Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

Oncogene

Volumn 15, Issue 11, 1997, Pages 1283-1288

  Lerner, Edwina C ^a,c   Zhang, Ting Ting ^a   Knowles, David B ^b   Qian, Yimin ^b   Hamilton, Andrew D ^b   Sebti, Saïd M ^a,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

FTase inhibitors; Human tumors; Prenylation; Ras

Indexed keywords

ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE; FARNESYLTRANSFERASE; GERANYLGERANYLTRANSFERASE 1; GGTI 286; GGTI 298; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; BLADDER CARCINOMA; CANCER INHIBITION; CELL STRAIN 3T3; CELL TRANSFORMATION; CONTROLLED STUDY; DRUG EFFECT; DRUG RESISTANCE; DRUG SENSITIVITY; HUMAN; HUMAN CELL; LUNG CARCINOMA; ONCOGENE H RAS; ONCOGENE K RAS; ONCOGENE N RAS; PANCREAS CARCINOMA; PRENYLATION; PRIORITY JOURNAL; TUMOR CELL LINE;

EID: 0030952552     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1201296     Document Type: Article

References (17)

1. Barbacid M. (1987). Annu. Rev. Biochem., 56, 779-827.
2. Buss JE and Marsters Jr JC. (1995). Chem. Biol., 2, 787-791.
3. James GL, Goldstein JL and Brown MS. (1995). J. Biol. Chem., 270, 6221-6226.
4. Lerner EC, Qian Y, Hamilton AD and Sebti SM. (1995a). J. Biol. Chem., 270, 26770-26773.
5. Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J, Cox AD, Der CJ, Hamilton AD and Sebti SM. (1995b). J. Biol. Chem., 270, 26802-26806.
6. McCormick F. (1993). Nature, 363, 15-16.
7. McGuire TF, Qian Y, Vogt A, Hamilton AD and Sebti SM. (1996). J. Biol. Chem., 271, 27402-27407.
8. Moomaw JF and Casey PJ. (1992). J. Biol. Chem., 267, 17438-17443.
9. Nagasu T, Yoshimatsu K, Rowell C, Lewis MD and Garcia AM. (1995). Cancer Res., 55, 5310-5314.
10. Prendergast GC, Davide JP, DeSolms SJ, Giuliani EA, Graham SL, Gibbs JB, Oliff A and Kohl NE. (1994). Mol. Cell. Biology, 14, 4193-4202.
11. Rowell CA, Kowalczyk JJ, Lewis MD and Garcia AM. (1997). J. Biol. Chem., 272, 14093-14097.
12. Sattler I and Tamanoi F. (1996). Regulation of the Ras Signaling Network. AW Burgess and H Maruta (ed.). R.G. Landers: Austin, Texas, pp. 95-137.
13. Sebti SM and Hamilton AD. (1997). Pharmacology and Therapeutics, Vol. 74, No. 2., 103-114.
14. Sepp-Lorenzino L, Ma Z, Rands E, Khol NE, Gibbs JB, Oliff A and Rosen N. (1995). Cancer Res., 55, 5302-5309.
15. Vogt A, Qian Y, McGuire TF, Hamilton AD and Sebti SM. (1996). Oncogene, 13, 1991-1996.
16. Whyte DB, Kirschmeier P, Hokenberry TN, Nunez-Oliva I, James L, Catino JJ, Bishop WR and Pai JK. (1997). J. Biol. Chem., 272, 14459-14464.
17. Zhang FL and Casey PJ. (1996). Annu. Rev. Biochem., 65, 241-269.