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Volumn 60, Issue 10, 2012, Pages 875-881

The controversies of statin therapy: Weighing the evidence

Author keywords

adverse effects; cancer; cognitive decline; diabetes mellitus; statins

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PLACEBO; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN;

EID: 84865497225     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2012.07.007     Document Type: Review
Times cited : (137)

References (70)
  • 1
    • 0029993565 scopus 로고    scopus 로고
    • Recent trends in acute coronary heart diseasemortality, morbidity, medical care, and risk factors: The Minnesota Heart Survey Investigators
    • P.G. McGovern, J.S. Pankow, E. Shahar Recent trends in acute coronary heart diseasemortality, morbidity, medical care, and risk factors The Minnesota Heart Survey Investigators N Engl J Med 334 1996 884 890
    • (1996) N Engl J Med , vol.334 , pp. 884-890
    • McGovern, P.G.1    Pankow, J.S.2    Shahar, E.3
  • 2
    • 84856104984 scopus 로고    scopus 로고
    • Adverse events associated with individual statin treatments for cardiovascular disease: An indirect comparison meta-analysis
    • M. Alberton, P. Wu, E. Druyts, M. Briel, E.J. Mills Adverse events associated with individual statin treatments for cardiovascular disease: an indirect comparison meta-analysis Q J Med 105 2012 145 157
    • (2012) Q J Med , vol.105 , pp. 145-157
    • Alberton, M.1    Wu, P.2    Druyts, E.3    Briel, M.4    Mills, E.J.5
  • 4
    • 84859704127 scopus 로고    scopus 로고
    • Is statin-associated cognitive impairment clinically relevant?: A narrative review and clinical recommendations
    • C.H. Rojas-Fernandez, J.C. Cameron Is statin-associated cognitive impairment clinically relevant? A narrative review and clinical recommendations Ann Pharmacother 46 2012 549 557
    • (2012) Ann Pharmacother , vol.46 , pp. 549-557
    • Rojas-Fernandez, C.H.1    Cameron, J.C.2
  • 5
    • 0038381775 scopus 로고    scopus 로고
    • Statin-associated memory loss: Analysis of 60 case reports and review of the literature
    • L.R. Wagstaff, M.W. Mitton, B.M. Arvik, P.M. Doraiswamy Statin-associated memory loss: analysis of 60 case reports and review of the literature Pharmacotherapy 23 2003 871 880
    • (2003) Pharmacotherapy , vol.23 , pp. 871-880
    • Wagstaff, L.R.1    Mitton, M.W.2    Arvik, B.M.3    Doraiswamy, P.M.4
  • 6
    • 41549117102 scopus 로고    scopus 로고
    • Observational research, randomised trials, and two views of medical science
    • J.P. Vandenbroucke Observational research, randomised trials, and two views of medical science PLoS Med 5 2008 e67
    • (2008) PLoS Med , vol.5 , pp. 67
    • Vandenbroucke, J.P.1
  • 7
    • 0024758829 scopus 로고
    • The importance of case reports
    • B.A. Morris The importance of case reports Can Med Assoc J 141 1989 875 876
    • (1989) Can Med Assoc J , vol.141 , pp. 875-876
    • Morris, B.A.1
  • 9
    • 0036305918 scopus 로고    scopus 로고
    • The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment
    • I. Hajjar, J. Schumpert, V. Hirth, D. Wieland, G.P. Eleazer The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment J Gerontol 57A 2002 M414 M418
    • (2002) J Gerontol , vol.57
    • Hajjar, I.1    Schumpert, J.2    Hirth, V.3    Wieland, D.4    Eleazer, G.P.5
  • 10
    • 0036126850 scopus 로고    scopus 로고
    • Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people
    • K. Rockwood, S. Kirkland, D.B. Hogan Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people Arch Neurol 59 2002 223 227
    • (2002) Arch Neurol , vol.59 , pp. 223-227
    • Rockwood, K.1    Kirkland, S.2    Hogan, D.B.3
  • 11
    • 0036186663 scopus 로고    scopus 로고
    • Serum lipoprotein levels, statin use, and cognitive function in older women
    • K. Yaffe, E. Barrett-Connor, F. Lin, D. Grady Serum lipoprotein levels, statin use, and cognitive function in older women Arch Neurol 59 2002 378 384
    • (2002) Arch Neurol , vol.59 , pp. 378-384
    • Yaffe, K.1    Barrett-Connor, E.2    Lin, F.3    Grady, D.4
  • 13
    • 33847285482 scopus 로고    scopus 로고
    • Effects of statin use on muscle strength, cognition, and depressive symptoms in older adults
    • J.V. Agostini, M.E. Tinetti, L. Han, G. McAvay, J.M. Foody, J. Concato Effects of statin use on muscle strength, cognition, and depressive symptoms in older adults J Am Geriatr Soc 55 2007 420 425
    • (2007) J Am Geriatr Soc , vol.55 , pp. 420-425
    • Agostini, J.V.1    Tinetti, M.E.2    Han, L.3    McAvay, G.4    Foody, J.M.5    Concato, J.6
  • 14
    • 52449134280 scopus 로고    scopus 로고
    • Delirium after elective surgery among elderly patients taking statins
    • D.A. Redelmeier, D. Thiruchelvam, N. Daneman Delirium after elective surgery among elderly patients taking statins Can Med Assoc J 179 2008 645 652
    • (2008) Can Med Assoc J , vol.179 , pp. 645-652
    • Redelmeier, D.A.1    Thiruchelvam, D.2    Daneman, N.3
  • 15
    • 77953163428 scopus 로고    scopus 로고
    • The association of statin use and statin type and cognitive performance: Analysis of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study
    • S.P. Glasser, V. Wadley, S. Judd The association of statin use and statin type and cognitive performance: analysis of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study Clin Cardiol 33 2010 280 288
    • (2010) Clin Cardiol , vol.33 , pp. 280-288
    • Glasser, S.P.1    Wadley, V.2    Judd, S.3
  • 16
    • 77954989381 scopus 로고    scopus 로고
    • Statins and cognitive functioning in the elderly: A population-based study
    • J. Benito-Leon, E.D. Louis, S. Vega, F. Bermejo-Pareja Statins and cognitive functioning in the elderly: a population-based study J Alzheimers Dis 21 2010 95 102
    • (2010) J Alzheimers Dis , vol.21 , pp. 95-102
    • Benito-Leon, J.1    Louis, E.D.2    Vega, S.3    Bermejo-Pareja, F.4
  • 17
    • 84856694624 scopus 로고    scopus 로고
    • Bias in observational studies of prevalent users: Lessons for comparative effectiveness research from a meta-analysis of statins
    • G. Danaei, M. Tavakkoli, M.A. Hernan Bias in observational studies of prevalent users: lessons for comparative effectiveness research from a meta-analysis of statins Am J Epidemiol 175 2012 250 262
    • (2012) Am J Epidemiol , vol.175 , pp. 250-262
    • Danaei, G.1    Tavakkoli, M.2    Hernan, M.A.3
  • 18
    • 64049113146 scopus 로고    scopus 로고
    • The HRT controversy: Observational studies and RCTs fall in line
    • J.P. Vandenbroucke The HRT controversy: observational studies and RCTs fall in line Lancet 373 2009 1233 1235
    • (2009) Lancet , vol.373 , pp. 1233-1235
    • Vandenbroucke, J.P.1
  • 19
    • 33644795219 scopus 로고    scopus 로고
    • Hormone therapy and cardiovascular disease: A systematic review and meta-analysis
    • D.J. Magliano, S.L. Rogers, M.J. Abramson, A.M. Tonkin Hormone therapy and cardiovascular disease: a systematic review and meta-analysis BJOG 113 2006 5 14
    • (2006) BJOG , vol.113 , pp. 5-14
    • Magliano, D.J.1    Rogers, S.L.2    Abramson, M.J.3    Tonkin, A.M.4
  • 20
    • 0025021856 scopus 로고
    • Cancer mortality and lipid and lipoprotein levels: Lipid Research Clinics Program mortality follow-up study
    • L.D. Cowan, D.L. O'Connell, M.H. Criqui, E. Barrett-Connor, T.L. Bush, R.B. Wallace Cancer mortality and lipid and lipoprotein levels Lipid Research Clinics Program mortality follow-up study Am J Epidemiol 131 1990 468 482
    • (1990) Am J Epidemiol , vol.131 , pp. 468-482
    • Cowan, L.D.1    O'Connell, D.L.2    Criqui, M.H.3    Barrett-Connor, E.4    Bush, T.L.5    Wallace, R.B.6
  • 21
    • 0028882612 scopus 로고
    • Low serum cholesterol and mortality: Which is the cause and which is the effect?
    • C. Iribarren, D.M. Reed, R. Chen, K. Yano, J.H. Dwyer Low serum cholesterol and mortality Which is the cause and which is the effect? Circulation 92 1995 2396 2403
    • (1995) Circulation , vol.92 , pp. 2396-2403
    • Iribarren, C.1    Reed, D.M.2    Chen, R.3    Yano, K.4    Dwyer, J.H.5
  • 22
    • 0021833710 scopus 로고
    • Serum cholesterol and cancer mortality in the Seven Countries Study
    • A. Keys, C. Aravanis, H. Blackburn Serum cholesterol and cancer mortality in the Seven Countries Study Am J Epidemiol 121 1985 870 883
    • (1985) Am J Epidemiol , vol.121 , pp. 870-883
    • Keys, A.1    Aravanis, C.2    Blackburn, H.3
  • 24
    • 0027287887 scopus 로고
    • Inverse association between serum total cholesterol and cancer mortality in Dutch civil servants
    • A.J. Schuit, C.E. Van Dijk, J.M. Dekker, E.G. Schouten, F.J. Kok Inverse association between serum total cholesterol and cancer mortality in Dutch civil servants Am J Epidemiol 137 1993 966 976
    • (1993) Am J Epidemiol , vol.137 , pp. 966-976
    • Schuit, A.J.1    Van Dijk, C.E.2    Dekker, J.M.3    Schouten, E.G.4    Kok, F.J.5
  • 26
    • 0026718746 scopus 로고
    • Serum cholesterol and cancer risk: An epidemiologic perspective
    • S.B. Kritchevsky, D. Kritchevsky Serum cholesterol and cancer risk: an epidemiologic perspective Annu Rev Nutr 12 1992 391 416
    • (1992) Annu Rev Nutr , vol.12 , pp. 391-416
    • Kritchevsky, S.B.1    Kritchevsky, D.2
  • 27
    • 70849119927 scopus 로고    scopus 로고
    • Apolipoprotein e genotype, plasma cholesterol, and cancer: A Mendelian randomization study
    • S. Trompet, J.W. Jukema, M.B. Katan Apolipoprotein E genotype, plasma cholesterol, and cancer: a Mendelian randomization study Am J Epidemiol 170 2009 1415 1421
    • (2009) Am J Epidemiol , vol.170 , pp. 1415-1421
    • Trompet, S.1    Jukema, J.W.2    Katan, M.B.3
  • 28
    • 67650702822 scopus 로고    scopus 로고
    • Effect of statins on fasting plasma glucose in diabetic and nondiabetic patients
    • R. Sukhija, S. Prayaga, M. Marashdeh Effect of statins on fasting plasma glucose in diabetic and nondiabetic patients J Invest Med 57 2009 495 499
    • (2009) J Invest Med , vol.57 , pp. 495-499
    • Sukhija, R.1    Prayaga, S.2    Marashdeh, M.3
  • 29
    • 84862908066 scopus 로고    scopus 로고
    • Statin use and risk of diabetes mellitus in postmenopausal women in the Women's Health Initiative
    • A.L. Culver, I.S. Ockene, R. Balasubramanian Statin use and risk of diabetes mellitus in postmenopausal women in the Women's Health Initiative Arch Intern Med 172 2012 144 152
    • (2012) Arch Intern Med , vol.172 , pp. 144-152
    • Culver, A.L.1    Ockene, I.S.2    Balasubramanian, R.3
  • 30
    • 0034702175 scopus 로고    scopus 로고
    • Randomized, controlled trials, observational studies, and the hierarchy of research designs
    • J. Concato, N. Shah, R.I. Horwitz Randomized, controlled trials, observational studies, and the hierarchy of research designs N Engl J Med 342 2000 1887 1892
    • (2000) N Engl J Med , vol.342 , pp. 1887-1892
    • Concato, J.1    Shah, N.2    Horwitz, R.I.3
  • 31
    • 2442647459 scopus 로고    scopus 로고
    • Beyond randomised versus observational studies
    • J. Concato, R.I. Horwitz Beyond randomised versus observational studies Lancet 363 2004 1660 1661
    • (2004) Lancet , vol.363 , pp. 1660-1661
    • Concato, J.1    Horwitz, R.I.2
  • 32
    • 0020960084 scopus 로고
    • The need for randomization in the study of intended effects
    • O.S. Miettinen The need for randomization in the study of intended effects Stat Med 2 1983 267 271
    • (1983) Stat Med , vol.2 , pp. 267-271
    • Miettinen, O.S.1
  • 33
    • 2442649987 scopus 로고    scopus 로고
    • When are observational studies as credible as randomised trials?
    • J.P. Vandenbroucke When are observational studies as credible as randomised trials? Lancet 363 2004 1728 1731
    • (2004) Lancet , vol.363 , pp. 1728-1731
    • Vandenbroucke, J.P.1
  • 34
    • 12744273863 scopus 로고    scopus 로고
    • Midlife cardiovascular risk factors and risk of dementia in late life
    • R.A. Whitmer, S. Sidney, J. Selby, S.C. Johnston, K. Yaffe Midlife cardiovascular risk factors and risk of dementia in late life Neurology 64 2005 277 281
    • (2005) Neurology , vol.64 , pp. 277-281
    • Whitmer, R.A.1    Sidney, S.2    Selby, J.3    Johnston, S.C.4    Yaffe, K.5
  • 35
    • 0035897938 scopus 로고    scopus 로고
    • Midlife vascular risk factors and Alzheimer's disease in later life: Longitudinal, population based study
    • M. Kivipelto, E.L. Helkala, M.P. Laakso Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study BMJ 322 2001 1447 1451
    • (2001) BMJ , vol.322 , pp. 1447-1451
    • Kivipelto, M.1    Helkala, E.L.2    Laakso, M.P.3
  • 37
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • E.E. Calle, C. Rodriguez, K. Walker-Thurmond, M.J. Thun Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults N Engl J Med 348 2003 1625 1638
    • (2003) N Engl J Med , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 38
    • 0035856017 scopus 로고    scopus 로고
    • Diet, lifestyle, and the risk of type 2 diabetes mellitus in women
    • F.B. Hu, J.E. Manson, M.J. Stampfer Diet, lifestyle, and the risk of type 2 diabetes mellitus in women N Engl J Med 345 2001 790 797
    • (2001) N Engl J Med , vol.345 , pp. 790-797
    • Hu, F.B.1    Manson, J.E.2    Stampfer, M.J.3
  • 39
    • 0034109077 scopus 로고    scopus 로고
    • Obesity, insulin resistance and diabetesa worldwide epidemic
    • J.C. Seidell Obesity, insulin resistance and diabetesa worldwide epidemic Br J Nutr 83 Suppl 1 2000 5 8
    • (2000) Br J Nutr , vol.83 , Issue.SUPPL. 1 , pp. 5-8
    • Seidell, J.C.1
  • 40
    • 0037164314 scopus 로고    scopus 로고
    • Pravastatin in Elderly Individuals at Risk of Vascular Disease (PROSPER): A randomised controlled trial
    • J. Shepherd, G.J. Blauw, M.B. Murphy Pravastatin in Elderly Individuals at Risk of Vascular Disease (PROSPER): a randomised controlled trial Lancet 360 2002 1623 1630
    • (2002) Lancet , vol.360 , pp. 1623-1630
    • Shepherd, J.1    Blauw, G.J.2    Murphy, M.B.3
  • 41
    • 1542345696 scopus 로고    scopus 로고
    • Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions
    • R. Collins, J. Armitage, S. Parish, P. Sleight, R. Peto Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions Lancet 363 2004 757 767
    • (2004) Lancet , vol.363 , pp. 757-767
    • Collins, R.1    Armitage, J.2    Parish, S.3    Sleight, P.4    Peto, R.5
  • 42
    • 74849094929 scopus 로고    scopus 로고
    • Pravastatin and cognitive function in the elderly: Results of the PROSPER study
    • S. Trompet, V.P. van, A.J. de Craen Pravastatin and cognitive function in the elderly Results of the PROSPER study J Neurol 257 2010 85 90
    • (2010) J Neurol , vol.257 , pp. 85-90
    • Trompet, S.1    Van, V.P.2    De Craen, A.J.3
  • 43
    • 33746597102 scopus 로고    scopus 로고
    • Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study
    • R. Clarke, P. Xu, D. Bennett Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study PLoS Genet 2 2006 e107
    • (2006) PLoS Genet , vol.2 , pp. 107
    • Clarke, R.1    Xu, P.2    Bennett, D.3
  • 45
    • 0028352357 scopus 로고
    • Do cholesterol-lowering agents affect brain activity?: A comparison of simvastatin, pravastatin, and placebo in healthy volunteers
    • R.W. Harrison, C.H. Ashton Do cholesterol-lowering agents affect brain activity? A comparison of simvastatin, pravastatin, and placebo in healthy volunteers Br J Clin Pharmacol 37 1994 231 236
    • (1994) Br J Clin Pharmacol , vol.37 , pp. 231-236
    • Harrison, R.W.1    Ashton, C.H.2
  • 46
    • 0028603352 scopus 로고
    • Central nervous system effects of HMG CoA reductase inhibitors: Lovastatin and pravastatin on sleep and cognitive performance in patients with hypercholesterolemia
    • J.B. Kostis, R.C. Rosen, A.C. Wilson Central nervous system effects of HMG CoA reductase inhibitors: lovastatin and pravastatin on sleep and cognitive performance in patients with hypercholesterolemia J Clin Pharmacol 34 1994 989 996
    • (1994) J Clin Pharmacol , vol.34 , pp. 989-996
    • Kostis, J.B.1    Rosen, R.C.2    Wilson, A.C.3
  • 47
    • 0028899215 scopus 로고
    • Effects of treatment with simvastatin and pravastatin on cognitive function in patients with hypercholesterolaemia
    • N. Cutler, J. Sramek, A. Veroff, G. Block, L. Stauffer, C. Lines Effects of treatment with simvastatin and pravastatin on cognitive function in patients with hypercholesterolaemia Br J Clin Pharmacol 39 1995 333 336
    • (1995) Br J Clin Pharmacol , vol.39 , pp. 333-336
    • Cutler, N.1    Sramek, J.2    Veroff, A.3    Block, G.4    Stauffer, L.5    Lines, C.6
  • 48
    • 0028967918 scopus 로고
    • Effects of treatment with lovastatin and pravastatin on daytime cognitive performance
    • F. Gengo, D. Cwudzinski, P. Kinkel, G. Block, L. Stauffer, C. Lines Effects of treatment with lovastatin and pravastatin on daytime cognitive performance Clin Cardiol 18 1995 209 214
    • (1995) Clin Cardiol , vol.18 , pp. 209-214
    • Gengo, F.1    Cwudzinski, D.2    Kinkel, P.3    Block, G.4    Stauffer, L.5    Lines, C.6
  • 49
    • 0031021211 scopus 로고    scopus 로고
    • Effect of pharmacologic lipid lowering on health-related quality of life in older persons: Results from the Cholesterol Reduction in Seniors Program (CRISP) pilot study
    • N.C. Santanello, B.L. Barber, W.B. Applegate Effect of pharmacologic lipid lowering on health-related quality of life in older persons: results from the Cholesterol Reduction in Seniors Program (CRISP) pilot study J Am Geriatr Soc 45 1997 8 14
    • (1997) J Am Geriatr Soc , vol.45 , pp. 8-14
    • Santanello, N.C.1    Barber, B.L.2    Applegate, W.B.3
  • 50
    • 3843148550 scopus 로고    scopus 로고
    • Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults
    • M.F. Muldoon, C.M. Ryan, S.M. Sereika, J.D. Flory, S.B. Manuck Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults Am J Med 117 2004 823 829
    • (2004) Am J Med , vol.117 , pp. 823-829
    • Muldoon, M.F.1    Ryan, C.M.2    Sereika, S.M.3    Flory, J.D.4    Manuck, S.B.5
  • 51
    • 0034015649 scopus 로고    scopus 로고
    • Effects of lovastatin on cognitive function and psychological well-being
    • M.F. Muldoon, S.D. Barger, C.M. Ryan Effects of lovastatin on cognitive function and psychological well-being Am J Med 108 2000 538 546
    • (2000) Am J Med , vol.108 , pp. 538-546
    • Muldoon, M.F.1    Barger, S.D.2    Ryan, C.M.3
  • 52
    • 0034876590 scopus 로고    scopus 로고
    • Effects of lovastatin and pravastatin on cognitive function in military aircrew
    • M.G. Gibellato, J.L. Moore, K. Selby, E.A. Bower Effects of lovastatin and pravastatin on cognitive function in military aircrew Aviat Space Environ Med 72 2001 805 812
    • (2001) Aviat Space Environ Med , vol.72 , pp. 805-812
    • Gibellato, M.G.1    Moore, J.L.2    Selby, K.3    Bower, E.A.4
  • 53
    • 67650806451 scopus 로고    scopus 로고
    • Do low dose statins affect cognition?
    • Results of the UCSD statin study
    • B.A. Golomb, J.E. Dimsdale, H.L. White, M.H. Criqui Results of the UCSD statin study Do low dose statins affect cognition? Circulation 114 2006 II289
    • (2006) Circulation , vol.114 , pp. 289
    • Golomb, B.A.1    Dimsdale, J.E.2    White, H.L.3    Criqui, M.H.4
  • 55
    • 33846846591 scopus 로고    scopus 로고
    • Effect of atorvastatin on cognitive function in patients from the Lipid Lowering and Onset of Renal Disease (LORD) trial
    • M.J. Summers, K.R. Oliver, J.S. Coombes, R.G. Fassett Effect of atorvastatin on cognitive function in patients from the Lipid Lowering and Onset of Renal Disease (LORD) trial Pharmacotherapy 27 2007 183 190
    • (2007) Pharmacotherapy , vol.27 , pp. 183-190
    • Summers, M.J.1    Oliver, K.R.2    Coombes, J.S.3    Fassett, R.G.4
  • 58
    • 0035873251 scopus 로고    scopus 로고
    • Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients: Results from the LIPID trial
    • D. Hunt, P. Young, J. Simes Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients: results from the LIPID trial Ann Intern Med 134 2001 931 940
    • (2001) Ann Intern Med , vol.134 , pp. 931-940
    • Hunt, D.1    Young, P.2    Simes, J.3
  • 59
    • 34548019063 scopus 로고    scopus 로고
    • Statins and the risk of colorectal cancer: A meta-analysis of 18 studies involving more than 1.5 million patients
    • S. Bonovas, K. Filioussi, C.S. Flordellis, N.M. Sitaras Statins and the risk of colorectal cancer: a meta-analysis of 18 studies involving more than 1.5 million patients J Clin Oncol 25 2007 3462 3468
    • (2007) J Clin Oncol , vol.25 , pp. 3462-3468
    • Bonovas, S.1    Filioussi, K.2    Flordellis, C.S.3    Sitaras, N.M.4
  • 60
    • 33947262642 scopus 로고    scopus 로고
    • Does pravastatin promote cancer in elderly patients?: A meta-analysis
    • S. Bonovas, N.M. Sitaras Does pravastatin promote cancer in elderly patients? A meta-analysis Can Med Assoc J 176 2007 649 654
    • (2007) Can Med Assoc J , vol.176 , pp. 649-654
    • Bonovas, S.1    Sitaras, N.M.2
  • 61
    • 78449281377 scopus 로고    scopus 로고
    • Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials
    • C. Baigent, L. Blackwell, J. Emberson Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials Lancet 376 2010 1670 1681
    • (2010) Lancet , vol.376 , pp. 1670-1681
    • Baigent, C.1    Blackwell, L.2    Emberson, J.3
  • 62
    • 67650094615 scopus 로고    scopus 로고
    • The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: Meta-analysis of randomised controlled trials
    • J.J. Brugts, T. Yetgin, S.E. Hoeks The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials BMJ 338 2009 b2376
    • (2009) BMJ , vol.338 , pp. 2376
    • Brugts, J.J.1    Yetgin, T.2    Hoeks, S.E.3
  • 64
    • 84930670749 scopus 로고    scopus 로고
    • Lack of effect of lowering LDL cholesterol on cancer: Meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy
    • J.R. Emberson, P.M. Kearney, L. Blackwell Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy PLoS One 7 2012 e29849
    • (2012) PLoS One , vol.7 , pp. 29849
    • Emberson, J.R.1    Kearney, P.M.2    Blackwell, L.3
  • 65
    • 79952046739 scopus 로고    scopus 로고
    • Efficacy and safety of more intensive lowering of LDL cholesterol
    • S. Bonovas, G. Nikolopoulos, N.M. Sitaras Efficacy and safety of more intensive lowering of LDL cholesterol Lancet 377 2011 715 716
    • (2011) Lancet , vol.377 , pp. 715-716
    • Bonovas, S.1    Nikolopoulos, G.2    Sitaras, N.M.3
  • 66
    • 77549087054 scopus 로고    scopus 로고
    • Statins and risk of incident diabetes: A collaborative meta-analysis of randomised statin trials
    • N. Sattar, D. Preiss, H.M. Murray Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials Lancet 375 2010 735 742
    • (2010) Lancet , vol.375 , pp. 735-742
    • Sattar, N.1    Preiss, D.2    Murray, H.M.3
  • 67
    • 56749106312 scopus 로고    scopus 로고
    • Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    • P.M. Ridker, E. Danielson, F.A. Fonseca Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein N Engl J Med 359 2008 2195 2207
    • (2008) N Engl J Med , vol.359 , pp. 2195-2207
    • Ridker, P.M.1    Danielson, E.2    Fonseca, F.A.3
  • 68
    • 0035936527 scopus 로고    scopus 로고
    • Pravastatin and the development of diabetes mellitus: Evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study
    • D.J. Freeman, J. Norrie, N. Sattar Pravastatin and the development of diabetes mellitus: evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study Circulation 103 2001 357 362
    • (2001) Circulation , vol.103 , pp. 357-362
    • Freeman, D.J.1    Norrie, J.2    Sattar, N.3
  • 69
    • 79959428660 scopus 로고    scopus 로고
    • Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: A meta-analysis
    • D. Preiss, S.R. Seshasai, P. Welsh Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis JAMA 305 2011 2556 2564
    • (2011) JAMA , vol.305 , pp. 2556-2564
    • Preiss, D.1    Seshasai, S.R.2    Welsh, P.3
  • 70
    • 58149307451 scopus 로고    scopus 로고
    • Blunted Akt/FOXO signalling and activation of genes controlling atrophy and fuel use in statin myopathy
    • J.E. Mallinson, D. Constantin-Teodosiu, J. Sidaway, F.R. Westwood, P.L. Greenhaff Blunted Akt/FOXO signalling and activation of genes controlling atrophy and fuel use in statin myopathy J Physiol 587 2009 219 230
    • (2009) J Physiol , vol.587 , pp. 219-230
    • Mallinson, J.E.1    Constantin-Teodosiu, D.2    Sidaway, J.3    Westwood, F.R.4    Greenhaff, P.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.