Stimulation of Rho signaling by pathologic mechanical stretch is a "second hit" to Rho-independent lung injury induced by IL-6

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 302, Issue 9, 2012, Pages

  Birukova, Anna A ^a   Tian, Yufeng ^a   Meliton, Angelo ^a   Leff, Alan ^a   Wu, Tinghuai ^a   Birukov, Konstantin G ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Actin; Cyclic stretch; Endothelium; Interleukin 6; Vascular permeability

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; RHO FACTOR; STAT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; ATTENUATION; CELL ADHESION; CELL COUNT; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG ENDOTHELIUM; LUNG LAVAGE; MALE; MONOLAYER CULTURE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TIDAL VOLUME; VENTILATOR INDUCED LUNG INJURY;

ACTIN CYTOSKELETON; ACUTE LUNG INJURY; AMIDES; ANIMALS; CELLS, CULTURED; CYTOSKELETAL PROTEINS; ELECTRIC IMPEDANCE; ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; MALE; MICE; MICE, INBRED C57BL; PERMEABILITY; PROTEOLYSIS; PULMONARY ARTERY; PYRIDINES; RANDOM ALLOCATION; RESPIRATION, ARTIFICIAL; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; STRESS, PHYSIOLOGICAL;

EID: 84860510967     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00292.2011     Document Type: Article

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