2001) J Appl Physiol , vol.91 , pp. 1269-1273
    • Mills, T.M.1    Chitaley, K.2    Wingard, C.J.3    Lewis, R.W.4    Webb, R.C.5
  • 89
    • 0034905717 scopus 로고    scopus 로고
    • Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes
    • Honjo M, Inatani M, Kido N, Sawamura T, Yue BY, Honda Y, Tanihara H (2001) Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes. Arch Ophthalmol 119:1171-1178
    • (2001) Arch Ophthalmol , vol.119 , pp. 1171-1178
    • Honjo, M.1    Inatani, M.2    Kido, N.3    Sawamura, T.4    Yue, B.Y.5    Honda, Y.6    Tanihara, H.7
  • 90
    • 0035066006 scopus 로고    scopus 로고
    • Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632
    • Rao PV, Deng PF, Kumar J, Epstein DL (2001) Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. Invest Ophthalmol Vis Sci 42:1029-1037
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 1029-1037
    • Rao, P.V.1    Deng, P.F.2    Kumar, J.3    Epstein, D.L.4
  • 91
    • 0033612371 scopus 로고
    • Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration
    • Seasholtz TM, Majumdar M, Kaplan DD, Brown JH (1992) Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration. Circ Res 84:1186-1193
    • (1992) Circ Res , vol.84 , pp. 1186-1193
    • Seasholtz, T.M.1    Majumdar, M.2    Kaplan, D.D.3    Brown, J.H.4
  • 92
    • 0033538615 scopus 로고    scopus 로고
    • Mechanotransduction of rat aortic vascular smooth muscle cells requires RhoA and intact actin filaments
    • Numaguchi K, Eguchi S, Yamakawa T, Motley ED, Inagami T (1999) Mechanotransduction of rat aortic vascular smooth muscle cells requires RhoA and intact actin filaments. Circ Res 85:5-11
    • (1999) Circ Res , vol.85 , pp. 5-11
    • Numaguchi, K.1    Eguchi, S.2    Yamakawa, T.3    Motley, E.D.4    Inagami, T.5
  • 95
    • 0024393107 scopus 로고
    • Restenosis after coronary angioplasty. Potential biologic determinants and role of intimal hyperplasia
    • Liu MW, Roubin GS, King SB 3rd (1989) Restenosis after coronary angioplasty. Potential biologic determinants and role of intimal hyperplasia. Circulation 79:1374-1387
    • (1989) Circulation , vol.79 , pp. 1374-1387
    • Liu, M.W.1    Roubin, G.S.2    King S.B. III3
  • 99
    • 0033592754 scopus 로고    scopus 로고
    • Signaling pathways for cardiac hypertrophy and failure
    • Hunter JJ, Chien KR (1999) Signaling pathways for cardiac hypertrophy and failure. N Engl J Med 341:1276-1283
    • (1999) N Engl J Med , vol.341 , pp. 1276-1283
    • Hunter, J.J.1    Chien, K.R.2
  • 100
    • 0032949682 scopus 로고    scopus 로고
    • Molecular mechanisms of myocardial remodeling
    • Swynghedauw B (1999) Molecular mechanisms of myocardial remodeling. Physiol Rev 79:215-262
    • (1999) Physiol Rev , vol.79 , pp. 215-262
    • Swynghedauw, B.1
  • 101
    • 0032571395 scopus 로고    scopus 로고
    • The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase
    • Hoshijima M, Sah VP, Wang Y, Chien KR, Brown JH (1998) The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase. J Biol Chem 273:7725-77230
    • (1998) J Biol Chem , vol.273 , pp. 7725-77230
    • Hoshijima, M.1    Sah, V.P.2    Wang, Y.3    Chien, K.R.4    Brown, J.H.5
  • 102
    • 0029658495 scopus 로고    scopus 로고
    • Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways
    • Sah VP, Hoshijima M, Chien KR, Brown JH (1996) Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways. J Biol Chem 271:31185-1190
    • (1996) J Biol Chem , vol.271 , pp. 31185-31190
    • Sah, V.P.1    Hoshijima, M.2    Chien, K.R.3    Brown, J.H.4
  • 104
    • 0037040943 scopus 로고    scopus 로고
    • Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy
    • Yanazume T, Hasegawa K, Wada H, Morimoto T, Abe M, Kawamura T, Sasayama S (2002) Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy. J Biol Chem 277:8618-8625
    • (2002) J Biol Chem , vol.277 , pp. 8618-8625
    • Yanazume, T.1    Hasegawa, K.2    Wada, H.3    Morimoto, T.4    Abe, M.5    Kawamura, T.6    Sasayama, S.7
  • 105
    • 0033946118 scopus 로고    scopus 로고
    • The Rho effector, PKN, regulates ANF gene transcription in cardiomyocytes through a serum response element
    • Morissette MR, Sah VP, Glembotski CC, Brown JH (2000) The Rho effector, PKN, regulates ANF gene transcription in cardiomyocytes through a serum response element. Am J Physiol Heart Circ Physiol 278:H1769-H1774
    • (2000) Am J Physiol Heart Circ Physiol , vol.278
    • Morissette, M.R.1    Sah, V.P.2    Glembotski, C.C.3    Brown, J.H.4
  • 106
    • 0032694585 scopus 로고    scopus 로고
    • Cardiac-specific over-expression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure
    • Sah VP, Minamisawa S, Tam SP, Wu TH, Dorn GW 2nd, Ross J Jr, Chien KR, Brown JH (1999) Cardiac-specific over-expression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure. J Clin Invest 103:1627-1634
    • (1999) J Clin Invest , vol.103 , pp. 1627-1634
    • Sah, V.P.1    Minamisawa, S.2    Tam, S.P.3    Wu, T.H.4    Dorn G.W. II5    Ross J., Jr.6    Chien, K.R.7    Brown, J.H.8
  • 108
    • 0032570796 scopus 로고    scopus 로고
    • Small GTP-binding protein Rho stimulates the actomyosin system, leading to invasion of tumor cells
    • Yoshioka K, Matsumura F, Akedo H, Itoh K (1998) Small GTP-binding protein Rho stimulates the actomyosin system, leading to invasion of tumor cells. J Biol Chem 273:5146-154
    • (1998) J Biol Chem , vol.273 , pp. 5146-5154
    • Yoshioka, K.1    Matsumura, F.2    Akedo, H.3    Itoh, K.4
  • 109
    • 0032935495 scopus 로고    scopus 로고
    • An essential part for Rho-associated kinase in the transcellular invasion of tumor cells
    • Itoh K, Yoshioka K, Akedo H, Uehata M, Ishizaki T, Narumiya S (1999) An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat Med 5:221-225
    • (1999) Nat Med , vol.5 , pp. 221-225
    • Itoh, K.1    Yoshioka, K.2    Akedo, H.3    Uehata, M.4    Ishizaki, T.5    Narumiya, S.6
  • 110
    • 0032870464 scopus 로고    scopus 로고
    • Cell motility mediated by rho and Rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma
    • Genda T, Sakamoto M, Ichida T, Asakura H, Kojiro M, Narumiya S, Hirohashi S (1999) Cell motility mediated by rho and Rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma. Hepatology 30:1027-1036
    • (1999) Hepatology , vol.30 , pp. 1027-1036
    • Genda, T.1    Sakamoto, M.2    Ichida, T.3    Asakura, H.4    Kojiro, M.5    Narumiya, S.6    Hirohashi, S.7
  • 112
    • 0037022256 scopus 로고    scopus 로고
    • Fundamentals of endothelial function for the clinical cardiologist
    • Verma S, Anderson TJ (2002) Fundamentals of endothelial function for the clinical cardiologist. Circulation 105:546-549
    • (2002) Circulation , vol.105 , pp. 546-549
    • Verma, S.1    Anderson, T.J.2
  • 113
    • 0030968580 scopus 로고    scopus 로고
    • Rho GTPases and signaling networks
    • Van Aelst L, D'Souza-Schorey C (1997) Rho GTPases and signaling networks. Genes Dev 11:2295-2322
    • (1997) Genes Dev , vol.11 , pp. 2295-2322
    • Van Aelst, L.1    D'Souza-Schorey, C.2
  • 115
    • 0034730781 scopus 로고    scopus 로고
    • Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells
    • Hernandez-Perera O, Perez-Sala D, Soria E, Lamas S (2000) Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells. Circ Res 87:616-622
    • (2000) Circ Res , vol.87 , pp. 616-622
    • Hernandez-Perera, O.1    Perez-Sala, D.2    Soria, E.3    Lamas, S.4
  • 116
    • 0032508533 scopus 로고    scopus 로고
    • Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
    • Laufs U, Liao JK (1998) Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem 273:24266-24271
    • (1998) J Biol Chem , vol.273 , pp. 24266-24271
    • Laufs, U.1    Liao, J.K.2
  • 117
    • 0035964808 scopus 로고    scopus 로고
    • Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin-converting enzyme-1 expression by distinct pathways: Role of Rho/ROCK and mitogen-activated protein kinase
    • Eto M, Barandier C, Rathgeb L, Kozai T, Joch H, Yang Z, Luscher TF (2001) Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin-converting enzyme-1 expression by distinct pathways: Role of Rho/ROCK and mitogen-activated protein kinase. Circ Res 89:583-590
    • (2001) Circ Res , vol.89 , pp. 583-590
    • Eto, M.1    Barandier, C.2    Rathgeb, L.3    Kozai, T.4    Joch, H.5    Yang, Z.6    Luscher, T.F.7
  • 119
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
    • West of Scotland Coronary Prevention Study Group
    • Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW, McKillop JH, Packard CJ (1995) Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med 333:1301-1307
    • (1995) N Engl J Med , vol.333 , pp. 1301-1307
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3    Isles, C.G.4    Lorimer, A.R.5    MacFarlane, P.W.6    McKillop, J.H.7    Packard, C.J.8
  • 120
    • 0030058148 scopus 로고    scopus 로고
    • Inhibition of the mevalonate pathway: Benefits beyond cholesterol reduction?
    • Massy ZA, Keane WF, Kasiske BL (1996) Inhibition of the mevalonate pathway: Benefits beyond cholesterol reduction? Lancet 347:102-103
    • (1996) Lancet , vol.347 , pp. 102-103
    • Massy, Z.A.1    Keane, W.F.2    Kasiske, B.L.3
  • 122
    • 0028939363 scopus 로고
    • The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion
    • Anderson TJ, Meredith IT, Yeung AC, Frei B, Selwyn AP, Ganz P (1995) The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. N Engl J Med 332:488-493
    • (1995) N Engl J Med , vol.332 , pp. 488-493
    • Anderson, T.J.1    Meredith, I.T.2    Yeung, A.C.3    Frei, B.4    Selwyn, A.P.5    Ganz, P.6
  • 123
    • 0031032831 scopus 로고    scopus 로고
    • Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month
    • O'Driscoll G, Green D, Taylor RR (1997) Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month. Circulation 95:1126-1131
    • (1997) Circulation , vol.95 , pp. 1126-1131
    • O'Driscoll, G.1    Green, D.2    Taylor, R.R.3
  • 126
    • 0033593667 scopus 로고    scopus 로고
    • 13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets
    • 13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol 144:745-754
    • (1999) J Cell Biol , vol.144 , pp. 745-754
    • Klages, B.1    Brandt, U.2    Simon, M.I.3    Schultz, G.4    Offermanns, S.5
  • 127
    • 0033199252 scopus 로고    scopus 로고
    • Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets
    • Bauer M, Retzer M, Wilde JI, Maschberger P, Essler M, Aepfelbacher M, Watson SP, Siess W (1999) Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets. Blood 94:1665-1672
    • (1999) Blood , vol.94 , pp. 1665-1672
    • Bauer, M.1    Retzer, M.2    Wilde, J.I.3    Maschberger, P.4    Essler, M.5    Aepfelbacher, M.6    Watson, S.P.7    Siess, W.8
  • 128
    • 0033214045 scopus 로고    scopus 로고
    • Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways
    • Paul BZ, Daniel JL, Kunapuli SP (1999) Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways. J Biol Chem 274:28293-28300
    • (1999) J Biol Chem , vol.274 , pp. 28293-28300
    • Paul, B.Z.1    Daniel, J.L.2    Kunapuli, S.P.3
  • 129
    • 0034623185 scopus 로고    scopus 로고
    • The effect of a Rho kinase inhibitor Y-27632 on superoxide production, aggregation and adhesion in human polymorphonuclear leukocytes
    • Kawaguchi A, Ohmori M, Harada K, Tsuruoka S, Sugimoto K, Fujimura A (2000) The effect of a Rho kinase inhibitor Y-27632 on superoxide production, aggregation and adhesion in human polymorphonuclear leukocytes. Eur J Pharmacol 403:203-208
    • (2000) Eur J Pharmacol , vol.403 , pp. 203-208
    • Kawaguchi, A.1    Ohmori, M.2    Harada, K.3    Tsuruoka, S.4    Sugimoto, K.5    Fujimura, A.6
  • 130
    • 0035889929 scopus 로고    scopus 로고
    • A role for a RhoA/ROCK/LIM-kinase pathway in the regulation of cytotoxic lymphocytes
    • Lou Z, Billadeau DD, Savoy DN, Schoon RA, Leibson PJ (2001) A role for a RhoA/ROCK/LIM-kinase pathway in the regulation of cytotoxic lymphocytes. J Immunol 167:5749-5757
    • (2001) J Immunol , vol.167 , pp. 5749-5757
    • Lou, Z.1    Billadeau, D.D.2    Savoy, D.N.3    Schoon, R.A.4    Leibson, P.J.5
  • 131
    • 0036136257 scopus 로고    scopus 로고
    • A role for the Rho-p160 Rho coiled-coil kinase axis in the chemokine stromal cell-derived factor-1alpha-induced lymphocyte actomyosin and microtubular organization and chemotaxis
    • Vicente-Manzanares M, Cabrero JR, Rey M, Perez-Martinez M, Ursa A, Itoh K, Sanchez-Madrid F (2002) A role for the Rho-p160 Rho coiled-coil kinase axis in the chemokine stromal cell-derived factor-1alpha-induced lymphocyte actomyosin and microtubular organization and chemotaxis. J Immunol 168:400-410
    • (2002) J Immunol , vol.168 , pp. 400-410
    • Vicente-Manzanares, M.1    Cabrero, J.R.2    Rey, M.3    Perez-Martinez, M.4    Ursa, A.5    Itoh, K.6    Sanchez-Madrid, F.7
  • 134
    • 0034574572 scopus 로고    scopus 로고
    • Rho GTPases in neuronal morphogenesis
    • Luo L (2000) Rho GTPases in neuronal morphogenesis. Nat Rev Neurosci 1:173-180
    • (2000) Nat Rev Neurosci , vol.1 , pp. 173-180
    • Luo, L.1
  • 135
    • 0035253071 scopus 로고    scopus 로고
    • Rho GTPases in growth cone guidance
    • Dickson BJ (2001) Rho GTPases in growth cone guidance. Curr Opin Neurobiol 11:103-110
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 103-110
    • Dickson, B.J.1
  • 136
    • 0035933870 scopus 로고    scopus 로고
    • Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function
    • Mehta D, Rahman A, Malik AB (2001) Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function. J Biol Chem 276:22614-22620
    • (2001) J Biol Chem , vol.276 , pp. 22614-22620
    • Mehta, D.1    Rahman, A.2    Malik, A.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.